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    Professor Tony Holland

    University Position
    Professor

    Interests

    The focus of our interdisciplinary research is on learning disabilities (intellectual disabilities/mental handicap) from different perspectives. Research to date has had the following main themes. First, the relationship between specific genetically determined neurodevelopmental disorders and patterns of development and associated co-morbidities. Research projects have included studies of Prader Willi Syndrome and the associated eating disorder and risks of psychiatric illness; and investigations of the links between Down's syndrome and the high risk for developing Alzheimer's disease. Secondly, studies investigating the interface between people with learning disabilities and the law. This has included research to inform the Mental Capacity Act 2005 and to investigate offending by people with learning disabilies. Thirdly, sociological studies broadly on the theme of 'citizenship' with respect to people with learning disabilities. Since 2008 our group has been part of the NIHR CLAHRC.

    Key Publications

    Clinical and biomarker changes of Alzheimer’s disease in adults with Down syndrome: a cross-sectional study.

    DOI: http://doi.org/10.1016/S0140-6736(20)30689-9
    Journal: Lancet
    E-pub date: 27 Jun 2020
    Authors: J Fortea, E Vilaplana, M Carmona-Iragui, B Benejam, L Videla, I Barroeta, S Fernández, M Altuna, J Pegueroles, V Montal, S Valldeneu, S Giménez, S González-Ortiz, L Muñoz, T Estellés, I Illán-Gala, O Belbin, V Camacho, LR Wilson, T Annus, RS Osorio, S Videla, S Lehmann, AJ Holland, D Alcolea, J Clarimón, SH Zaman, R Blesa, A Lleó

    A review of psychiatric conceptions of mental and behavioural disorders in Prader-Willi syndrome.

    DOI: http://doi.org/10.1016/j.neubiorev.2018.10.006
    Journal: Neurosci Biobehav Rev
    E-pub date: 1 Dec 2018
    Authors: J Whittington, A Holland

    Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer’s Disease Pathology in Down Syndrome.

    DOI: http://doi.org/10.3233/JAD-170814
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2018
    Authors: R Raha-Chowdhury, JW Henderson, AA Raha, SRW Stott, R Vuono, S Foscarin, L Wilson, T Annus, R Fincham, K Allinson, V Devalia, RP Friedland, A Holland, SH Zaman

    Publications

    Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down’s syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2022.02.013
    Journal: Neurobiol Aging
    E-pub date: 1 Jul 2022
    Authors: SSG Brown, E Mak, I Clare, M Grigorova, J Beresford-Webb, M Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimer’s, and Parkinson’s Diseases.

    DOI: http://doi.org/10.3390/ijms23031060
    Journal: Int J Mol Sci
    E-pub date: 19 Jan 2022
    Authors: AA Raha, A Biswas, J Henderson, S Chakraborty, A Holland, RP Friedland, E Mukaetova-Ladinska, S Zaman, R Raha-Chowdhury

    Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study.

    DOI: http://doi.org/10.1002/dad2.12288
    Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
    E-pub date: 1 Jan 2022
    Authors: C Padilla, V Montal, MJ Walpert, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, SL Hartley, AD Cohen, DL Tudorascu, BT Christian, BL Handen, WE Klunk, AJ Holland, SH Zaman

    Amyloid and tau deposition influences cognitive decline in Down syndrome

    DOI: http://doi.org/10.1002/alz.056384
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2021
    Authors: M Grigorova, E Mak, J Beresford‐Webb, SSG Brown, E Jones, I Clare, T Holland, YT Hong, TD Fryer, JP Coles, GB Williams, FI Aigbirhio, BM Ances, BT Christian, BL Handen, WE Klunk, CM Laymon, DL Tudorascu, S Zaman

    Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study.

    DOI: http://doi.org/10.1016/S1474-4422(21)00129-0
    Journal: Lancet Neurol
    E-pub date: 31 Aug 2021
    Authors: M Carmona-Iragui, D Alcolea, I Barroeta, L Videla, L Muñoz, KL Van Pelt, FA Schmitt, DD Lightner, LM Koehl, G Jicha, S Sacco, C Mircher, SE Pape, R Hithersay, ICH Clare, AJ Holland, G Nübling, J Levin, SH Zaman, A Strydom, A-S Rebillat, E Head, R Blesa, A Lleó, J Fortea

    Isolating residents including wandering residents in care and group homes: Medical ethics and English law in the context of Covid-19.

    DOI: http://doi.org/10.1016/j.ijlp.2020.101649
    Journal: Int J Law Psychiatry
    E-pub date: 1 Aug 2021
    Authors: K Liddell, A Ruck Keene, A Holland, J Huppert, BR Underwood, O Clark, SIG Barclay

    Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

    DOI: http://doi.org/10.1093/braincomms/fcaa198
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    Hepcidin Increases Cytokines in Alzheimer’s Disease and Down’s Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation.

