• Medical Genetics
  • Research Focus


  • Medicinal Chemistry
  • Neuroinflammation
  • Proteostasis
  • Clinical Conditions

  • Alzheimer's disease
  • Parkinson's disease
  • Equipment & Techniques

  • Computational modelling
  • Back

    Dr Tim Rooney

    University Position
    Senior Research Associate


    I am a research associate at the Alzheimer's Research UK Drug Discovery Institute where I work as a medicinal chemist on a variety of projects related to neurodegeneration. With expertise in drug discovery, organic chemistry and chemical biology, I work alongside the other scientists at the DDI to help translate the latest ideas in dementia research into new drug discovery projects.

    Key Publications

    The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)

    Journal: RSC Med Chem
    E-pub date: 18 Oct 2023
    Authors: GG Aldred, TPC Rooney, HMG Willems, HK Boffey, C Green, D Winpenny, J Skidmore, JH Clarke, SP Andrews

    The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules.

    Journal: J Med Chem
    E-pub date: 12 Jan 2023
    Authors: TPC Rooney, GG Aldred, HK Boffey, HMG Willems, S Edwards, SJ Chawner, DE Scott, C Green, D Winpenny, J Skidmore, JH Clarke, SP Andrews

    Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.

    Journal: J Med Chem
    E-pub date: 24 Feb 2022
    Authors: HK Boffey, TPC Rooney, HMG Willems, S Edwards, C Green, T Howard, D Ogg, T Romero, DE Scott, D Winpenny, J Duce, J Skidmore, JH Clarke, SP Andrews

    Systematic Investigation of the Permeability of Androgen Receptor PROTACs.

    Journal: ACS Med Chem Lett
    E-pub date: 13 Aug 2020
    Authors: DE Scott, TPC Rooney, ED Bayle, T Mirza, HMG Willems, JH Clarke, SP Andrews, J Skidmore