Equipment & Techniques
I am a neurology registrar with an interest in neuromuscular disorders and nerve repair. I have recently been awarded a Wellcome Trust Clinical Career Development Fellowship, to work with Professor Michael Coleman?s group at the John Van Geest Centre for Brain Repair. My research is focused on how the nerve supporting cells, Schwann cells, transform after injury into a specialized cell type called Repair Schwann cells, to help promote both nerve cell (neuron) survival and regrowth. I am using a variety of techniques, including live imaging of Schwann cells-neuronal interactions in zebrafish, mammalian Schwann cells/neuron co-cultures in microfluidic chambers, genetic mouse models and viral vectors. My long-term career aim is to translate my research to help generate new treatments, particularly using gene therapy for traumatic nerve injury and neuromuscular disease.
Myelinating Schwann cell neuron culture
Myelinating Schwann cell Dorsal root ganglion coculture in microfluidic chambers