Dr Sungmin Son

(he/him/his)

University Position

Senior Research Associate

Dr Sungmin Son is pleased to consider applications from prospective PhD students.

Interests

Regulatory pathways governing mTOR signaling and autophagy in healthy and neurodegenerative diseases brains

Key Publications

Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.

DOI: http://doi.org/10.1016/j.devcel.2021.05.010
Journal: Dev Cell
E-pub date: 12 Jul 2021
Authors: C Karabiyik, M Vicinanza, SM Son, DC Rubinsztein

Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.

DOI: https://doi.org/10.1016/j.neuron.2025.03.028
Journal: Neuron
Year: 2025
Authors: Son SM, Siddiqi FH, Lopez A, Ansari R, Tyrkalska SD, Park SJ, Kunath T, Metzakopian E, Fleming A, Rubinsztein DC.

p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome.

DOI: https://doi.org/10.1038/s41556-023-01338-y
Journal: Nat Cell Biol.
Year: 2024
Authors: Son SM, Park SJ, Breusegem SY, Larrieu D, Rubinsztein DC.

Leucine regulates autophagy via acetylation of the mTORC1 component raptor.

DOI: https://doi.org/10.1038/s41467-020-16886-2.
Journal: Nat Commun.
Year: 2020
Authors: Son SM, Park SJ, Stamatakou E, Vicinanza M, Menzies FM, Rubinsztein DC.

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A.

DOI: https://doi.org/10.1016/j.cmet.2018.08.013.
Journal: Cell Metab.
Year: 2019
Authors: Son SM, Park SJ, Lee H, Siddiqi F, Lee JE, Menzies FM, Rubinsztein DC.

Publications

Autophagy, aging, and age-related neurodegeneration.

DOI: https://doi.org/10.1016/j.neuron.2024.09.015
Journal: Neuron
Year: 2025
Authors: Palmer JE, Wilson N, Son SM, Obrocki P, Wrobel L, Rob M, Takla M, Korolchuk VI, Rubinsztein DC.

The different autophagy degradation pathways and neurodegeneration.

DOI: https://doi.org/10.1016/j.neuron.2022.01.017.
Journal: Neuron
Year: 2022
Authors: Fleming A, Bourdenx M, Fujimaki M, Karabiyik C, Krause GJ, Lopez A, Martín-Segura A, Puri C, Scrivo A, Skidmore J, Son SM, Stamatakou E, Wrobel L, Zhu Y, Cuervo AM, Rubinsztein DC.