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Department
  • Psychiatry
    • Institute
  • Cambridge Intellectual & Developmental Disabilities Research Group
    • Research Theme Lifelong Brain Development and Brain Ageing Brains and Machines
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    Dr Stephanie Brown

    University Position
    Research Fellow

    Interests

    My research leverages advanced MR technologies and 7 Tesla MRI to address pertinent questions in the fields of neurodegeneration and neurodevelopment. Particularly, my work focusses on the development of dementia in Down syndrome, sleep as a mediating factor in the onset of Alzheimer's disease and the neurological basis for difficult to manage behavioural aspects of Prader-Willi syndrome.

    Associated News Items

    Key Publications

    Publications

    Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2022.07.003
    Journal: Neurobiol Aging
    E-pub date: 1 Nov 2022
    Authors: M Grigorova, E Mak, SSG Brown, J Beresford-Webb, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, B Ances, BL Handen, CM Laymon, WE Klunk, ICH Clare, AJ Holland, SH Zaman

    Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down’s syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2022.02.013
    Journal: Neurobiol Aging
    E-pub date: 1 Jul 2022
    Authors: SSG Brown, E Mak, I Clare, M Grigorova, J Beresford-Webb, M Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    Amyloid and tau deposition influences cognitive decline in Down syndrome

    DOI: http://doi.org/10.1002/alz.056384
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2021
    Authors: M Grigorova, E Mak, J Beresford‐Webb, SSG Brown, E Jones, I Clare, T Holland, YT Hong, TD Fryer, JP Coles, GB Williams, FI Aigbirhio, BM Ances, BT Christian, BL Handen, WE Klunk, CM Laymon, DL Tudorascu, S Zaman

    Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

    DOI: http://doi.org/10.1093/braincomms/fcaa198
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman