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EMAIL ls514@cam.ac.uk
College Clare Hall
Department
  • Psychiatry
    • Research Theme Lifelong Brain Development and Brain Ageing Brains and Machines Adaptive Brain Computations
    Research Focus

    Keywords

  • EEG/MEG
  • 7T MRI
  • Dementia

    • Clinical Conditions

  • Dementia

    • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Positron Emission Tomography (PET)

    • Back

    Professor Li Su

    University Position
    Principal Research Associate
    Professor Li Su is pleased to consider applications from prospective PhD students.

    Interests

    I lead Artificial Intelligence and Computational Neuroscience group. I am Chair of Neuroimaging in Neuroscience Institute at University of Sheffield and Principal Research Fellow (Professor Grade 11) at Department of Psychiatry at University of Cambridge. I am also a Fellow at Clare Hall, Cambridge (https://www.clarehall.cam.ac.uk/our-people/professor-li-su).

    Key Publications

    Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild Traumatic Brain Injury in the PREVENT Dementia Study.

    DOI: http://doi.org/10.1001/jamanetworkopen.2024.26774
    Journal: JAMA Netw Open
    E-pub date: 1 Aug 2024
    Authors: A Low, E McKiernan, MA Prats-Sedano, SF Carter, JD Stefaniak, L Su, M-E Dounavi, G Muniz-Terrera, N Jenkins, K Bridgeman, K Ritchie, B Lawlor, L Naci, P Malhotra, C Mackay, I Koychev, T Thayanandan, V Raymont, CW Ritchie, W Stewart, JT O'Brien, PREVENT Dementia Investigators

    Illuminating neurodegeneration: a future perspective on near-infrared spectroscopy in dementia research.

    DOI: http://doi.org/10.1117/1.NPh.10.2.023514
    Journal: Neurophotonics
    E-pub date: 1 Apr 2023
    Authors: S Srinivasan, E Butters, L Collins-Jones, L Su, J O'Brien, G Bale

    Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy.

    DOI: http://doi.org/10.1136/jnnp-2021-327788
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jun 2022
    Authors: L Chouliaras, A Thomas, M Malpetti, P Donaghy, J Kane, E Mak, G Savulich, MA Prats-Sedano, AJ Heslegrave, H Zetterberg, L Su, JB Rowe, JT O'Brien

    In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease.

    DOI: http://doi.org/10.1136/jnnp-2020-323894
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 11 Sep 2020
    Authors: A Low, E Mak, M Malpetti, L Passamonti, N Nicastro, JD Stefaniak, G Savulich, L Chouliaras, L Su, JB Rowe, HS Markus, JT O'Brien

    Publications

    APOE e4 exacerbates age-dependent deficits in cortical microstructure

    DOI: http://doi.org/10.1093/braincomms/fcad351
    Journal: Brain Commun
    E-pub date: 1 Aug 2024
    Authors: F Mak, M-E Dounavi, G Operto, Z Elina, J P Simon, A Low, P Swann, C Newton, G Terrera, P Malhotra, I Koychev, C Falcon, C Mackay, B Lawlor, L Naci, K Wells, C Ritchie, K Ritchie, L Su, JD Gispert, J O'Brien

    The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia

    DOI: http://doi.org/10.1093/braincomms/fcae189
    Journal: Brain Commun
    E-pub date: 1 Aug 2024
    Authors: CW Ritchie, K Bridgeman, S Gregory, JT O’Brien, SO Danso, M-E Dounavi, I Carriere, D Driscoll, R Hillary, I Koychev, B Lawlor, L Naci, L Su, A Low, E Mak, P Malhotra, J Manson, R Marioni, L Murphy, G Ntailianis, W Stewart, G Muniz-Terrera, K Ritchie

    Genetic risk factors of Alzheimer’s Disease disrupt resting-state functional connectivity in cognitively intact young individuals.

    DOI: http://doi.org/10.1007/s00415-023-11809-9
    Journal: J Neurol
    E-pub date: 1 Oct 2023
    Authors: L Kucikova, J Zeng, C Muñoz-Neira, G Muniz-Terrera, W Huang, S Gregory, C Ritchie, J O'Brien, L Su

    Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife.

