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Institute
  • Neurology Unit
    • Research Theme Lifelong Brain Development and Brain Ageing Neurons, Circuits and Networks
    Research Focus

    Keywords

  • Dementia

    • Clinical Conditions

  • Alzheimer's disease
  • Frontotemporal dementia
  • Progressive supranuclear palsy
  • Aphasia
  • Dementia

    • Equipment & Techniques

  • Behavioural analysis
  • Magnetic resonance imaging (MRI)
  • Randomised control trials

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    Alexander Murley

    University Position
    Clinical Lecturer
    Dr Alexander Murley is pleased to consider applications from prospective PhD students.

    Interests

    I am a clinical lecturer and neurology registrar with a research interest in neurodegeneration and specifically the clinical syndromes associated with frontotemporal lobar degeneration. The cause of the variability of these diseases is poorly understood and an important obstacle to developing effective treatments. I am investigating how changes in genetic variation; brain volume and neurotransmitter concentration contribute to this variability in clinical phenotype and prognosis. My long-term objective is to link pre-clinical to clinical research, translating research progress to the patients I see in clinic

    Key Publications

    Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction.

    DOI: http://doi.org/10.1016/j.biopsych.2020.12.009
    Journal: Biol Psychiatry
    E-pub date: 15 May 2021
    Authors: KD Ersche, TV Lim, AG Murley, C Rua, MM Vaghi, TL White, GB Williams, TW Robbins

    Publications

    Locus coeruleus integrity is linked to response inhibition deficits in Parkinson’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1523/JNEUROSCI.0289-22.2023
    Journal: J Neurosci
    E-pub date: 18 Oct 2023
    Authors: R Ye, FH Hezemans, C O'Callaghan, KA Tsvetanov, C Rua, PS Jones, N Holland, M Malpetti, AG Murley, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy.

    DOI: http://doi.org/10.1016/j.neuroimage.2023.120193
    Journal: Neuroimage
    E-pub date: 1 Aug 2023
    Authors: A Jafarian, LE Hughes, NE Adams, JH Lanskey, M Naessens, MA Rouse, AG Murley, KJ Friston, JB Rowe

    Network connectivity and structural correlates of survival in progressive supranuclear palsy and corticobasal syndrome.

    DOI: http://doi.org/10.1002/hbm.26342
    Journal: Hum Brain Mapp
    E-pub date: 1 Aug 2023
    Authors: DJ Whiteside, D Street, AG Murley, PS Jones, M Malpetti, BCP Ghosh, I Coyle-Gilchrist, A Gerhard, MT Hu, JC Klein, PN Leigh, A Church, DJ Burn, HR Morris, JB Rowe, T Rittman

    Syndromes associated with frontotemporal lobar degeneration change response patterns on visual analogue scales.

    DOI: http://doi.org/10.1038/s41598-023-35758-5
    Journal: Sci Rep
    E-pub date: 2 Jun 2023
    Authors: RS Williams, NE Adams, LE Hughes, MA Rouse, AG Murley, M Naessens, D Street, N Holland, JB Rowe

    Neurophysiological consequences of synapse loss in progressive supranuclear palsy.

    DOI: http://doi.org/10.1093/brain/awac471
    Journal: Brain
    E-pub date: 1 Jun 2023
    Authors: NE Adams, A Jafarian, A Perry, MA Rouse, AD Shaw, AG Murley, TE Cope, WR Bevan-Jones, L Passamonti, D Street, N Holland, D Nesbitt, LE Hughes, KJ Friston, JB Rowe

    Incidence of Syndromes Associated With Frontotemporal Lobar Degeneration in 9 European Countries.

