Our interest is in the identification of the mechanisms leading to neuronal death and clinical phenotype in diseases such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia. In particular we study the role of microtubule-associated protein tau and alpha-synuclein aggregation in the pathogenesis of tauopathies and alpha-synucleinopathies. Our work extends from genetic studies in patients to disease models. The aim is to identify mechanism-based therapies for these disorders.
