Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson’s Disease Dementia.

DOI: http://doi.org/10.1002/mdc3.13752 Journal: Mov Disord Clin Pract E-pub date: 1 Jun 2023 Authors: MC Gonzalez, DA Tovar-Rios, G Alves, I Dalen, CH Williams-Gray, M Camacho, L Forsgren, D Bäckström, RA Lawson, AD Macleod, CE Counsell, C Paquet, C DeLena, F D'Antonio, A Pilotto, A Padovani, F Blanc, C Falup-Pecurariu, SJG Lewis, K Rejdak, E Papuc, J Hort, Z Nedelska, J O'Brien, L Bonanni, M Marquié, M Boada, V Pytel, C Abdelnour, D Alcolea, K Beyer, O-B Tysnes, D Aarsland, J Maple-Grødem

Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson’s Disease Dementia.

Abstract:

BACKGROUND: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). OBJECTIVES: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts. METHODS: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157). RESULTS: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (-1.8 [95% CI -2.3, -1.3] vs. -1.9 [95% CI -2.6, -1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]). CONCLUSIONS: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.