Research Focus


  • Neuro-Ophthalmology
  • Mitochondrial Disease
  • Optic Neuropathies
  • Gene Therapy
  • Clinical Conditions

  • Genetic disorders
  • Equipment & Techniques

  • Other
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    Professor Patrick Yu-Wai-Man BMedSci, MBBS, PhD, FRCPath, FRCOphth

    University Position
    Professor Patrick Yu-Wai-Man is pleased to consider applications from prospective PhD students.


    I am an academic neuro-ophthalmologist with a major research interest in optic neuropathies, neurogenetics and mitochondrial eye diseases. I hold joint clinical appointments at Addenbrooke's Hospital in Cambridge and Moorfields Eye Hospital in London as an Honorary Consultant. My research programme is currently focused on dissecting the disease mechanisms leading to progressive retinal ganglion cell loss in inherited optic neuropathies by using a combination of patient tissues, induced pluripotent stem cells and animal models. I was awarded an NIHR Advanced Fellowship (2021-2026) to evaluate patient outcomes and fast track the development of effective therapies for this group of disorders, in particular novel gene therapy approaches. I am the Director of the Cambridge Clinical Vision Laboratory (CCVL) that was set up as a cross-cutting facility to support advanced therapeutics on the Cambridge Biomedical Campus.

    Key Publications


    [11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease.

    Journal: Neurology
    E-pub date: 21 Apr 2021
    Authors: J van den Ameele, Y Hong, R Manavaki, A Kouli, H Biggs, Z MacIntyre, R Horvath, P Yu-Wai-Man, E Reid, CH Williams-Gray, E Bullmore, F Aigbirhio, T Fryer, P Chinnery