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EMAIL shz10@cam.ac.uk
College Churchill College
Department
  • Psychiatry
    • School
  • Clinical Medicine
    • Institute
  • Cambridge Intellectual & Developmental Disabilities Research Group
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    Research Theme Lifelong Brain Development and Brain Ageing

    Other Interdiciplinary Incentives

  • Neuroscience

    • Research Focus

    Keywords

  • Ageing
  • Alzheimer's Disease
  • Biomarkers
  • Autism Spectrum Disorder
  • EEG
  • Retinal Biomarkers
  • Brain Imaging
  • Muscle
  • Neuropathology
  • Artificial Intelligence
  • Intellectual Disabilities
  • Vagus Nerve
  • Cognitive Decline

    • Clinical Conditions

  • Alzheimer's disease
  • Autism spectrum condition
  • Cognitive impairment
  • Dementia
  • Learning disabilities
  • Genetic disorders
  • Vascular dementia

    • Equipment & Techniques

  • Electroencephalography (EEG)

    • Science Culture

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    Dr Shahid Zaman MB PhD MD FRCP FRCPsych

    (he/him/his)
    University Position
    Assistant Professor
    Group Leader
    Honorary Consultant

    Interests

    The main theme of our research is to understand the role of amyloid, tau, inflammation and mitochondrial dysfunction in the genesis of cognitive impairment and dementia in people with Down's syndrome.

    Collaborators

    External

    • Key Publications

    Publications

    Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study.

    DOI: http://doi.org/10.1002/dad2.12288
    Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
    E-pub date: 1 Jan 2022
    Authors: C Padilla, V Montal, MJ Walpert, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, SL Hartley, AD Cohen, DL Tudorascu, BT Christian, BL Handen, WE Klunk, AJ Holland, SH Zaman

    Amyloid and tau deposition influences cognitive decline in Down syndrome

    DOI: http://doi.org/10.1002/alz.056384
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2021
    Authors: M Grigorova, E Mak, J Beresford‐Webb, SSG Brown, E Jones, I Clare, T Holland, YT Hong, TD Fryer, JP Coles, GB Williams, FI Aigbirhio, BM Ances, BT Christian, BL Handen, WE Klunk, CM Laymon, DL Tudorascu, S Zaman

    Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

    DOI: http://doi.org/10.1093/braincomms/fcaa198
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    Diffusion structural network metrics as a predictor for Alzheimer’s disease diagnosis in Down syndrome using support vector machine classification

    DOI: http://doi.org/10.1002/alz.040261
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: SSG Brown, E Mak, M Grigorova, J Beresford‐Webb, MJ Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BL Handen, BT Christian, WE Klunk, DK Menon, PJ Nestor, AJ Holland, S Zaman

    Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report.

    DOI: http://doi.org/10.1016/j.dadm.2019.04.006
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: E Mak, A Bickerton, C Padilla, MJ Walpert, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, SH Zaman, AJ Holland

    Differential effects of Down’s syndrome and Alzheimer’s neuropathology on default mode connectivity.

    DOI: http://doi.org/10.1002/hbm.24720
    Journal: Hum Brain Mapp
    E-pub date: 15 Oct 2019
    Authors: LR Wilson, D Vatansever, T Annus, GB Williams, YT Hong, TD Fryer, PJ Nestor, AJ Holland, SH Zaman

    Delineating the topography of amyloid-associated cortical atrophy in Down syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2019.02.018
    Journal: Neurobiol Aging
    E-pub date: 31 Aug 2019
    Authors: E Mak, C Padilla, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, SH Zaman, AJ Holland

    Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2017.04.006
    Journal: Neurobiol Aging
    E-pub date: 31 Aug 2017
    Authors: JH Cole, T Annus, LR Wilson, R Remtulla, YT Hong, TD Fryer, J Acosta-Cabronero, A Cardenas-Blanco, R Smith, DK Menon, SH Zaman, PJ Nestor, AJ Holland

    The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2017.01.009
    Journal: Neurobiol Aging
    E-pub date: 1 May 2017
    Authors: T Annus, LR Wilson, J Acosta-Cabronero, A Cardenas-Blanco, YT Hong, TD Fryer, JP Coles, DK Menon, SH Zaman, AJ Holland, PJ Nestor

    The pattern of amyloid accumulation in the brains of adults with Down syndrome.

    DOI: http://doi.org/10.1016/j.jalz.2015.07.490
    Journal: Alzheimers Dement
    E-pub date: 1 May 2016
    Authors: T Annus, LR Wilson, YT Hong, J Acosta-Cabronero, TD Fryer, A Cardenas-Blanco, R Smith, I Boros, JP Coles, FI Aigbirhio, DK Menon, SH Zaman, PJ Nestor, AJ Holland

    Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility.

    DOI: http://doi.org/10.1001/archneurol.2011.36
    Journal: Arch Neurol
    E-pub date: 1 Jul 2011
    Authors: J Landt, JC D'Abrera, AJ Holland, FI Aigbirhio, TD Fryer, R Canales, YT Hong, DK Menon, J-C Baron, SH Zaman