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Department
  • Psychology
    • Research Theme Lifelong Brain Development and Brain Ageing Brains and Machines
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    Professor Lorraine Tyler

    University Position
    Professor

    Interests

    The interdisciplinary research in my lab combines cognitive models with multi-modal imaging to understand the neurobiological substrate for language functions, and the extent to which they are adaptive and capable of reorganisation following either brain damage or the normal brain changes that occur with healthy aging. We also study object processing in the ventral stream, using fMRI and MEG together with DNN models to construct a cognitively- motivated neurobiological account of how visual inputs become meaningful objects over time. I am also PI on the Cambridge Centre for Ageing and Neuroscience project (CamCan; http://www.cam-can.org/). CamCan is a University-wide consortium, funded by the BBSRC, to study ?The Resilient Brain? - how age-related changes in brain structure and function relate to patterns of preserved and declining cognitive functions with age.

    Key Publications

    Oscillatory Dynamics of Perceptual to Conceptual Transformations in the Ventral Visual Pathway.

    DOI: http://doi.org/10.1162/jocn_a_01325
    Journal: Journal of Cognitive Neuroscience
    E-pub date: 28 Sep 2018
    Authors: A Clarke, BJ Devereux, LK Tyler

    Understanding What We See: How We Derive Meaning From Vision.

    DOI: http://doi.org/10.1016/j.tics.2015.08.008
    Journal: Trends Cogn Sci
    E-pub date: 1 Nov 2015
    Authors: A Clarke, LK Tyler

    Object-specific semantic coding in human perirhinal cortex.

    DOI: http://doi.org/10.1523/JNEUROSCI.2828-13.2014
    Journal: J Neurosci
    E-pub date: 2 Apr 2014
    Authors: A Clarke, LK Tyler

    Publications

    Neural dynamics of semantic composition.

    DOI: http://doi.org/10.1073/pnas.1903402116
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 15 Oct 2019
    Authors: B Lyu, HS Choi, WD Marslen-Wilson, A Clarke, B Randall, LK Tyler

    Perceptual and conceptual processing of visual objects across the adult lifespan.

    DOI: http://doi.org/10.1038/s41598-019-50254-5
    Journal: Sci Rep
    E-pub date: 24 Sep 2019
    Authors: R Bruffaerts, LK Tyler, M Shafto, KA Tsvetanov, Cambridge Centre for Ageing and Neuroscience, A Clarke

    Integrated deep visual and semantic attractor neural networks predict fMRI pattern-information along the ventral object processing pathway.

    DOI: http://doi.org/10.1038/s41598-018-28865-1
    Journal: Scientific Reports
    E-pub date: 13 Jul 2018
    Authors: BJ Devereux, A Clarke, LK Tyler

    Decoding the Cortical Dynamics of Sound-Meaning Mapping.

    DOI: http://doi.org/10.1523/JNEUROSCI.2858-16.2016
    Journal: J Neurosci
    E-pub date: 1 Feb 2017
    Authors: E Kocagoncu, A Clarke, BJ Devereux, LK Tyler

    Learning Warps Object Representations in the Ventral Temporal Cortex.

    DOI: http://doi.org/10.1162/jocn_a_00951
    Journal: J Cogn Neurosci
    E-pub date: 1 Jul 2016
    Authors: A Clarke, PJ Pell, C Ranganath, LK Tyler

    Predicting the Time Course of Individual Objects with MEG.

    DOI: http://doi.org/10.1093/cercor/bhu203
    Journal: Cereb Cortex
    E-pub date: 1 Oct 2015
    Authors: A Clarke, BJ Devereux, B Randall, LK Tyler

    The perirhinal cortex and conceptual processing: Effects of feature-based statistics following damage to the anterior temporal lobes.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2015.01.041
    Journal: Neuropsychologia
    E-pub date: 1 Sep 2015
    Authors: P Wright, B Randall, A Clarke, LK Tyler

    Optimally efficient neural systems for processing spoken language.

    DOI: http://doi.org/10.1093/cercor/bhs366
    Journal: Cereb Cortex
    E-pub date: 1 Apr 2014
    Authors: J Zhuang, LK Tyler, B Randall, EA Stamatakis, WD Marslen-Wilson

    Age-related functional reorganization, structural changes, and preserved cognition.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2013.07.003
    Journal: Neurobiol Aging
    E-pub date: 1 Jan 2014
    Authors: D Meunier, EA Stamatakis, LK Tyler

    Representational similarity analysis reveals commonalities and differences in the semantic processing of words and objects.

    DOI: http://doi.org/10.1523/JNEUROSCI.3809-13.2013
    Journal: J Neurosci
    E-pub date: 27 Nov 2013
    Authors: BJ Devereux, A Clarke, A Marouchos, LK Tyler

    Objects and categories: feature statistics and object processing in the ventral stream.

    DOI: http://doi.org/10.1162/jocn_a_00419
    Journal: J Cogn Neurosci
    E-pub date: 1 Oct 2013
    Authors: LK Tyler, S Chiu, J Zhuang, B Randall, BJ Devereux, P Wright, A Clarke, KI Taylor

    Syntactic computations in the language network: characterizing dynamic network properties using representational similarity analysis.

    DOI: http://doi.org/10.3389/fpsyg.2013.00271
    Journal: Front Psychol
    E-pub date: 1 Aug 2013
    Authors: LK Tyler, TPL Cheung, BJ Devereux, A Clarke

    From perception to conception: how meaningful objects are processed over time.

    DOI: http://doi.org/10.1093/cercor/bhs002
    Journal: Cereb Cortex
    E-pub date: 1 Jan 2013
    Authors: A Clarke, KI Taylor, B Devereux, B Randall, LK Tyler

    Functional organization of the neural language system: dorsal and ventral pathways are critical for syntax.

    DOI: http://doi.org/10.1093/cercor/bhr386
    Journal: Cereb Cortex
    E-pub date: 1 Jan 2013
    Authors: JD Griffiths, WD Marslen-Wilson, EA Stamatakis, LK Tyler

    Differentiating hemispheric contributions to syntax and semantics in patients with left-hemisphere lesions.

    DOI: http://doi.org/10.1523/JNEUROSCI.0485-12.2012
    Journal: J Neurosci
    E-pub date: 13 Jun 2012
    Authors: P Wright, EA Stamatakis, LK Tyler

    Age-related neural reorganization during spoken word recognition: the interaction of form and meaning.

    DOI: http://doi.org/10.1162/jocn_a_00218
    Journal: J Cogn Neurosci
    E-pub date: 1 Jun 2012
    Authors: M Shafto, B Randall, EA Stamatakis, P Wright, LK Tyler

    The interaction of lexical semantics and cohort competition in spoken word recognition: an fMRI study.

    DOI: http://doi.org/10.1162/jocn_a_00046
    Journal: J Cogn Neurosci
    E-pub date: 1 Dec 2011
    Authors: J Zhuang, B Randall, EA Stamatakis, WD Marslen-Wilson, LK Tyler

    Dynamic processing in the human language system: synergy between the arcuate fascicle and extreme capsule.

    DOI: http://doi.org/10.1523/JNEUROSCI.2725-11.2011
    Journal: J Neurosci
    E-pub date: 23 Nov 2011
    Authors: T Rolheiser, EA Stamatakis, LK Tyler

    Is left fronto-temporal connectivity essential for syntax? Effective connectivity, tractography and performance in left-hemisphere damaged patients.

    DOI: http://doi.org/10.1016/j.neuroimage.2011.06.036
    Journal: Neuroimage
    E-pub date: 15 Sep 2011
    Authors: M Papoutsi, EA Stamatakis, J Griffiths, WD Marslen-Wilson, LK Tyler

    The evolution of meaning: spatio-temporal dynamics of visual object recognition.

    DOI: http://doi.org/10.1162/jocn.2010.21544
    Journal: J Cogn Neurosci
    E-pub date: 31 Aug 2011
    Authors: A Clarke, KI Taylor, LK Tyler

    Left inferior frontal cortex and syntax: function, structure and behaviour in patients with left hemisphere damage.

    DOI: http://doi.org/10.1093/brain/awq369
    Journal: Brain
    E-pub date: 1 Feb 2011
    Authors: LK Tyler, WD Marslen-Wilson, B Randall, P Wright, BJ Devereux, J Zhuang, M Papoutsi, EA Stamatakis

    White matter changes and word finding failures with increasing age.

    DOI: http://doi.org/10.1371/journal.pone.0014496
    Journal: PLoS One
    E-pub date: 7 Jan 2011
    Authors: EA Stamatakis, MA Shafto, G Williams, P Tam, LK Tyler

    Reorganization of syntactic processing following left-hemisphere brain damage: does right-hemisphere activity preserve function?

    DOI: http://doi.org/10.1093/brain/awq262
    Journal: Brain
    E-pub date: 1 Nov 2010
    Authors: LK Tyler, P Wright, B Randall, WD Marslen-Wilson, EA Stamatakis

    Word retrieval failures in old age: the relationship between structure and function.

    DOI: http://doi.org/10.1162/jocn.2009.21321
    Journal: J Cogn Neurosci
    E-pub date: 1 Jul 2010
    Authors: MA Shafto, EA Stamatakis, PP Tam, LK Tyler

    Preserving syntactic processing across the adult life span: the modulation of the frontotemporal language system in the context of age-related atrophy.

    DOI: http://doi.org/10.1093/cercor/bhp105
    Journal: Cereb Cortex
    E-pub date: 1 Feb 2010
    Authors: LK Tyler, MA Shafto, B Randall, P Wright, WD Marslen-Wilson, EA Stamatakis

    Complementary hemispheric asymmetries in object naming and recognition: a voxel-based correlational study.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2009.02.024
    Journal: Neuropsychologia
    E-pub date: 1 Jul 2009
    Authors: K Acres, KI Taylor, HE Moss, EA Stamatakis, LK Tyler

    Crossmodal integration of object features: voxel-based correlations in brain-damaged patients.

    DOI: http://doi.org/10.1093/brain/awn361
    Journal: Brain
    E-pub date: 1 Mar 2009
    Authors: KI Taylor, EA Stamatakis, LK Tyler

    Modulation of motor and premotor cortices by actions, action words and action sentences.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2008.09.017
    Journal: Neuropsychologia
    E-pub date: 1 Jan 2009
    Authors: A Raposo, HE Moss, EA Stamatakis, LK Tyler

    Cortical differentiation for nouns and verbs depends on grammatical markers.

    DOI: http://doi.org/10.1162/jocn.2008.20095
    Journal: J Cogn Neurosci
    E-pub date: 31 Aug 2008
    Authors: LK Tyler, B Randall, EA Stamatakis

    Longitudinal studies of semantic dementia: the relationship between structural and functional changes over time.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2008.02.019
    Journal: Neuropsychologia
    E-pub date: 1 Aug 2008
    Authors: P Bright, HE Moss, EA Stamatakis, LK Tyler

    On the tip-of-the-tongue: neural correlates of increased word-finding failures in normal aging.

    DOI: http://doi.org/10.1162/jocn.2007.19.12.2060
    Journal: J Cogn Neurosci
    E-pub date: 1 Dec 2007
    Authors: MA Shafto, DM Burke, EA Stamatakis, PP Tam, LK Tyler

    Differentiating morphology, form, and meaning: neural correlates of morphological complexity.

    DOI: http://doi.org/10.1162/jocn.2007.19.9.1464
    Journal: J Cogn Neurosci
    E-pub date: 1 Sep 2007
    Authors: M Bozic, WD Marslen-Wilson, EA Stamatakis, MH Davis, LK Tyler

    Grammatical categories in the brain: the role of morphological structure.

    DOI: http://doi.org/10.1093/cercor/bhl099
    Journal: Cereb Cortex
    E-pub date: 31 Aug 2007
    Authors: O Longe, B Randall, EA Stamatakis, LK Tyler

    Conceptual structure modulates anteromedial temporal involvement in processing verbally presented object properties.

    DOI: http://doi.org/10.1093/cercor/bhl016
    Journal: Cereb Cortex
    E-pub date: 1 May 2007
    Authors: P Bright, HE Moss, O Longe, EA Stamatakis, LK Tyler

    Temporal lobe lesions and semantic impairment: a comparison of herpes simplex virus encephalitis and semantic dementia.

    DOI: http://doi.org/10.1093/brain/awl344
    Journal: Brain
    E-pub date: 1 Apr 2007
    Authors: U Noppeney, K Patterson, LK Tyler, H Moss, EA Stamatakis, P Bright, C Mummery, CJ Price

    Repetition suppression and semantic enhancement: an investigation of the neural correlates of priming.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2006.05.017
    Journal: Neuropsychologia
    E-pub date: 1 Aug 2006
    Authors: A Raposo, HE Moss, EA Stamatakis, LK Tyler

    Binding crossmodal object features in perirhinal cortex.

