Institute

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Research Theme Lifelong Brain Development and Brain Ageing Neurons, Circuits and Networks

Research Focus

Keywords

Dementia

Clinical Conditions

Alzheimer's disease

Frontotemporal dementia

Progressive supranuclear palsy

Aphasia

Dementia

Equipment & Techniques

Behavioural analysis

Magnetic resonance imaging (MRI)

Randomised control trials

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Alexander Murley

University Position

Clinical Lecturer

Dr Alexander Murley is pleased to consider applications from prospective PhD students.

Interests

I am a clinical lecturer in neurology with a research interest in neurodegenerative diseases that cause early-onset dementia. The cause of the variability of these diseases is poorly understood and an important obstacle to developing effective treatments. I investigate how changes in brain structure and function contribute to the variability in clinical phenotype and prognosis of these diseases. I run clinical trials testing new and repurposed treatments for dementia.

Key Publications

Publications

Blood inflammation relates to neuroinflammation and survival in frontotemporal lobar degeneration

DOI: http://doi.org/10.1093/brain/awae269
Journal: Brain
E-pub date: 3 Feb 2025
Authors: M Malpetti, P Swann, KA Tsvetanov, L Chouliaras, A Strauss, T Chikaura, AG Murley, NJ Ashton, P Barker, PS Jones, TD Fryer, YT Hong, TE Cope, G Savulich, D Street, WR Bevan-Jones, T Rittman, K Blennow, H Zetterberg, FI Aigbirhio, JT O’Brien, JB Rowe

Caregiver perspectives enable accurate diagnosis of neurodegenerative disease

DOI: http://doi.org/10.1002/alz.14377
Journal: Alzheimer's & Dementia
E-pub date: 1 Jan 2025
Authors: AG Murley, L Bowns, M Camacho, CH Williams‐Gray, KA Tsvetanov, T Rittman, RA Barker, JT O'Brien, JB Rowe

Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival.

DOI: http://doi.org/10.1038/s41380-024-02809-w
Journal: Mol Psychiatry
E-pub date: 29 Oct 2024
Authors: A Strauss, P Swann, SL Kigar, R Christou, N Savinykh Yarkoni, L Turner, AG Murley, L Chouliaras, N Shapiro, NJ Ashton, G Savulich, WR Bevan-Jones, A Surendranthan, K Blennow, H Zetterberg, JT O'Brien, JB Rowe, M Malpetti

Predictors of Care Home Admission and Survival Rate in Patients With Syndromes Associated With Frontotemporal Lobar Degeneration in Europe.

DOI: http://doi.org/10.1212/WNL.0000000000209793
Journal: Neurology
E-pub date: 8 Oct 2024
Authors: B Borroni, B Tarantino, C Graff, J Krüger, AC Ludolph, F Moreno, M Otto, JB Rowe, H Seelaar, E Solje, E Stefanova, LD Traykov, V Jelic, S Anderl-Straub, AM Portaankorva, M Barandiaran, A Gabilondo, AG Murley, T Rittman, E Van Der Ende, JC Van Swieten, P Hartikainen, GM Stojmenović, S Mehrabian, R Ghidoni, AC Alberici, MT Dell'Abate, C Zecca, M Grassi, G Logroscino, for FRONTIERS

Noradrenergic modulation of saccades in Parkinson’s disease

DOI: http://doi.org/10.1101/2024.01.04.24300879
Journal:
E-pub date: 1 Aug 2024
Authors: IF Orlando, FH Hezemans, R Ye, AG Murley, N Holland, R Regenthal, RA Barker, CH Williams-Gray, L Passamonti, TW Robbins, JB Rowe, C O’Callaghan

Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival

DOI: http://doi.org/10.1101/2024.01.16.24301348
Journal:
E-pub date: 1 Aug 2024
Authors: A Strauss, P Swann, S Kigar, R Christou, NS Yarkoni, A Murley, L Chouliaras, G Savulich, R Bevan-Jones, A Surendranthan, J O’Brien, J Rowe, M Malpetti

Peripheral inflammatory markers relate to central inflammation and survival in syndromes associated with frontotemporal lobar degeneration

DOI: http://doi.org/10.1101/2024.01.31.24302080
Journal:
E-pub date: 1 Aug 2024
Authors: M Malpetti, P Swann, KA Tsvetanov, L Chouliaras, A Strauss, T Chikaura, AG Murley, N Ashton, P Barker, PS Jones, TD Fryer, YT Hong, TE Cope, G Savulich, D Street, WR Bevan-Jones, T Rittman, K Blennow, H Zetterberg, FI Aigbirhio, JT O’Brien, JB Rowe

