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EMAIL sk2226@cam.ac.uk
College Christ's College
Department
  • Yusuf Hamied Department of Chemistry
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    Research Theme Lifelong Brain Development and Brain Ageing Neurons, Circuits and Networks Beyond the Neuron
    Research Focus

    Keywords

  • Super-Resolution Microscopy
  • Superresolution Microscopy
  • Synapse
  • Tau Pathology
  • PSP

    • Clinical Conditions

  • Alzheimer's disease
  • Parkinson's disease
  • Progressive supranuclear palsy

    • Equipment & Techniques

  • Fluorescence microscopy
  • Microscopy
  • Cell culture

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    Dr Shekhar Kedia

    (he/him/his)
    University Position
    Research Associate

    Interests

    My research interests lie in understanding the nanoscale triggers of neurodegenerative disorders using biophysical approaches and how these alterations at the synapses contribute towards the onset of such diseases. It was piqued during my PhD research and continues to grow within postdoctoral research. I am attempting to address the challenges associated with rapid extraction and nanoscale imaging of synapses from brain tissues.

    Key Publications

    Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.isci.2020.101924
    Journal: iScience
    E-pub date: 22 Jan 2021
    Authors: S Kedia, P Ramakrishna, PR Netrakanti, N Singh, SS Sisodia, M Jose, S Kumar, A Mahadevan, N Ramanan, S Nadkarni, D Nair

    Real-time nanoscale organization of amyloid precursor protein.

    DOI: http://doi.org/10.1039/d0nr00052c
    Journal: Nanoscale
    E-pub date: 21 Apr 2020
    Authors: S Kedia, P Ramakrishna, PR Netrakanti, M Jose, J-B Sibarita, S Nadkarni, D Nair

    Publications

    Real-time heterogeneity of supramolecular assembly of amyloid precursor protein is modulated by an endocytic risk factor PICALM.

    DOI: http://doi.org/10.1007/s00018-023-04939-w
    Journal: Cell Mol Life Sci
    E-pub date: 20 Sep 2023
    Authors: V Belapurkar, HS Mahadeva Swamy, N Singh, S Kedia, SRG Setty, M Jose, D Nair

    Golgi fragmentation – One of the earliest organelle phenotypes in Alzheimer’s disease neurons.

    DOI: http://doi.org/10.3389/fnins.2023.1120086
    Journal: Front Neurosci
    E-pub date: 1 Aug 2023
    Authors: H Haukedal, GI Corsi, VP Gadekar, NT Doncheva, S Kedia, N de Haan, A Chandrasekaran, P Jensen, P Schiønning, S Vallin, FR Marlet, A Poon, C Pires, FK Agha, HH Wandall, S Cirera, AH Simonsen, TT Nielsen, JE Nielsen, P Hyttel, R Muddashetty, BI Aldana, J Gorodkin, D Nair, M Meyer, MR Larsen, K Freude

    Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains.

    DOI: http://doi.org/10.1186/s13041-021-00855-x
    Journal: Mol Brain
    E-pub date: 13 Oct 2021
    Authors: S Kedia, K Mandal, PR Netrakanti, M Jose, SS Sisodia, D Nair

    Quantifying molecular aggregation by super resolution microscopy within an excitatory synapse from mouse hippocampal neurons.

    DOI: http://doi.org/10.1016/j.xpro.2021.100470
    Journal: STAR Protoc
    E-pub date: 18 Jun 2021
    Authors: S Kedia, N Ramanan, D Nair

    Does Altered Probability of Real Time Diffusional Collisions of Membrane Molecules Trigger or Delay Alzheimers Disease

    DOI: http://doi.org/10.22580/iscinotej5.5.3
    Journal: iScience Notes
    E-pub date: 24 Dec 2020
    Authors: D Nair, S Kedia, M Jose

    Nanoscale rearrangement of APP organization as a therapeutic target for Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.mehy.2020.110143
    Journal: Med Hypotheses
    E-pub date: 1 Oct 2020
    Authors: S Kedia, D Nair