• Veterinary Medicine
  • Research Theme Beyond the Neuron

    Dr Raymond Bujdoso

    University Position
    Associate Professor


    Prion diseases such as scrapie of sheep and goats, BSE of cattle and CJD of humans are transmissible neurodegenerative diseases. The research of our prion group is concerned with providing knowledge to try and answer some of the important questions related to aspects of prion disease pathogenesis, diagnosis and therapeutic strategy. These questions include defining the nature of the infectious agent, determining the molecular basis of prion strain diversity, understanding the mechanism of protein misfolding as PrPC converts into PrPSc, and identification of molecular targets for diagnostic and potential therapeutic interventions. These aspects of PrP biology are being pursued in our attempts to identify and quantify abnormal PrP in the blood of individuals with pre-clinical prion disease. These studies underpin our efforts to develop an effective ante-mortem blood test for prion disease.

    Key Publications

    A new model for sensitive detection of zoonotic prions by PrP transgenic Drosophila.

    Journal: J Biol Chem
    E-pub date: 31 Aug 2021
    Authors: AM Thackray, O Andréoletti, J Spiropoulos, R Bujdoso


    Clearance of variant Creutzfeldt-Jakob disease prions in vivo by the Hsp70 disaggregase system.

    Journal: Brain
    E-pub date: 14 Sep 2022
    Authors: AM Thackray, B Lam, EE McNulty, AV Nalls, CK Mathiason, SS Magadi, WS Jackson, O Andréoletti, C Marrero-Winkens, H Schätzl, R Bujdoso

    Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease

    Journal: Biochemical Journal
    E-pub date: 28 Feb 2020
    Authors: A Thackray, B Lam, A Shahira Binti Ab Razak, G Yeo, R Bujdoso