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Department
  • Clinical Neurosciences
    • Institute
  • John van Geest Centre for Brain Repair
    • Research Theme Beyond the Neuron
    Research Focus

    Keywords

  • Repair Schwann Cell
  • Schwann Cells
  • Glia
  • Axon & Neuronal Degeneration
  • Injury & Regeneration
  • Peripheral Nerve Repair
  • Neuromuscular

    • Clinical Conditions

  • Other 

    • Equipment & Techniques

  • Cell culture
  • Confocal microscopy
  • Other

    • Science Culture

  • Reproducibility in Science
  • Open Access
  • Mentorship
  • Industry Engagement

    • Back

    Dr Peter Arthur-Farraj MRCP MBBS BSc PhD

    University Position
    Visiting Scientist

    Interests

    I am a neurology registrar with an interest in neuromuscular disorders and nerve repair. I have recently been awarded a Wellcome Trust Clinical Career Development Fellowship, to work with Professor Michael Coleman?s group at the John Van Geest Centre for Brain Repair. My research is focused on how the nerve supporting cells, Schwann cells, transform after injury into a specialized cell type called Repair Schwann cells, to help promote both nerve cell (neuron) survival and regrowth. I am using a variety of techniques, including live imaging of Schwann cells-neuronal interactions in zebrafish, mammalian Schwann cells/neuron co-cultures in microfluidic chambers, genetic mouse models and viral vectors. My long-term career aim is to translate my research to help generate new treatments, particularly using gene therapy for traumatic nerve injury and neuromuscular disease.

    Myelinating Schwann cell neuron culture

    Myelinating Schwann cell Dorsal root ganglion coculture in microfluidic chambers

    Collaborators

    Cambridge
  • Michael Coleman
  • Roger Barker
    • External
  • Jose Gomez-Sanchez
  • Hugo Cabedo
  • Ruth Stassart
  • Robert Fledrich

    • Key Publications

    Repair Schwann cell update: Adaptive reprogramming, EMT, and stemness in regenerating nerves.

    DOI: http://doi.org/10.1002/glia.23532
    Journal: Glia
    E-pub date: 1 Mar 2019
    Authors: KR Jessen, P Arthur-Farraj

    Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury.

    DOI: http://doi.org/10.1016/j.celrep.2017.08.064
    Journal: Cell Rep
    E-pub date: 12 Sep 2017
    Authors: PJ Arthur-Farraj, CC Morgan, M Adamowicz, JA Gomez-Sanchez, SV Fazal, A Beucher, B Razzaghi, R Mirsky, KR Jessen, TJ Aitman

    c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration.

    DOI: http://doi.org/10.1016/j.neuron.2012.06.021
    Journal: Neuron
    E-pub date: 23 Aug 2012
    Authors: PJ Arthur-Farraj, M Latouche, DK Wilton, S Quintes, E Chabrol, A Banerjee, A Woodhoo, B Jenkins, M Rahman, M Turmaine, GK Wicher, R Mitter, L Greensmith, A Behrens, G Raivich, R Mirsky, KR Jessen

    Publications

    A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.

    DOI: http://doi.org/10.7554/eLife.72917
    Journal: Elife
    E-pub date: 25 Jan 2022
    Authors: S Velasco-Aviles, N Patel, A Casillas-Bajo, L Frutos-Rincón, E Velasco, J Gallar, P Arthur-Farraj, JA Gomez-Sanchez, H Cabedo

    Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.

    DOI: http://doi.org/10.7554/eLife.72823
    Journal: Elife
    E-pub date: 6 Dec 2021
    Authors: A Loreto, C Angeletti, W Gu, A Osborne, B Nieuwenhuis, J Gilley, E Merlini, P Arthur-Farraj, A Amici, Z Luo, L Hartley-Tassell, T Ve, LM Desrochers, Q Wang, B Kobe, G Orsomando, MP Coleman

    Lessons from Injury: How Nerve Injury Studies Reveal Basic Biological Mechanisms and Therapeutic Opportunities for Peripheral Nerve Diseases.

    DOI: http://doi.org/10.1007/s13311-021-01125-3
    Journal: Neurotherapeutics
    E-pub date: 1 Oct 2021
    Authors: P Arthur-Farraj, MP Coleman

    Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study.

    DOI: http://doi.org/10.1016/S0140-6736(21)01608-1
    Journal: Lancet
    E-pub date: 25 Sep 2021
    Authors: RJ Perry, A Tamborska, B Singh, B Craven, R Marigold, P Arthur-Farraj, JM Yeo, L Zhang, G Hassan-Smith, M Jones, C Hutchcroft, E Hobson, D Warcel, D White, P Ferdinand, A Webb, T Solomon, M Scully, DJ Werring, C Roffe, CVT After Immunisation Against COVID-19 (CAIAC) collaborators

    Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study.

