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Research Theme Neurons, Circuits and Networks Beyond the Neuron
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Professor Peter Hutchinson

University Position
Professor

Interests

I am a NIHR Research Professor at the Department of Clinical Neurosciences, University of Cambridge and Honorary Consultant Neurosurgeon at Addenbrooke's Hospital, Cambridge. I have a general neurosurgical practice with a subspecialist interest in the management of patients with neurological trauma. My research interests include traumatic brain injury (Chief Investigator of the MRC/NIHR-funded RESCUEicp decompressive study), multimodality monitoring in neurocritical care, and functional brain imaging. I was the previous Chair of the European Association of Neurological Societies (EANS) Research Committee and am now a Vice President of the EANS. I am also the Neurosurgical Specialty Lead at the Royal College of Surgeons of England; Chair of the Society of British Neurological Surgeons (SBNS) Neurotrauma Group; a member of the SBNS Council; Director of Clinical Studies and Fellow at Robinson College, Cambridge; and Chief Medical Officer for the Formula 1 British Grand Prix.

Key Publications

Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury.

DOI: http://doi.org/10.1093/brain/awad056
Journal: Brain
E-pub date: 1 Aug 2023
Authors: RE Woodrow, S Winzeck, AI Luppi, IR Kelleher-Unger, LRB Spindler, JTL Wilson, VFJ Newcombe, JP Coles, CENTER-TBI MRI Substudy Participants and Investigators, DK Menon, EA Stamatakis

Serum biomarkers identify critically ill traumatic brain injury patients for MRI

DOI: http://doi.org/10.1186/s13054-022-04250-3
Journal: Crit Care
E-pub date: 29 Nov 2022
Authors: S Richter, S Winzeck, E Czeiter, K Amrein, EN Kornaropoulos, J Verheyden, G Sugar, Z Yang, K Wang, AIR Maas, E Steyerberg, A Büki, VFJ Newcombe, DK Menon, K Amrein, N Andelic, L Andreassen, A Anke, P Azouvi, B Bellander, H Benali, A Buki, A Caccioppola, E Calappi, M Carbonara, G Citerio, H Clusmann, M Coburn, J Coles, M Correia, E Czeiter, V De Keyser, V Degos, B Depreitere, L Eikenes, E Ezer, K Foks, S Frisvold, D Galanaud, A Ghuysen, B Glocker, A Haberg, I Haitsma, E Helseth, PJ Hutchinson, E Kornaropoulos, N Kovács, A Kowark, S Laureys, D Ledoux, H Lingsma, AIR Maas, G Manley, DK Menon, T Menovsky, B Misset, V Muraleedharan, I Nakken, V Newcombe, W Nordhøy, J Nyirádi, F Ortolano, PM Parizel, V Perlbarg, P Persona, W Peul, JP Posti, L Puybasset, S Richter, C Roe, O Roise, R Rossaint, S Rossi, D Rueckert, T Skandsen, A Sorinola, E Stamatakis, EW Steyerberg, N Stocchetti, R Takala, V Tamás, O Tenovuo, Z Vámos, G Van der Steen, W Van Hecke, TV Vyvere, J Verheyden, A Vik, V Volovici, LT Westlye, G Williams, S Winzeck, P Ylén, T Zoerle

Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury.

DOI: http://doi.org/10.1093/brain/awab255
Journal: Brain
E-pub date: 16 Dec 2021
Authors: J Hermanides, YT Hong, M Trivedi, J Outtrim, F Aigbirhio, PJ Nestor, M Guilfoyle, S Winzeck, VFJ Newcombe, T Das, MM Correia, KLH Carpenter, PJA Hutchinson, AK Gupta, TD Fryer, JD Pickard, DK Menon, JP Coles

Spatial and Temporal Pattern of Ischemia and Abnormal Vascular Function Following Traumatic Brain Injury.

DOI: http://doi.org/10.1001/jamaneurol.2019.3854
Journal: JAMA Neurol
E-pub date: 1 Mar 2020
Authors: Y Launey, TD Fryer, YT Hong, LA Steiner, J Nortje, TV Veenith, PJ Hutchinson, A Ercole, AK Gupta, FI Aigbirhio, JD Pickard, JP Coles, DK Menon

Diffusion limited oxygen delivery following head injury.

DOI: http://doi.org/10.1097/01.ccm.0000127777.16609.08
Journal: Crit Care Med
E-pub date: 1 Jun 2004
Authors: DK Menon, JP Coles, AK Gupta, TD Fryer, P Smielewski, DA Chatfield, F Aigbirhio, JN Skepper, PS Minhas, PJ Hutchinson, TA Carpenter, JC Clark, JD Pickard

Incidence and mechanisms of cerebral ischemia in early clinical head injury.

