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EMAIL msc72@cam.ac.uk
Department
  • Clinical Neurosciences
    • School
  • Clinical Medicine
    • Institute
  • John van Geest Centre for Brain Repair
    • ORCID iDClick to view ORCID profile
    Research Theme Lifelong Brain Development and Brain Ageing Beyond the Neuron
    Research Focus

    Keywords

  • Gut-Brain Axis
  • Dementia
  • Parkinson's Disease

    • Clinical Conditions

  • Parkinson's disease
  • Dementia

    • Equipment & Techniques

  • Enzyme assays
  • Neuropsychological testing
  • Randomised control trials
  • Statistical analysis

    • Back

    M Camacho

    University Position
    Research Associate
    Dr M Camacho is pleased to consider applications from prospective PhD students.

    Interests

    My research is focused on the gut-brain axis, particularly how constipation is associated with cognitive decline and faster progression to dementia in Parkinson's disease (PD), and the mediating mechanisms underlying this relationship. We work with cohort studies of people with Parkinson's disease and at risk of developing PD (REM Sleep Behaviour Disorders) which are observational studies tracking the progression of PD over several years so that we can better understand how the disease behaves over time. A subset of patients have brain scans (MRI, PET), blood tests and lumbar punctures and with these tools we are investigating the role of the immune system (both peripheral and CNS inflammation) in the gut-brain axis.

    Key Publications

    Neuroinflammation is linked to dementia risk in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awad322
    Journal: Brain
    E-pub date: 1 Mar 2024
    Authors: A Kouli, LRB Spindler, TD Fryer, YT Hong, M Malpetti, FI Aigbirhio, SR White, M Camacho, JT O'Brien, CH Williams-Gray

    The Endotoxin Hypothesis of Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mds.29432
    Journal: Movement Disorders
    E-pub date: 1 Jul 2023
    Authors: GC Brown, M Camacho, CH Williams-Gray

    T lymphocyte senescence is attenuated in Parkinson’s disease.

    DOI: http://doi.org/10.1186/s12974-021-02287-9
    Journal: J Neuroinflammation
    E-pub date: 13 Oct 2021
    Authors: A Kouli, M Jensen, V Papastavrou, KM Scott, C Kolenda, C Parker, IH Solim, M Camacho, C Martin-Ruiz, CH Williams-Gray

    The Gastrointestinal Dysfunction Scale for Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mds.28675
    Journal: Mov Disord
    E-pub date: 1 Oct 2021
    Authors: M Camacho, JC Greenland, CH Williams-Gray

    Neuroinflammation and protein pathology in Parkinson’s disease dementia.

    DOI: http://doi.org/10.1186/s40478-020-01083-5
    Journal: Acta Neuropathol Commun
    E-pub date: 3 Dec 2020
    Authors: A Kouli, M Camacho, K Allinson, CH Williams-Gray

    Impact of GBA1 variants on long-term clinical progression and mortality in incident Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp-2020-322857
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2020
    Authors: TB Stoker, M Camacho, S Winder-Rhodes, G Liu, CR Scherzer, T Foltynie, J Evans, DP Breen, RA Barker, CH Williams-Gray

    Early constipation predicts faster dementia onset in Parkinson’s disease

    DOI: https://doi.org/10.1038/s41531-021-00191-w
    Journal: npj Parkinson's Disease
    Year: 2021
    Authors: Marta Camacho, Angus D Macleod, Jodi Maple-Grødem, Jonathan R Evans, David P Breen, G Cummins, RS Wijeyekoon, JC Greenland, Guido Alves, Ole-Bjørn Tysnes, Rachel A Lawson, Roger A Barker, Caroline H Williams-Gray

    The Gastrointestinal Dysfunction Scale for Parkinson's Disease

    DOI: https://doi.org/10.1002/mds.28675
    Journal: Movement Disorders
    Year: 2021
    Authors: Marta Camacho, Julia C Greenland, Caroline H Williams‐Gray

