Professor Fiona Gribble

University Position


Endocrine communication between the gut and brain, relaying food-related signals that control appetite and metabolism.

Key Publications

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.

Journal: Mol Metab
E-pub date: 1 Nov 2018
Authors: P Kirwan, RG Kay, B Brouwers, V Herranz-Pérez, M Jura, P Larraufie, J Jerber, J Pembroke, T Bartels, A White, FM Gribble, F Reimann, IS Farooqi, S O'Rahilly, FT Merkle

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.

Journal: Diabetologia
E-pub date: 1 Oct 2016
Authors: AE Adriaenssens, B Svendsen, BYH Lam, GSH Yeo, JJ Holst, F Reimann, FM Gribble


Obesity medication lorcaserin requires brainstem GLP-1 neurons to reduce food intake in mice

E-pub date: 1 Aug 2022
Authors: S Wagner, D Brierley, A Leeson-Payne, W Jiang, R Chianese, B Lam, G Dowsett, C Cristiano, D Lyons, F Reimann, F Gribble, GSH Yeo, S Trapp, L Heisler

Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells.

Journal: Mol Metab
E-pub date: 1 Nov 2019
Authors: LJ Billing, P Larraufie, J Lewis, A Leiter, J Li, B Lam, GS Yeo, DA Goldspink, RG Kay, FM Gribble, F Reimann

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling.

Journal: Diabetes
E-pub date: 1 May 2019
Authors: GP Roberts, P Larraufie, P Richards, RG Kay, SG Galvin, EL Miedzybrodzka, A Leiter, HJ Li, LL Glass, MKL Ma, B Lam, GSH Yeo, R Scharfmann, D Chiarugi, RH Hardwick, F Reimann, FM Gribble

Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.

Journal: Nat Commun
E-pub date: 4 Mar 2019
Authors: VB Lu, J Rievaj, EA O'Flaherty, CA Smith, R Pais, LA Pattison, G Tolhurst, AB Leiter, DC Bulmer, FM Gribble, F Reimann

Comparison of human and murine enteroendocrine cells by transcriptomic and peptidomic profiling

E-pub date: 1 Aug 2018
Authors: G Roberts, P Larraufie, P Richards, R Kay, S Galvin, E Miedzybrodzka, A Leiter, H Joyce Li, L Glass, MKL Ma, B Lam, GSH Yeo, R Scharfmann, D Chiarugi, R Hardwick, F Reimann, F Gribble

A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium.

Journal: Endocrinology
E-pub date: 1 Nov 2015
Authors: A Adriaenssens, BYH Lam, L Billing, K Skeffington, S Sewing, F Reimann, F Gribble