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Department
  • Psychiatry
    • Institute
  • Brain Mapping Unit
  • MRC Laboratory of Molecular Biology
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    Research Theme Neurons, Circuits and Networks Lifelong Brain Development and Brain Ageing Brains and Machines

    Other Interdiciplinary Incentives

  • Neuroscience

    • Research Focus

    Keywords

  • Systems Neuroscience
  • Brain Networks
  • Computational Psychiatry
  • Brain Development

    • Clinical Conditions

  • Schizophrenia
  • Depressive disorders
  • Rett syndrome

    • Equipment & Techniques

  • Computational modelling

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    Professor Petra Vertes

    University Position
    Professor

    Interests

    I lead the Systems and Computational Neuroscience group in the Department of Psychiatry, and I am a visiting scientist at the MRC Laboratory of Molecular Biology. I am also one of the co-founders of the Cambridge Networks Network - a forum for academics across different disciplines who share an interest in Network Science. My research applies tools from physics, engineering and network science to fundamental problems in neuroscience and mental health. In particular, I am interested in the structure-function relationship in brain networks, from the microscopic scale of neurons to the large-scale connectivity of brain regions, in both health and disease. I work with a wide variety of multivariate data, including genetic and transcriptomic data, flow cytometry and neuroimaging data. I also study simpler organisms, such as C. elegans, which provide a testbed for methodological innovations as well as insights into generalisable aspects of brain organisation, brain development, network dysfunction and repair.

    Associated News Items

    Key Publications

    Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia.

    DOI: http://doi.org/10.1038/s41593-024-01624-4
    Journal: Nat Neurosci
    E-pub date: 1 Jun 2024
    Authors: R Dear, K Wagstyl, J Seidlitz, RD Markello, A Arnatkevičiūtė, KM Anderson, RAI Bethlehem, Lifespan Brain Chart Consortium, A Raznahan, ET Bullmore, PE Vértes

    conn2res: A toolbox for connectome-based reservoir computing

    DOI: http://doi.org/10.21203/rs.3.rs-3084265/v1
    Journal:
    E-pub date: 1 Aug 2023
    Authors: B Misic, L Suarez, A Mihalik, F Milisav, K Marshall, M Li, P Vertes, G Lajoie

    The neuropeptidergic connectome ofC. elegans

    DOI: http://doi.org/10.1101/2022.10.30.514396
    Journal:
    E-pub date: 31 Oct 2022
    Authors: L Ripoll-Sánchez, J Watteyne, H Sun, R Fernandez, SR Taylor, A Weinreb, M Hammarlund, DM Miller, O Hobert, I Beets, PE Vértes, WR Schafer

    Three components of human brain gene expression reflect normative developmental programmes with specific links to neurodevelopmental disorders

    DOI: http://doi.org/10.1101/2022.10.05.510582
    Journal:
    E-pub date: 1 Aug 2022
    Authors: R Dear, K Wagstyl, J Seidlitz, R Markello, A Arnatkevičiūtė, K Anderson, RAI Bethlehem, A Raznahan, E Bullmore, P Vértes, Lifespan Brain Chart Consortium

    Sexually divergent development of depression-related brain networks during healthy human adolescence.

    DOI: http://doi.org/10.1126/sciadv.abm7825
    Journal: Sci Adv
    E-pub date: 27 May 2022
    Authors: L Dorfschmidt, RA Bethlehem, J Seidlitz, F Váša, SR White, R Romero-García, MG Kitzbichler, AR Aruldass, SE Morgan, IM Goodyer, P Fonagy, PB Jones, RJ Dolan, NSPN Consortium, NA Harrison, PE Vértes, ET Bullmore

