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    Dr Rodrigo Siqueira

    (he/him/his)
    University Position
    Wellcome Early Career Fellow

    Interests

    I began my academic journey with an undergraduate degree in biology, focusing on zoology and evolution, at the University of Brazil. During this time, I published a paper in 2010 on the 3D modelling of fossils, showcasing my early interest in computational applications. My affinity for technology led me to projects involving modelling, which paved the way for my master's degree in neuroscience at the same institution. My master's research centred on brain evolution and neuroanatomy, particularly studying the brains of artiodactyls, a project that culminated in a significant publication in Frontiers in Neuroanatomy in 2014. Additionally, in 2019, I co-authored a paper published in PNAS. I was awarded a scholarship by the CNPq of Brazil to pursue a PhD in Cybernetics at the University of Reading, where I developed a toolbox for analyzing neuronal signals. This project combined my skills in programming and neuroscience, resulting in publicly available software. Upon completing my PhD, I joined the Active Touch Laboratory at the University of Sheffield, where I focused on computational neuroscience and neuroprosthetics. My postdoctoral research there earned the best research prize at the INSIGNEO Institute and was published in the journal iScience in 2022. Currently, I am a member of the Bayraktar group at the Sanger Institute, focusing on glioblastoma multiforme (GBM) characterisation. My work here involves exploring the genetic and molecular underpinnings of GBM, contributing to cutting-edge research in cancer neuroscience. My research interests include general intelligence, network neuroscience, brain development and brain evolution.

    Selective detachment

    Evolution of a simulated neuronal network that evolved with selective neuronal death and selective synaptic pruning

    Key Publications

    Cellular scaling rules for the brain of Artiodactyla include a highly folded cortex with few neurons

    DOI: https://doi.org/10.3389/fnana.2014.00128
    Journal: Frontiers in Neuroanatomy
    Year: 2014
    Authors: Rodrigo Siqueira Kazu, Jose Maldonado, Bruno Mota, Paul Manger, Suzana Herculano-Houzel

    Modeling foot sole cutaneous afferents: FootSim

    DOI: https://doi.org/10.1016/j.isci.2022.105874
    Journal: iScience
    Year: 2023
    Authors: Rodrigo Kazu Siqueira, Natalija Katic, Luke Cleland, Nicholas Strzalkowski, Leah Bent, Stanisa Raspopovic, Hannes Saal

    Selective pruning and neuronal death generate scale-invariant neuronal networks

    DOI: http://dx.doi.org/10.13140/RG.2.2.21806.52804
    Journal: arXiV
    Year: 2024
    Authors: Rodrigo Kazu Siqueira, Kleber Neves, Bruno Mota

    Publications

    White matter volume and white/gray matter ratio in mammalian species as a consequence of the universal scaling of cortical folding

    DOI: https://doi.org/10.1073/pnas.1716956116
    Journal: PNAS
    Year: 2019
    Authors: Bruno Mota, Sandra E. Dos Santos, Lissa Ventura-Antunes, Débora Jardim-Messeder, Kleber Neves, Rodrigo S. Kazu, Stephen Noctor, Kelly Lambert, Mads F. Bertelsen, Paul R. Manger, Chet C. Sherwood, Jon H. Kaas jon.h.kaas@vanderbilt.edu, and Suzana Herculano-Houzel

    Modelagem 3D e suas aplicações na pesquisa paleontológica.

    DOI: https://doi.org/10.4013/gaea.2010.62.04
    Journal: Gaea: Journal of Geoscience
    Year: 2010
    Authors: Ulisses Dardon, Rodrigo Siqueira de Souza, Carla Terezinha Serio Abranches, Lílian Paglarelli Bergqvist