    DOI: http://doi.org/10.1177/0271678X231173587
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Oct 2023
    Authors: M-E Dounavi, E Mak, P Swann, A Low, G Muniz-Terrera, A McKeever, M Pope, GB Williams, K Wells, B Lawlor, L Naci, P Malhotra, C Mackay, I Koychev, K Ritchie, L Su, CW Ritchie, JT O'Brien

    A promising tool to explore functional impairment in neurodegeneration: A systematic review of near-infrared spectroscopy in dementia.

    DOI: http://doi.org/10.1016/j.arr.2023.101992
    Journal: Ageing Res Rev
    E-pub date: 1 Sep 2023
    Authors: E Butters, S Srinivasan, JT O'Brien, L Su, G Bale

    Genetic risks of Alzheimer’s by APOE and MAPT on cortical morphology in young healthy adults.

    DOI: http://doi.org/10.1093/braincomms/fcad234
    Journal: Brain Commun
    E-pub date: 1 Aug 2023
    Authors: W Huang, J Zeng, L Jia, D Zhu, J O'Brien, C Ritchie, N Shu, L Su

    Path integration selectively predicts midlife risk of Alzheimer’s disease.

    DOI: http://doi.org/10.1101/2023.01.31.526473
    Journal:
    E-pub date: 3 Feb 2023
    Authors: C Newton, M Pope, C Rua, R Henson, Z Ji, N Burgess, CT Rodgers, M Stangl, M-E Dounavi, A Castegnaro, I Koychev, P Malhotra, T Wolbers, K Ritchie, CW Ritchie, J O'Brien, L Su, D Chan, PREVENT Dementia Research Programme

    Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1186/s13195-022-01095-4
    Journal: Alzheimer's Research & Therapy
    E-pub date: 12 Oct 2022
    Authors: A Low, MA Prats-Sedano, E McKiernan, SF Carter, JD Stefaniak, S Nannoni, L Su, M-E Dounavi, G Muniz-Terrera, K Ritchie, B Lawlor, L Naci, P Malhotra, C Mackay, I Koychev, CW Ritchie, HS Markus, JT O'Brien

    Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1007/s00415-022-11061-7
    Journal: J Neurol
    E-pub date: 31 Aug 2022
    Authors: M-E Dounavi, C Newton, N Jenkins, E Mak, A Low, G Muniz-Terrera, GB Williams, B Lawlor, L Naci, P Malhotra, CE Mackay, I Koychev, K Ritchie, CW Ritchie, L Su, JT O'Brien

    On the similarities of representations in artificial and brain neural networks for speech recognition.

    DOI: http://doi.org/10.3389/fncom.2022.1057439
    Journal: Front Comput Neurosci
    E-pub date: 1 Aug 2022
    Authors: C Wingfield, C Zhang, B Devereux, E Fonteneau, A Thwaites, X Liu, P Woodland, W Marslen-Wilson, L Su

    Fluid-attenuated inversion recovery magnetic resonance imaging textural features as sensitive markers of white matter damage in midlife adults.

    DOI: http://doi.org/10.1093/braincomms/fcac116
    Journal: Brain Commun
    E-pub date: 1 Aug 2022
    Authors: M-E Dounavi, A Low, G Muniz-Terrera, K Ritchie, CW Ritchie, L Su, HS Markus, JT O'Brien

    A systematic review of near-infrared spectroscopy in dementia

    DOI: http://doi.org/10.1101/2022.11.23.22282361
    Journal:
    E-pub date: 1 Aug 2022
    Authors: E Butters, S Srinivasan, J O’Brien, L Su, G Bale

    Functional and structural brain network correlates of visual hallucinations in Lewy body dementia.

    DOI: http://doi.org/10.1093/brain/awac094
    Journal: Brain
    E-pub date: 30 Jun 2022
    Authors: R Mehraram, LR Peraza, NRE Murphy, RA Cromarty, S Graziadio, JT O'Brien, A Killen, SJ Colloby, M Firbank, L Su, D Collerton, JP Taylor, M Kaiser

    CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1136/jnnp-2021-327462
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2022
    Authors: A Low, MA Prats-Sedano, JD Stefaniak, EF McKiernan, SF Carter, M-E Douvani, E Mak, L Su, O Stupart, G Muniz, K Ritchie, CW Ritchie, HS Markus, JT O'Brien

    Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study.

