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    Dr Sarah Crisp

    University Position
    Clinical Lecturer


    My goal is to advance our understanding of the mechanisms underlying neurological diseases associated with autoantibodies. These diseases include forms of encephalitis, epilepsy, demyelination, movement disorders and peripheral neuropathies amongst others. Although individually rare, these disorders are collectively recognized as the cause of significant morbidity and mortality. The pathophysiology of most autoimmune conditions remains poorly understood: in many cases the relative roles of antibodies and T cells in driving the disease process are unclear, and the identity of the antigenic target of the immune response is unknown. This lack of understanding underpins the difficulties clinicians face in diagnosing and treating patients with autoimmune neurological disorders. I use whole cell patch clamp to interrogate the effects of patient autoantibodies on neuronal function.

    Key Publications


    Susac’s syndrome as an autoimmune complication of alemtuzumab-associated immune reconstitution.

    Journal: J Neurol
    E-pub date: 1 Mar 2022
    Authors: A Ahmed, ZQ Kok, A Coles, DJ Scoffings, SJ Crisp

    Plasma cell depletion with bortezomib in the treatment of refractory N-methyl-d-aspartate (NMDA) receptor antibody encephalitis. Rational developments in neuroimmunological treatment.

    Journal: Eur J Neurol
    E-pub date: 1 Nov 2018
    Authors: S Keddie, SJ Crisp, J Blackaby, A Cox, A Coles, M Hart, AJ Church, A Vincent, M Zandi, MP Lunn