    Publications

    Caregiver perspectives enable accurate diagnosis of neurodegenerative disease

    DOI: http://doi.org/10.1002/alz.14377
    Journal: Alzheimers Dement
    E-pub date: 1 Jan 2025
    Authors: AG Murley, L Bowns, M Camacho, CH Williams‐Gray, KA Tsvetanov, T Rittman, RA Barker, JT O'Brien, JB Rowe

    Validation of a 5-Year Prognostic Model for Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mdc3.14215
    Journal: Movement Disorders Clinical Practice
    E-pub date: 1 Nov 2024
    Authors: J Ribeiro, M Camacho, KM Scott, JC Greenland, JR Evans, DP Breen, RS Wijeyekoon, RA Barker, CH Williams-Gray

    Natural killer cells have an activated profile in early Parkinson’s disease.

    DOI: http://doi.org/10.1016/j.jneuroim.2023.578154
    Journal: J Neuroimmunol
    E-pub date: 15 Sep 2023
    Authors: J Holbrook, B Patel, M Camacho, L Kahanawita, J Greenland, CH Williams-Gray

    The dilemma between milestones of progression versus clinical scales in Parkinson’s disease.

    DOI: http://doi.org/10.1016/B978-0-323-85538-9.00010-9
    Journal: Handb Clin Neurol
    E-pub date: 1 Aug 2023
    Authors: JC Greenland, M Camacho, CH Williams-Gray

    Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson’s Disease Dementia.

    DOI: http://doi.org/10.1002/mdc3.13752
    Journal: Mov Disord Clin Pract
    E-pub date: 1 Jun 2023
    Authors: MC Gonzalez, DA Tovar-Rios, G Alves, I Dalen, CH Williams-Gray, M Camacho, L Forsgren, D Bäckström, RA Lawson, AD Macleod, CE Counsell, C Paquet, C DeLena, F D'Antonio, A Pilotto, A Padovani, F Blanc, C Falup-Pecurariu, SJG Lewis, K Rejdak, E Papuc, J Hort, Z Nedelska, J O'Brien, L Bonanni, M Marquié, M Boada, V Pytel, C Abdelnour, D Alcolea, K Beyer, O-B Tysnes, D Aarsland, J Maple-Grødem

    Embracing Monogenic Parkinson’s Disease: The MJFF Global Genetic PD Cohort.

    DOI: http://doi.org/10.1002/mds.29288
    Journal: Mov Disord
    E-pub date: 1 Feb 2023
    Authors: E-J Vollstedt, S Schaake, K Lohmann, S Padmanabhan, A Brice, S Lesage, C Tesson, M Vidailhet, I Wurster, F Hentati, A Mirelman, N Giladi, K Marder, C Waters, S Fahn, M Kasten, N Brüggemann, M Borsche, T Foroud, E Tolosa, A Garrido, G Annesi, M Gagliardi, M Bozi, L Stefanis, JJ Ferreira, L Correia Guedes, M Avenali, S Petrucci, L Clark, EY Fedotova, NY Abramycheva, V Alvarez, M Menéndez-González, S Jesús Maestre, P Gómez-Garre, P Mir, AC Belin, C Ran, C-H Lin, M-C Kuo, D Crosiers, ZK Wszolek, OA Ross, J Jankovic, K Nishioka, M Funayama, J Clarimon, CH Williams-Gray, M Camacho, M Cornejo-Olivas, L Torres-Ramirez, Y-R Wu, G-J Lee-Chen, A Morgadinho, T Pulkes, P Termsarasab, D Berg, G Kuhlenbäumer, AA Kühn, F Borngräber, G de Michele, A De Rosa, A Zimprich, A Puschmann, GD Mellick, J Dorszewska, J Carr, R Ferese, S Gambardella, B Chase, K Markopoulou, W Satake, T Toda, M Rossi, M Merello, T Lynch, DA Olszewska, S-Y Lim, A Ahmad-Annuar, AH Tan, B Al-Mubarak, H Hanagasi, D Koziorowski, S Ertan, G Genç, P de Carvalho Aguiar, M Barkhuizen, MMG Pimentel, R Saunders-Pullman, B van de Warrenburg, S Bressman, M Toft, S Appel-Cresswell, AE Lang, M Skorvanek, AJW Boon, R Krüger, EM Sammler, V Tumas, B-R Zhang, G Garraux, SJ Chung, YJ Kim, J Winkelmann, CM Sue, E-K Tan, J Damásio, P Klivényi, VS Kostic, D Arkadir, M Martikainen, V Borges, JM Hertz, L Brighina, M Spitz, O Suchowersky, O Riess, P Das, B Mollenhauer, EM Gatto, MS Petersen, N Hattori, R-M Wu, SN Illarioshkin, EM Valente, JO Aasly, A Aasly, RN Alcalay, A Thaler, MJ Farrer, K Brockmann, J-C Corvol, C Klein, MJFF Global Genetic Parkinson's Disease Study Group

