Author: Stephanie Brown

Interests

My research leverages advanced MR technologies and 7 Tesla MRI to address pertinent questions in the fields of neurodegeneration and neurodevelopment. Particularly, my work focusses on the development of dementia in Down syndrome, sleep as a mediating factor in the onset of Alzheimer's disease and the neurological basis for difficult to manage behavioural aspects of Prader-Willi syndrome.

Associated News Items

Volunteers wanted for a study on brain, appetite and metabolism
Nov 11, 2026
Cambridge researchers are looking for adults who experience challenges with weight management to help advance…
Catch up on CNS2024: Sleep, Consciousness and Cognition
Apr 23, 2024
On April 5th 2024, we welcomed more than 240 delegates to Queens’ College for our…

Key Publications

Publications

Amyloid and tau deposition influences cognitive and functional decline in Down Syndrome

DOI: http://doi.org/10.1002/alz.062617
Journal: Alzheimer's & Dementia
E-pub date: 1 Jun 2023
Authors: M Grigorova, E Mak, SSG Brown, J Beresford‐Webb, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DL Tudorascu, AD Cohen, BT Christian, B Ances, BL Handen, CM Laymon, WE Klunk, I Clare, AJ Holland, S Zaman

Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome.

DOI: http://doi.org/10.1016/j.neurobiolaging.2022.07.003
Journal: Neurobiol Aging
E-pub date: 1 Nov 2022
Authors: M Grigorova, E Mak, SSG Brown, J Beresford-Webb, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, B Ances, BL Handen, CM Laymon, WE Klunk, ICH Clare, AJ Holland, SH Zaman

Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down’s syndrome.

DOI: http://doi.org/10.1016/j.neurobiolaging.2022.02.013
Journal: Neurobiol Aging
E-pub date: 1 Jul 2022
Authors: SSG Brown, E Mak, I Clare, M Grigorova, J Beresford-Webb, M Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, AJ Holland, SH Zaman

Amyloid and tau deposition influences cognitive decline in Down syndrome

DOI: http://doi.org/10.1002/alz.056384
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2021
Authors: M Grigorova, E Mak, J Beresford‐Webb, SSG Brown, E Jones, I Clare, T Holland, YT Hong, TD Fryer, JP Coles, GB Williams, FI Aigbirhio, BM Ances, BT Christian, BL Handen, WE Klunk, CM Laymon, DL Tudorascu, S Zaman

Acute Regression in Down Syndrome.

DOI: http://doi.org/10.3390/brainsci11081109
Journal: Brain Sci
E-pub date: 23 Aug 2021
Authors: B Handen, I Clare, C Laymon, M Petersen, S Zaman, S O'Bryant, D Minhas, D Tudorascu, S Brown, B Christian

Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

DOI: http://doi.org/10.1093/braincomms/fcaa198
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

Multi-Modal Imaging in Down’s Syndrome: Maximizing Utility Through Innovative Neuroimaging Approaches.

DOI: http://doi.org/10.3389/fneur.2020.629463
Journal: Front Neurol
E-pub date: 1 Aug 2020
Authors: SSG Brown, E Mak, S Zaman

Dr Stephanie Brown