    DOI: http://doi.org/10.1016/S2215-0366(20)30287-X
    Journal: Lancet Psychiatry
    E-pub date: 1 Oct 2020
    Authors: A Varatharaj, N Thomas, MA Ellul, NWS Davies, TA Pollak, EL Tenorio, M Sultan, A Easton, G Breen, M Zandi, JP Coles, H Manji, R Al-Shahi Salman, DK Menon, TR Nicholson, LA Benjamin, A Carson, C Smith, MR Turner, T Solomon, R Kneen, SL Pett, I Galea, RH Thomas, BD Michael, CoroNerve Study Group

    DNA methylation in Schwann cells and in oligodendrocytes.

    DOI: http://doi.org/10.1002/glia.23784
    Journal: Glia
    E-pub date: 31 Aug 2020
    Authors: P Arthur-Farraj, S Moyon

    Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

    DOI: http://doi.org/10.1101/2020.10.06.327957
    Journal:
    E-pub date: 1 Aug 2020
    Authors: LJ Wagstaff, JA Gomez-Sanchez, SV Fazal, GW Otto, AM Kilpatrick, K Michael, LYN Wong, KH Ma, M Turmaine, J Svaren, T Gordon, P Arthur-Farraj, S Velasco-Aviles, H Cabedo, C Benito, R Mirsky, KR Jessen

    The Role of Cell Plasticity in Tissue Repair: Adaptive Cellular Reprogramming.

    DOI: http://doi.org/10.1016/j.devcel.2015.09.005
    Journal: Dev Cell
    E-pub date: 28 Sep 2015
    Authors: KR Jessen, R Mirsky, P Arthur-Farraj

    Longevity and Patau syndrome: what determines survival?

    DOI: http://doi.org/10.1136/bcr-06-2011-4381
    Journal: BMJ Case Rep
    E-pub date: 6 Dec 2012
    Authors: S Peroos, E Forsythe, JH Pugh, P Arthur-Farraj, D Hodes

    Hand weakness in Charcot-Marie-Tooth disease 1X.

    DOI: http://doi.org/10.1016/j.nmd.2012.02.008
    Journal: Neuromuscul Disord
    E-pub date: 1 Jul 2012
    Authors: PJ Arthur-Farraj, SM Murphy, M Laura, MP Lunn, H Manji, J Blake, G Ramdharry, Z Fox, MM Reilly

    Mouse schwann cells need both NRG1 and cyclic AMP to myelinate.

    DOI: http://doi.org/10.1002/glia.21144
    Journal: Glia
    E-pub date: 1 May 2011
    Authors: P Arthur-Farraj, K Wanek, J Hantke, CM Davis, A Jayakar, DB Parkinson, R Mirsky, KR Jessen

    Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation.

    DOI: http://doi.org/10.1111/j.1529-8027.2008.00168.x
    Journal: J Peripher Nerv Syst
    E-pub date: 1 Jun 2008
    Authors: R Mirsky, A Woodhoo, DB Parkinson, P Arthur-Farraj, A Bhaskaran, KR Jessen

    c-Jun is a negative regulator of myelination.

    DOI: http://doi.org/10.1083/jcb.200803013
    Journal: J Cell Biol
    E-pub date: 19 May 2008
    Authors: DB Parkinson, A Bhaskaran, P Arthur-Farraj, LA Noon, A Woodhoo, AC Lloyd, ML Feltri, L Wrabetz, A Behrens, R Mirsky, KR Jessen

    A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy.

    DOI: http://doi.org/10.1016/j.nbd.2006.06.006
    Journal: Neurobiol Dis
    E-pub date: 1 Oct 2006
    Authors: P Arthur-Farraj, R Mirsky, DB Parkinson, KR Jessen

    Schwann cells are axo-protective after injury irrespective of myelination status in mouse Schwann cell–neuron cocultures

    DOI: https://doi.org/10.1242/jcs.261557
    Journal: Journal of Cell Science
    Year: 2023
    Authors: Clara Mutschler, Shaline V. Fazal, Nathalie Schumacher, Andrea Loreto, Michael P. Coleman, Peter Arthur-Farraj

    SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice

    DOI: http://doi.org/10.3389/fncel.2023.1158388
    Journal: Frontiers in Cellular Neuroscience
    Year: 2023
    Authors: Shaline V Fazal, Clara Mutschler, Civia Z Chen, Mark Turmaine, Chiung-Ya Chen, Yi-Ping Hsueh, Andrea Ibañez-Grau, Andrea Loreto, Angeles Casillas-Bajo, Hugo Cabedo, Robin JM Franklin, Roger A Barker, Kelly R Monk, Benjamin J Steventon, Michael P Coleman, Jose A Gomez-Sanchez, Peter Arthur-Farraj