Professor Tony Holland

University Position

Professor

Interests

The focus of our interdisciplinary research is on learning disabilities (intellectual disabilities/mental handicap) from different perspectives. Research to date has had the following main themes. First, the relationship between specific genetically determined neurodevelopmental disorders and patterns of development and associated co-morbidities. Research projects have included studies of Prader Willi Syndrome and the associated eating disorder and risks of psychiatric illness; and investigations of the links between Down's syndrome and the high risk for developing Alzheimer's disease. Secondly, studies investigating the interface between people with learning disabilities and the law. This has included research to inform the Mental Capacity Act 2005 and to investigate offending by people with learning disabilies. Thirdly, sociological studies broadly on the theme of 'citizenship' with respect to people with learning disabilities. Since 2008 our group has been part of the NIHR CLAHRC.

Key Publications

A review of psychiatric conceptions of mental and behavioural disorders in Prader-Willi syndrome.

DOI: http://doi.org/10.1016/j.neubiorev.2018.10.006
Journal: Neurosci Biobehav Rev
E-pub date: 1 Dec 2018
Authors: J Whittington, A Holland

Cognition in people with Prader-Willi syndrome: Insights into genetic influences on cognitive and social development.

DOI: http://doi.org/10.1016/j.neubiorev.2016.09.013
Journal: Neurosci Biobehav Rev
E-pub date: 1 Jan 2017
Authors: J Whittington, A Holland

Publications

Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down’s syndrome.

DOI: http://doi.org/10.1016/j.neurobiolaging.2022.02.013
Journal: Neurobiol Aging
E-pub date: 1 Jul 2022
Authors: SSG Brown, E Mak, I Clare, M Grigorova, J Beresford-Webb, M Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, AJ Holland, SH Zaman

Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study.

DOI: http://doi.org/10.1002/dad2.12288
Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
E-pub date: 1 Jan 2022
Authors: C Padilla, V Montal, MJ Walpert, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, SL Hartley, AD Cohen, DL Tudorascu, BT Christian, BL Handen, WE Klunk, AJ Holland, SH Zaman

Amyloid and tau deposition influences cognitive decline in Down syndrome

DOI: http://doi.org/10.1002/alz.056384
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2021
Authors: M Grigorova, E Mak, J Beresford‐Webb, SSG Brown, E Jones, I Clare, T Holland, YT Hong, TD Fryer, JP Coles, GB Williams, FI Aigbirhio, BM Ances, BT Christian, BL Handen, WE Klunk, CM Laymon, DL Tudorascu, S Zaman

Isolating residents including wandering residents in care and group homes: Medical ethics and English law in the context of Covid-19.

DOI: http://doi.org/10.1016/j.ijlp.2020.101649
Journal: Int J Law Psychiatry
E-pub date: 1 Aug 2021
Authors: K Liddell, A Ruck Keene, A Holland, J Huppert, BR Underwood, O Clark, SIG Barclay

Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

DOI: http://doi.org/10.1093/braincomms/fcaa198
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

Diffusion structural network metrics as a predictor for Alzheimer’s disease diagnosis in Down syndrome using support vector machine classification

DOI: http://doi.org/10.1002/alz.040261
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2020
Authors: SSG Brown, E Mak, M Grigorova, J Beresford‐Webb, MJ Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BL Handen, BT Christian, WE Klunk, DK Menon, PJ Nestor, AJ Holland, S Zaman

Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report.

DOI: http://doi.org/10.1016/j.dadm.2019.04.006
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Dec 2019
Authors: E Mak, A Bickerton, C Padilla, MJ Walpert, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, SH Zaman, AJ Holland

Differential effects of Down’s syndrome and Alzheimer’s neuropathology on default mode connectivity.

DOI: http://doi.org/10.1002/hbm.24720
Journal: Hum Brain Mapp
E-pub date: 15 Oct 2019
Authors: LR Wilson, D Vatansever, T Annus, GB Williams, YT Hong, TD Fryer, PJ Nestor, AJ Holland, SH Zaman

Delineating the topography of amyloid-associated cortical atrophy in Down syndrome.

DOI: http://doi.org/10.1016/j.neurobiolaging.2019.02.018
Journal: Neurobiol Aging
E-pub date: 31 Aug 2019
Authors: E Mak, C Padilla, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, SH Zaman, AJ Holland

Brain-stem serotonin transporter availability in maternal uniparental disomy and deletion Prader-Willi syndrome.

