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Research Focus

Keywords

  • Activity-Dependent Myelination
  • Myelin
  • Brain Plasticity
  • Clinical Conditions

  • Multiple sclerosis
  • Depressive disorders
  • Dementia
  • Equipment & Techniques

  • Fluorescence microscopy
  • Microscopy
  • Immunohistochemistry
  • Science Culture

  • Teaching
  • History of Science
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    Dr Sebastian Timmler

    (he/him/his)
    University Position
    Research Associate

    Interests

    I study molecular mechanisms of activity-dependent myelination in the central nervous system. I combine the use of primary rat cell culture with optogenetice, light and electron microscopy and proteomics to understand how neuronal activity regulates myelin formation and how myelin influences the function of neuronal circuits.  When I am not in the lab, I enjoys cycling through the English countryside, firing up the barbecue and gardening.

    overlapping myelin sheaths in a mouse with reduced axon-glia interaction

    electron micrograph, mouse optic nerve

    Collaborators

    Key Publications

    Focal white matter lesions drive grey matter inflammation and synapse loss.

    DOI: http://doi.org/10.1038/s41586-026-10414-w
    Journal: Nature
    E-pub date: 1 Jun 2026
    Authors: O de Faria, S Vagionitis, A Lopez-Lopez, M Perry, JJY Wong, L Rodríguez-Kirby, B Hervé, BV Varga, E Agirre, S Ghosh, S Timmler, M Yucel, AT Setley, KA Evans, TM Birgisdóttir, S Gíslason, YT Ng, C Kremler, HOB Gautier, Y Kamen, H Pivonkova, K Volbracht, F Hildebrand, CA Cepeda, J Rueda-Carrasco, S Hong, G Malliaras, S Dietmann, G Castelo-Branco, RT Káradóttir

    Periods of synchronized myelin changes shape brain function and plasticity.

    DOI: http://doi.org/10.1038/s41593-021-00917-2
    Journal: Nat Neurosci
    E-pub date: 1 Nov 2021
    Authors: O de Faria, H Pivonkova, B Varga, S Timmler, KA Evans, RT Káradóttir

    Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS.

    DOI: http://doi.org/10.1038/s41467-019-12789-z
    Journal: Nat Commun
    E-pub date: 22 Oct 2019
    Authors: M Djannatian, S Timmler, M Arends, M Luckner, M-T Weil, I Alexopoulos, N Snaidero, B Schmid, T Misgeld, W Möbius, M Schifferer, E Peles, M Simons

    Publications

    Grey matter myelination.

    DOI: http://doi.org/10.1002/glia.23614
    Journal: Glia
    E-pub date: 1 Nov 2019
    Authors: S Timmler, M Simons

    Myelin in the Central Nervous System: Structure, Function, and Pathology.

    DOI: http://doi.org/10.1152/physrev.00031.2018
    Journal: Physiol Rev
    E-pub date: 1 Jul 2019
    Authors: C Stadelmann, S Timmler, A Barrantes-Freer, M Simons