Dr Tim Rooney

(he/him/his)

University Position

Senior Research Associate

Interests

I am a research associate at the Alzheimer's Research UK Drug Discovery Institute where I work as a medicinal chemist on a variety of projects related to neurodegeneration. With expertise in drug discovery, organic chemistry and chemical biology, I work alongside the other scientists at the DDI to help translate the latest ideas in dementia research into new drug discovery projects.

Key Publications

The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)

DOI: http://doi.org/10.1039/d3md00355h
Journal: RSC Med Chem
E-pub date: 18 Oct 2023
Authors: GG Aldred, TPC Rooney, HMG Willems, HK Boffey, C Green, D Winpenny, J Skidmore, JH Clarke, SP Andrews

The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules.

DOI: http://doi.org/10.1021/acs.jmedchem.2c01693
Journal: J Med Chem
E-pub date: 12 Jan 2023
Authors: TPC Rooney, GG Aldred, HK Boffey, HMG Willems, S Edwards, SJ Chawner, DE Scott, C Green, D Winpenny, J Skidmore, JH Clarke, SP Andrews

Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.

DOI: http://doi.org/10.1021/acs.jmedchem.1c01819
Journal: J Med Chem
E-pub date: 24 Feb 2022
Authors: HK Boffey, TPC Rooney, HMG Willems, S Edwards, C Green, T Howard, D Ogg, T Romero, DE Scott, D Winpenny, J Duce, J Skidmore, JH Clarke, SP Andrews

Systematic Investigation of the Permeability of Androgen Receptor PROTACs.

DOI: http://doi.org/10.1021/acsmedchemlett.0c00194
Journal: ACS Med Chem Lett
E-pub date: 13 Aug 2020
Authors: DE Scott, TPC Rooney, ED Bayle, T Mirza, HMG Willems, JH Clarke, SP Andrews, J Skidmore