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  • Metabolism
  • Glia
  • Neuron
  • Structural Plasticity
  • Myelin
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    Thomas Brown

    (he/him/his)
    University Position
    Research Associate

    Interests

    Thomas Brown began his academic journey studying archaeology at the University of Sheffield. During his undergraduate degree, he took a part-time job at a nursing home across the street, an experience that sparked his interest in neuroscience. Motivated to explore the complexities of the brain, particularly in the context of neurodegeneration and regeneration, he pursued a Master’s in Translational Neuroscience at the University of Sheffield before embarking on a PhD at McGill University in Montreal. During his doctoral research in the lab of Dr Michel Cayouette (IRCM), Thomas co-authored a project that identified Pou3f1 as a key gene in the development of binocular retinal projections. He also led a second project which uncovered a role of glial cell signalling in shaping the light-sensitive circuits which regulate the sleep-wake cycle. A passionate enthusiast of glial cells, Thomas has since shifted his focus to the hypothalamus. In the lab of Professor Clémence Blouet at the Institute of Metabolic Science, he is helping to investigate a particularly dynamic population of oligodendrocytes, the myelin-producing cells that insulate neuronal electrical signals. Beyond his research, Thomas is a dedicated advocate for science communication and public engagement. He has participated in and coordinated multiple outreach projects in UK and Canada, striving to make neuroscience more accessible to wider audiences. He remains actively involved in outreach and engagement initiatives at the university and with the wider-community.

    Key Publications

    Retinal glia regulate development of the circadian photoentrainment circuits

    DOI:
    Journal: Cell Reports
    Year: 2025
    Authors: Brown, TW*. Vilallongue, N*. Hales, SC. Srikanta, SB. Rochon, P. Olguin, AGR. Waxman, SB. Tufford, A. Van Prooijen, J. Krishnaswamy, A. Cermakian, N. Cayouette, M (*co-first author)

    Pou3f1 orchestrates a gene regulatory network controlling contralateral retinogeniculate projections

    DOI:
    Journal: Cell Reports
    Year: 2023
    Authors: Fries M*, Brown TW*, Jolicoeur C, Boulan B, Boudreau-Pinsonneault C, Javed A, Abram P, Cayouette M. (*co-first author)

    Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism.

    DOI:
    Journal: Cell Metabolism
    Year: 2025
    Authors: Hansford R, Buller S, Tsang AH, Benoit S, Roberts AG, Erskine E, Brown T, Pirro V, Reimann F, Harada N, Inagaki N, Samms RJ, Broichhagen J, Hodson DJ, Adriaenssens A, Park S, Blouet C.

    Publications

    The Deubiquitinase USP2 Modulates Photic Entrainment of the Circadian Clock at the Level of the Suprachiasmatic Nucleus.

    DOI:
    Journal: Journal of Neurochemistry
    Year: 2025
    Authors: Srikanta SB, Brown TW, Malescot A, Cloutier MÈ, Zhu L, Coutanson C, Malki M, Storch KF, Rungta R, Cayouette M, Dkhissi-Benyahya O, Cermakian N

    Cadherin 4 assembles a family of color-preferring retinal circuits that respond to light offset

    DOI:
    Journal: Current Biology
    Year: 2025
    Authors: Olguin AGR, Rochon PL, Theriault C, Brown T, Yao H, Cayouette M, Cook EP, Krishnaswamy A.

    Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models

    DOI:
    Journal: Science Advances
    Year: 2022
    Authors: Lacomme M, Hales SC, Brown TW, Stevanovic K, Jolicoeur C, Cai J, Bois T, Desrosiers M, Dalkara D, Cayouette M.