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EMAIL op210@cam.ac.uk
College St John's College
Department
  • Physiology, Development and Neuroscience
    • School
  • Biological Sciences
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    ORCID iDClick to view ORCID profile
    Research Theme Neurons, Circuits and Networks Adaptive Brain Computations Lifelong Brain Development and Brain Ageing

    Other Interdiciplinary Incentives

  • Neuroscience

    • Research Focus

    Keywords

  • Learning & Memory
  • Memory Reconsolidation
  • Synaptic Plasticity
  • Long-Term Potentiation
  • Cortical Network
  • Oscillations
  • Acetylcholine
  • Dopamine

    • Clinical Conditions

  • Dementia
  • Alzheimer's disease
  • Frontotemporal dementia
  • Autism spectrum condition
  • Rett syndrome

    • Equipment & Techniques

  • Behavioural analysis
  • Calcium imaging
  • Cell culture
  • Electrophysiological recording techniques
  • Intracellular recording
  • Whole cell patch clamp

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    Professor Ole Paulsen

    University Position
    Professor
    Professor Ole Paulsen is pleased to consider applications from prospective PhD students.

    Interests

    The primary interest of our group is the relationship between network oscillations and synaptic plasticity. Network oscillations naturally organise spike timing conducive to spike timing-dependent plasticity (STDP), a strong candidate for a mechanism involved in neural development as well as learning and memory processes. We aim to gain insight into how information can be stored and retrieved as changes of synaptic weights in neural networks displaying oscillatory activity. To this end, we use a combination of techniques, including whole-cell patch-clamp and planar multi-electrode recording, calcium imaging and light-activated channels (channelrhodopsins). We are also interested in understanding synaptic plasticity in disease processes during development (neurodevelopmental disorders) as well as during aging (neurodegenerative disorders). For this, we use both mouse models and human cerebral organoids.

    Associated News Items

    Key Publications

    Postsynaptic burst reactivation of hippocampal neurons enables associative plasticity of temporally discontiguous inputs.

    DOI: http://doi.org/10.7554/eLife.81071
    Journal: Elife
    E-pub date: 13 Oct 2022
    Authors: T Fuchsberger, C Clopath, P Jarzebowski, Z Brzosko, H Wang, O Paulsen

    Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology.

    DOI: http://doi.org/10.1038/s41593-021-00923-4
    Journal: Nat Neurosci
    E-pub date: 1 Nov 2021
    Authors: K Szebényi, LMD Wenger, Y Sun, AWE Dunn, CA Limegrover, GM Gibbons, E Conci, O Paulsen, SB Mierau, G Balmus, A Lakatos

    Thalamus mediates neocortical Down state transition via GABAB-receptor-targeting interneurons.

    DOI: http://doi.org/10.1016/j.neuron.2021.06.030
    Journal: Neuron
    E-pub date: 1 Sep 2021
    Authors: YA Hay, N Deperrois, T Fuchsberger, TM Quarrell, A-L Koerling, O Paulsen

    Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output.

    DOI: http://doi.org/10.1038/s41593-019-0350-2
    Journal: Nat Neurosci
    E-pub date: 1 Apr 2019
    Authors: SL Giandomenico, SB Mierau, GM Gibbons, LMD Wenger, L Masullo, T Sit, M Sutcliffe, J Boulanger, M Tripodi, E Derivery, O Paulsen, A Lakatos, MA Lancaster

    Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo.

    DOI: http://doi.org/10.1016/j.neuron.2018.01.047
    Journal: Neuron
    E-pub date: 21 Mar 2018
    Authors: A González-Rueda, V Pedrosa, RC Feord, C Clopath, O Paulsen

    Matching storage and recall: hippocampal spike timing-dependent plasticity and phase response curves.

    DOI: http://doi.org/10.1038/nn1561
    Journal: Nat Neurosci
    E-pub date: 1 Dec 2005
    Authors: M Lengyel, J Kwag, O Paulsen, P Dayan

    Dissociation of experience-dependent and -independent changes in excitatory synaptic transmission during development of barrel cortex

    DOI: http://doi.org/10.1073/pnas.0402915101
    Journal: P NATL ACAD SCI USA
    E-pub date: 26 Oct 2004
    Authors: SB Mierau, RM Meredith, AL Upton, O Paulsen

    Publications

    Different encoding of reward location in dorsal and intermediate hippocampus.

    DOI: http://doi.org/10.1016/j.cub.2021.12.024
    Journal: Curr Biol
    E-pub date: 28 Feb 2022
    Authors: P Jarzebowski, YA Hay, BF Grewe, O Paulsen

    An emergent neural coactivity code for dynamic memory.

    DOI: http://doi.org/10.1038/s41593-021-00820-w
    Journal: Nat Neurosci
    E-pub date: 1 May 2021
    Authors: M El-Gaby, HM Reeve, V Lopes-Dos-Santos, N Campo-Urriza, PV Perestenko, A Morley, LAM Strickland, IP Lukács, O Paulsen, D Dupret

    Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location.

    DOI: http://doi.org/10.7554/eLife.65998
    Journal: Elife
    E-pub date: 6 Apr 2021
    Authors: P Jarzebowski, CS Tang, O Paulsen, YA Hay

    Neuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future.

    DOI: http://doi.org/10.1016/j.neuron.2019.05.041
    Journal: Neuron
    E-pub date: 21 Aug 2019
    Authors: Z Brzosko, SB Mierau, O Paulsen

    Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus.

    DOI: http://doi.org/10.1093/cercor/bhw172
    Journal: Cereb Cortex
    E-pub date: 31 Aug 2016
    Authors: Y Andrade-Talavera, P Duque-Feria, O Paulsen, A Rodríguez-Moreno

    Archaerhodopsin Selectively and Reversibly Silences Synaptic Transmission through Altered pH.

