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Department
  • Psychiatry
  • Research Focus

    Keywords

  • Impulsivity/Compulsivity
  • Reward/ Risk
  • Motivation
  • Emotion
  • Oscillations
  • Connectivity
  • Brain Computer Interface
  • Clinical Conditions

  • Addiction
  • Depressive disorders
  • Epilepsy
  • Obsessive compulsive disorder
  • Parkinson's disease
  • Equipment & Techniques

  • Behavioural analysis
  • Electroencephalography (EEG)
  • Magnetic resonance imaging (MRI)
  • Field potential recording
  • Back

    Dr Luis Manssuer BSc, MSc, PhD

    University Position
    Research Associate

    Interests

    I work in the research group of Professor Valerie Voon. The lab uses a range of methods to understand the neural basis of neuropsychiatric disorders. My primary role in the lab is to make sense of intracranial neurophysiological data acquired from patients undergoing deep brain stimulation therapy or Stereo-EEG monitoring for epilepsy. Such cases give us the rare opportunity to record neural activity directly from the human brain with exquisite spatial and temporal resolution, which no other neuroimaging method can achieve individually. I'm responsible for designing and programming behavioural tasks to isolate processes of interest and analysing the local field potentials (LFP's).

    Key Publications

    Reward recalibrates rule representations in human amygdala and hippocampus intracranial recordings

    DOI:
    Journal: Nature Communications
    Year: 2024
    Authors: Manssuer, L., Ding, Q., Feng, Y., Yang, R., Liu, W., Sun, B., Zhan, S., & Voon, V.

    Risk and aversion coding in human habenula high gamma activity

    DOI:
    Journal: Brain
    Year: 2023
    Authors: Manssuer, L., Ding, Q., Zhang, Y., Gong, H., Liu, W., Yang, R., Zhang, C., Zhao, Y., Pan, Y., Shan, S., Li, D., Sun, B., & Voon, V.

    Integrated Amygdala, Orbitofrontal and Hippocampal Contributions to Reward and Loss Coding Revealed with Human Intracranial EEG

    DOI:
    Journal: The Journal of neuroscience
    Year: 2022
    Authors: Manssuer, L., Qiong, D., Wei, L., Yang, R., Zhang, C., Zhao, Y., Sun, B., Zhan, S., & Voon, V.

    Publications

    Reward recalibrates rule representations in human amygdala and hippocampus intracranial recordings

    DOI:
    Journal: Nature Communications
    Year: 2024
    Authors: Manssuer, L., Ding, Q., Feng, Y., Yang, R., Liu, W., Sun, B., Zhan, S., & Voon, V.

    Subthalamic stimulation causally modulates human voluntary decision-making to stay or go.

    DOI:
    Journal: NPJ Parkinson's disease
    Year: 2024
    Authors: Wang, Y., Wang, L., Manssuer, L., Zhao, Y. J., Ding, Q., Pan, Y., Huang, P., Li, D., & Voon, V.

    Modeling impulsivity and risk aversion in the subthalamic nucleus with deep brain stimulation

    DOI:
    Journal: Nature Mental Health
    Year: 2024
    Authors: Voon, V., Manssuer, L., Zhao, Y. J., Ding, Q., Zhao, Y., Wang, L., Wang, T., Huang, P., Pan, Y., Sun, B., & Li, D.

    Evidence Accumulation and Neural Correlates of Uncertainty in Obsessive-Compulsive Disorder

    DOI:
    Journal: Biological psychiatry. Cognitive neuroscience and neuroimaging
    Year: 2023
    Authors: Zhao, Y. J., Zhang, Y., Wang, Q., Manssuer, L., Cui, H., Ding, Q., Sun, B., Liu, W., & Voon, V.

    Mechanisms underlying capsulotomy for refractory obsessive-compulsive disorder: neural correlates of negative affect processing overlap with deep brain stimulation targets

    DOI:
    Journal: Molecular psychiatry
    Year: 2023
    Authors: Cui, H., Zhang, Y., Zhao, Y., Zhao, Y., Ding, Q., Chen, R., Manssuer, L., Zhang, C., Liu, W., Li, D., Sun, B., & Voon, V.