    DOI: http://doi.org/10.1073/pnas.0509704103
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 23 May 2006
    Authors: KI Taylor, HE Moss, EA Stamatakis, LK Tyler

    Cingulate control of fronto-temporal integration reflects linguistic demands: a three-way interaction in functional connectivity.

    DOI: http://doi.org/10.1016/j.neuroimage.2005.06.012
    Journal: Neuroimage
    E-pub date: 15 Oct 2005
    Authors: EA Stamatakis, WD Marslen-Wilson, LK Tyler, PC Fletcher

    Identifying lesions on structural brain images–validation of the method and application to neuropsychological patients.

    DOI: http://doi.org/10.1016/j.bandl.2004.12.010
    Journal: Brain Lang
    E-pub date: 31 Aug 2005
    Authors: EA Stamatakis, LK Tyler

    Temporal and frontal systems in speech comprehension: an fMRI study of past tense processing.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2005.03.008
    Journal: Neuropsychologia
    E-pub date: 1 Aug 2005
    Authors: LK Tyler, EA Stamatakis, B Post, B Randall, W Marslen-Wilson

    Evidence for altered functional connectivity in a language comprehension task following stroke

    DOI: http://doi.org/10.1016/j.bandl.2005.07.007
    Journal: Brain and Language
    E-pub date: 1 Aug 2005
    Authors: EA Stamatakis, WD Marslen-Wilson, LK Tyler, PC Fletcher

    Differentiating the neural language system: Contrasting the regular and irregular past tense

    DOI: http://doi.org/10.1016/j.bandl.2005.07.093
    Journal: Brain and Language
    E-pub date: 1 Aug 2005
    Authors: LK Tyler, E Stamatakis, WD Marslen-Wilson

    Dissociating neuro-cognitive component processes: voxel-based correlational methodology.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2004.07.020
    Journal: Neuropsychologia
    E-pub date: 1 Aug 2005
    Authors: LK Tyler, W Marslen-Wilson, EA Stamatakis

    The anatomy of object processing: the role of anteromedial temporal cortex.

    DOI: http://doi.org/10.1080/02724990544000013
    Journal: Q J Exp Psychol B
    E-pub date: 1 Aug 2005
    Authors: P Bright, HE Moss, EA Stamatakis, LK Tyler

    Differentiating lexical form, meaning, and structure in the neural language system.

    DOI: http://doi.org/10.1073/pnas.0408213102
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 7 Jun 2005
    Authors: LK Tyler, WD Marslen-Wilson, EA Stamatakis

    Anteromedial temporal cortex supports fine-grained differentiation among objects.

    DOI: http://doi.org/10.1093/cercor/bhh163
    Journal: Cereb Cortex
    E-pub date: 1 May 2005
    Authors: HE Moss, JM Rodd, EA Stamatakis, P Bright, LK Tyler

    Deficits for semantics and the irregular past tense: a causal relationship?

    DOI: http://doi.org/10.1162/0898929041920559
    Journal: J Cogn Neurosci
    E-pub date: 1 Sep 2004
    Authors: LK Tyler, EA Stamatakis, RW Jones, P Bright, K Acres, WD Marslen-Wilson

    Neural processing of nouns and verbs: the role of inflectional morphology.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2003.10.001
    Journal: Neuropsychologia
    E-pub date: 1 Aug 2004
    Authors: LK Tyler, P Bright, P Fletcher, EA Stamatakis

    Processing objects at different levels of specificity.

    DOI: http://doi.org/10.1162/089892904322926692
    Journal: J Cogn Neurosci
    E-pub date: 1 Apr 2004
    Authors: LK Tyler, EA Stamatakis, P Bright, K Acres, S Abdallah, JM Rodd, HE Moss

    Objects and their actions: evidence for a neurally distributed semantic system.

    DOI: http://doi.org/10.1016/s1053-8119(02)00047-2
    Journal: Neuroimage
    E-pub date: 1 Feb 2003
    Authors: LK Tyler, EA Stamatakis, E Dick, P Bright, P Fletcher, H Moss