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Institute
  • Wellcome – MRC Cambridge Stem Cell Institute
    • Research Theme Beyond the Neuron Lifelong Brain Development and Brain Ageing Brains and Machines
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    Professor Robin Franklin FMedSci, FRS

    University Position
    Professor

    Interests

    Robin Franklin is a Principal Investigator at Altos Las - Cambridge Institute having previously been Professor of Stem Cell Medicine at the Wellcome Trust-MRC Cambridge Stem Cell Institute. His lab works on the mechanisms of CNS regeneration with a particular focus on remyelination, an adult stem/progenitor cell-mediated process in which new myelin sheaths are restored to demyelinated axons. Using a wide range of in vitro and in vivo models, we are examining extrinsic (environmental) and intrinsic (transcriptional, epigenetic) factors that govern the differentiation of adult neural stem cells into oligodendrocytes and other glia following CNS injury. Robin Franklin is a Fellow of the Academy of Medical Sciences, and a Fellow of the Royal Society. He won the Barancik Prize in 2017 and the King Faisal Prize for Medicine in 2021

    Key Publications

    Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study.

    DOI: http://doi.org/10.1016/S1474-4422(21)00179-4
    Journal: Lancet Neurol
    E-pub date: 1 Sep 2021
    Authors: JWL Brown, NG Cunniffe, F Prados, B Kanber, JL Jones, E Needham, Z Georgieva, D Rog, OR Pearson, J Overell, D MacManus, RS Samson, J Stutters, C Ffrench-Constant, CAM Gandini Wheeler-Kingshott, C Moran, PD Flynn, AW Michell, RJM Franklin, S Chandran, DR Altmann, DT Chard, P Connick, AJ Coles

    The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination.

    DOI: http://doi.org/10.1073/pnas.1905787116
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 10 Dec 2019
    Authors: CE McMurran, A Guzman de la Fuente, R Penalva, O Ben Menachem-Zidon, Y Dombrowski, J Falconer, GA Gonzalez, C Zhao, FN Krause, AMH Young, JL Griffin, CA Jones, C Hollins, MM Heimesaat, DC Fitzgerald, RJM Franklin

    Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice.

    DOI: http://doi.org/10.1016/j.stemcr.2017.01.007
    Journal: Stem Cell Reports
    E-pub date: 14 Mar 2017
    Authors: I Kazanis, KA Evans, E Andreopoulou, C Dimitriou, C Koutsakis, RT Karadottir, RJM Franklin

    Lesion-induced accumulation of platelets promotes survival of adult neural stem / progenitor cells.

    DOI: http://doi.org/10.1016/j.expneurol.2015.03.018
    Journal: Exp Neurol
    E-pub date: 1 Jul 2015
    Authors: I Kazanis, M Feichtner, S Lange, P Rotheneichner, S Hainzl, M Öller, K Schallmoser, E Rohde, HA Reitsamer, S Couillard-Despres, H-C Bauer, RJM Franklin, L Aigner, FJ Rivera

    Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression.

    DOI: http://doi.org/10.1038/ncomms5294
    Journal: Nat Commun
    E-pub date: 11 Jul 2014
    Authors: GE Tyzack, S Sitnikov, D Barson, KL Adams-Carr, NK Lau, JC Kwok, C Zhao, RJM Franklin, RT Karadottir, JW Fawcett, A Lakatos

    Publications

    Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.

    DOI: http://doi.org/10.1016/j.celrep.2021.109362
    Journal: Cell Rep
    E-pub date: 13 Jul 2021
    Authors: S Kohnke, S Buller, D Nuzzaci, K Ridley, B Lam, H Pivonkova, MA Bentsen, KM Alonge, C Zhao, J Tadross, S Holmqvist, T Shimizu, H Hathaway, H Li, W Macklin, MW Schwartz, WD Richardson, GSH Yeo, RJM Franklin, RT Karadottir, DH Rowitch, C Blouet

    A map of transcriptional heterogeneity and regulatory variation in human microglia.

    DOI: http://doi.org/10.1038/s41588-021-00875-2
    Journal: Nat Genet
    E-pub date: 1 Jun 2021
    Authors: AMH Young, N Kumasaka, F Calvert, TR Hammond, A Knights, N Panousis, JS Park, J Schwartzentruber, J Liu, K Kundu, M Segel, NA Murphy, CE McMurran, H Bulstrode, J Correia, KP Budohoski, A Joannides, MR Guilfoyle, R Trivedi, R Kirollos, R Morris, MR Garnett, I Timofeev, I Jalloh, K Holland, R Mannion, R Mair, C Watts, SJ Price, PJ Kirkpatrick, T Santarius, E Mountjoy, M Ghoussaini, N Soranzo, OA Bayraktar, B Stevens, PJ Hutchinson, RJM Franklin, DJ Gaffney

    Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing.

    DOI: http://doi.org/10.1074/mcp.RA120.002102
    Journal: Mol Cell Proteomics
    E-pub date: 31 Aug 2020
    Authors: AG de la Fuente, RML Queiroz, T Ghosh, CE McMurran, JF Cubillos, DE Bergles, DC Fitzgerald, CA Jones, KS Lilley, CP Glover, RJM Franklin

    Toxin-Based Models to Investigate Demyelination and Remyelination.

    DOI: http://doi.org/10.1007/978-1-4939-9072-6_21
    Journal: Methods Mol Biol
    E-pub date: 1 Aug 2019
    Authors: CE McMurran, C Zhao, RJM Franklin

    SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke.

    DOI: http://doi.org/10.1016/j.ebiom.2019.03.035
    Journal: EBioMedicine
    E-pub date: 1 Apr 2019
    Authors: JD Bernstock, L Peruzzotti-Jametti, T Leonardi, N Vicario, D Ye, Y-J Lee, D Maric, KR Johnson, Y Mou, A Van Den Bosch, M Winterbone, GK Friedman, RJM Franklin, JM Hallenbeck, S Pluchino

    Clinical implications of myelin regeneration in the central nervous system.

    DOI: http://doi.org/10.1080/14737175.2018.1421458
    Journal: Expert Rev Neurother
    E-pub date: 1 Feb 2018
    Authors: CE McMurran, S Kodali, A Young, RJ Franklin

    CNS Remyelination and the Innate Immune System.

    DOI: http://doi.org/10.3389/fcell.2016.00038
    Journal: Front Cell Dev Biol
    E-pub date: 1 Aug 2016
    Authors: CE McMurran, CA Jones, DC Fitzgerald, RJM Franklin

    The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche.

    DOI: http://doi.org/10.1016/j.expneurol.2013.06.025
    Journal: Exp Neurol
    E-pub date: 1 Oct 2013
    Authors: I Kazanis, N Gorenkova, J-W Zhao, RJM Franklin, M Modo, C Ffrench-Constant