    GBA and APOE Impact Cognitive Decline in Parkinson’s Disease: A 10-Year Population-Based Study.

    DOI: http://doi.org/10.1002/mds.28932
    Journal: Movement Disorders
    E-pub date: 1 May 2022
    Authors: AA Szwedo, I Dalen, KF Pedersen, M Camacho, D Bäckström, L Forsgren, C Tzoulis, S Winder-Rhodes, G Hudson, G Liu, CR Scherzer, RA Lawson, AJ Yarnall, CH Williams-Gray, AD Macleod, CE Counsell, O-B Tysnes, G Alves, J Maple-Grødem, Parkinson's Incidence Cohorts Collaboration

    Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases.

    DOI: http://doi.org/10.1038/s41591-021-01441-3
    Journal: Nat Med
    E-pub date: 1 Sep 2021
    Authors: N Cai, A Gomez-Duran, E Yonova-Doing, K Kundu, AI Burgess, ZJ Golder, C Calabrese, MJ Bonder, M Camacho, RA Lawson, L Li, CH Williams-Gray, ICICLE-PD Study Group, E Di Angelantonio, DJ Roberts, NA Watkins, WH Ouwehand, AS Butterworth, ID Stewart, M Pietzner, NJ Wareham, C Langenberg, J Danesh, K Walter, PM Rothwell, JMM Howson, O Stegle, PF Chinnery, N Soranzo

    Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson’s Disease in the ICICLE-PD Cohort.

    DOI: http://doi.org/10.3233/JPD-212581
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2021
    Authors: RA Lawson, CH Williams-Gray, M Camacho, GW Duncan, TK Khoo, DP Breen, RA Barker, L Rochester, DJ Burn, AJ Yarnall, ICICLE-PD study group

    Early constipation predicts faster dementia onset in Parkinson’s disease.

    DOI: http://doi.org/10.1038/s41531-021-00191-w
    Journal: NPJ Parkinsons Dis
    E-pub date: 26 May 2021
    Authors: M Camacho, AD Macleod, J Maple-Grødem, JR Evans, DP Breen, G Cummins, RS Wijeyekoon, JC Greenland, G Alves, OB Tysnes, RA Lawson, RA Barker, CH Williams-Gray

    Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson’s disease.

    DOI: http://doi.org/10.1016/j.parkreldis.2020.05.034
    Journal: Parkinsonism Relat Disord
    E-pub date: 1 Jul 2020
    Authors: N Ramsay, AD Macleod, G Alves, M Camacho, L Forsgren, RA Lawson, J Maple-Grødem, O-B Tysnes, CH Williams-Gray, AJ Yarnall, CE Counsell, Parkinson's Incidence Cohorts Collaboration, PINE Study, CamPaIGN study, PICNICS study, NYPUM Study, ParkWest Study: ParkWest Principal investigators, Study personnel, ICICLE-PD Study

    A common polymorphism in SNCA is associated with accelerated motor decline in GBA-Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp-2019-322210
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jun 2020
    Authors: TB Stoker, M Camacho, S Winder-Rhodes, G Liu, CR Scherzer, T Foltynie, RA Barker, CH Williams-Gray

    Using global team science to identify genetic parkinson’s disease worldwide.

    DOI: http://doi.org/10.1002/ana.25514
    Journal: Ann Neurol
    E-pub date: 31 Aug 2019
    Authors: E-J Vollstedt, M Kasten, C Klein, MJFF Global Genetic Parkinson's Disease Study Group