GABAergic modulation of beta power enhances motor adaptation in frontotemporal lobar degeneration

DOI: http://doi.org/10.1101/2024.06.28.24309636
Journal:
E-pub date: 1 Aug 2024
Authors: LE Hughes, NE Adams, M Rouse, M Naessens, AD Shaw, AG Murley, TE Cope, N Holland, D Nesbitt, D Street, DJ Whiteside, JB Rowe

The Cambridge Questionnaire for Apathy and Impulsivity Traits (CamQUAIT): a novel assessment tool for frontotemporal lobar degeneration-related syndromes

DOI: http://doi.org/10.1101/2024.07.01.24309762
Journal:
E-pub date: 1 Aug 2024
Authors: CJ Lansdall, R Williams, I Coyle-Gilchrist, AG Murley, MA Rouse, A Bateman, JB Rowe

Noradrenergic modulation of saccades in Parkinson’s disease

DOI: http://doi.org/10.1093/braincomms/fcae297
Journal: Brain Commun
E-pub date: 1 Aug 2024
Authors: IF Orlando, FH Hezemans, R Ye, AG Murley, N Holland, R Regenthal, RA Barker, CH Williams-Gray, L Passamonti, TW Robbins, JB Rowe, C O’Callaghan

Frontotemporal lobar degeneration changes neuronal beta-frequency dynamics during the mismatch negativity response.

DOI: http://doi.org/10.1016/j.nicl.2024.103671
Journal: Neuroimage Clin
E-pub date: 1 Aug 2024
Authors: A Perry, LE Hughes, NE Adams, M Naessens, NA Kloosterman, MA Rouse, AG Murley, D Street, PS Jones, JB Rowe

7T MRI detects widespread brain iron deposition in neuroferritinopathy.

DOI: http://doi.org/10.1002/acn3.52053
Journal: Ann Clin Transl Neurol
E-pub date: 1 May 2024
Authors: AG Murley, C Rua, H Biggs, CT Rodgers, T Matys, J van den Ameele, R Horvath, PF Chinnery

Peripheral and central markers of inflammation increased in frontotemporal dementia and related conditions

DOI: http://doi.org/10.1002/alz.075722
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2023
Authors: M Malpetti, P Swann, L Chouliaras, KA Tsvetanov, PS Jones, TE Cope, WR Bevan‐Jones, G Savulich, D Street, DJ Whiteside, T Rittman, AG Murley, K Stockton, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

A Neurodegenerative Cascade of Causality

DOI: http://doi.org/10.1017/9781911623137.076
Journal:
E-pub date: 16 Nov 2023
Authors: J B. Rowe, A G. Murley

Locus coeruleus integrity is linked to response inhibition deficits in Parkinson’s disease and progressive supranuclear palsy.

DOI: http://doi.org/10.1523/JNEUROSCI.0289-22.2023
Journal: J Neurosci
E-pub date: 18 Oct 2023
Authors: R Ye, FH Hezemans, C O'Callaghan, KA Tsvetanov, C Rua, PS Jones, N Holland, M Malpetti, AG Murley, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy.

DOI: http://doi.org/10.1016/j.neuroimage.2023.120193
Journal: Neuroimage
E-pub date: 1 Aug 2023
Authors: A Jafarian, LE Hughes, NE Adams, JH Lanskey, M Naessens, MA Rouse, AG Murley, KJ Friston, JB Rowe

Network connectivity and structural correlates of survival in progressive supranuclear palsy and corticobasal syndrome.

DOI: http://doi.org/10.1002/hbm.26342
Journal: Hum Brain Mapp
E-pub date: 1 Aug 2023
Authors: DJ Whiteside, D Street, AG Murley, PS Jones, M Malpetti, BCP Ghosh, I Coyle-Gilchrist, A Gerhard, MT Hu, JC Klein, PN Leigh, A Church, DJ Burn, HR Morris, JB Rowe, T Rittman

Syndromes associated with frontotemporal lobar degeneration change response patterns on visual analogue scales.

DOI: http://doi.org/10.1038/s41598-023-35758-5
Journal: Sci Rep
E-pub date: 2 Jun 2023
Authors: RS Williams, NE Adams, LE Hughes, MA Rouse, AG Murley, M Naessens, D Street, N Holland, JB Rowe

Neurophysiological consequences of synapse loss in progressive supranuclear palsy.