    Brain charts for the human lifespan

    DOI: http://doi.org/10.1101/2021.06.08.447489
    Journal:
    E-pub date: 1 Aug 2021
    Authors: RAI Bethlehem, J Seidlitz, SR White, JW Vogel, KM Anderson, C Adamson, S Adler, GS Alexopoulos, E Anagnostou, A Areces-Gonzalez, DE Astle, B Auyeung, M Ayub, G Ball, S Baron-Cohen, R Beare, SA Bedford, V Benegal, F Beyer, J Bin Bae, J Blangero, M Blesa Cábez, JP Boardman, M Borzage, JF Bosch-Bayard, N Bourke, VD Calhoun, MM Chakravarty, C Chen, C Chertavian, G Chetelat, YS Chong, JH Cole, A Corvin, M Costantino, E Courchesne, F Crivello, VL Cropley, J Crosbie, N Crossley, M Delarue, R Delorme, S Desrivieres, G Devenyi, MA Di Biase, R Dolan, KA Donald, G Donohoe, K Dunlop, AD Edwards, JT Elison, CT Ellis, JA Elman, L Eyler, DA Fair, E Feczko, PC Fletcher, P Fonagy, CE Franz, L Galan-Garcia, A Gholipour, J Giedd, JH Gilmore, DC Glahn, I Goodyer, PE Grant, NA Groenewold, FM Gunning, RE Gur, RC Gur, CF Hammill, O Hansson, T Hedden, A Heinz, RN Henson, K Heuer, J Hoare, B Holla, AJ Holmes, R Holt, H Huang, K Im, J Ipser, CR Jack, AP Jackowski, T Jia, KA Johnson, PB Jones, DT Jones, R Kahn, H Karlsson, L Karlsson, R Kawashima, EA Kelley, S Kern, K Kim, MG Kitzbichler, WS Kremen, F Lalonde, B Landeau, S Lee, J Lerch, JD Lewis, J Li, W Liao, C Liston, MV Lombardo, J Lv, C Lynch, TT Mallard, M Marcelis, RD Markello, SR Mathias, B Mazoyer, P McGuire, MJ Meaney, A Mechelli, N Medic, B Misic, SE Morgan, D Mothersill, J Nigg, MQW Ong, C Ortinau, C Ortinau, R Ossenkoppele, M Ouyang, L Palaniyappan, L Paly, PM Pan, C Pantelis, MM Park, T Paus, Z Pausova, D Paz-Linares, A Pichet Binette, K Pierce, X Qian, J Qiu, A Qiu, A Raznahan, T Rittman, A Rodrigue, CK Rollins, R Romero-Garcia, L Ronan, MD Rosenberg, DH Rowitch, GA Salum, TD Satterthwaite, HL Schaare, RJ Schachar, AP Schultz, G Schumann, M Schöll, D Sharp, RT Shinohara, I Skoog, CD Smyser, RA Sperling, DJ Stein, A Stolicyn, J Suckling, G Sullivan, Y Taki, B Thyreau, R Toro, N Traut, KA Tsvetanov, NB Turk-Browne, JJ Tuulari, C Tzourio, É Vachon-Presseau, MJ Valdes-Sosa, PA Valdes-Sosa, SL Valk, T van Amelsvoort, SN Vandekar, L Vasung, LW Victoria, S Villeneuve, A Villringer, A Villringer, PE Vértes, K Wagstyl, YS Wang, SK Warfield, V Warrier, E Westman, ML Westwater, HC Whalley, AV Witte, N Yang, B Yeo, H Yun, A Zalesky, HJ Zar, A Zettergren, JH Zhou, H Ziauddeen, A Zugman, XN Zuo, ET Bullmore, AF Alexander-Bloch, 3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, UMN BCP, CALM Team, Cam-CAN, CCNP, COBRE, Developing Human Connectome Project, ENIGMA Developmental Brain Age working group, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, The Mayo Clinic Study of Aging, NSPN, POND, The PREVENT-AD Research Group, VETSA

    A generative network model of neurodevelopmental diversity in structural brain organization.

    DOI: http://doi.org/10.1038/s41467-021-24430-z
    Journal: Nat Commun
    E-pub date: 9 Jul 2021
    Authors: D Akarca, PE Vértes, ET Bullmore, CALM team, DE Astle

    Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population

    DOI: http://doi.org/10.1101/668939
    Journal:
    E-pub date: 1 Aug 2019
    Authors: M Montagnese, F Knolle, J Haarsma, JD Griffin, A Richards, P Vertes, B Kiddle, PC Fletcher, PB Jones, MJ Owen, P Fonagy, ET Bullmore, R Dolan, NSPN Consortium, M Moutoussis, I Goodyer, GK Murray

    Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes.

