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    Research Theme Beyond the Neuron
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  • Parkinson's Disease
  • Inflammation & Immunity
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    Dr Caroline Williams-Gray BMBCh MRCP PhD

    University Position
    Principal Research Associate
    Dr Caroline Williams-Gray is pleased to consider applications from prospective PhD students.

    Interests

    I am a clinician scientist and consultant neurologist specializing in Parkinson’s disease. The overarching aims of my research are to better understand the variability of Parkinson's and to develop targeted disease-modifying therapies for different Parkinson's subtypes. I lead the Cambridge Parkinson’s Disease Research Clinic and community-based longitudinal cohort studies which allow us to study the natural history of the disease and biomarkers of progression. A key focus of my lab is investigating the role of the immune system in driving disease progression in Parkinson's. We are studying this using blood and CSF-based markers, PET neuroimaging and neuropathological studies, and we are testing immunosuppressive therapies for Parkinson's disease in clinical trials.

    Neuroinflammation is linked to dementia risk in Parkinson's disease

    The NET-PDD study is investigating the contribution of brain inflammation and tau accumulation to the development of dementia in Parkinson’s disease. Neuroinflammation, measured using [11C]PK11195 PET imaging, is elevated in newly-diagnosed Parkinson’s patients at high dementia risk, compared to patients at low dementia risk and controls. In contrast, tau accumulation in the brain, measured using [18F]AV1451 PET, is minimal in early Parkinson’s and does not differ across dementia risk groups. (Figure produced by Dr Lennart Spindler. Kouli, Spindler, et al. Brain, 2023, https://doi.org/10.1093/brain/awad322)

    Collaborators

    Cambridge
  • Roger Barker
  • David Klenerman
  • Joanne Jones
  • Franklin Aigbirhio
  • John O'Brien
    • External
  • Clemens Scherzer, Harvard University
  • Mike Nalls, NIH
  • Jodi Maple-Grodem, University of Stavanger
  • Michele Hu, University of Oxford
  • Alison Yarnall, Newcastle University
  • Angus MacLeod, University of Aberdeen

    • Key Publications

    B lymphocyte responses in Parkinson’s disease and their possible significance in disease progression.

    DOI: http://doi.org/10.1093/braincomms/fcad060
    Journal: Brain Commun
    E-pub date: 1 Aug 2023
    Authors: KM Scott, YT Chong, S Park, RS Wijeyekoon, S Hayat, RJ Mathews, Z Fitzpatrick, P Tyers, G Wright, J Whitby, RA Barker, MT Hu, CH Williams-Gray, MR Clatworthy

    The Endotoxin Hypothesis of Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mds.29432
    Journal: Movement Disorders
    E-pub date: 1 Jul 2023
    Authors: GC Brown, M Camacho, CH Williams-Gray

    Linking Immune Activation and Parkinson’s Disease.

    DOI: http://doi.org/10.3233/JPD-229005
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2022
    Authors: BR Bloem, P Brundin, A Harms, C Lindestam Arlehamn, E-K Tan, CH Williams-Gray

    Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awab306
    Journal: Brain
    E-pub date: 18 Apr 2022
    Authors: E Lobanova, D Whiten, FS Ruggeri, CG Taylor, A Kouli, Z Xia, D Emin, YP Zhang, JYL Lam, CH Williams-Gray, D Klenerman

    T lymphocyte senescence is attenuated in Parkinson’s disease.

    DOI: http://doi.org/10.1186/s12974-021-02287-9
    Journal: J Neuroinflammation
    E-pub date: 13 Oct 2021
    Authors: A Kouli, M Jensen, V Papastavrou, KM Scott, C Kolenda, C Parker, IH Solim, M Camacho, C Martin-Ruiz, CH Williams-Gray

    The Gastrointestinal Dysfunction Scale for Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mds.28675
    Journal: Mov Disord
    E-pub date: 1 Oct 2021
    Authors: M Camacho, JC Greenland, CH Williams-Gray

    Neuroinflammation and protein pathology in Parkinson’s disease dementia.

    DOI: http://doi.org/10.1186/s40478-020-01083-5
    Journal: Acta Neuropathol Commun
    E-pub date: 3 Dec 2020
    Authors: A Kouli, M Camacho, K Allinson, CH Williams-Gray

    Azathioprine immunosuppression and disease modification in Parkinson’s disease (AZA-PD): a randomised double-blind placebo-controlled phase II trial protocol.