    Frequency dependent emotion differentiation and directional coupling in amygdala, orbitofrontal and medial prefrontal cortex network with intracranial recordings

    DOI:
    Journal: Molecular psychiatry
    Year: 2023
    Authors: Sonkusare, S., Qiong, D., Zhao, Y., Liu, W., Yang, R., Mandali, A., Manssuer, L., Zhang, C., Cao, C., Sun, B., Zhan, S., & Voon, V.

    Risk and aversion coding in human habenula high gamma activity

    DOI:
    Journal: Brain
    Year: 2023
    Authors: Manssuer, L., Ding, Q., Zhang, Y., Gong, H., Liu, W., Yang, R., Zhang, C., Zhao, Y., Pan, Y., Shan, S., Li, D., Sun, B., & Voon, V.

    Subthalamic Oscillatory Activity of Reward and Loss Processing Using the Monetary Incentive Delay Task in Parkinson Disease

    DOI:
    Journal: Neuromodulation
    Year: 2023
    Authors: Manssuer, L., Wang, L., Ding, Q., Li, J., Zhang, Y., Zhang, C., Hallett, M., Li, D., Sun, B., & Voon, V.

    Power signatures of habenular neuronal signals in patients with bipolar or unipolar depressive disorders correlate with their disease severity

    DOI:
    Journal: Translational psychiatry
    Year: 2022
    Authors: Sonkusare, S., Ding, Q., Zhang, Y., Wang, L., Gong, H., Mandali, A., Manssuer, L., Zhao, Y. J., Pan, Y., Zhang, C., Li, D., Sun, B., & Voon, V.

    Integrated Amygdala, Orbitofrontal and Hippocampal Contributions to Reward and Loss Coding Revealed with Human Intracranial EEG

    DOI:
    Journal: The Journal of neuroscience
    Year: 2022
    Authors: Manssuer, L., Qiong, D., Wei, L., Yang, R., Zhang, C., Zhao, Y., Sun, B., Zhan, S., & Voon, V.

    Acute Time-Locked Alpha Frequency Subthalamic Stimulation Reduces Negative Emotional Bias in Parkinson's Disease

    DOI:
    Journal: Biological psychiatry. Cognitive neuroscience and neuroimaging
    Year: 2021
    Authors: Mandali, A., Manssuer, L., Zhao, Y., Zhang, C., Wang, L., Ding, Q., Pan, Y., Li, D., Sun, B., & Voon, V.

    Incidental learning of trust from eye-gaze: Effects of race and facial trustworthiness

    DOI:
    Journal: Visual Cognition
    Year: 2017
    Authors: Strachan, J.W., Kirkham, A.J., Manssuer, L.R., Over, H., & Tipper, S.P.

    Incidental learning of trust: Examining the role of emotion and visuomotor fluency

    DOI:
    Journal: Journal of experimental psychology. Learning, memory, and cognition
    Year: 2016
    Authors: Strachan, J. W., Kirkham, A. J., Manssuer, L. R., & Tipper, S. P.

    The role of emotion in learning trustworthiness from eye-gaze: Evidence from facial electromyography

    DOI:
    Journal: Cognitive neuroscience
    Year: 2016
    Authors: Manssuer, L. R., Pawling, R., Hayes, A. E., & Tipper, S. P.

    The late positive potential indexes a role for emotion during learning of trust from eye-gaze cues

    DOI:
    Journal: Social neuroscience
    Year: 2015
    Authors: Manssuer, L. R., Roberts, M. V., & Tipper, S. P.

    Neural responses to facial expressions support the role of the amygdala in processing threat

    DOI:
    Journal: Social cognitive and affective neuroscience
    Year: 2014
    Authors: Mattavelli, G., Sormaz, M., Flack, T., Asghar, A. U., Fan, S., Frey, J., Manssuer, L., Usten, D., Young, A. W., & Andrews, T. J.