    DOI: http://doi.org/10.1016/j.celrep.2016.07.057
    Journal: Cell Rep
    E-pub date: 23 Aug 2016
    Authors: M El-Gaby, Y Zhang, K Wolf, CJ Schwiening, O Paulsen, OA Shipton

    Emergence of rich-club topology and coordinated dynamics in development of hippocampal functional networks in vitro.

    DOI: http://doi.org/10.1523/JNEUROSCI.4259-14.2015
    Journal: J Neurosci
    E-pub date: 8 Apr 2015
    Authors: MS Schroeter, P Charlesworth, MG Kitzbichler, O Paulsen, ET Bullmore

    Left-right dissociation of hippocampal memory processes in mice.

    DOI: http://doi.org/10.1073/pnas.1405648111
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 21 Oct 2014
    Authors: OA Shipton, M El-Gaby, J Apergis-Schoute, K Deisseroth, DM Bannerman, O Paulsen, MM Kohl

    NMDA spikes enhance action potential generation during sensory input.

    DOI: http://doi.org/10.1038/nn.3646
    Journal: Nature Neuroscience
    E-pub date: 1 Mar 2014
    Authors: LM Palmer, AS Shai, JE Reeve, HL Anderson, O Paulsen, ME Larkum

    GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity.

    DOI: http://doi.org/10.1098/rstb.2013.0163
    Journal: Philos Trans R Soc Lond B Biol Sci
    E-pub date: 5 Jan 2014
    Authors: OA Shipton, O Paulsen

    Presynaptic self-depression at developing neocortical synapses.

    DOI: http://doi.org/10.1016/j.neuron.2012.10.035
    Journal: Neuron
    E-pub date: 9 Jan 2013
    Authors: A Rodríguez-Moreno, A González-Rueda, A Banerjee, AL Upton, MT Craig, O Paulsen

    Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity.

    DOI: http://doi.org/10.1038/nn.2915
    Journal: Nature Neuroscience
    E-pub date: 1 Nov 2011
    Authors: MM Kohl, OA Shipton, RM Deacon, JNP Rawlins, K Deisseroth, O Paulsen

    Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.

    DOI: http://doi.org/10.1523/JNEUROSCI.2610-10.2011
    Journal: J Neurosci
    E-pub date: 2 Feb 2011
    Authors: OA Shipton, JR Leitz, J Dworzak, CEJ Acton, EM Tunbridge, F Denk, HN Dawson, MP Vitek, R Wade-Martins, O Paulsen, M Vargas-Caballero

    Double dissociation of spike timing-dependent potentiation and depression by subunit-preferring NMDA receptor antagonists in mouse barrel cortex.

    DOI: http://doi.org/10.1093/cercor/bhp067
    Journal: Cereb Cortex
    E-pub date: 1 Dec 2009
    Authors: A Banerjee, RM Meredith, A Rodríguez-Moreno, SB Mierau, YP Auberson, O Paulsen

    The timing of external input controls the sign of plasticity at local synapses.

    DOI: http://doi.org/10.1038/nn.2388
    Journal: Nat Neurosci
    E-pub date: 1 Oct 2009
    Authors: J Kwag, O Paulsen

    Distinct roles of GABA(A) and GABA(B) receptors in balancing and terminating persistent cortical activity.

    DOI: http://doi.org/10.1523/JNEUROSCI.6162-08.2009
    Journal: J Neurosci
    E-pub date: 10 Jun 2009
    Authors: EO Mann, MM Kohl, O Paulsen

    Spike timing-dependent long-term depression requires presynaptic NMDA receptors.

    DOI: http://doi.org/10.1038/nn.2125
    Journal: Nat Neurosci
    E-pub date: 1 Jul 2008
    Authors: A Rodríguez-Moreno, O Paulsen

    Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro.

    DOI: http://doi.org/10.1016/j.neuron.2004.12.016
    Journal: Neuron
    E-pub date: 6 Jan 2005
    Authors: EO Mann, JM Suckling, N Hajos, SA Greenfield, O Paulsen

    Distinct frequency preferences of different types of rat hippocampal neurones in response to oscillatory input currents.

    DOI: http://doi.org/10.1111/j.1469-7793.2000.00205.x
    Journal: J Physiol
    E-pub date: 15 Nov 2000
    Authors: FG Pike, RS Goddard, JM Suckling, P Ganter, N Kasthuri, O Paulsen

    Rapid report: postsynaptic bursting is essential for ‘Hebbian’ induction of associative long-term potentiation at excitatory synapses in rat hippocampus.

    DOI: http://doi.org/10.1111/j.1469-7793.1999.0571p.x
    Journal: J Physiol
    E-pub date: 15 Jul 1999
    Authors: FG Pike, RM Meredith, AW Olding, O Paulsen

    Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro.

    DOI: http://doi.org/10.1038/28179
    Journal: Nature
    E-pub date: 9 Jul 1998
    Authors: A Fisahn, FG Pike, EH Buhl, O Paulsen

    Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons.

    DOI: http://doi.org/10.1038/378075a0
    Journal: Nature
    E-pub date: 2 Nov 1995
    Authors: SR Cobb, EH Buhl, K Halasy, O Paulsen, P Somogyi

    The quantal size at retinogeniculate synapses determined from spontaneous and evoked EPSCs in guinea-pig thalamic slices.

    DOI: http://doi.org/10.1113/jphysiol.1994.sp020379
    Journal: J Physiol
    E-pub date: 1 Nov 1994
    Authors: O Paulsen, P Heggelund