    DOI: http://doi.org/10.1136/bmjopen-2020-040527
    Journal: BMJ Open
    E-pub date: 23 Nov 2020
    Authors: JC Greenland, E Cutting, S Kadyan, S Bond, A Chhabra, CH Williams-Gray

    Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson’s disease.

    DOI: http://doi.org/10.1016/j.bbi.2020.01.018
    Journal: Brain Behav Immun
    E-pub date: 1 Jul 2020
    Authors: RS Wijeyekoon, D Kronenberg-Versteeg, KM Scott, S Hayat, W-L Kuan, JR Evans, DP Breen, G Cummins, JL Jones, MR Clatworthy, RA Floto, RA Barker, CH Williams-Gray

    Impact of GBA1 variants on long-term clinical progression and mortality in incident Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp-2020-322857
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2020
    Authors: TB Stoker, M Camacho, S Winder-Rhodes, G Liu, CR Scherzer, T Foltynie, J Evans, DP Breen, RA Barker, CH Williams-Gray

    Cerebrospinal Fluid Cytokines and Neurodegeneration-Associated Proteins in Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mds.28015
    Journal: Mov Disord
    E-pub date: 1 Jun 2020
    Authors: RS Wijeyekoon, SF Moore, K Farrell, DP Breen, RA Barker, CH Williams-Gray

    Toll-like receptors and their therapeutic potential in Parkinson’s disease and α-synucleinopathies.

    DOI: http://doi.org/10.1016/j.bbi.2019.06.042
    Journal: Brain Behav Immun
    E-pub date: 1 Oct 2019
    Authors: A Kouli, CB Horne, CH Williams-Gray

    Monocyte Function in Parkinson’s Disease and the Impact of Autologous Serum on Phagocytosis.

    DOI: http://doi.org/10.3389/fneur.2018.00870
    Journal: Front Neurol
    E-pub date: 1 Aug 2018
    Authors: RS Wijeyekoon, D Kronenberg-Versteeg, KM Scott, S Hayat, JL Jones, MR Clatworthy, RA Floto, RA Barker, CH Williams-Gray

    The Peripheral Inflammatory Response to Alpha-Synuclein and Endotoxin in Parkinson’s Disease.

    DOI: http://doi.org/10.3389/fneur.2018.00946
    Journal: Front Neurol
    E-pub date: 1 Aug 2018
    Authors: AJ White, RS Wijeyekoon, KM Scott, NP Gunawardana, S Hayat, IH Solim, HT McMahon, RA Barker, CH Williams-Gray

    Abnormalities of age-related T cell senescence in Parkinson’s disease.

    DOI: http://doi.org/10.1186/s12974-018-1206-5
    Journal: J Neuroinflammation
    E-pub date: 28 May 2018
    Authors: CH Williams-Gray, RS Wijeyekoon, KM Scott, S Hayat, RA Barker, JL Jones

    Serum immune markers and disease progression in an incident Parkinson’s disease cohort (ICICLE-PD).

    DOI: http://doi.org/10.1002/mds.26563
    Journal: Mov Disord
    E-pub date: 1 Jul 2016
    Authors: CH Williams-Gray, R Wijeyekoon, AJ Yarnall, RA Lawson, DP Breen, JR Evans, GA Cummins, GW Duncan, TK Khoo, DJ Burn, RA Barker, ICICLE-PD study group

    Development and external validation of a prognostic model in newly diagnosed Parkinson disease.

    DOI: http://doi.org/10.1212/WNL.0000000000002437
    Journal: Neurology
    E-pub date: 15 Mar 2016
    Authors: DC Velseboer, RMA de Bie, L Wieske, JR Evans, SL Mason, T Foltynie, B Schmand, RJ de Haan, B Post, RA Barker, CH Williams-Gray

    The CamPaIGN study of Parkinson’s disease: 10-year outlook in an incident population-based cohort.

    DOI: http://doi.org/10.1136/jnnp-2013-305277
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Nov 2013
    Authors: CH Williams-Gray, SL Mason, JR Evans, T Foltynie, C Brayne, TW Robbins, RA Barker

    Association of the human leucocyte antigen region with susceptibility to Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp.2008.162883
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 31 Aug 2010
    Authors: M Saiki, A Baker, CH Williams-Gray, T Foltynie, RS Goodman, CJ Taylor, DAS Compston, RA Barker, SJ Sawcer, A Goris

    The distinct cognitive syndromes of Parkinson’s disease: 5 year follow-up of the CamPaIGN cohort.

