Equipment & Techniques
My interests lie in the mechanisms underlying neuronal and network function; IE intrinsic neuronal properties, neurotransmission, synchronisation, and network dynamics. Following my PhD in NMDA receptor function and regulation in midbrain dopaminergic neurons, I worked at Bristol (Physiology) and Bath (Physics) Universities characterising single brainstem respiratory CPG neurons for replication as a low power solid-state neuronal circuit for medical device application. My current work, with Professor Allan Herbison, explores the mechanisms underlying episodic neuronal synchronisation within the kisspeptin neuronal network in the hypothalamic arcuate nucleus, essential for normal fertility and sexual development. I recently developed an acute slice preparation exhibiting spontaneous synchronisations similar to those observed in vivo, and can record from 100+ neurons bilaterally. My interest within this project is investigating the mechanisms underlying such activity as well as the structure of the network.