DOI: http://doi.org/10.1097/01.WCB.0000103022.98348.24
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Feb 2004
Authors: JP Coles, TD Fryer, P Smielewski, DA Chatfield, LA Steiner, AJ Johnston, SPMJ Downey, GB Williams, F Aigbirhio, PJ Hutchinson, K Rice, TA Carpenter, JC Clark, JD Pickard, DK Menon

Publications

How prolonged is a prolonged disorder of consciousness? Longterm follow-up of 71 consecutive admissions

DOI: http://doi.org/10.1136/jnnp-2022-abn.16
Journal: Journal of Neurology, Neurosurgery & Psychiatry
E-pub date: 1 Jun 2022
Authors: J Allanson, T Holland, J Pickard, E Kamau, C Bareham, N Roberts, E Stamatakis, D Menon, P Hutchinson, S Barclay

Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients.

DOI: http://doi.org/10.1089/neu.2020.7300
Journal: J Neurotrauma
E-pub date: 15 May 2021
Authors: SA Dijkland, IRAR Helmrich, D Nieboer, M van der Jagt, DWJ Dippel, DK Menon, N Stocchetti, AIR Maas, HF Lingsma, EW Steyerberg, CENTER-TBI Participants and Investigators

A map of transcriptional heterogeneity and regulatory variation in human microglia

DOI: http://doi.org/10.1101/2019.12.20.874099
Journal:
E-pub date: 1 Aug 2019
Authors: AMH Young, N Kumasaka, F Calvert, T Hammond, A Knights, N Panousis, J Schwartzentruber, J Liu, K Kundu, M Segel, N Murphy, C McMurran, H Bulstrode, J Correia, K Budohoski, A Joannides, M Guilfoyle, R Trivedi, R Kirollos, R Morris, M Garnett, H Fernandes, I Timofeev, I Jalloh, K Holland, R Mannion, R Mair, C Watts, S Price, P Kirkpatrick, T Santarius, N Soranzo, B Stevens, P Hutchinson, RJM Franklin, D Gaffney

Dynamic Changes in White Matter Abnormalities Correlate With Late Improvement and Deterioration Following TBI: A Diffusion Tensor Imaging Study.

DOI: http://doi.org/10.1177/1545968315584004
Journal: Neurorehabil Neural Repair
E-pub date: 1 Jan 2016
Authors: VFJ Newcombe, MM Correia, C Ledig, MG Abate, JG Outtrim, D Chatfield, T Geeraerts, AE Manktelow, E Garyfallidis, JD Pickard, BJ Sahakian, PJA Hutchinson, D Rueckert, JP Coles, GB Williams, DK Menon

Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study.

DOI: http://doi.org/10.1227/NEU.0000000000000575
Journal: Neurosurgery
E-pub date: 1 Jan 2015
Authors: AIR Maas, DK Menon, EW Steyerberg, G Citerio, F Lecky, GT Manley, S Hill, V Legrand, A Sorgner, CENTER-TBI Participants and Investigators

Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.

DOI: http://doi.org/10.1001/jamaneurol.2013.4847
Journal: JAMA Neurol
E-pub date: 1 Jan 2014
Authors: YT Hong, T Veenith, D Dewar, JG Outtrim, V Mani, C Williams, S Pimlott, PJA Hutchinson, A Tavares, R Canales, CA Mathis, WE Klunk, FI Aigbirhio, JP Coles, J-C Baron, JD Pickard, TD Fryer, W Stewart, DK Menon

Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging.

DOI: http://doi.org/10.1038/jcbfm.2013.11
Journal: Journal of Cerebral Blood Flow and Metabolism
E-pub date: 1 Jun 2013
Authors: VFJ Newcombe, GB Williams, JG Outtrim, D Chatfield, M Gulia Abate, T Geeraerts, A Manktelow, H Room, L Mariappen, PJ Hutchinson, JP Coles, DK Menon

Critical thresholds for cerebrovascular reactivity after traumatic brain injury.

DOI: http://doi.org/10.1007/s12028-011-9630-8
Journal: Neurocrit Care
E-pub date: 1 Apr 2012
Authors: E Sorrentino, J Diedler, M Kasprowicz, KP Budohoski, C Haubrich, P Smielewski, JG Outtrim, A Manktelow, PJ Hutchinson, JD Pickard, DK Menon, M Czosnyka

Correlation of MR relative cerebral blood volume measurements with cellular density and proliferation in high-grade gliomas: an image-guided biopsy study.

DOI: http://doi.org/10.3174/ajnr.A2312
Journal: AJNR Am J Neuroradiol
E-pub date: 1 Mar 2011
Authors: SJ Price, HAL Green, AF Dean, J Joseph, PJ Hutchinson, JH Gillard

In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines.