    DOI: http://doi.org/10.1093/brain/awp245
    Journal: Brain
    E-pub date: 1 Nov 2009
    Authors: CH Williams-Gray, JR Evans, A Goris, T Foltynie, M Ban, TW Robbins, C Brayne, BS Kolachana, DR Weinberger, SJ Sawcer, RA Barker

    Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson’s disease.

    DOI: http://doi.org/10.1007/s00415-009-0119-8
    Journal: J Neurol
    E-pub date: 1 Mar 2009
    Authors: CH Williams-Gray, A Goris, M Saiki, T Foltynie, DAS Compston, SJ Sawcer, RA Barker

    Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson’s disease.

    DOI: http://doi.org/10.1002/ana.21192
    Journal: Ann Neurol
    E-pub date: 31 Aug 2007
    Authors: A Goris, CH Williams-Gray, GR Clark, T Foltynie, SJG Lewis, J Brown, M Ban, MG Spillantini, A Compston, DJ Burn, PF Chinnery, RA Barker, SJ Sawcer

    Evolution of cognitive dysfunction in an incident Parkinson’s disease cohort.

    DOI: http://doi.org/10.1093/brain/awm111
    Journal: Brain
    E-pub date: 1 Jul 2007
    Authors: CH Williams-Gray, T Foltynie, CEG Brayne, TW Robbins, RA Barker

    Neuroinflammation is linked to dementia risk in Parkinson's disease

    DOI: https://doi.org/10.1093/brain/awad322
    Journal: Brain
    Year: 2023
    Authors: Kouli, Antonina; Spindler, Lennart R. B.; Fryer, Tim D.; Hong, Young T.; Malpetti, Maura; Aigbirhio, Franklin I.; White, Simon R.; Camacho, Marta; O'Brien, John T.; Williams-Gray, Caroline H.

    Publications

    Locus coeruleus integrity is linked to response inhibition deficits in Parkinson’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1523/JNEUROSCI.0289-22.2023
    Journal: J Neurosci
    E-pub date: 18 Oct 2023
    Authors: R Ye, FH Hezemans, C O'Callaghan, KA Tsvetanov, C Rua, PS Jones, N Holland, M Malpetti, AG Murley, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Neuroinflammation is linked to dementia risk in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awad322
    Journal: Brain
    E-pub date: 27 Sep 2023
    Authors: A Kouli, LRB Spindler, TD Fryer, YT Hong, M Malpetti, FI Aigbirhio, SR White, M Camacho, JT O'Brien, CH Williams-Gray

    Natural killer cells have an activated profile in early Parkinson’s disease.

    DOI: http://doi.org/10.1016/j.jneuroim.2023.578154
    Journal: J Neuroimmunol
    E-pub date: 15 Sep 2023
    Authors: J Holbrook, B Patel, M Camacho, L Kahanawita, J Greenland, CH Williams-Gray

    Parkinson’s disease and related conditions

    DOI: http://doi.org/10.1016/j.mpmed.2023.06.004
    Journal: Medicine (United Kingdom)
    E-pub date: 1 Sep 2023
    Authors: CH Williams-Gray, PF Worth

    The dilemma between milestones of progression versus clinical scales in Parkinson’s disease.

    DOI: http://doi.org/10.1016/B978-0-323-85538-9.00010-9
    Journal: Handb Clin Neurol
    E-pub date: 1 Aug 2023
    Authors: JC Greenland, M Camacho, CH Williams-Gray

    Outcome Measures for Disease-Modifying Trials in Parkinson’s Disease: Consensus Paper by the EJS ACT-PD Multi-Arm Multi-Stage Trial Initiative.

    DOI: http://doi.org/10.3233/JPD-230051
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2023
    Authors: C Gonzalez-Robles, RS Weil, D van Wamelen, M Bartlett, M Burnell, CS Clarke, MT Hu, B Huxford, A Jha, C Lambert, M Lawton, G Mills, A Noyce, P Piccini, K Pushparatnam, L Rochester, C Siu, CH Williams-Gray, M-L Zeissler, H Zetterberg, CB Carroll, T Foltynie, A Schrag, EJS ACT-PD Consortium

    Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson’s Disease Dementia.

