Maria-Eleni Dounavi

University Position

Research Associate

Interests

I am an Alzheimer's Society Research Fellow at the department of Psychiatry (Old Age Psychiatry research group). My research is focused on multi-modal MR brain imaging and utilisation of state-of-the-art image processing tools to investigate early changes occurring at the preclinical stage of Alzheimer's dementia (PREVENT-dementia project).

Key Publications

Publications

APOE e4 exacerbates age-dependent deficits in cortical microstructure

DOI: http://doi.org/10.1093/braincomms/fcad351
Journal: Brain Commun
E-pub date: 1 Aug 2024
Authors: F Mak, M-E Dounavi, G Operto, Z Elina, J P Simon, A Low, P Swann, C Newton, G Terrera, P Malhotra, I Koychev, C Falcon, C Mackay, B Lawlor, L Naci, K Wells, C Ritchie, K Ritchie, L Su, JD Gispert, J O'Brien

The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia

DOI: http://doi.org/10.1093/braincomms/fcae189
Journal: Brain Commun
E-pub date: 1 Aug 2024
Authors: CW Ritchie, K Bridgeman, S Gregory, JT O’Brien, SO Danso, M-E Dounavi, I Carriere, D Driscoll, R Hillary, I Koychev, B Lawlor, L Naci, L Su, A Low, E Mak, P Malhotra, J Manson, R Marioni, L Murphy, G Ntailianis, W Stewart, G Muniz-Terrera, K Ritchie

Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife.

DOI: http://doi.org/10.1177/0271678X231173587
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Oct 2023
Authors: M-E Dounavi, E Mak, P Swann, A Low, G Muniz-Terrera, A McKeever, M Pope, GB Williams, K Wells, B Lawlor, L Naci, P Malhotra, C Mackay, I Koychev, K Ritchie, L Su, CW Ritchie, JT O'Brien

Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study.

DOI: http://doi.org/10.1007/s00415-022-11061-7
Journal: J Neurol
E-pub date: 31 Aug 2022
Authors: M-E Dounavi, C Newton, N Jenkins, E Mak, A Low, G Muniz-Terrera, GB Williams, B Lawlor, L Naci, P Malhotra, CE Mackay, I Koychev, K Ritchie, CW Ritchie, L Su, JT O'Brien

Fluid-attenuated inversion recovery magnetic resonance imaging textural features as sensitive markers of white matter damage in midlife adults.

DOI: http://doi.org/10.1093/braincomms/fcac116
Journal: Brain Commun
E-pub date: 1 Aug 2022
Authors: M-E Dounavi, A Low, G Muniz-Terrera, K Ritchie, CW Ritchie, L Su, HS Markus, JT O'Brien

Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study.

DOI: http://doi.org/10.1177/0271678X211020863
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Nov 2021
Authors: M-E Dounavi, A Low, EF McKiernan, E Mak, G Muniz-Terrera, K Ritchie, CW Ritchie, L Su, JT O'Brien

Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals.

DOI: http://doi.org/10.1007/s00415-020-10383-8
Journal: J Neurol
E-pub date: 1 May 2021
Authors: X Liu, M-E Dounavi, K Ritchie, K Wells, CW Ritchie, L Su, G Muniz-Terrera, JT O'Brien

Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study.

DOI: http://doi.org/10.1016/j.neuroimage.2021.117749
Journal: Neuroimage
E-pub date: 1 Apr 2021
Authors: E Mak, M-E Dounavi, A Low, SF Carter, E McKiernan, GB Williams, PS Jones, I Carriere, GT Muniz, K Ritchie, C Ritchie, L Su, JT O'Brien

Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.

DOI: http://doi.org/10.1016/j.neurobiolaging.2020.10.029
Journal: Neurobiol Aging
E-pub date: 1 Feb 2021
Authors: A Low, L Su, JD Stefaniak, E Mak, M-E Dounavi, G Muniz-Terrera, K Ritchie, CW Ritchie, HS Markus, JT O'Brien