EMAIL ac584@cam.ac.uk

Department

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Research Theme Adaptive Brain Computations Brains and Machines Neurons, Circuits and Networks

Research Focus

Keywords

Neuroimaging

Memory

Perception

Semantic Cognition

Clinical Conditions

Dementia

Equipment & Techniques

Behavioural analysis

Magnetic resonance imaging (MRI)

Electroencephalography (EEG)

Computational modelling

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Dr Alex Clarke

University Position

Sir Henry Dale Postdoctoral Fellow
Senior Research Associate

Interests

How does the brain make sense of the world? We can recognise tens of thousands of objects, but despite this vast number, our recognition is remarkably quick and accurate, completed within a few hundred milliseconds. My research ask what are the neural dynamics and mechanisms by which vision activates semantics, and how does our knowledge about the world around us change these dynamics? Through combining MEG, EEG, fMRI, Neuropsychology and Augmented Reality, we can take a multi-modal approach to gain a deeper understanding of the nature of semantic representations in the brain.

Key Publications

Contextual Expectations Shape Cortical Reinstatement of Sensory Representations.

DOI: http://doi.org/10.1523/JNEUROSCI.2045-21.2022
Journal: J Neurosci
E-pub date: 27 Jul 2022
Authors: A Clarke, J Crivelli-Decker, C Ranganath

Towards real-world neuroscience using mobile EEG and augmented reality.

DOI: http://doi.org/10.1038/s41598-022-06296-3
Journal: Scientific Reports
E-pub date: 10 Feb 2022
Authors: A Krugliak, A Clarke

Oscillatory Dynamics of Perceptual to Conceptual Transformations in the Ventral Visual Pathway.

DOI: http://doi.org/10.1162/jocn_a_01325
Journal: Journal of Cognitive Neuroscience
E-pub date: 28 Sep 2018
Authors: A Clarke, BJ Devereux, LK Tyler

Understanding What We See: How We Derive Meaning From Vision.

DOI: http://doi.org/10.1016/j.tics.2015.08.008
Journal: Trends Cogn Sci
E-pub date: 1 Nov 2015
Authors: A Clarke, LK Tyler

Object-specific semantic coding in human perirhinal cortex.

DOI: http://doi.org/10.1523/JNEUROSCI.2828-13.2014
Journal: J Neurosci
E-pub date: 2 Apr 2014
Authors: A Clarke, LK Tyler

Publications

Parameters of prediction: Multidimensional characterization of top-down influence in visual perception.

DOI: http://doi.org/10.1016/j.neubiorev.2023.105369
Journal: Neurosci Biobehav Rev
E-pub date: 1 Oct 2023
Authors: J Ortiz-Tudela, VI Nicholls, A Clarke

Context effects on object recognition in real-world environments: A study protocol

DOI: http://doi.org/10.12688/wellcomeopenres.17856.3
Journal:
E-pub date: 1 Aug 2023
Authors: V Nicholls, B Alsbury-Nealy, A Krugliak, A Clarke

Goal-oriented representations in the human hippocampus during planning and navigation.

DOI: http://doi.org/10.1038/s41467-023-35967-6
Journal: Nat Commun
E-pub date: 23 May 2023
Authors: J Crivelli-Decker, A Clarke, SA Park, DJ Huffman, ED Boorman, C Ranganath

The visual and semantic features that predict object memory: Concept property norms for 1,000 object images.

DOI: http://doi.org/10.3758/s13421-020-01130-5
Journal: Mem Cognit
E-pub date: 1 May 2021
Authors: M Hovhannisyan, A Clarke, BR Geib, R Cicchinelli, Z Monge, T Worth, A Szymanski, R Cabeza, SW Davis

Dynamic activity patterns in the anterior temporal lobe represents object semantics.

DOI: http://doi.org/10.1080/17588928.2020.1742678
Journal: Cogn Neurosci
E-pub date: 1 Jul 2020
Authors: A Clarke

Neural dynamics of semantic composition.

DOI: http://doi.org/10.1073/pnas.1903402116
Journal: Proc Natl Acad Sci U S A
E-pub date: 15 Oct 2019
Authors: B Lyu, HS Choi, WD Marslen-Wilson, A Clarke, B Randall, LK Tyler

Perceptual and conceptual processing of visual objects across the adult lifespan.

DOI: http://doi.org/10.1038/s41598-019-50254-5
Journal: Sci Rep
E-pub date: 24 Sep 2019
Authors: R Bruffaerts, LK Tyler, M Shafto, KA Tsvetanov, Cambridge Centre for Ageing and Neuroscience, A Clarke

Neural dynamics of visual and semantic object processing

DOI: http://doi.org/10.1016/bs.plm.2019.03.002
Journal:
E-pub date: 1 Jan 2019
Authors: A Clarke

Neural reactivation in parietal cortex enhances memory for episodically linked information.