    DOI: http://doi.org/10.1002/mdc3.13752
    Journal: Mov Disord Clin Pract
    E-pub date: 1 Jun 2023
    Authors: MC Gonzalez, DA Tovar-Rios, G Alves, I Dalen, CH Williams-Gray, M Camacho, L Forsgren, D Bäckström, RA Lawson, AD Macleod, CE Counsell, C Paquet, C DeLena, F D'Antonio, A Pilotto, A Padovani, F Blanc, C Falup-Pecurariu, SJG Lewis, K Rejdak, E Papuc, J Hort, Z Nedelska, J O'Brien, L Bonanni, M Marquié, M Boada, V Pytel, C Abdelnour, D Alcolea, K Beyer, O-B Tysnes, D Aarsland, J Maple-Grødem

    Selective neurodegeneration generated by intravenous α-synuclein pre-formed fibril administration is not associated with endogenous α-synuclein levels in the rat brain.

    DOI: http://doi.org/10.1111/bpa.13128
    Journal: Brain Pathol
    E-pub date: 1 May 2023
    Authors: W-L Kuan, M Alfaidi, CB Horne, B Vallin, S Fox, SV Fazal, CH Williams-Gray, RA Barker

    Embracing Monogenic Parkinson’s Disease: The MJFF Global Genetic PD Cohort.

    DOI: http://doi.org/10.1002/mds.29288
    Journal: Mov Disord
    E-pub date: 1 Feb 2023
    Authors: E-J Vollstedt, S Schaake, K Lohmann, S Padmanabhan, A Brice, S Lesage, C Tesson, M Vidailhet, I Wurster, F Hentati, A Mirelman, N Giladi, K Marder, C Waters, S Fahn, M Kasten, N Brüggemann, M Borsche, T Foroud, E Tolosa, A Garrido, G Annesi, M Gagliardi, M Bozi, L Stefanis, JJ Ferreira, L Correia Guedes, M Avenali, S Petrucci, L Clark, EY Fedotova, NY Abramycheva, V Alvarez, M Menéndez-González, S Jesús Maestre, P Gómez-Garre, P Mir, AC Belin, C Ran, C-H Lin, M-C Kuo, D Crosiers, ZK Wszolek, OA Ross, J Jankovic, K Nishioka, M Funayama, J Clarimon, CH Williams-Gray, M Camacho, M Cornejo-Olivas, L Torres-Ramirez, Y-R Wu, G-J Lee-Chen, A Morgadinho, T Pulkes, P Termsarasab, D Berg, G Kuhlenbäumer, AA Kühn, F Borngräber, G de Michele, A De Rosa, A Zimprich, A Puschmann, GD Mellick, J Dorszewska, J Carr, R Ferese, S Gambardella, B Chase, K Markopoulou, W Satake, T Toda, M Rossi, M Merello, T Lynch, DA Olszewska, S-Y Lim, A Ahmad-Annuar, AH Tan, B Al-Mubarak, H Hanagasi, D Koziorowski, S Ertan, G Genç, P de Carvalho Aguiar, M Barkhuizen, MMG Pimentel, R Saunders-Pullman, B van de Warrenburg, S Bressman, M Toft, S Appel-Cresswell, AE Lang, M Skorvanek, AJW Boon, R Krüger, EM Sammler, V Tumas, B-R Zhang, G Garraux, SJ Chung, YJ Kim, J Winkelmann, CM Sue, E-K Tan, J Damásio, P Klivényi, VS Kostic, D Arkadir, M Martikainen, V Borges, JM Hertz, L Brighina, M Spitz, O Suchowersky, O Riess, P Das, B Mollenhauer, EM Gatto, MS Petersen, N Hattori, R-M Wu, SN Illarioshkin, EM Valente, JO Aasly, A Aasly, RN Alcalay, A Thaler, MJ Farrer, K Brockmann, J-C Corvol, C Klein, MJFF Global Genetic Parkinson's Disease Study Group

    Mitochondrial haplogroups and cognitive progression in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awac327
    Journal: Brain
    E-pub date: 5 Jan 2023
    Authors: G Liu, C Ni, J Zhan, W Li, J Luo, Z Liao, JJ Locascio, W Xian, L Chen, Z Pei, J-C Corvol, J Maple-Grødem, MC Campbell, A Elbaz, S Lesage, A Brice, AY Hung, MA Schwarzschild, MT Hayes, A-M Wills, B Ravina, I Shoulson, P Taba, S Kõks, TG Beach, F Cormier-Dequaire, G Alves, O-B Tysnes, JS Perlmutter, P Heutink, JJ van Hilten, RA Barker, CH Williams-Gray, CR Scherzer, International Genetics of Parkinson Disease Progression (IGPP) Consortium

    DCTN1 mutation associated parkinsonism: case series of three new families with perry syndrome.

