My main interest is in innate immunity, inflammation and brain iron homeostasis. Inflammation and innate immunity are key players in Alzheimer?s disease (AD) and Down syndrome (DS). Individuals with DS have a spectrum of hematopoietic dysfunctions, and by 40 years almost all develop AD neuropathology. We are currently investigating the function of TREM2 in DS and have reported its crucial role in brain neuroprotection and plasticity (Raha et al., 2016). Hepcidin is the principle regulator of systemic iron homeostasis, which has been shown to be impaired in the brain in many neurological disorders ranging from acute brain injury, cerebrovascular haemorrhage, Down Syndrome, Parkinson?s diseases and Alzheimer?s disease (Raha-Chowdhury et al., 2015; Raha et al., 2013).