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Research Theme Beyond the Neuron Brains and Machines
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Professor Marek Czosnyka

University Position
Professor

Interests

Brain Physics summarizes physical interactions between volumes, flows and pressures in brain. Measurement, data processing and analysis, forecasting and modeling of various cerebral phenomena as autoregulation of CBF or pressure-volume compensation of CSF indicate first-line priorities of Brain Physics. Complete list of ongoing projects include: 1. Brain Autoregulation 2. Cerebrospinal fluid dynamics (hydrocephalus, IIH). Multi-modal brain monitoring (head trauma, poor grade SAH, stroke) 3. Mathematical modeling of cerebrospinal dynamics 4. Hydrodynamic properties of hydrocephalus shunts 5. Software for brain monitoring ICM+ (lead author : Dr.P.Smielewski): www.neurosurg.cam.ac.uk/icmplus NEW!: For details see 30 Lectures in Brain Physics- not only for Engineers: http://www.neurosurg.cam.ac.uk/pages/brainphys/ NEW! Brain Physics Seminars:Tuesdays at 11:00, University Neurosurgery, Old Library, Block A, Level 4, Addenbrookes Hospital- Find us at Facebook: Brain Physics Cambridge

Key Publications

Publications

Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study.

DOI: http://doi.org/10.1227/NEU.0000000000000575
Journal: Neurosurgery
E-pub date: 1 Jan 2015
Authors: AIR Maas, DK Menon, EW Steyerberg, G Citerio, F Lecky, GT Manley, S Hill, V Legrand, A Sorgner, CENTER-TBI Participants and Investigators

Critical thresholds for cerebrovascular reactivity after traumatic brain injury.

DOI: http://doi.org/10.1007/s12028-011-9630-8
Journal: Neurocrit Care
E-pub date: 1 Apr 2012
Authors: E Sorrentino, J Diedler, M Kasprowicz, KP Budohoski, C Haubrich, P Smielewski, JG Outtrim, A Manktelow, PJ Hutchinson, JD Pickard, DK Menon, M Czosnyka

Imaging of cerebral blood flow and metabolism in brain injury in the ICU.

DOI: http://doi.org/10.1007/3-211-32318-X_94
Journal: Acta Neurochirurgica, Supplementum
E-pub date: 1 Jan 2005
Authors: JD Pickard, PJ Hutchinson, JP Coles, LA Steiner, AJ Johnston, TD Fryer, MR Coleman, P Smielewski, DA Chatfield, F Aigbirhio, GB Williams, K Rice, JC Clark, CH Salmond, BJ Sahakian, PG Bradley, TA Carpenter, R Salvador, A Pena, JH Gillard, AS Cunningham, S Piechnik, M Czosnyka, DK Menon

Changes in cerebral blood flow during cerebrospinal fluid pressure manipulation in patients with normal pressure hydrocephalus: a methodological study.

DOI: http://doi.org/10.1097/00004647-200405000-00012
Journal: J Cereb Blood Flow Metab
E-pub date: 1 May 2004
Authors: BK Owler, A Pena, S Momjian, Z Czosnyka, M Czosnyka, NG Harris, P Smielewski, T Fryer, T Donvan, A Carpenter, JD Pickard

Normal pressure hydrocephalus and cerebral blood flow: a PET study of baseline values.

DOI: http://doi.org/10.1097/01.WCB.0000093326.88757.49
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Jan 2004
Authors: BK Owler, S Momjian, Z Czosnyka, M Czosnyka, A Péna, NG Harris, P Smielewski, T Fryer, T Donovan, J Coles, A Carpenter, JD Pickard

Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure.

DOI: http://doi.org/10.1097/01.WCB.0000090861.67713.10
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Nov 2003
Authors: LA Steiner, JP Coles, AJ Johnston, M Czosnyka, TD Fryer, P Smielewski, DA Chatfield, R Salvador, FI Aigbirhio, JC Clark, DK Menon, JD Pickard

Assessment of cerebrovascular autoregulation in head-injured patients: a validation study.

DOI: http://doi.org/10.1161/01.STR.0000089014.59668.04
Journal: Stroke
E-pub date: 1 Oct 2003
Authors: LA Steiner, JP Coles, AJ Johnston, DA Chatfield, P Smielewski, TD Fryer, FI Aigbirhio, JC Clark, JD Pickard, DK Menon, M Czosnyka

Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury.

DOI: http://doi.org/10.1136/jnnp.74.6.765
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Jun 2003
Authors: LA Steiner, JP Coles, M Czosnyka, PS Minhas, TD Fryer, FI Aigbirhio, JC Clark, P Smielewski, DA Chatfield, T Donovan, JD Pickard, DK Menon

A case study of hemispatial neglect using finite element analysis and positron emission tomography.

DOI: http://doi.org/10.1111/j.1552-6569.2002.tb00145.x
Journal: J Neuroimaging
E-pub date: 1 Oct 2002
Authors: A Peña, BK Owler, TD Fryer, P Minhas, M Czosnyka, PJ Crawford, JD Pickard