I study the precise anatomical and functional organization of domain-general brain regions using mutlimodal MRI techniques of the Human Connectome Project (HCP) and invasive electrophysiology data from human patients. Domain-general or Multiple-demand (MD) brain regions are co-activated accompanying many tasks and are hypothesised to play a central role in cognitive control and supporting human intelligence. However, the limited spatial localization provided by traditional brain imaging methods precluded a consensus regarding its anatomy and physiology. In my PhD work at the MRC Cognition and Brain Sciences Unit with John Duncan, I used HCP's high-resolution MRI acquisition and analysis methods to precisely delineate a whole brain MD system, consisting of 9 cortical patches and specific subcortical and cerebellar regions. In my post-doc, I continue to probe how MD regions function under diverse cognitive demands.