Professor Robin Franklin FMedSci, FRS

University Position


Robin Franklin is a Principal Investigator at Altos Las - Cambridge Institute having previously been Professor of Stem Cell Medicine at the Wellcome Trust-MRC Cambridge Stem Cell Institute. His lab works on the mechanisms of CNS regeneration with a particular focus on remyelination, an adult stem/progenitor cell-mediated process in which new myelin sheaths are restored to demyelinated axons. Using a wide range of in vitro and in vivo models, we are examining extrinsic (environmental) and intrinsic (transcriptional, epigenetic) factors that govern the differentiation of adult neural stem cells into oligodendrocytes and other glia following CNS injury. Robin Franklin is a Fellow of the Academy of Medical Sciences, and a Fellow of the Royal Society. He won the Barancik Prize in 2017 and the King Faisal Prize for Medicine in 2021

Key Publications

Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study.

Journal: Lancet Neurol
E-pub date: 1 Sep 2021
Authors: JWL Brown, NG Cunniffe, F Prados, B Kanber, JL Jones, E Needham, Z Georgieva, D Rog, OR Pearson, J Overell, D MacManus, RS Samson, J Stutters, C Ffrench-Constant, CAM Gandini Wheeler-Kingshott, C Moran, PD Flynn, AW Michell, RJM Franklin, S Chandran, DR Altmann, DT Chard, P Connick, AJ Coles

Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice.

Journal: Stem Cell Reports
E-pub date: 14 Mar 2017
Authors: I Kazanis, KA Evans, E Andreopoulou, C Dimitriou, C Koutsakis, RT Karadottir, RJM Franklin

Lesion-induced accumulation of platelets promotes survival of adult neural stem / progenitor cells.

Journal: Exp Neurol
E-pub date: 1 Jul 2015
Authors: I Kazanis, M Feichtner, S Lange, P Rotheneichner, S Hainzl, M Öller, K Schallmoser, E Rohde, HA Reitsamer, S Couillard-Despres, H-C Bauer, RJM Franklin, L Aigner, FJ Rivera

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression.

Journal: Nat Commun
E-pub date: 11 Jul 2014
Authors: GE Tyzack, S Sitnikov, D Barson, KL Adams-Carr, NK Lau, JC Kwok, C Zhao, RJM Franklin, RT Karadottir, JW Fawcett, A Lakatos


Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.

Journal: Cell Rep
E-pub date: 13 Jul 2021
Authors: S Kohnke, S Buller, D Nuzzaci, K Ridley, B Lam, H Pivonkova, MA Bentsen, KM Alonge, C Zhao, J Tadross, S Holmqvist, T Shimizu, H Hathaway, H Li, W Macklin, MW Schwartz, WD Richardson, GSH Yeo, RJM Franklin, RT Karadottir, DH Rowitch, C Blouet

SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke.

Journal: EBioMedicine
E-pub date: 1 Apr 2019
Authors: JD Bernstock, L Peruzzotti-Jametti, T Leonardi, N Vicario, D Ye, Y-J Lee, D Maric, KR Johnson, Y Mou, A Van Den Bosch, M Winterbone, GK Friedman, RJM Franklin, JM Hallenbeck, S Pluchino

The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche.

Journal: Exp Neurol
E-pub date: 1 Oct 2013
Authors: I Kazanis, N Gorenkova, J-W Zhao, RJM Franklin, M Modo, C Ffrench-Constant