    DOI: http://doi.org/10.1007/s00415-022-11308-3
    Journal: J Neurol
    E-pub date: 1 Dec 2022
    Authors: TB Stoker, V Dostal, J Cochius, CH Williams-Gray, CR Scherzer, J Wang, G Liu, I Coyle-Gilchrist

    An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson’s disease patients.

    DOI: http://doi.org/10.1039/d2sc00066k
    Journal: Chem Sci
    E-pub date: 30 Nov 2022
    Authors: K Kulenkampff, D Emin, R Staats, YP Zhang, L Sakhnini, A Kouli, O Rimon, E Lobanova, CH Williams-Gray, FA Aprile, P Sormanni, D Klenerman, M Vendruscolo

    RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia-an international Delphi consensus.

    DOI: http://doi.org/10.1186/s13195-022-01103-7
    Journal: Alzheimers Res Ther
    E-pub date: 11 Nov 2022
    Authors: JT O'Brien, L Chouliaras, J Sultana, J-P Taylor, C Ballard, RENEWAL Study Group

    Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease

    DOI: http://doi.org/10.1038/s41467-022-33252-6
    Journal: Nat Commun
    E-pub date: 20 Sep 2022
    Authors: D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman

    Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian Disorders.

    DOI: http://doi.org/10.1002/mds.29072
    Journal: Mov Disord
    E-pub date: 31 Aug 2022
    Authors: R Ye, C O'Callaghan, C Rua, FH Hezemans, N Holland, M Malpetti, PS Jones, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, J Rowe

    Age-Related Adaptive Immune Changes in Parkinson’s Disease.

    DOI: http://doi.org/10.3233/JPD-223228
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2022
    Authors: A Kouli, CH Williams-Gray

    Genome-wide determinants of mortality and motor progression in Parkinson’s disease

    DOI: http://doi.org/10.1101/2022.07.07.22277297
    Journal:
    E-pub date: 10 Jul 2022
    Authors: MMX Tan, MA Lawton, MI Pollard, E Brown, R Real, A Martinez Carrasco, S Bekadar, E Jabbari, RH Reynolds, H Iwaki, C Blauwendraat, S Kanavou, L Hubbard, N Malek, KA Grosset, N Bajaj, RA Barker, DJ Burn, C Bresner, T Foltynie, NW Wood, CH Williams-Gray, OA Andreassen, M Toft, A Elbaz, F Artaud, A Brice, J-C Corvol, J Aasly, MJ Farrer, MA Nalls, AB Singleton, NM Williams, Y Ben-Shlomo, J Hardy, MTM Hu, DG Grosset, M Shoai, L Pihlstrøm, HR Morris

    In Vivo 18F-Flortaucipir PET Does Not Accurately Support the Staging of Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.2967/jnumed.121.262985
    Journal: J Nucl Med
    E-pub date: 1 Jul 2022
    Authors: M Malpetti, SS Kaalund, KA Tsvetanov, T Rittman, M Briggs, KSJ Allinson, L Passamonti, N Holland, PS Jones, TD Fryer, YT Hong, A Kouli, WR Bevan-Jones, E Mak, G Savulich, MG Spillantini, FI Aigbirhio, CH Williams-Gray, JT O'Brien, JB Rowe

    Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes.

    DOI: http://doi.org/10.1371/journal.pcbi.1010079
    Journal: PLoS Comput Biol
    E-pub date: 1 May 2022
    Authors: FH Hezemans, N Wolpe, C O'Callaghan, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson’s Disease Dementia.

    DOI: http://doi.org/10.1002/mdc3.13451
    Journal: Mov Disord Clin Pract
    E-pub date: 1 May 2022
    Authors: JA Boel, RMA de Bie, BA Schmand, JC Dalrymple-Alford, C Marras, CH Adler, JG Goldman, AI Tröster, DJ Burn, I Litvan, GJ Geurtsen, MDS Study Group Mild Cognitive Impairment in Parkinson's Disease

    GBA and APOE Impact Cognitive Decline in Parkinson’s Disease: A 10-Year Population-Based Study.