    DOI: http://doi.org/10.1073/pnas.1820754116
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 7 May 2019
    Authors: SE Morgan, J Seidlitz, KJ Whitaker, R Romero-Garcia, NE Clifton, C Scarpazza, T van Amelsvoort, M Marcelis, J van Os, G Donohoe, D Mothersill, A Corvin, A Pocklington, A Raznahan, P McGuire, PE Vértes, ET Bullmore

    Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder.

    DOI: http://doi.org/10.1126/scitranslmed.aal3236
    Journal: Sci Transl Med
    E-pub date: 3 Apr 2019
    Authors: A Etkin, A Maron-Katz, W Wu, GA Fonzo, J Huemer, PE Vértes, B Patenaude, J Richiardi, MS Goodkind, CJ Keller, J Ramos-Cejudo, YV Zaiko, KK Peng, E Shpigel, P Longwell, RT Toll, A Thompson, S Zack, B Gonzalez, R Edelstein, J Chen, I Akingbade, E Weiss, R Hart, S Mann, K Durkin, SH Baete, FE Boada, A Genfi, J Autea, J Newman, DJ Oathes, SE Lindley, D Abu-Amara, BA Arnow, N Crossley, J Hallmayer, S Fossati, BO Rothbaum, CR Marmar, ET Bullmore, R O'Hara

    Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder.

    DOI: http://doi.org/10.1016/j.biopsych.2017.01.021
    Journal: Biol Psychiatry
    E-pub date: 1 Jan 2018
    Authors: GGR Leday, PE Vértes, S Richardson, JR Greene, T Regan, S Khan, R Henderson, TC Freeman, CM Pariante, NA Harrison, MRC Immunopsychiatry Consortium, VH Perry, WC Drevets, GM Wittenberg, ET Bullmore

    Network control principles predict neuron function in the Caenorhabditis elegans connectome.

    DOI: http://doi.org/10.1038/nature24056
    Journal: Nature
    E-pub date: 26 Oct 2017
    Authors: G Yan, PE Vértes, EK Towlson, YL Chew, DS Walker, WR Schafer, A-L Barabási

    The Multilayer Connectome of Caenorhabditis elegans.

    DOI: http://doi.org/10.1371/journal.pcbi.1005283
    Journal: PLoS Comput Biol
    E-pub date: 1 Dec 2016
    Authors: B Bentley, R Branicky, CL Barnes, YL Chew, E Yemini, ET Bullmore, PE Vértes, WR Schafer

    Phase transition in the economically modeled growth of a cellular nervous system.

    DOI: http://doi.org/10.1073/pnas.1300753110
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 7 May 2013
    Authors: V Nicosia, PE Vértes, WR Schafer, V Latora, ET Bullmore

    The rich club of the C. elegans neuronal connectome.

    DOI: http://doi.org/10.1523/JNEUROSCI.3784-12.2013
    Journal: J Neurosci
    E-pub date: 10 Apr 2013
    Authors: EK Towlson, PE Vértes, SE Ahnert, WR Schafer, ET Bullmore

    Simple models of human brain functional networks.

    DOI: http://doi.org/10.1073/pnas.1111738109
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 10 Apr 2012
    Authors: PE Vértes, AF Alexander-Bloch, N Gogtay, JN Giedd, JL Rapoport, ET Bullmore

    Publications

    The impact of the initial COVID-19 outbreak on young adults’ mental health: a longitudinal study of risk and resilience factors.

    DOI: http://doi.org/10.1038/s41598-022-21053-2
    Journal: Sci Rep
    E-pub date: 5 Oct 2022
    Authors: A Wiedemann, J Stochl, SAS Neufeld, J Fritz, J Bhatti, RW Hook, NSPN Consortium, IM Goodyer, RJ Dolan, ET Bullmore, SR Chamberlain, P Fonagy, J Perez, PB Jones