DOI: http://doi.org/10.1093/brain/awac471
Journal: Brain
E-pub date: 1 Jun 2023
Authors: NE Adams, A Jafarian, A Perry, MA Rouse, AD Shaw, AG Murley, TE Cope, WR Bevan-Jones, L Passamonti, D Street, N Holland, D Nesbitt, LE Hughes, KJ Friston, JB Rowe

Incidence of Syndromes Associated With Frontotemporal Lobar Degeneration in 9 European Countries.

DOI: http://doi.org/10.1001/jamaneurol.2022.5128
Journal: JAMA Neurol
E-pub date: 1 Mar 2023
Authors: G Logroscino, M Piccininni, C Graff, O Hardiman, AC Ludolph, F Moreno, M Otto, AM Remes, JB Rowe, H Seelaar, E Solje, E Stefanova, L Traykov, V Jelic, MT Rydell, N Pender, S Anderl-Straub, M Barandiaran, A Gabilondo, J Krüger, AG Murley, T Rittman, EL van der Ende, JC van Swieten, P Hartikainen, GM Stojmenovic, S Mehrabian, L Benussi, A Alberici, MT Dell'Abate, C Zecca, B Borroni, FRONTIERS group

High-Depth PRNP Sequencing in Brains With Sporadic Creutzfeldt-Jakob Disease.

DOI: http://doi.org/10.1212/NXG.0000000000200054
Journal: Neurol Genet
E-pub date: 1 Feb 2023
Authors: AG Murley, Y Nie, Z Golder, MJ Keogh, C Smith, JW Ironside, PF Chinnery

The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration.

DOI: http://doi.org/10.1038/s41398-022-02114-6
Journal: Transl Psychiatry
E-pub date: 27 Aug 2022
Authors: A Perry, LE Hughes, N Adams, M Naessens, AG Murley, MA Rouse, D Street, PS Jones, TE Cope, E Kocagoncu, JB Rowe

Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy

DOI: http://doi.org/10.1101/2022.06.17.493881
Journal:
E-pub date: 1 Aug 2022
Authors: A Jafarian, L Hughes, N Adams, J Lanskey, M Naessens, M Rouse, A Murley, K Friston, J Rowe

Neurophysiological consequences of synapse loss in progressive supranuclear palsy

DOI: http://doi.org/10.1101/2022.06.22.22276697
Journal:
E-pub date: 1 Aug 2022
Authors: N Adams, A Jafarian, A Perry, M Rouse, A Shaw, A Murley, T Cope, R Bevan-Jones, L Passamonti, D Street, N Holland, D Nesbitt, L Hughes, K Friston, J Rowe

SURVIVAL IN FRONTOTEMPORAL LOBAR DEGENERATION: IDENTIFYING BLOOD, BRAIN AND BEHAVIOURAL PREDICTORS OF SURVIVAL

DOI: http://doi.org/10.1136/jnnp-2022-abn2.89
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
E-pub date: 1 Aug 2022
Authors: K Stockton, M Naessens, A Murley, I Coyle-Gilchrist, C Lansdall, J Rowe

The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration

DOI: http://doi.org/10.21203/rs.3.rs-1609477/v1
Journal:
E-pub date: 1 Aug 2022
Authors: A Perry, L Hughes, N Adams, M Naessens, A Murley, M Rouse, D Street, S Jones, T Cope, E Kocagoncu, J Rowe

Heteroplasmic mitochondrial DNA mutations in frontotemporal lobar degeneration.

DOI: http://doi.org/10.1007/s00401-022-02423-6
Journal: Acta Neuropathol
E-pub date: 1 Jun 2022
Authors: Y Nie, A Murley, Z Golder, JB Rowe, K Allinson, PF Chinnery

Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes.

DOI: http://doi.org/10.1371/journal.pcbi.1010079
Journal: PLoS Comput Biol
E-pub date: 1 May 2022
Authors: FH Hezemans, N Wolpe, C O'Callaghan, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

Characterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior.

DOI: http://doi.org/10.1038/s41398-022-01872-7
Journal: Translational Psychiatry
E-pub date: 15 Mar 2022
Authors: ML Westwater, AG Murley, KMJ Diederen, TA Carpenter, H Ziauddeen, PC Fletcher

Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes.

DOI: http://doi.org/10.1016/j.neurobiolaging.2021.10.012
Journal: Neurobiol Aging
E-pub date: 1 Mar 2022
Authors: AG Murley, KA Tsvetanov, MA Rouse, PS Jones, K Sværke, W Li, A Carpenter, JB Rowe

Co-Occurrence of Apathy and Impulsivity in Progressive Supranuclear Palsy.

DOI: http://doi.org/10.1002/mdc3.13339
Journal: Mov Disord Clin Pract
E-pub date: 1 Nov 2021
Authors: ZQ Kok, AG Murley, T Rittman, J Rowe, L Passamonti

Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease.

