Professor Patrick Yu-Wai-Man BMedSci, MBBS, PhD, FRCPath, FRCOphth

University Position

Professor

Professor Patrick Yu-Wai-Man is pleased to consider applications from prospective PhD students.

Interests

I am an academic neuro-ophthalmologist with a major research interest in optic neuropathies, neurogenetics and mitochondrial eye diseases. I hold joint clinical appointments at Addenbrooke's Hospital in Cambridge and Moorfields Eye Hospital in London as an Honorary Consultant. My research programme is currently focused on dissecting the disease mechanisms leading to progressive retinal ganglion cell loss in inherited optic neuropathies by using a combination of patient tissues, induced pluripotent stem cells and animal models. I was awarded an NIHR Advanced Fellowship (2021-2026) to evaluate patient outcomes and fast track the development of effective therapies for this group of disorders, in particular novel gene therapy approaches. I am the Director of the Cambridge Clinical Vision Laboratory (CCVL) that was set up as a cross-cutting facility to support advanced therapeutics on the Cambridge Biomedical Campus. https://pubmed.ncbi.nlm.nih.gov/?term=Yu-Wai-Man+P&sort=pubdate

Key Publications

Publications

Randomized trial of bilateral gene therapy injection for m.11778G>A MT-ND4 Leber optic neuropathy.

DOI: http://doi.org/10.1093/brain/awac421
Journal: Brain
E-pub date: 19 Apr 2023
Authors: NJ Newman, P Yu-Wai-Man, PS Subramanian, ML Moster, A-G Wang, SP Donahue, BP Leroy, V Carelli, V Biousse, C Vignal-Clermont, RC Sergott, AA Sadun, G Rebolleda Fernández, BK Chwalisz, R Banik, F Bazin, M Roux, ED Cox, M Taiel, J-A Sahel, LHON REFLECT Study Group

OPA1 disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion.

DOI: http://doi.org/10.1073/pnas.2207471120
Journal: Proc Natl Acad Sci U S A
E-pub date: 21 Mar 2023
Authors: B Cartes-Saavedra, D Lagos, J Macuada, D Arancibia, F Burté, MK Sjöberg-Herrera, ME Andrés, R Horvath, P Yu-Wai-Man, G Hajnóczky, V Eisner

Early detection of visual impairment in young children using a smartphone-based deep learning system.

DOI: http://doi.org/10.1038/s41591-022-02180-9
Journal: Nat Med
E-pub date: 1 Feb 2023
Authors: W Chen, R Li, Q Yu, A Xu, Y Feng, R Wang, L Zhao, Z Lin, Y Yang, D Lin, X Wu, J Chen, Z Liu, Y Wu, K Dang, K Qiu, Z Wang, Z Zhou, D Liu, Q Wu, M Li, Y Xiang, X Li, Z Lin, D Zeng, Y Huang, S Mo, X Huang, S Sun, J Hu, J Zhao, M Wei, S Hu, L Chen, B Dai, H Yang, D Huang, X Lin, L Liang, X Ding, Y Yang, P Wu, F Zheng, N Stanojcic, J-PO Li, CY Cheung, E Long, C Chen, Y Zhu, P Yu-Wai-Man, R Wang, W-S Zheng, X Ding, H Lin

A digital mask to safeguard patient privacy.

DOI: http://doi.org/10.1038/s41591-022-01966-1
Journal: Nat Med
E-pub date: 1 Sep 2022
Authors: Y Yang, J Lyu, R Wang, Q Wen, L Zhao, W Chen, S Bi, J Meng, K Mao, Y Xiao, Y Liang, D Zeng, Z Du, Y Wu, T Cui, L Liu, WC Iao, X Li, CY Cheung, J Zhou, Y Hu, L Wei, IF Lai, X Yu, J Chen, Z Wang, Z Mao, H Ye, W Xiao, H Yang, D Huang, X Lin, W-S Zheng, R Wang, P Yu-Wai-Man, F Xu, Q Dai, H Lin

Induced Pluripotent Stem Cells for Inherited Optic Neuropathies-Disease Modeling and Therapeutic Development.

DOI: http://doi.org/10.1097/WNO.0000000000001375
Journal: J Neuroophthalmol
E-pub date: 1 Mar 2022
Authors: JP Harvey, PE Sladen, P Yu-Wai-Man, ME Cheetham

Dominant optic atrophy: Culprit mitochondria in the optic nerve.

DOI: http://doi.org/10.1016/j.preteyeres.2020.100935
Journal: Prog Retin Eye Res
E-pub date: 1 Jul 2021
Authors: G Lenaers, A Neutzner, Y Le Dantec, C Jüschke, T Xiao, S Decembrini, S Swirski, S Kieninger, C Agca, US Kim, P Reynier, P Yu-Wai-Man, J Neidhardt, B Wissinger

[11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease.

DOI: http://doi.org/10.1212/WNL.0000000000012033
Journal: Neurology
E-pub date: 31 May 2021
Authors: J van den Ameele, Y Hong, R Manavaki, A Kouli, H Biggs, Z MacIntyre, R Horvath, P Yu-Wai-Man, E Reid, CH Williams-Gray, E Bullmore, F Aigbirhio, T Fryer, P Chinnery

Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset.

DOI: http://doi.org/10.1016/j.ophtha.2020.12.012
Journal: Ophthalmology
E-pub date: 1 May 2021
Authors: NJ Newman, P Yu-Wai-Man, V Carelli, ML Moster, V Biousse, C Vignal-Clermont, RC Sergott, T Klopstock, AA Sadun, P Barboni, AA DeBusk, JF Girmens, G Rudolph, R Karanjia, M Taiel, L Blouin, G Smits, B Katz, J-A Sahel, LHON Study Group

Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy.

DOI: http://doi.org/10.1126/scitranslmed.aaz7423
Journal: Sci Transl Med
E-pub date: 9 Dec 2020
Authors: P Yu-Wai-Man, NJ Newman, V Carelli, ML Moster, V Biousse, AA Sadun, T Klopstock, C Vignal-Clermont, RC Sergott, G Rudolph, C La Morgia, R Karanjia, M Taiel, L Blouin, P Burguière, G Smits, C Chevalier, H Masonson, Y Salermo, B Katz, S Picaud, DJ Calkins, J-A Sahel

SSBP1 mutations in dominant optic atrophy with variable retinal degeneration.

DOI: http://doi.org/10.1002/ana.25550
Journal: Ann Neurol
E-pub date: 1 Sep 2019
Authors: N Jurkute, C Leu, H-M Pogoda, G Arno, AG Robson, G Nürnberg, J Altmüller, H Thiele, S Motameny, MR Toliat, K Powell, W Höhne, M Michaelides, AR Webster, AT Moore, M Hammerschmidt, P Nürnberg, P Yu-Wai-Man, M Votruba

International Consensus Statement on the Clinical and Therapeutic Management of Leber Hereditary Optic Neuropathy.

DOI: http://doi.org/10.1097/WNO.0000000000000570
Journal: J Neuroophthalmol
E-pub date: 1 Dec 2017
Authors: V Carelli, M Carbonelli, IF de Coo, A Kawasaki, T Klopstock, WA Lagrèze, C La Morgia, NJ Newman, C Orssaud, JWR Pott, AA Sadun, J van Everdingen, C Vignal-Clermont, M Votruba, P Yu-Wai-Man, P Barboni