    Brain charts for the human lifespan

    DOI: http://doi.org/10.1038/s41586-022-04554-y
    Journal: Nature
    E-pub date: 6 Apr 2022
    Authors: RAI Bethlehem, J Seidlitz, SR White, JW Vogel, KM Anderson, C Adamson, S Adler, GS Alexopoulos, E Anagnostou, A Areces-Gonzalez, DE Astle, B Auyeung, M Ayub, G Ball, S Baron-Cohen, R Beare, SA Bedford, V Benegal, F Beyer, J Bin Bae, J Blangero, M Blesa Cábez, JP Boardman, M Borzage, JF Bosch-Bayard, N Bourke, VD Calhoun, MM Chakravarty, C Chen, C Chertavian, G Chetelat, YS Chong, JH Cole, A Corvin, E Courchesne, F Crivello, VL Cropley, J Crosbie, N Crossley, M Delarue, S Desrivieres, G Devenyi, MA Di Biase, R Dolan, KA Donald, G Donohoe, K Dunlop, AD Edwards, JT Elison, CT Ellis, JA Elman, L Eyler, DA Fair, PC Fletcher, P Fonagy, CE Franz, L Galan-Garcia, A Gholipour, J Giedd, JH Gilmore, DC Glahn, I Goodyer, PE Grant, NA Groenewold, FM Gunning, RE Gur, RC Gur, CF Hammill, O Hansson, T Hedden, A Heinz, R Henson, K Heuer, J Hoare, B Holla, AJ Holmes, R Holt, H Huang, K Im, J Ipser, CR Jack, AP Jackowski, T Jia, KA Johnson, PB Jones, DT Jones, R Kahn, H Karlsson, L Karlsson, R Kawashima, EA Kelley, S Kern, K Kim, MG Kitzbichler, WS Kremen, F Lalonde, B Landeau, S Lee, J Lerch, JD Lewis, J Li, W Liao, DP Linares, C Liston, MV Lombardo, J Lv, C Lynch, TT Mallard, M Marcelis, RD Markello, B Mazoyer, P McGuire, MJ Meaney, A Mechelli, N Medic, B Misic, SE Morgan, D Mothersill, J Nigg, MQW Ong, C Ortinau, R Ossenkoppele, M Ouyang, L Palaniyappan, L Paly, PM Pan, C Pantelis, MM Park, T Paus, Z Pausova, A Pichet Binette, K Pierce, X Qian, J Qiu, A Qiu, A Raznahan, T Rittman, CK Rollins, R Romero-Garcia, L Ronan, MD Rosenberg, DH Rowitch, GA Salum, TD Satterthwaite, HL Schaare, RJ Schachar, AP Schultz, G Schumann, M Schöll, D Sharp, RT Shinohara, I Skoog, CD Smyser, RA Sperling, DJ Stein, A Stolicyn, J Suckling, G Sullivan, Y Taki, B Thyreau, R Toro, KA Tsvetanov, NB Turk-Browne, JJ Tuulari, C Tzourio, É Vachon-Presseau, MJ Valdes-Sosa, PA Valdes-Sosa, SL Valk, T van Amelsvoort, SN Vandekar, L Vasung, LW Victoria, S Villeneuve, A Villringer, PE Vértes, K Wagstyl, YS Wang, SK Warfield, V Warrier, E Westman, ML Westwater, HC Whalley, AV Witte, N Yang, BTT Yeo, HJ Yun, A Zalesky, HJ Zar, A Zettergren, JH Zhou, H Ziauddeen, A Zugman, XN Zuo, AF Alexander-Bloch, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, ASRB, CALM Team, Cam-CAN, CCNP, 3R-BRAIN, COBRE, ENIGMA Developmental Brain Age working group, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, NSPN, OASIS-3, OpenPain Project, POND, The PREVENT-AD Research Group, VETSA, Bullmore, E.T

    Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression.

    DOI: http://doi.org/10.1016/j.bbi.2021.08.226
    Journal: Brain Behav Immun
    E-pub date: 1 Nov 2021
    Authors: AR Aruldass, MG Kitzbichler, SE Morgan, S Lim, M-E Lynall, L Turner, P Vertes, Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer’s Disease (NIMA), J Cavanagh, P Cowen, CM Pariante, NA Harrison, ET Bullmore

    A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index.