    DOI: http://doi.org/10.1177/0271678X211020863
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Nov 2021
    Authors: M-E Dounavi, A Low, EF McKiernan, E Mak, G Muniz-Terrera, K Ritchie, CW Ritchie, L Su, JT O'Brien

    Simulating a Community Mental Health Service During the COVID-19 Pandemic: Effects of Clinician-Clinician Encounters, Clinician-Patient-Family Encounters, Symptom-Triggered Protective Behaviour, and Household Clustering.

    DOI: http://doi.org/10.3389/fpsyt.2021.620842
    Journal: Front Psychiatry
    E-pub date: 1 Aug 2021
    Authors: RN Cardinal, CE Meiser-Stedman, DM Christmas, AC Price, C Denman, BR Underwood, S Chen, S Banerjee, SR White, L Su, TJ Ford, SR Chamberlain, CM Walsh

    Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

    Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals.

    DOI: http://doi.org/10.1007/s00415-020-10383-8
    Journal: J Neurol
    E-pub date: 1 May 2021
    Authors: X Liu, M-E Dounavi, K Ritchie, K Wells, CW Ritchie, L Su, G Muniz-Terrera, JT O'Brien

    Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study.

    DOI: http://doi.org/10.1016/j.neuroimage.2021.117749
    Journal: Neuroimage
    E-pub date: 1 Apr 2021
    Authors: E Mak, M-E Dounavi, A Low, SF Carter, E McKiernan, GB Williams, PS Jones, I Carriere, GT Muniz, K Ritchie, C Ritchie, L Su, JT O'Brien

    Relationship between tau, neuroinflammation and atrophy in Alzheimer’s disease: The NIMROD study

    DOI: http://doi.org/10.1016/j.inffus.2020.10.006
    Journal: Information Fusion
    E-pub date: 1 Mar 2021
    Authors: L Su, A Surendranathan, Y Huang, WR Bevan-Jones, L Passamonti, YT Hong, R Arnold, PV Rodríguez, Y Wang, E Mak, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien

    Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.10.029
    Journal: Neurobiol Aging
    E-pub date: 1 Feb 2021
    Authors: A Low, L Su, JD Stefaniak, E Mak, M-E Dounavi, G Muniz-Terrera, K Ritchie, CW Ritchie, HS Markus, JT O'Brien

    The prognostic role of microglia and tau PET in Alzheimer’s disease

    DOI: http://doi.org/10.1002/alz.039817
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan‐Jones, L Su, YT Hong, TD Fryer, FI Aigbirho, JT O'Brien, JB Rowe

    Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study.

    DOI: http://doi.org/10.1136/jnnp-2020-323823
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 21 Oct 2020
    Authors: K Ritchie, I Carrière, S Gregory, T Watermeyer, S Danso, L Su, CW Ritchie, JT O'Brien

    Simulating a community mental health service during the COVID-19 pandemic: effects of clinician–clinician encounters, clinician–patient–family encounters, symptom-triggered protective behaviour, and household clustering

    DOI: http://doi.org/10.1101/2020.04.27.20081505
    Journal:
    E-pub date: 1 Aug 2020
    Authors: R Cardinal, C Meiser-Stedman, D Christmas, A Price, C Denman, B Underwood, S Chen, S Banerjee, S White, L Su, T Ford, S Chamberlain, C Walsh

    Correlation of microglial activation with white matter changes in dementia with Lewy bodies.

    DOI: http://doi.org/10.1016/j.nicl.2020.102200
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2020
    Authors: N Nicastro, E Mak, GB Williams, A Surendranathan, WR Bevan-Jones, L Passamonti, P Vàzquez Rodrìguez, L Su, R Arnold, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

    Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia.

    DOI: http://doi.org/10.3233/JAD-200238
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2020
    Authors: A McKeever, AF Paris, J Cullen, L Hayes, CW Ritchie, K Ritchie, AD Waldman, K Wells, A Busza, I Carriere, JT O'Brien, L Su

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awaa088
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Asymmetrical atrophy of thalamic subnuclei in Alzheimer’s disease and amyloid-positive mild cognitive impairment is associated with key clinical features.

    DOI: http://doi.org/10.1016/j.dadm.2019.08.001
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: A Low, E Mak, M Malpetti, L Chouliaras, N Nicastro, L Su, N Holland, T Rittman, PV Rodríguez, L Passamonti, WR Bevan-Jones, PS Jones, JB Rowe, JT O'Brien

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s Disease

    DOI: http://doi.org/10.1101/19011189
    Journal:
    E-pub date: 1 Aug 2019
    Authors: M Malpetti, R Kievit, L Passamonti, S Jones, K Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    Early microglial activation and peripheral inflammation in dementia with Lewy bodies.