DOI: http://doi.org/10.1192/bjp.2017.7
Journal: Br J Psychiatry
E-pub date: 1 Jan 2018
Authors: R Krishnadas, S-A Cooper, A Nicol, S Pimlott, S Soni, AJ Holland, L McArthur, J Cavanagh

Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline.

DOI: http://doi.org/10.1016/j.neurobiolaging.2017.04.006
Journal: Neurobiol Aging
E-pub date: 31 Aug 2017
Authors: JH Cole, T Annus, LR Wilson, R Remtulla, YT Hong, TD Fryer, J Acosta-Cabronero, A Cardenas-Blanco, R Smith, DK Menon, SH Zaman, PJ Nestor, AJ Holland

The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis.

DOI: http://doi.org/10.1016/j.neurobiolaging.2017.01.009
Journal: Neurobiol Aging
E-pub date: 1 May 2017
Authors: T Annus, LR Wilson, J Acosta-Cabronero, A Cardenas-Blanco, YT Hong, TD Fryer, JP Coles, DK Menon, SH Zaman, AJ Holland, PJ Nestor

Psychosis in autism: comparison of the features of both conditions in a dually affected cohort.

DOI: http://doi.org/10.1192/bjp.bp.116.187682
Journal: Br J Psychiatry
E-pub date: 1 Apr 2017
Authors: FV Larson, AP Wagner, PB Jones, D Tantam, M-C Lai, S Baron-Cohen, AJ Holland

The pattern of amyloid accumulation in the brains of adults with Down syndrome.

DOI: http://doi.org/10.1016/j.jalz.2015.07.490
Journal: Alzheimers Dement
E-pub date: 1 May 2016
Authors: T Annus, LR Wilson, YT Hong, J Acosta-Cabronero, TD Fryer, A Cardenas-Blanco, R Smith, I Boros, JP Coles, FI Aigbirhio, DK Menon, SH Zaman, PJ Nestor, AJ Holland

Testing the ‘Extreme Female Brain’ Theory of Psychosis in Adults with Autism Spectrum Disorder with or without Co-Morbid Psychosis.

DOI: http://doi.org/10.1371/journal.pone.0128102
Journal: PLoS One
E-pub date: 1 Aug 2015
Authors: FV Larson, M-C Lai, AP Wagner, MRC AIMS Consortium, S Baron-Cohen, AJ Holland

Ageing in people with Prader-Willi syndrome: mortality in the UK population cohort and morbidity in an older sample of adults.

DOI: http://doi.org/10.1017/S0033291714001755
Journal: Psychological Medicine
E-pub date: 12 Feb 2015
Authors: JE Whittington, AJ Holland, T Webb

Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility.

DOI: http://doi.org/10.1001/archneurol.2011.36
Journal: Arch Neurol
E-pub date: 1 Jul 2011
Authors: J Landt, JC D'Abrera, AJ Holland, FI Aigbirhio, TD Fryer, R Canales, YT Hong, DK Menon, J-C Baron, SH Zaman

Recognition of emotion in facial expression by people with Prader-Willi syndrome.

DOI: http://doi.org/10.1111/j.1365-2788.2010.01348.x
Journal: J Intellect Disabil Res
E-pub date: 1 Jan 2011
Authors: J Whittington, T Holland

Relationship between the IQ of people with Prader-Willi syndrome and that of their siblings: evidence for imprinted gene effects.

DOI: http://doi.org/10.1111/j.1365-2788.2009.01157.x
Journal: J Intellect Disabil Res
E-pub date: 1 May 2009
Authors: J Whittington, A Holland, T Webb

Pre-, peri- and postnatal complications in Prader-Willi syndrome in a UK sample.

DOI: http://doi.org/10.1016/j.earlhumdev.2007.08.007
Journal: Early Hum Dev
E-pub date: 1 May 2008
Authors: JE Whittington, JV Butler, AJ Holland

Changing rates of genetic subtypes of Prader-Willi syndrome in the UK.

DOI: http://doi.org/10.1038/sj.ejhg.5201716
Journal: Eur J Hum Genet
E-pub date: 1 Jan 2007
Authors: JE Whittington, JV Butler, AJ Holland