    DOI: http://doi.org/10.1016/j.bpsc.2020.12.017
    Journal: Biol Psychiatry Cogn Neurosci Neuroimaging
    E-pub date: 1 Jul 2021
    Authors: JJ Schubert, M Veronese, TD Fryer, R Manavaki, MG Kitzbichler, MA Nettis, V Mondelli, CM Pariante, ET Bullmore, NIMA Consortium, FE Turkheimer

    Decision-making ability, psychopathology, and brain connectivity.

    DOI: http://doi.org/10.1016/j.neuron.2021.04.019
    Journal: Neuron
    E-pub date: 16 Jun 2021
    Authors: M Moutoussis, B Garzón, S Neufeld, DR Bach, F Rigoli, I Goodyer, E Bullmore, NSPN Consortium, M Guitart-Masip, RJ Dolan

    Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population.

    DOI: http://doi.org/10.1016/j.schres.2020.04.022
    Journal: Schizophr Res
    E-pub date: 31 Aug 2020
    Authors: M Montagnese, F Knolle, J Haarsma, JD Griffin, A Richards, PE Vertes, B Kiddle, PC Fletcher, PB Jones, MJ Owen, P Fonagy, ET Bullmore, RJ Dolan, NSPN Consortium, M Moutoussis, IM Goodyer, GK Murray

    Adolescence is Associated with Genomically Patterned Consolidation of the Hubs of the Human Brain Connectome

    DOI: http://doi.org/10.1016/j.biopsych.2017.02.390
    Journal: BIOLOGICAL PSYCHIATRY
    E-pub date: 1 Aug 2017
    Authors: K Whitaker, P Vertes, R Romero-Garcia, F Vasa, M Moutoussis, G Prabhub, N Weiskopf, M Callaghan, K Wagstyl, T Rittman, R Tait, C Ooi, J Suckling, B Inkster, P Fonagy, R Dolan, P Jones, I Goodyer, E Bullmore

    Intra-cortical myelination during adolescence: linking MRI networks with gene transcription profiles

    DOI: http://doi.org/10.1016/S0924-977X(17)31087-8
    Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
    E-pub date: 1 Aug 2017
    Authors: K Whitaker, P Vertes, R Romero-Garcia, F Vasa, M Moutoussis, G Prabhu, N Weiskopf, MF Callaghan, K Wagstyl, T Rittman, R Tait, C Ooi, J Suckling, B Inkster, P Fonagy, RJ Dolan, PB Jones, IM Goodyer, ET Bullmore

    Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2016.09.001
    Journal: Neurobiol Aging
    E-pub date: 1 Dec 2016
    Authors: T Rittman, M Rubinov, PE Vértes, AX Patel, CE Ginestet, BCP Ghosh, RA Barker, MG Spillantini, ET Bullmore, JB Rowe

    Gene transcription profiles associated with inter-modular hubs and connection distance in human functional magnetic resonance imaging networks.

    DOI: http://doi.org/10.1098/rstb.2015.0362
    Journal: Philos Trans R Soc Lond B Biol Sci
    E-pub date: 5 Oct 2016
    Authors: PE Vértes, T Rittman, KJ Whitaker, R Romero-Garcia, F Váša, MG Kitzbichler, K Wagstyl, P Fonagy, RJ Dolan, PB Jones, IM Goodyer, NSPN Consortium, ET Bullmore

    Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome.

    DOI: http://doi.org/10.1073/pnas.1601745113
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 9 Aug 2016
    Authors: KJ Whitaker, PE Vértes, R Romero-Garcia, F Váša, M Moutoussis, G Prabhu, N Weiskopf, MF Callaghan, K Wagstyl, T Rittman, R Tait, C Ooi, J Suckling, B Inkster, P Fonagy, RJ Dolan, PB Jones, IM Goodyer, NSPN Consortium, ET Bullmore

    Peripheral Immune Cell Populations Associated with Cognitive Deficits and Negative Symptoms of Treatment-Resistant Schizophrenia.

    DOI: http://doi.org/10.1371/journal.pone.0155631
    Journal: PLoS One
    E-pub date: 1 Aug 2016
    Authors: E Fernandez-Egea, PE Vértes, SM Flint, L Turner, S Mustafa, A Hatton, KGC Smith, PA Lyons, ET Bullmore