Stavros Vagionitis

University Position

Research Associate

Dr Stavros Vagionitis is pleased to consider applications from prospective PhD students.

Interests

I'm a Research Fellow at the Cambridge Centre for Myelin Repair and the Cambridge Stem Cell Institute, working in the lab of Prof. Ragnhildur Thóra Káradóttir. I'm interested in how myelin — the fatty sheath made by oligodendrocytes that wraps around axons — changes throughout life, either in response to neuronal activity or during repair after demyelinating injury. I use rodent models and techniques spanning stereotactic brain injections, confocal, light-sheet, and super-resolution microscopy.

OPC differentiation in the cortex

Oligodendrocyte progenitors as they differentiate into oligodendrocytes increase the expression of this marker and start making nascent sheaths

Key Publications

Focal white matter lesions drive grey matter inflammation and synapse loss.

DOI: http://doi.org/10.1038/s41586-026-10414-w
Journal: Nature
E-pub date: 1 Jun 2026
Authors: O de Faria, S Vagionitis, A Lopez-Lopez, M Perry, JJY Wong, L Rodríguez-Kirby, B Hervé, BV Varga, E Agirre, S Ghosh, S Timmler, M Yucel, AT Setley, KA Evans, TM Birgisdóttir, S Gíslason, YT Ng, C Kremler, HOB Gautier, Y Kamen, H Pivonkova, K Volbracht, F Hildebrand, CA Cepeda, J Rueda-Carrasco, S Hong, G Malliaras, S Dietmann, G Castelo-Branco, RT Káradóttir

Clusters of neuronal neurofascin prefigure the position of a subset of nodes of Ranvier along individual central nervous system axons in vivo.

DOI: http://doi.org/10.1016/j.celrep.2022.110366
Journal: Cell Rep
E-pub date: 15 Feb 2022
Authors: S Vagionitis, F Auer, Y Xiao, RG Almeida, DA Lyons, T Czopka

Evidence for Myelin Sheath Remodeling in the CNS Revealed by In Vivo Imaging.

DOI: http://doi.org/10.1016/j.cub.2018.01.017
Journal: Curr Biol
E-pub date: 19 Feb 2018
Authors: F Auer, S Vagionitis, T Czopka

Publications

Myelin basic protein is an RNA chaperone in microglial nuclear retro-transport

DOI: http://doi.org/10.64898/2026.05.14.725089
Journal:
E-pub date: 21 Jun 2026
Authors: G LAM, Z Xu, AM Vaquie, S Vagionitis, M Perry, O de Faria, G Solomou, JH Stockley, GC Girdler, D Yamamoto, JA Oses, Q Zhang, G Jordan, LR Morcom, J Stillman, HS Mousa, A Burlingame, M Stewart, HB Werner, A Lakatos, H Bulstrode, DP Schafer, JL Jones, RT Karadottir, DH Rowitch

Constitutive DREADD signalling modulates oligodendrocyte precursor cell bioelectrical membrane properties and fate

DOI: http://doi.org/10.64898/2025.12.22.695316
Journal:
E-pub date: 26 Dec 2025
Authors: Y Kamen, S Vagionitis, O de Faria, RT Káradóttir

Functional implication for myelin regeneration in recovery from ischaemic stroke.

DOI: http://doi.org/10.1093/brain/awae080
Journal: Brain
E-pub date: 4 Apr 2024
Authors: S Vagionitis, RT Káradóttir

Expression of glucose transporter-2 in murine retina: Evidence for glucose transport from horizontal cells to photoreceptor synapses.

DOI: http://doi.org/10.1111/jnc.15533
Journal: J Neurochem
E-pub date: 1 Jan 2022
Authors: M Yang, Y Chen, S Vagionitis, E Körtvely, M Ueffing, O Schmachtenberg, Z Hu, K Jiao, F Paquet-Durand

Visualization and Time-Lapse Microscopy of Myelinating Glia In Vivo in Zebrafish.

DOI: http://doi.org/10.1007/978-1-4939-7862-5_3
Journal:
E-pub date: 1 Aug 2018
Authors: S Vagionitis, T Czopka