• Psychiatry
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    Dr Leonidas Chouliaras

    University Position
    Assistant Professor


    My research interests include the role of epigenetic mechanisms in neurodegeneration, and particularly in Lewy Body Dementia, Alzheimer's disease and mild cognitive impairment. My projects focus on genome-wide profiling of DNA methylation and hydroxymethylation in post-mortem brain tissues and also in peripheral blood.Exploring disease driven changes in the epigenetic landscape has the potential to improve our understanding of the pathophysiology of neurodegenerative disorders and aid in the identification of novel pathways as therapeutic targets. Work on peripheral epigenetic profiling in combination with multimodal neuroimaging techniques can aid in the development of early risk markers of disease before the onset of any symptoms.

    Key Publications

    Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy.

    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jun 2022
    Authors: L Chouliaras, A Thomas, M Malpetti, P Donaghy, J Kane, E Mak, G Savulich, MA Prats-Sedano, AJ Heslegrave, H Zetterberg, L Su, JB Rowe, JT O'Brien


    The use of neuroimaging techniques in the early and differential diagnosis of dementia.

    Journal: Mol Psychiatry
    E-pub date: 1 Oct 2023
    Authors: L Chouliaras, JT O'Brien

    From protein biomarkers to proteomics in dementia with Lewy Bodies.

    Journal: Ageing Res Rev
    E-pub date: 1 Jan 2023
    Authors: A Tsamourgelis, P Swann, L Chouliaras, JT O'Brien

    RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia-an international Delphi consensus.

    Journal: Alzheimers Res Ther
    E-pub date: 11 Nov 2022
    Authors: JT O'Brien, L Chouliaras, J Sultana, J-P Taylor, C Ballard, RENEWAL Study Group

    The promise of amplification assays for accurate early detection of α-synucleinopathies: A review.

    Journal: Exp Gerontol
    E-pub date: 31 Aug 2022
    Authors: R Kurapova, L Chouliaras, JT O'Brien

    A role for epigenetic mechanisms in Lewy body dementias

    Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
    E-pub date: 1 Dec 2021
    Authors: JL Imm, J Harvey, E Pishva, B Creese, L Chouliaras, E Dempster, C Ballard, JT O'Brien, D Aarsland, J Mill, K Lunnon

    Efficacy of a dementia intensive support (DIS) service at preventing admissions to medical and psychiatric wards: qualitative and quantitative evaluation.

    Journal: BJPsych Bull
    E-pub date: 1 Dec 2020
    Authors: JS Rubinsztein, C Hatfield, L High, R Krishnan, NA Arnaoutoglou, P Goulia, R Dudas, S Ruhi, K Wildschut, L Chouliaras, BR Underwood

    In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease.

    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 11 Sep 2020
    Authors: A Low, E Mak, M Malpetti, L Passamonti, N Nicastro, JD Stefaniak, G Savulich, L Chouliaras, L Su, JB Rowe, HS Markus, JT O'Brien

    Epigenetic regulation in the pathophysiology of Lewy body dementia.

    Journal: Prog Neurobiol
    E-pub date: 1 Sep 2020
    Authors: L Chouliaras, GS Kumar, AJ Thomas, K Lunnon, PF Chinnery, JT O'Brien

    Peak Width of Skeletonized Mean Diffusivity as a Marker of Diffuse Cerebrovascular Damage.

    Journal: Front Neurosci
    E-pub date: 1 Aug 2020
    Authors: A Low, E Mak, JD Stefaniak, M Malpetti, N Nicastro, G Savulich, L Chouliaras, HS Markus, JB Rowe, JT O'Brien

    Asymmetrical atrophy of thalamic subnuclei in Alzheimer’s disease and amyloid-positive mild cognitive impairment is associated with key clinical features.

    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: A Low, E Mak, M Malpetti, L Chouliaras, N Nicastro, L Su, N Holland, T Rittman, PV Rodríguez, L Passamonti, WR Bevan-Jones, PS Jones, JB Rowe, JT O'Brien