    DOI: http://doi.org/10.1001/jamaneurol.2022.5128
    Journal: JAMA Neurol
    E-pub date: 1 Mar 2023
    Authors: G Logroscino, M Piccininni, C Graff, O Hardiman, AC Ludolph, F Moreno, M Otto, AM Remes, JB Rowe, H Seelaar, E Solje, E Stefanova, L Traykov, V Jelic, MT Rydell, N Pender, S Anderl-Straub, M Barandiaran, A Gabilondo, J Krüger, AG Murley, T Rittman, EL van der Ende, JC van Swieten, P Hartikainen, GM Stojmenovic, S Mehrabian, L Benussi, A Alberici, MT Dell'Abate, C Zecca, B Borroni, FRONTIERS group

    High-Depth PRNP Sequencing in Brains With Sporadic Creutzfeldt-Jakob Disease.

    DOI: http://doi.org/10.1212/NXG.0000000000200054
    Journal: Neurol Genet
    E-pub date: 1 Feb 2023
    Authors: AG Murley, Y Nie, Z Golder, MJ Keogh, C Smith, JW Ironside, PF Chinnery

    The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration.

    DOI: http://doi.org/10.1038/s41398-022-02114-6
    Journal: Transl Psychiatry
    E-pub date: 27 Aug 2022
    Authors: A Perry, LE Hughes, N Adams, M Naessens, AG Murley, MA Rouse, D Street, PS Jones, TE Cope, E Kocagoncu, JB Rowe

    Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy

    DOI: http://doi.org/10.1101/2022.06.17.493881
    Journal:
    E-pub date: 1 Aug 2022
    Authors: A Jafarian, L Hughes, N Adams, J Lanskey, M Naessens, M Rouse, A Murley, K Friston, J Rowe

    Neurophysiological consequences of synapse loss in progressive supranuclear palsy

    DOI: http://doi.org/10.1101/2022.06.22.22276697
    Journal:
    E-pub date: 1 Aug 2022
    Authors: N Adams, A Jafarian, A Perry, M Rouse, A Shaw, A Murley, T Cope, R Bevan-Jones, L Passamonti, D Street, N Holland, D Nesbitt, L Hughes, K Friston, J Rowe

    Heteroplasmic mitochondrial DNA mutations in frontotemporal lobar degeneration.

    DOI: http://doi.org/10.1007/s00401-022-02423-6
    Journal: Acta Neuropathol
    E-pub date: 1 Jun 2022
    Authors: Y Nie, A Murley, Z Golder, JB Rowe, K Allinson, PF Chinnery

    Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes.

    DOI: http://doi.org/10.1371/journal.pcbi.1010079
    Journal: PLoS Comput Biol
    E-pub date: 1 May 2022
    Authors: FH Hezemans, N Wolpe, C O'Callaghan, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Characterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior.

    DOI: http://doi.org/10.1038/s41398-022-01872-7
    Journal: Translational Psychiatry
    E-pub date: 15 Mar 2022
    Authors: ML Westwater, AG Murley, KMJ Diederen, TA Carpenter, H Ziauddeen, PC Fletcher

    Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2021.10.012
    Journal: Neurobiol Aging
    E-pub date: 1 Mar 2022
    Authors: AG Murley, KA Tsvetanov, MA Rouse, PS Jones, K Sværke, W Li, A Carpenter, JB Rowe

    Co-Occurrence of Apathy and Impulsivity in Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.1002/mdc3.13339
    Journal: Mov Disord Clin Pract
    E-pub date: 1 Nov 2021
    Authors: ZQ Kok, AG Murley, T Rittman, J Rowe, L Passamonti

    Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awab142
    Journal: Brain
    E-pub date: 4 Sep 2021
    Authors: C O'Callaghan, FH Hezemans, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, N Wolpe, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    GABAergic cortical network physiology in frontotemporal lobar degeneration.

    DOI: http://doi.org/10.1093/brain/awab097
    Journal: Brain
    E-pub date: 17 Aug 2021
    Authors: NE Adams, LE Hughes, MA Rouse, HN Phillips, AD Shaw, AG Murley, TE Cope, WR Bevan-Jones, L Passamonti, D Street, N Holland, D Nesbitt, K Friston, JB Rowe

    Clinical progression of progressive supranuclear palsy: impact of trials bias and phenotype variants.

