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EMAIL tf337@cam.ac.uk
Department
  • Physiology, Development and Neuroscience
    • Research Theme Neurons, Circuits and Networks Adaptive Brain Computations Lifelong Brain Development and Brain Ageing
    Research Focus

    Keywords

  • Hippocampal Neurons
  • Synaptic Plasticity
  • Learning & Memory
  • Protein Synthesis

    • Clinical Conditions

  • Alzheimer's disease

    • Equipment & Techniques

  • Electrophysiological recording techniques
  • Field potential recording
  • Fluorescence microscopy
  • Whole cell patch clamp
  • Immunohistochemistry

    • Science Culture

  • Science Communication
  • Philosophy of Science

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    Dr Tanja Fuchsberger

    University Position
    Research Associate

    Interests

    My research focuses on understanding neuronal and synaptic mechanisms underlying learning and memory. My work integrates experimental approaches to investigate the effects of synaptic transmission and plasticity that enable encoding of information. In my current project, I study how neuronal activity patterns and neuromodulators drive protein synthesis dynamics in neurons and glia cells. Furthermore, I also investigate how these processes are altered in neurodegenerative disorders, particularly in the neuropathophysiology of Alzheimer's disease.

    Key Publications

    Postsynaptic burst reactivation of hippocampal neurons enables associative plasticity of temporally discontiguous inputs

    DOI: https://doi.org/10.7554/eLife.81071
    Journal: elife
    Year: 2022
    Authors: Tanja Fuchsberger, Claudia Clopath, Przemyslaw Jarzebowski, Zuzanna Brzosko, Hongbing Wang, Ole Paulsen

    Modulation of hippocampal plasticity in learning and memory

    DOI: https://doi.org/10.1016/j.conb.2022.102558
    Journal: Current Opinion in Neurobiology
    Year: 2022
    Authors: Tanja Fuchsberger and Ole Paulsen

    Thalamus mediates neocortical Down state transition via GABAB-receptor-targeting interneurons

    DOI: https://doi.org/10.1016/j.neuron.2021.06.030
    Journal: Neuron
    Year: 2021
    Authors: Hay YA, Deperrois N, Fuchsberger T, Quarrell TM, Koerling AL, Paulsen O

    Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival.

    DOI: https://doi.org/10.1038/srep31158
    Journal: Scientific Reports
    Year: 2016
    Authors: Fuchsberger T; Martínez-Bellver S; Giraldo E; Teruel-Martí V; Lloret A; Viña J

    Publications

    Oral Monosodium Glutamate Administration Causes Early Onset of Alzheimer’s Disease-Like Pathophysiology in APP/PS1 Mice

    DOI: https://pubmed.ncbi.nlm.nih.gov/31658055/
    Journal: Journal of Alzheimer’s Disease
    Year: 2019
    Authors: Fuchsberger T, Yuste R, Martinez-Bellver S, Blanco-Gandia MC, Torres-Cuevas I, Blasco-Serra A, Arango R, Miñarro J, Rodríguez-Arias M, Teruel-Marti V, Lloret A, Viña J

    Partial restoration of physiological UP-state activity by GABA pathway modulation in an acute brain slice model of epilepsy

    DOI: https://doi.org/10.1016/j.neuropharm.2018.11.032
    Journal: Neuropharmacology
    Year: 2019
    Authors: Anna-Lucia Koerling, Tanja Fuchsberger, Ole Paulsen, Y. Audrey Hay

    New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer's Disease.

    DOI: https://doi.org/10.3390/ijms18051057
    Journal: Int. J. Mol. Sci.
    Year: 2017
    Authors: Fuchsberger T; Lloret A; Viña J