Research Focus


  • Super-Resolution Microscopy
  • Superresolution Microscopy
  • Synapse
  • Tau Pathology
  • PSP
  • Clinical Conditions

  • Alzheimer's disease
  • Parkinson's disease
  • Progressive supranuclear palsy
  • Equipment & Techniques

  • Fluorescence microscopy
  • Microscopy
  • Cell culture
  • Back

    Dr Shekhar Kedia

    University Position
    Research Associate


    My research interests lie in understanding the nanoscale triggers of neurodegenerative disorders using biophysical approaches and how these alterations at the synapses contribute towards the onset of such diseases. It was piqued during my PhD research and continues to grow within postdoctoral research. I am attempting to address the challenges associated with rapid extraction and nanoscale imaging of synapses from brain tissues.

    Key Publications

    Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer’s disease.

    Journal: iScience
    E-pub date: 22 Jan 2021
    Authors: S Kedia, P Ramakrishna, PR Netrakanti, N Singh, SS Sisodia, M Jose, S Kumar, A Mahadevan, N Ramanan, S Nadkarni, D Nair

    Real-time nanoscale organization of amyloid precursor protein.

    Journal: Nanoscale
    E-pub date: 21 Apr 2020
    Authors: S Kedia, P Ramakrishna, PR Netrakanti, M Jose, J-B Sibarita, S Nadkarni, D Nair


    Real-time heterogeneity of supramolecular assembly of amyloid precursor protein is modulated by an endocytic risk factor PICALM.

    Journal: Cell Mol Life Sci
    E-pub date: 20 Sep 2023
    Authors: V Belapurkar, HS Mahadeva Swamy, N Singh, S Kedia, SRG Setty, M Jose, D Nair

    Golgi fragmentation – One of the earliest organelle phenotypes in Alzheimer’s disease neurons.

    Journal: Front Neurosci
    E-pub date: 1 Aug 2023
    Authors: H Haukedal, GI Corsi, VP Gadekar, NT Doncheva, S Kedia, N de Haan, A Chandrasekaran, P Jensen, P Schiønning, S Vallin, FR Marlet, A Poon, C Pires, FK Agha, HH Wandall, S Cirera, AH Simonsen, TT Nielsen, JE Nielsen, P Hyttel, R Muddashetty, BI Aldana, J Gorodkin, D Nair, M Meyer, MR Larsen, K Freude

    Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains.

    Journal: Mol Brain
    E-pub date: 13 Oct 2021
    Authors: S Kedia, K Mandal, PR Netrakanti, M Jose, SS Sisodia, D Nair