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    Dr Matthias Landgraf

    University Position


    We seek to understand how neural networks are specified and how they assemble during development. The locomotor network of the Drosophila embryo and larva serves as a powerful experimental model. Composed of identified neurons whose connections have been reconstructed, we use genetics, imaging and electrophysiology to study fundamental questions about synapse development, dendritic growth and the regulation of plasticity. Current research topics include: Charting the developmental logic of neurotransmitters specification Determining how patterned growth during development leads to patterns of synaptic connections Activity dependent structural homeostasis and the maturation of network properties Reactive oxygen species seen in a different light, as newly identified regulators of synaptic growth Connectomics of memory circuits

    Key Publications

    Comparative Connectomics Reveals How Partner Identity, Location, and Activity Specify Synaptic Connectivity in Drosophila.

    Journal: Neuron
    E-pub date: 6 Jan 2021
    Authors: J Valdes-Aleman, RD Fetter, EC Sales, EL Heckman, L Venkatasubramanian, CQ Doe, M Landgraf, A Cardona, M Zlatic


    Activity-regulated growth of motoneurons at the neuromuscular junction is mediated by NADPH oxidases

    E-pub date: 1 Aug 2022
    Authors: D Sobrido-Cameán, M Oswald, D Bailey, A Mukherjee, M Landgraf

    Selective Inhibition Mediates the Sequential Recruitment of Motor Pools.

    Journal: Neuron
    E-pub date: 17 Aug 2016
    Authors: MF Zwart, SR Pulver, JW Truman, A Fushiki, RD Fetter, A Cardona, M Landgraf