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Department
  • Psychiatry
    • Institute
  • Brain Mapping Unit
    • Research Theme Beyond the Neuron Adaptive Brain Computations
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    Miss Margaret Westwater

    University Position
    PhD student

    Interests

    My primary scientific aim is to examine the interaction between peripheral metabolic signaling and neural activity in individuals with healthy and disordered eating behaviors. This work involves measurement of metabolic functioning (e.g., body composition, gut hormones), brain structure (cortical thickness), and brain activity using MRI. By using this integrated approach, I hope to identify mechanisms by which disturbances in gastrointestinal functioning modulate activity of brain regions involved in higher-order cognition and feeding behaviour. I am also particularly interested in the role of stress in eating disorders and related psychiatric disorders.

    Key Publications

    Brain charts for the human lifespan

    DOI: http://doi.org/10.1101/2021.06.08.447489
    Journal:
    E-pub date: 1 Aug 2021
    Authors: RAI Bethlehem, J Seidlitz, SR White, JW Vogel, KM Anderson, C Adamson, S Adler, GS Alexopoulos, E Anagnostou, A Areces-Gonzalez, DE Astle, B Auyeung, M Ayub, G Ball, S Baron-Cohen, R Beare, SA Bedford, V Benegal, F Beyer, J Bin Bae, J Blangero, M Blesa Cábez, JP Boardman, M Borzage, JF Bosch-Bayard, N Bourke, VD Calhoun, MM Chakravarty, C Chen, C Chertavian, G Chetelat, YS Chong, JH Cole, A Corvin, M Costantino, E Courchesne, F Crivello, VL Cropley, J Crosbie, N Crossley, M Delarue, R Delorme, S Desrivieres, G Devenyi, MA Di Biase, R Dolan, KA Donald, G Donohoe, K Dunlop, AD Edwards, JT Elison, CT Ellis, JA Elman, L Eyler, DA Fair, E Feczko, PC Fletcher, P Fonagy, CE Franz, L Galan-Garcia, A Gholipour, J Giedd, JH Gilmore, DC Glahn, I Goodyer, PE Grant, NA Groenewold, FM Gunning, RE Gur, RC Gur, CF Hammill, O Hansson, T Hedden, A Heinz, RN Henson, K Heuer, J Hoare, B Holla, AJ Holmes, R Holt, H Huang, K Im, J Ipser, CR Jack, AP Jackowski, T Jia, KA Johnson, PB Jones, DT Jones, R Kahn, H Karlsson, L Karlsson, R Kawashima, EA Kelley, S Kern, K Kim, MG Kitzbichler, WS Kremen, F Lalonde, B Landeau, S Lee, J Lerch, JD Lewis, J Li, W Liao, C Liston, MV Lombardo, J Lv, C Lynch, TT Mallard, M Marcelis, RD Markello, SR Mathias, B Mazoyer, P McGuire, MJ Meaney, A Mechelli, N Medic, B Misic, SE Morgan, D Mothersill, J Nigg, MQW Ong, C Ortinau, C Ortinau, R Ossenkoppele, M Ouyang, L Palaniyappan, L Paly, PM Pan, C Pantelis, MM Park, T Paus, Z Pausova, D Paz-Linares, A Pichet Binette, K Pierce, X Qian, J Qiu, A Qiu, A Raznahan, T Rittman, A Rodrigue, CK Rollins, R Romero-Garcia, L Ronan, MD Rosenberg, DH Rowitch, GA Salum, TD Satterthwaite, HL Schaare, RJ Schachar, AP Schultz, G Schumann, M Schöll, D Sharp, RT Shinohara, I Skoog, CD Smyser, RA Sperling, DJ Stein, A Stolicyn, J Suckling, G Sullivan, Y Taki, B Thyreau, R Toro, N Traut, KA Tsvetanov, NB Turk-Browne, JJ Tuulari, C Tzourio, É Vachon-Presseau, MJ Valdes-Sosa, PA Valdes-Sosa, SL Valk, T van Amelsvoort, SN Vandekar, L Vasung, LW Victoria, S Villeneuve, A Villringer, A Villringer, PE Vértes, K Wagstyl, YS Wang, SK Warfield, V Warrier, E Westman, ML Westwater, HC Whalley, AV Witte, N Yang, B Yeo, H Yun, A Zalesky, HJ Zar, A Zettergren, JH Zhou, H Ziauddeen, A Zugman, XN Zuo, ET Bullmore, AF Alexander-Bloch, 3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, UMN BCP, CALM Team, Cam-CAN, CCNP, COBRE, Developing Human Connectome Project, ENIGMA Developmental Brain Age working group, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, The Mayo Clinic Study of Aging, NSPN, POND, The PREVENT-AD Research Group, VETSA

