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College Darwin College
Research Focus

Keywords

  • Behaviour
  • Dopamine
  • Olfactory System
  • Equipment & Techniques

  • Behavioural analysis
  • Whole cell patch clamp
  • Science Culture

  • Open-Source Science
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    Dr Chloé Guillaume

    (she/her/hers)
    University Position
    Research Associate

    Interests

    Role of morphologically and developmetally diverse dopaminergic neurons in olfactory circuit processing": The goal of the project is to uncover how axon-bearing/embryonic-born and anaxonic/adult-born dopaminergic neurons differentially contribute to olfactory processing and behaviour. This project combines cutting-edge techniques in the field of neuroscience from the cellular to the behavioural level. In fact, whole-cell patch-clamp, optogenetic and chemogenetic, as well as the use of an AutonoMouse system built by our lab, could allow us to elucidate what is the impact of the dopaminergic bulbar population as a whole, and divided in developmetally-defined subtypes, on basic olfactory performance, sensitivity and discrimination. In parallele, I develop the Cambridge Open Lab (UK local hub of the Open Lab Network all around the world) to promote Open Science.

    Key Publications

    Reactivating an Engram: Context Matters

    DOI: https://doi.org/10.1523/JNEUROSCI.0650-24.2024
    Journal: Journal of Neuroscience
    Year: 2024
    Authors: Connor Doyle, Chloé Guillaume

    Publications

    Ex vivo functional characterization of mouse olfactory bulb projection neurons reveals a heterogenous continuum

    DOI: https://doi.org/10.1101/2024.07.17.603915
    Journal: BioRxiv
    Year: 2024
    Authors: Sana Gadiwalla, Chloé Guillaume, Li Huang, Samuel JB White, Nihal Basha, Pétur Henry Petersen, Elisa Galliano

    Cholecystokinin exerts a major control on corticostriatal synapse and motor behavior

    DOI: https://doi.org/10.1101/2022.11.28.518143
    Journal: BioRxiv
    Year: 2022
    Authors: Chloé Guillaume, María Sáez, Blandine Castellano, Patricia Parnet, Ramon Reig, Vincent Paillé