DOI: http://doi.org/10.1007/s11060-009-9990-5
Journal: J Neurooncol
E-pub date: 1 Mar 2010
Authors: HJ Marcus, KLH Carpenter, SJ Price, PJ Hutchinson

Imaging regional variation of cellular proliferation in gliomas using 3′-deoxy-3′-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study.

DOI: http://doi.org/10.1016/j.crad.2008.01.016
Journal: Clin Radiol
E-pub date: 1 Jan 2009
Authors: SJ Price, TD Fryer, MC Cleij, AF Dean, J Joseph, R Salvador, DD Wang, PJ Hutchinson, JC Clark, NG Burnet, JD Pickard, FI Aigbirhio, JH Gillard

A combined microdialysis and FDG-PET study of glucose metabolism in head injury.

DOI: http://doi.org/10.1007/s00701-008-0169-1
Journal: ACTA NEUROCHIR
E-pub date: 1 Jan 2009
Authors: PJ Hutchinson, MT O'Connell, A Seal, J Nortje, I Timofeev, PG Al-Rawi, JP Coles, TD Fryer, DK Menon, JD Pickard, KLH Carpenter

Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings.

DOI: http://doi.org/10.1097/01.CCM.0000292014.60835.15
Journal: Crit Care Med
E-pub date: 1 Jan 2008
Authors: J Nortje, JP Coles, I Timofeev, TD Fryer, FI Aigbirhio, P Smielewski, JG Outtrim, DA Chatfield, JD Pickard, PJ Hutchinson, AK Gupta, DK Menon

Coexisting low cerebral blood flow and volume in head injury is due to microvascular ischaemia, not hypometabolism

DOI: http://doi.org/10.1097/00003643-200509001-00072
Journal: European Journal of Anaesthesiology
E-pub date: 1 Sep 2005
Authors: JP Coles, DK Menon, TD Fryer, DA Chatfield, AK Gupta, LA Steiner, AJ Johnston, J Nortje, PJA Hutchinson, FI Aigbirhio, JC Clark, JD Pickard

Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury.

DOI: http://doi.org/10.1097/01.ccm.0000149837.09225.bd
Journal: Crit Care Med
E-pub date: 1 Jan 2005
Authors: AJ Johnston, LA Steiner, JP Coles, DA Chatfield, TD Fryer, P Smielewski, PJ Hutchinson, MT O'Connell, PG Al-Rawi, FI Aigbirihio, JC Clark, JD Pickard, AK Gupta, DK Menon

Glucose metabolism in traumatic brain injury: a combined microdialysis and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) study.

DOI: http://doi.org/10.1007/3-211-32318-X_35
Journal: Acta Neurochirurgica, Supplementum
E-pub date: 1 Jan 2005
Authors: MT O'Connell, A Seal, J Nortje, PG Al-Rawi, JP Coles, TD Fryer, DK Menon, JD Pickard, PJ Hutchinson

Imaging of cerebral blood flow and metabolism in brain injury in the ICU.

DOI: http://doi.org/10.1007/3-211-32318-X_94
Journal: Acta Neurochirurgica, Supplementum
E-pub date: 1 Jan 2005
Authors: JD Pickard, PJ Hutchinson, JP Coles, LA Steiner, AJ Johnston, TD Fryer, MR Coleman, P Smielewski, DA Chatfield, F Aigbirhio, GB Williams, K Rice, JC Clark, CH Salmond, BJ Sahakian, PG Bradley, TA Carpenter, R Salvador, A Pena, JH Gillard, AS Cunningham, S Piechnik, M Czosnyka, DK Menon

Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study.

DOI: http://doi.org/10.1097/00004647-200206000-00012
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Jun 2002
Authors: PJ Hutchinson, AK Gupta, TF Fryer, PG Al-Rawi, DA Chatfield, JP Coles, MT O'Connell, R Kett-White, PS Minhas, FI Aigbirhio, JC Clark, PJ Kirkpatrick, DK Menon, JD Pickard

Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method.

DOI: http://doi.org/10.3171/jns.2002.96.2.0263
Journal: J Neurosurg
E-pub date: 1 Feb 2002
Authors: AK Gupta, PJ Hutchinson, T Fryer, PG Al-Rawi, DA Parry, PS Minhas, R Kett-White, PJ Kirkpatrick, JC Mathews, S Downey, F Aigbirhio, J Clark, JD Pickard, DK Menon

Potential role of NovoSeven in the prevention of rebleeding following aneurysmal subarachnoid haemorrhage.

DOI: http://doi.org/10.1097/00001721-200004001-00022
Journal: Blood Coagul Fibrinolysis
E-pub date: 1 Apr 2000
Authors: JD Pickard, PJ Kirkpatrick, T Melsen, RB Andreasen, L Gelling, T Fryer, J Matthews, P Minhas, PJ Hutchinson, D Menon, SP Downey, I Kendall, J Clark, TA Carpenter, E Williams, L Persson