• Biochemistry
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    Timothy Birkle

    University Position
    PhD student


    Within the lab of Prof. Guy Brown, I investigate druggable targets within microglial cells which may be useful for tackling neurodegenerative diseases such as Alzheimer's disease. In particular, we are interested in targets which modulate inflammation and phagocytosis, such that inhibiting them might be beneficial in neuroinflammatory conditions. To carry out this research, we mostly use primary cell cultures, automated image analysis, and other functional assays to assess cellular dynamics, morphology, and activity.

    Key Publications


    Disease phenotypic screening in neuron-glia cocultures identifies blockers of inflammatory neurodegeneration.

    Journal: iScience
    E-pub date: 19 Apr 2024
    Authors: TJY Birkle, HMG Willems, J Skidmore, GC Brown

    Syk inhibitors protect against microglia-mediated neuronal loss in culture.

    Journal: Front Aging Neurosci
    E-pub date: 1 Aug 2023
    Authors: TJY Birkle, GC Brown