    DOI: http://doi.org/10.3389/fnagi.2021.653591
    Journal: Front Aging Neurosci
    E-pub date: 1 Aug 2021
    Authors: AA Raha, SD Ghaffari, J Henderson, S Chakraborty, K Allinson, RP Friedland, A Holland, SH Zaman, EB Mukaetova-Ladinska, R Raha-Chowdhury

    Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome.

    DOI: http://doi.org/10.1001/jamaneurol.2021.1893
    Journal: JAMA Neurol
    E-pub date: 1 Aug 2021
    Authors: A Bejanin, MF Iulita, E Vilaplana, M Carmona-Iragui, B Benejam, L Videla, I Barroeta, S Fernandez, M Altuna, J Pegueroles, V Montal, S Valldeneu, S Giménez, S González-Ortiz, L Muñoz, C Padilla, MR Aranha, T Estellés, I Illán-Gala, O Belbin, V Camacho, LR Wilson, T Annus, RS Osorio, S Videla, S Lehmann, AJ Holland, H Zetterberg, K Blennow, D Alcolea, J Clarimon, SH Zaman, R Blesa, A Lleó, J Fortea

    Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.

    DOI: http://doi.org/10.3390/jcm10132909
    Journal: J Clin Med
    E-pub date: 29 Jun 2021
    Authors: R Raha-Chowdhury, AA Raha, J Henderson, SD Ghaffari, M Grigorova, J Beresford-Webb, K Allinson, S Chakraborty, A Holland, SH Zaman

    Diffusion structural network metrics as a predictor for Alzheimer’s disease diagnosis in Down syndrome using support vector machine classification

    DOI: http://doi.org/10.1002/alz.040261
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: SSG Brown, E Mak, M Grigorova, J Beresford‐Webb, MJ Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BL Handen, BT Christian, WE Klunk, DK Menon, PJ Nestor, AJ Holland, S Zaman

    Amnestic and non-amnestic symptoms of dementia: An international study of Alzheimer’s disease in people with Down’s syndrome.

    DOI: http://doi.org/10.1002/gps.5283
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Jun 2020
    Authors: LM Fonseca, C Padilla, E Jones, N Neale, GG Haddad, GP Mattar, E Barros, ICH Clare, GF Busatto, CMC Bottino, MQ Hoexter, AJ Holland, S Zaman

    Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report.

    DOI: http://doi.org/10.1016/j.dadm.2019.04.006
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: E Mak, A Bickerton, C Padilla, MJ Walpert, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, SH Zaman, AJ Holland

    Age-related retinal thickness in Down’s syndrome: A high-risk population for dementia.

    DOI: http://doi.org/10.1016/j.dadm.2019.08.007
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: MJ Walpert, EM Normando, T Annus, SR Jennings, LR Wilson, P Watson, SH Zaman, MF Cordeiro, AJ Holland

    Differential effects of Down’s syndrome and Alzheimer’s neuropathology on default mode connectivity.

    DOI: http://doi.org/10.1002/hbm.24720
    Journal: Hum Brain Mapp
    E-pub date: 15 Oct 2019
    Authors: LR Wilson, D Vatansever, T Annus, GB Williams, YT Hong, TD Fryer, PJ Nestor, AJ Holland, SH Zaman

    Delineating the topography of amyloid-associated cortical atrophy in Down syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2019.02.018
    Journal: Neurobiol Aging
    E-pub date: 31 Aug 2019
    Authors: E Mak, C Padilla, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, SH Zaman, AJ Holland

    The validity and reliability of the CAMDEX-DS for assessing dementia in adults with Down syndrome in Brazil.

    DOI: http://doi.org/10.1590/1516-4446-2018-0033
    Journal: Braz J Psychiatry
    E-pub date: 1 Aug 2019
    Authors: LM Fonseca, GG Haddad, GP Mattar, MCD Oliveira, SS Simon, LM Guilhoto, GF Busatto, S Zaman, AJ Holland, MQ Hoexter, CM Bottino

    TREM2, Tau and ApoE in choroid plexus in AD pathology

    DOI: http://doi.org/10.3233/JAD-181179
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2019
    Authors: A Holland, R Raha-Chowdhury, JW Henderson, AA Raha, R Vuono, A Bickerton, E Jones, R Fincham, K Allinson, S Zaman

    Frontal-subcortical behaviors during Alzheimer’s disease in individuals with Down syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2019.02.028
    Journal: Neurobiol Aging
    E-pub date: 1 Jun 2019
    Authors: LM Fonseca, GP Mattar, GG Haddad, AS Gonçalves, ADQC Miguel, LM Guilhoto, S Zaman, AJ Holland, CMDC Bottino, MQ Hoexter

    Neuroimaging and other modalities to assess Alzheimer’s disease in Down syndrome.

