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    Dr Rodrigo Siqueira de Souza

    (he/him/his)
    University Position
    Wellcome Early Career Fellow

    Interests

    I started my education with an undergrad in biology heavily focused on zoology and evolution at the University of Brazil, from where I got my quantifiable output in 2010, a publication dealing with the 3D modelling of fossils. I always had an aptitude for computers, gravitating towards projects that involved modelling. This profile led me to a master's in neuroscience at the same institution. There I worked with brain evolution and neuroanatomy, describing the brains of a whole mammalian order, the artiodactyls, which was the main publication of this period in the Frontiers in Neuroanatomy journal (in 2014). This period had an additional publication in the journal PNAS that came in 2019. I spent a significant amount of time during these early years studying programming and statistics to better understand and analyse my data. After graduating I was awarded a scholarship by the CNPq of Brazil to pursue my PhD. I chose the degree of Cybernetics at the University of Reading. There, I developed a complete toolbox to analyse the electrical signals derived from neuronal cell cultures placed onto multielectrode arrays. My work included the complete cycle, from developing a protocol to differentiating neurons from stem cells to writing the complete code of the toolbox, available in a public repository. The conclusion of my PhD allowed me to be hired by the Active Touch Laboratory at the University of Sheffield to work with computational neuroscience and neuroprosthetics. My project during this post-doc won the best research prize at the INSIGNEO Institute and was published in the journal iScience (2022). Now, affiliated with the Wellcome Sanger Institute, my research interests include general intelligence, network neuroscience, brain development and brain evolution. Additionally, I am trying to understand cell fates in Glioblastoma Multiforme.

    Selective detachment

    Evolution of a simulated neuronal network that evolved with selective neuronal death and selective synaptic pruning

    Key Publications

    Cellular scaling rules for the brain of Artiodactyla include a highly folded cortex with few neurons

    DOI: https://doi.org/10.3389/fnana.2014.00128
    Journal: Frontiers in Neuroanatomy
    Year: 2014
    Authors: Rodrigo Siqueira Kazu, Jose Maldonado, Bruno Mota, Paul Manger, Suzana Herculano-Houzel

    Modeling foot sole cutaneous afferents: FootSim

    DOI: https://doi.org/10.1016/j.isci.2022.105874
    Journal: iScience
    Year: 2023
    Authors: Rodrigo Kazu Siqueira, Natalija Katic, Luke Cleland, Nicholas Strzalkowski, Leah Bent, Stanisa Raspopovic, Hannes Saal

    Publications

    White matter volume and white/gray matter ratio in mammalian species as a consequence of the universal scaling of cortical folding

    DOI: https://doi.org/10.1073/pnas.1716956116
    Journal: PNAS
    Year: 2019
    Authors: Bruno Mota, Sandra E. Dos Santos, Lissa Ventura-Antunes, Débora Jardim-Messeder, Kleber Neves, Rodrigo S. Kazu, Stephen Noctor, Kelly Lambert, Mads F. Bertelsen, Paul R. Manger, Chet C. Sherwood, Jon H. Kaas jon.h.kaas@vanderbilt.edu, and Suzana Herculano-Houzel

    Modelagem 3D e suas aplicações na pesquisa paleontológica.

    DOI: https://doi.org/10.4013/gaea.2010.62.04
    Journal: Gaea: Journal of Geoscience
    Year: 2010
    Authors: Ulisses Dardon, Rodrigo Siqueira de Souza, Carla Terezinha Serio Abranches, Lílian Paglarelli Bergqvist