DOI: http://doi.org/10.1073/pnas.1800006115
Journal: Proc Natl Acad Sci U S A
E-pub date: 23 Oct 2018
Authors: TR Jonker, H Dimsdale-Zucker, M Ritchey, A Clarke, C Ranganath

Theta oscillations promote temporal sequence learning.

DOI: http://doi.org/10.1016/j.nlm.2018.05.001
Journal: Neurobiol Learn Mem
E-pub date: 1 Sep 2018
Authors: J Crivelli-Decker, L-T Hsieh, A Clarke, C Ranganath

Entrainment enhances theta oscillations and improves episodic memory.

DOI: http://doi.org/10.1080/17588928.2018.1521386
Journal: Cogn Neurosci
E-pub date: 1 Aug 2018
Authors: BM Roberts, A Clarke, RJ Addante, C Ranganath

Integrated deep visual and semantic attractor neural networks predict fMRI pattern-information along the ventral object processing pathway.

DOI: http://doi.org/10.1038/s41598-018-28865-1
Journal: Scientific Reports
E-pub date: 13 Jul 2018
Authors: BJ Devereux, A Clarke, LK Tyler

Neural oscillations during conditional associative learning.

DOI: http://doi.org/10.1016/j.neuroimage.2018.03.053
Journal: Neuroimage
E-pub date: 1 Jul 2018
Authors: A Clarke, BM Roberts, C Ranganath

Spatiotemporal dynamics of word retrieval in speech production revealed by cortical high-frequency band activity.

DOI: http://doi.org/10.1073/pnas.1620669114
Journal: Proc Natl Acad Sci U S A
E-pub date: 6 Jun 2017
Authors: SK Riès, RK Dhillon, A Clarke, D King-Stephens, KD Laxer, PB Weber, RA Kuperman, KI Auguste, P Brunner, G Schalk, JJ Lin, J Parvizi, NE Crone, NF Dronkers, RT Knight

Brain oscillations in language comprehension

DOI: http://doi.org/10.1080/23273798.2017.1297842
Journal: Language, Cognition and Neuroscience
E-pub date: 28 May 2017
Authors: O Hauk, AL Giraud, A Clarke

Decoding the Cortical Dynamics of Sound-Meaning Mapping.

DOI: http://doi.org/10.1523/JNEUROSCI.2858-16.2016
Journal: J Neurosci
E-pub date: 1 Feb 2017
Authors: E Kocagoncu, A Clarke, BJ Devereux, LK Tyler

Learning Warps Object Representations in the Ventral Temporal Cortex.

DOI: http://doi.org/10.1162/jocn_a_00951
Journal: J Cogn Neurosci
E-pub date: 1 Jul 2016
Authors: A Clarke, PJ Pell, C Ranganath, LK Tyler

Predicting the Time Course of Individual Objects with MEG.

DOI: http://doi.org/10.1093/cercor/bhu203
Journal: Cereb Cortex
E-pub date: 1 Oct 2015
Authors: A Clarke, BJ Devereux, B Randall, LK Tyler

The perirhinal cortex and conceptual processing: Effects of feature-based statistics following damage to the anterior temporal lobes.

DOI: http://doi.org/10.1016/j.neuropsychologia.2015.01.041
Journal: Neuropsychologia
E-pub date: 1 Sep 2015
Authors: P Wright, B Randall, A Clarke, LK Tyler

Dynamic information processing states revealed through neurocognitive models of object semantics.

DOI: http://doi.org/10.1080/23273798.2014.970652
Journal: Lang Cogn Neurosci
E-pub date: 21 Apr 2015
Authors: A Clarke

Representational similarity analysis reveals commonalities and differences in the semantic processing of words and objects.

DOI: http://doi.org/10.1523/JNEUROSCI.3809-13.2013
Journal: J Neurosci
E-pub date: 27 Nov 2013
Authors: BJ Devereux, A Clarke, A Marouchos, LK Tyler

Objects and categories: feature statistics and object processing in the ventral stream.

DOI: http://doi.org/10.1162/jocn_a_00419
Journal: J Cogn Neurosci
E-pub date: 1 Oct 2013
Authors: LK Tyler, S Chiu, J Zhuang, B Randall, BJ Devereux, P Wright, A Clarke, KI Taylor

Syntactic computations in the language network: characterizing dynamic network properties using representational similarity analysis.

DOI: http://doi.org/10.3389/fpsyg.2013.00271
Journal: Front Psychol
E-pub date: 1 Aug 2013
Authors: LK Tyler, TPL Cheung, BJ Devereux, A Clarke