    DOI: http://doi.org/10.1016/j.nicl.2017.10.022
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2018
    Authors: N Neale, C Padilla, LM Fonseca, T Holland, S Zaman

    Brain-stem serotonin transporter availability in maternal uniparental disomy and deletion Prader-Willi syndrome.

    DOI: http://doi.org/10.1192/bjp.2017.7
    Journal: Br J Psychiatry
    E-pub date: 1 Jan 2018
    Authors: R Krishnadas, S-A Cooper, A Nicol, S Pimlott, S Soni, AJ Holland, L McArthur, J Cavanagh

    Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2017.04.006
    Journal: Neurobiol Aging
    E-pub date: 31 Aug 2017
    Authors: JH Cole, T Annus, LR Wilson, R Remtulla, YT Hong, TD Fryer, J Acosta-Cabronero, A Cardenas-Blanco, R Smith, DK Menon, SH Zaman, PJ Nestor, AJ Holland

    The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2017.01.009
    Journal: Neurobiol Aging
    E-pub date: 1 May 2017
    Authors: T Annus, LR Wilson, J Acosta-Cabronero, A Cardenas-Blanco, YT Hong, TD Fryer, JP Coles, DK Menon, SH Zaman, AJ Holland, PJ Nestor

    Psychosis in autism: comparison of the features of both conditions in a dually affected cohort.

    DOI: http://doi.org/10.1192/bjp.bp.116.187682
    Journal: Br J Psychiatry
    E-pub date: 1 Apr 2017
    Authors: FV Larson, AP Wagner, PB Jones, D Tantam, M-C Lai, S Baron-Cohen, AJ Holland

    The Early Presentation of Dementia in People with Down Syndrome: a Systematic Review of Longitudinal Studies.

    DOI: http://doi.org/10.1007/s11065-017-9341-9
    Journal: Neuropsychol Rev
    E-pub date: 1 Mar 2017
    Authors: BA Lautarescu, AJ Holland, SH Zaman

    The pattern of amyloid accumulation in the brains of adults with Down syndrome.

    DOI: http://doi.org/10.1016/j.jalz.2015.07.490
    Journal: Alzheimers Dement
    E-pub date: 1 May 2016
    Authors: T Annus, LR Wilson, YT Hong, J Acosta-Cabronero, TD Fryer, A Cardenas-Blanco, R Smith, I Boros, JP Coles, FI Aigbirhio, DK Menon, SH Zaman, PJ Nestor, AJ Holland

    Testing the ‘Extreme Female Brain’ Theory of Psychosis in Adults with Autism Spectrum Disorder with or without Co-Morbid Psychosis.

    DOI: http://doi.org/10.1371/journal.pone.0128102
    Journal: PLoS One
    E-pub date: 1 Aug 2015
    Authors: FV Larson, M-C Lai, AP Wagner, MRC AIMS Consortium, S Baron-Cohen, AJ Holland

    A neuroimaging proof of principle study of Down’s syndrome and dementia: ethical and methodological challenges in intrusive research.

    DOI: http://doi.org/10.1111/j.1365-2788.2011.01495.x
    Journal: Journal of Intellectual Disability Research
    E-pub date: 1 Feb 2013
    Authors: JC d'Abrera, AJ Holland, J Landt, G Stocks-Gee, SH Zaman

    Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility.

    DOI: http://doi.org/10.1001/archneurol.2011.36
    Journal: Arch Neurol
    E-pub date: 1 Jul 2011
    Authors: J Landt, JC D'Abrera, AJ Holland, FI Aigbirhio, TD Fryer, R Canales, YT Hong, DK Menon, J-C Baron, SH Zaman

    IC‐P‐156: Imaging brain fibrillar β‐amyloid in adults with Down syndrome (DS) using [11C] PiB‐PET: acceptability, feasibility and preliminary results

    DOI: http://doi.org/10.1016/j.jalz.2011.05.170
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Jul 2011
    Authors: Jean‐Claude Baron, J Landt, JC D'Abrera, A Holland, F Aigbirhio, T Fryer, R Canales, Y Hong, D Menon, J Baron, S Zaman

    Recognition of emotion in facial expression by people with Prader-Willi syndrome.

    DOI: http://doi.org/10.1111/j.1365-2788.2010.01348.x
    Journal: J Intellect Disabil Res
    E-pub date: 1 Jan 2011
    Authors: J Whittington, T Holland

    Pre-, peri- and postnatal complications in Prader-Willi syndrome in a UK sample.

    DOI: http://doi.org/10.1016/j.earlhumdev.2007.08.007
    Journal: Early Hum Dev
    E-pub date: 1 May 2008
    Authors: JE Whittington, JV Butler, AJ Holland

    Changing rates of genetic subtypes of Prader-Willi syndrome in the UK.

    DOI: http://doi.org/10.1038/sj.ejhg.5201716
    Journal: Eur J Hum Genet
    E-pub date: 1 Jan 2007
    Authors: JE Whittington, JV Butler, AJ Holland