DOI: http://doi.org/10.1093/brain/awab142
Journal: Brain
E-pub date: 4 Sep 2021
Authors: C O'Callaghan, FH Hezemans, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, N Wolpe, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

GABAergic cortical network physiology in frontotemporal lobar degeneration.

DOI: http://doi.org/10.1093/brain/awab097
Journal: Brain
E-pub date: 17 Aug 2021
Authors: NE Adams, LE Hughes, MA Rouse, HN Phillips, AD Shaw, AG Murley, TE Cope, WR Bevan-Jones, L Passamonti, D Street, N Holland, D Nesbitt, K Friston, JB Rowe

Clinical progression of progressive supranuclear palsy: impact of trials bias and phenotype variants.

DOI: http://doi.org/10.1093/braincomms/fcab206
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: D Street, M Malpetti, T Rittman, BCP Ghosh, AG Murley, I Coyle-Gilchrist, L Passamonti, JB Rowe

Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes

DOI: http://doi.org/10.1101/2021.01.11.21249589
Journal:
E-pub date: 1 Aug 2021
Authors: A Murley, K Tsvetanov, M Rouse, S Jones, K Sværke, W Li, A Carpenter, J Rowe

Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes

DOI: http://doi.org/10.1101/2021.07.04.21259922
Journal:
E-pub date: 1 Aug 2021
Authors: F Hezemans, N Wolpe, C O’Callaghan, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

Characterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior

DOI: http://doi.org/10.1101/2021.09.12.21263466
Journal:
E-pub date: 1 Aug 2021
Authors: M Westwater, A Murley, KMJ Diederen, A Carpenter, H Ziauddeen, P Fletcher

Reduced locus coeruleus integrity linked to response inhibition deficits in parkinsonian disorders

DOI: http://doi.org/10.1101/2021.10.14.21264996
Journal:
E-pub date: 1 Aug 2021
Authors: R Ye, F Hezemans, C O’Callaghan, K Tsvetanov, C Rua, S Jones, N Holland, M Malpetti, A Murley, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

Co-occurrence of apathy and impulsivity in progressive supranuclear palsy

DOI: http://doi.org/10.1101/2021.02.26.21252350
Journal:
E-pub date: 1 Aug 2021
Authors: ZQ Kok, A Murley, T Rittman, J Rowe, L Passamonti

Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes.

DOI: http://doi.org/10.1136/jnnp-2020-324903
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Jul 2021
Authors: AG Murley, MA Rouse, ITS Coyle-Gilchrist, PS Jones, W Li, J Wiggins, C Lansdall, P Vázquez Rodríguez, A Wilcox, K Patterson, JB Rowe

Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction.

DOI: http://doi.org/10.1016/j.biopsych.2020.12.009
Journal: Biol Psychiatry
E-pub date: 15 May 2021
Authors: KD Ersche, TV Lim, AG Murley, C Rua, MM Vaghi, TL White, GB Williams, TW Robbins

GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition.

DOI: http://doi.org/10.1093/brain/awaa305
Journal: Brain
E-pub date: 5 Dec 2020
Authors: AG Murley, MA Rouse, PS Jones, R Ye, FH Hezemans, C O'Callaghan, P Frangou, Z Kourtzi, C Rua, TA Carpenter, CT Rodgers, JB Rowe

Metabolomic changes associated with frontotemporal lobar degeneration syndromes.

DOI: http://doi.org/10.1007/s00415-020-09824-1
Journal: J Neurol
E-pub date: 31 Aug 2020
Authors: AG Murley, PS Jones, I Coyle Gilchrist, L Bowns, J Wiggins, KA Tsvetanov, JB Rowe

Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease

DOI: http://doi.org/10.1101/2020.09.03.20176800
Journal:
E-pub date: 1 Aug 2020
Authors: C O’Callaghan, F Hezemans, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, N Wolpe, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

Metabolomic changes associated with frontotemporal lobar degeneration syndromes

DOI: http://doi.org/10.1101/2020.02.10.20021758
Journal:
E-pub date: 1 Aug 2020
Authors: A Murley, S Jones, IC Gilchrist, L Bowns, J Wiggins, K Tsvetanov, J Rowe

Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes.

DOI: http://doi.org/10.1093/brain/awaa097
Journal: Brain
E-pub date: 1 May 2020
Authors: AG Murley, I Coyle-Gilchrist, MA Rouse, PS Jones, W Li, J Wiggins, C Lansdall, PV Rodríguez, A Wilcox, KA Tsvetanov, K Patterson, MA Lambon Ralph, JB Rowe