    DOI: http://doi.org/10.1093/brain/awy265
    Journal: Brain
    E-pub date: 1 Dec 2018
    Authors: A Surendranathan, L Su, E Mak, L Passamonti, YT Hong, R Arnold, P Vázquez Rodríguez, WR Bevan-Jones, SAE Brain, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    In vivo coupling of tau pathology and cortical thinning in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.dadm.2018.08.005
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Aug 2018
    Authors: E Mak, RAI Bethlehem, R Romero-Garcia, S Cervenka, T Rittman, S Gabel, A Surendranathan, RW Bevan-Jones, L Passamonti, P Vázquez Rodríguez, L Su, R Arnold, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1212/WNL.0000000000005610
    Journal: Neurology
    E-pub date: 29 May 2018
    Authors: L Passamonti, PV Rodríguez, YT Hong, KSJ Allinson, WR Bevan-Jones, D Williamson, PS Jones, R Arnold, RJ Borchert, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    The midlife cognitive profiles of adults at high risk of late-onset Alzheimer’s disease: The PREVENT study.

    DOI: http://doi.org/10.1016/j.jalz.2017.02.008
    Journal: Alzheimers Dement
    E-pub date: 1 Oct 2017
    Authors: K Ritchie, I Carrière, L Su, JT O'Brien, S Lovestone, K Wells, CW Ritchie

    Relating dynamic brain states to dynamic machine states: Human and machine solutions to the speech recognition problem.

    DOI: http://doi.org/10.1371/journal.pcbi.1005617
    Journal: PLoS Comput Biol
    E-pub date: 1 Sep 2017
    Authors: C Wingfield, L Su, X Liu, C Zhang, P Woodland, A Thwaites, E Fonteneau, WD Marslen-Wilson

    18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1093/brain/aww340
    Journal: Brain
    E-pub date: 1 Mar 2017
    Authors: L Passamonti, P Vázquez Rodríguez, YT Hong, KSJ Allinson, D Williamson, RJ Borchert, S Sami, TE Cope, WR Bevan-Jones, PS Jones, R Arnold, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses.

    DOI: http://doi.org/10.1136/bmjopen-2016-013187
    Journal: BMJ Open
    E-pub date: 7 Jan 2017
    Authors: WR Bevan-Jones, A Surendranathan, L Passamonti, P Vázquez Rodríguez, R Arnold, E Mak, L Su, JP Coles, TD Fryer, YT Hong, G Williams, F Aigbirhio, JB Rowe, JT O'Brien

    Neuroinflammatory and morphological changes in late-life depression: the NIMROD study.

    DOI: http://doi.org/10.1192/bjp.bp.116.190165
    Journal: BRITISH JOURNAL OF PSYCHIATRY
    E-pub date: 1 Dec 2016
    Authors: L Su, YO Faluyi, YT Hong, TD Fryer, E Mak, S Gabel, L Hayes, S Soteriades, GB Williams, R Arnold, L Passamonti, PV Rodríguez, A Surendranathan, RW Bevan-Jones, J Coles, F Aigbirhio, JB Rowe, JT O'Brien

    Whole-brain patterns of (1)H-magnetic resonance spectroscopy imaging in Alzheimer’s disease and dementia with Lewy bodies.

    DOI: http://doi.org/10.1038/tp.2016.140
    Journal: Transl Psychiatry
    E-pub date: 30 Aug 2016
    Authors: L Su, AM Blamire, R Watson, J He, L Hayes, JT O'Brien

    Cortical and Subcortical Changes in Alzheimer’s Disease: A Longitudinal and Quantitative MRI Study.

    DOI: http://doi.org/10.2174/1567205013666151116141416
    Journal: Curr Alzheimer Res
    E-pub date: 1 Aug 2016
    Authors: L Su, AM Blamire, R Watson, J He, B Aribisala, JT O'Brien

    Tissue microstructural changes in dementia with Lewy bodies revealed by quantitative MRI.

    DOI: http://doi.org/10.1007/s00415-014-7541-2
    Journal: J Neurol
    E-pub date: 1 Jan 2015
    Authors: L Su, AM Blamire, R Watson, J He, B Aribisala, JT O'Brien