College Trinity College
Research Focus


  • Cellular Neurophysiology
  • Network Neuroscience
  • Ionotropic Receptors
  • G-Protein Coupled Receptors
  • Patch-Clamp Electrophysiology
  • Calcium Imaging
  • Synaptic Transmission
  • Neuroendocrinology
  • Equipment & Techniques

  • Whole cell patch clamp
  • Calcium imaging
  • Fluorescence microscopy
  • Signal processing
  • Intracellular recording
  • Statistical analysis
  • Back

    Dr Paul G. Morris

    University Position
    Research Associate


    My interests lie in the mechanisms underlying neuronal and network function; IE intrinsic neuronal properties, neurotransmission, synchronisation, and network dynamics. Following my PhD in NMDA receptor function and regulation in midbrain dopaminergic neurons, I worked at Bristol (Physiology) and Bath (Physics) Universities characterising single brainstem respiratory CPG neurons for replication as a low power solid-state neuronal circuit for medical device application. My current work, with Professor Allan Herbison, explores the mechanisms underlying episodic neuronal synchronisation within the kisspeptin neuronal network in the hypothalamic arcuate nucleus, essential for maintaining fertility. I recently developed an acute slice preparation exhibiting spontaneous synchronisations similar to those observed in vivo, and can record from 100+ neurons bilaterally. My interest within this project is investigating the mechanisms underlying such activity as well as the structure of the network.

    Key Publications

    Mechanism of kisspeptin neuron synchronization for pulsatile hormone secretion in male mice.

    Journal: Cell Rep
    E-pub date: 31 Jan 2023
    Authors: SY Han, PG Morris, J-C Kim, S Guru, M Pardo-Navarro, S-H Yeo, HJ McQuillan, AE Herbison

    Optimal solid state neurons.

    Journal: Nat Commun
    E-pub date: 3 Dec 2019
    Authors: K Abu-Hassan, JD Taylor, PG Morris, E Donati, ZA Bortolotto, G Indiveri, JFR Paton, A Nogaret


    Visualisation of Kiss1 Neurone Distribution Using a Kiss1-CRE Transgenic Mouse.

    Journal: J Neuroendocrinol
    E-pub date: 1 Nov 2016
    Authors: S-H Yeo, V Kyle, PG Morris, S Jackman, LC Sinnett-Smith, M Schacker, C Chen, WH Colledge

    An Evaluation of Matrix-Containing and Humanised Matrix-Free 3-Dimensional Cell Culture Systems for Studying Breast Cancer.

    Journal: PLoS One
    E-pub date: 1 Aug 2016
    Authors: GC Roberts, PG Morris, MA Moss, SL Maltby, CA Palmer, CE Nash, E Smart, DL Holliday, V Speirs