    DOI: http://doi.org/10.1093/braincomms/fcab206
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: D Street, M Malpetti, T Rittman, BCP Ghosh, AG Murley, I Coyle-Gilchrist, L Passamonti, JB Rowe

    Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes

    DOI: http://doi.org/10.1101/2021.01.11.21249589
    Journal:
    E-pub date: 1 Aug 2021
    Authors: A Murley, K Tsvetanov, M Rouse, S Jones, K Sværke, W Li, A Carpenter, J Rowe

    Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes

    DOI: http://doi.org/10.1101/2021.07.04.21259922
    Journal:
    E-pub date: 1 Aug 2021
    Authors: F Hezemans, N Wolpe, C O’Callaghan, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Characterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior

    DOI: http://doi.org/10.1101/2021.09.12.21263466
    Journal:
    E-pub date: 1 Aug 2021
    Authors: M Westwater, A Murley, KMJ Diederen, A Carpenter, H Ziauddeen, P Fletcher

    Reduced locus coeruleus integrity linked to response inhibition deficits in parkinsonian disorders

    DOI: http://doi.org/10.1101/2021.10.14.21264996
    Journal:
    E-pub date: 1 Aug 2021
    Authors: R Ye, F Hezemans, C O’Callaghan, K Tsvetanov, C Rua, S Jones, N Holland, M Malpetti, A Murley, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Co-occurrence of apathy and impulsivity in progressive supranuclear palsy

    DOI: http://doi.org/10.1101/2021.02.26.21252350
    Journal:
    E-pub date: 1 Aug 2021
    Authors: ZQ Kok, A Murley, T Rittman, J Rowe, L Passamonti

    Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes.

    DOI: http://doi.org/10.1136/jnnp-2020-324903
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2021
    Authors: AG Murley, MA Rouse, ITS Coyle-Gilchrist, PS Jones, W Li, J Wiggins, C Lansdall, P Vázquez Rodríguez, A Wilcox, K Patterson, JB Rowe

    GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition.

    DOI: http://doi.org/10.1093/brain/awaa305
    Journal: Brain
    E-pub date: 5 Dec 2020
    Authors: AG Murley, MA Rouse, PS Jones, R Ye, FH Hezemans, C O'Callaghan, P Frangou, Z Kourtzi, C Rua, TA Carpenter, CT Rodgers, JB Rowe

    Metabolomic changes associated with frontotemporal lobar degeneration syndromes.

    DOI: http://doi.org/10.1007/s00415-020-09824-1
    Journal: J Neurol
    E-pub date: 31 Aug 2020
    Authors: AG Murley, PS Jones, I Coyle Gilchrist, L Bowns, J Wiggins, KA Tsvetanov, JB Rowe

    Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease

    DOI: http://doi.org/10.1101/2020.09.03.20176800
    Journal:
    E-pub date: 1 Aug 2020
    Authors: C O’Callaghan, F Hezemans, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, N Wolpe, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes.

    DOI: http://doi.org/10.1093/brain/awaa097
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: AG Murley, I Coyle-Gilchrist, MA Rouse, PS Jones, W Li, J Wiggins, C Lansdall, PV Rodríguez, A Wilcox, KA Tsvetanov, K Patterson, MA Lambon Ralph, JB Rowe

    GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography.

    DOI: http://doi.org/10.1523/JNEUROSCI.1689-19.2019
    Journal: J Neurosci
    E-pub date: 19 Feb 2020
    Authors: NE Adams, LE Hughes, HN Phillips, AD Shaw, AG Murley, D Nesbitt, TE Cope, WR Bevan-Jones, L Passamonti, JB Rowe

    GABA-ergic dynamics in human frontotemporal networks confirmed by pharmaco-magnetoencephalography

    DOI: http://doi.org/10.1101/803924
    Journal:
    E-pub date: 1 Aug 2019
    Authors: N Adams, L Hughes, H Phillips, A Shaw, A Murley, T Cope, R Bevan-Jones, L Passamonti, J Rowe