    Publications

    Brain charts for the human lifespan

    DOI: http://doi.org/10.1038/s41586-022-04554-y
    Journal: Nature
    E-pub date: 6 Apr 2022
    Authors: RAI Bethlehem, J Seidlitz, SR White, JW Vogel, KM Anderson, C Adamson, S Adler, GS Alexopoulos, E Anagnostou, A Areces-Gonzalez, DE Astle, B Auyeung, M Ayub, G Ball, S Baron-Cohen, R Beare, SA Bedford, V Benegal, F Beyer, J Bin Bae, J Blangero, M Blesa Cábez, JP Boardman, M Borzage, JF Bosch-Bayard, N Bourke, VD Calhoun, MM Chakravarty, C Chen, C Chertavian, G Chetelat, YS Chong, JH Cole, A Corvin, E Courchesne, F Crivello, VL Cropley, J Crosbie, N Crossley, M Delarue, S Desrivieres, G Devenyi, MA Di Biase, R Dolan, KA Donald, G Donohoe, K Dunlop, AD Edwards, JT Elison, CT Ellis, JA Elman, L Eyler, DA Fair, PC Fletcher, P Fonagy, CE Franz, L Galan-Garcia, A Gholipour, J Giedd, JH Gilmore, DC Glahn, I Goodyer, PE Grant, NA Groenewold, FM Gunning, RE Gur, RC Gur, CF Hammill, O Hansson, T Hedden, A Heinz, R Henson, K Heuer, J Hoare, B Holla, AJ Holmes, R Holt, H Huang, K Im, J Ipser, CR Jack, AP Jackowski, T Jia, KA Johnson, PB Jones, DT Jones, R Kahn, H Karlsson, L Karlsson, R Kawashima, EA Kelley, S Kern, K Kim, MG Kitzbichler, WS Kremen, F Lalonde, B Landeau, S Lee, J Lerch, JD Lewis, J Li, W Liao, DP Linares, C Liston, MV Lombardo, J Lv, C Lynch, TT Mallard, M Marcelis, RD Markello, B Mazoyer, P McGuire, MJ Meaney, A Mechelli, N Medic, B Misic, SE Morgan, D Mothersill, J Nigg, MQW Ong, C Ortinau, R Ossenkoppele, M Ouyang, L Palaniyappan, L Paly, PM Pan, C Pantelis, MM Park, T Paus, Z Pausova, A Pichet Binette, K Pierce, X Qian, J Qiu, A Qiu, A Raznahan, T Rittman, CK Rollins, R Romero-Garcia, L Ronan, MD Rosenberg, DH Rowitch, GA Salum, TD Satterthwaite, HL Schaare, RJ Schachar, AP Schultz, G Schumann, M Schöll, D Sharp, RT Shinohara, I Skoog, CD Smyser, RA Sperling, DJ Stein, A Stolicyn, J Suckling, G Sullivan, Y Taki, B Thyreau, R Toro, KA Tsvetanov, NB Turk-Browne, JJ Tuulari, C Tzourio, É Vachon-Presseau, MJ Valdes-Sosa, PA Valdes-Sosa, SL Valk, T van Amelsvoort, SN Vandekar, L Vasung, LW Victoria, S Villeneuve, A Villringer, PE Vértes, K Wagstyl, YS Wang, SK Warfield, V Warrier, E Westman, ML Westwater, HC Whalley, AV Witte, N Yang, BTT Yeo, HJ Yun, A Zalesky, HJ Zar, A Zettergren, JH Zhou, H Ziauddeen, A Zugman, XN Zuo, AF Alexander-Bloch, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, ASRB, CALM Team, Cam-CAN, CCNP, 3R-BRAIN, COBRE, ENIGMA Developmental Brain Age working group, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, NSPN, OASIS-3, OpenPain Project, POND, The PREVENT-AD Research Group, VETSA, Bullmore, E.T

    Dissociable hormonal profiles for psychopathology and stress in anorexia and bulimia nervosa.

    DOI: http://doi.org/10.1017/S0033291720001440
    Journal: Psychol Med
    E-pub date: 1 Dec 2021
    Authors: ML Westwater, F Mancini, J Shapleske, J Serfontein, M Ernst, H Ziauddeen, PC Fletcher

    Characterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior

    DOI: http://doi.org/10.1101/2021.09.12.21263466
    Journal:
    E-pub date: 1 Aug 2021
    Authors: M Westwater, A Murley, KMJ Diederen, A Carpenter, H Ziauddeen, P Fletcher

    Prefrontal Responses during Proactive and Reactive Inhibition Are Differentially Impacted by Stress in Anorexia and Bulimia Nervosa.

    DOI: http://doi.org/10.1523/JNEUROSCI.2853-20.2021
    Journal: J Neurosci
    E-pub date: 19 May 2021
    Authors: ML Westwater, F Mancini, AX Gorka, J Shapleske, J Serfontein, C Grillon, M Ernst, H Ziauddeen, PC Fletcher

    Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa

    DOI: http://doi.org/10.1101/2020.02.27.968719
    Journal:
    E-pub date: 1 Aug 2020
    Authors: ML Westwater, F Mancini, AX Gorka, J Shapleske, J Serfontein, C Grillon, M Ernst, H Ziauddeen, PC Fletcher

    Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood.

    DOI: http://doi.org/10.1016/j.dcn.2019.100728
    Journal: Dev Cogn Neurosci
    E-pub date: 1 Dec 2019
    Authors: ML Westwater, R Vilar-López, H Ziauddeen, A Verdejo-García, PC Fletcher

    Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood

    DOI: http://doi.org/10.1101/596064
    Journal:
    E-pub date: 1 Aug 2019
    Authors: M Westwater, R Vilar-López, H Ziauddeen, A Verdejo-García, P Fletcher

    Sugar addiction: the state of the science.

    DOI: http://doi.org/10.1007/s00394-016-1229-6
    Journal: Eur J Nutr
    E-pub date: 1 Nov 2016
    Authors: ML Westwater, PC Fletcher, H Ziauddeen