    DOI: http://doi.org/10.1002/mds.28932
    Journal: Movement Disorders
    E-pub date: 1 May 2022
    Authors: AA Szwedo, I Dalen, KF Pedersen, M Camacho, D Bäckström, L Forsgren, C Tzoulis, S Winder-Rhodes, G Hudson, G Liu, CR Scherzer, RA Lawson, AJ Yarnall, CH Williams-Gray, AD Macleod, CE Counsell, O-B Tysnes, G Alves, J Maple-Grødem, Parkinson's Incidence Cohorts Collaboration

    Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awab142
    Journal: Brain
    E-pub date: 4 Sep 2021
    Authors: C O'Callaghan, FH Hezemans, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, N Wolpe, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases.

    DOI: http://doi.org/10.1038/s41591-021-01441-3
    Journal: Nat Med
    E-pub date: 1 Sep 2021
    Authors: N Cai, A Gomez-Duran, E Yonova-Doing, K Kundu, AI Burgess, ZJ Golder, C Calabrese, MJ Bonder, M Camacho, RA Lawson, L Li, CH Williams-Gray, ICICLE-PD Study Group, E Di Angelantonio, DJ Roberts, NA Watkins, WH Ouwehand, AS Butterworth, ID Stewart, M Pietzner, NJ Wareham, C Langenberg, J Danesh, K Walter, PM Rothwell, JMM Howson, O Stegle, PF Chinnery, N Soranzo

    A Disease Progression Model to Quantify the Nonmotor Symptoms of Parkinson’s Disease in Participants With Leucine-Rich Repeat Kinase 2 Mutation.

    DOI: http://doi.org/10.1002/cpt.2277
    Journal: Clin Pharmacol Ther
    E-pub date: 31 Aug 2021
    Authors: M Ahamadi, N Mehrotra, N Hanan, K Lai Yee, F Gheyas, J Anton, M Bani, B Boroojerdi, H Smit, J Weidemann, S Macha, V Thuillier, C Chen, M Yang, CH Williams-Gray, GT Stebbins, G Pagano, Y Hang, K Marek, CS Venuto, M Javidnia, D Dexter, A Pedata, B Stafford, M Akalu, D Stephenson, K Romero, V Sinha, Critical Path for Parkinson’s Consortium

    Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes

    DOI: http://doi.org/10.1101/2021.07.04.21259922
    Journal:
    E-pub date: 1 Aug 2021
    Authors: F Hezemans, N Wolpe, C O’Callaghan, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Reduced locus coeruleus integrity linked to response inhibition deficits in parkinsonian disorders

    DOI: http://doi.org/10.1101/2021.10.14.21264996
    Journal:
    E-pub date: 1 Aug 2021
    Authors: R Ye, F Hezemans, C O’Callaghan, K Tsvetanov, C Rua, S Jones, N Holland, M Malpetti, A Murley, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson’s Disease in the ICICLE-PD Cohort.

    DOI: http://doi.org/10.3233/JPD-212581
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2021
    Authors: RA Lawson, CH Williams-Gray, M Camacho, GW Duncan, TK Khoo, DP Breen, RA Barker, L Rochester, DJ Burn, AJ Yarnall, ICICLE-PD study group

    The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features.

    DOI: http://doi.org/10.3389/fnagi.2021.685594
    Journal: Front Aging Neurosci
    E-pub date: 1 Aug 2021
    Authors: WJ Griffiths, J Abdel-Khalik, SF Moore, RS Wijeyekoon, PJ Crick, E Yutuc, K Farrell, DP Breen, CH Williams-Gray, S Theofilopoulos, E Arenas, M Trupp, RA Barker, Y Wang

    Locus Coeruleus Integrity from 7T MRI Relates to Apathy and Cognition in Parkinson’s Disease and Progressive Supranuclear Palsy

    DOI: http://doi.org/10.1101/2021.04.19.21255762
    Journal:
    E-pub date: 1 Aug 2021
    Authors: R Ye, C O’Callaghan, C Rua, F Hezemans, N Holland, M Malpetti, S Jones, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Neurodegenerative Disease and the NLRP3 Inflammasome.

    DOI: http://doi.org/10.3389/fphar.2021.643254
    Journal: Front Pharmacol
    E-pub date: 1 Aug 2021
    Authors: JA Holbrook, HH Jarosz-Griffiths, E Caseley, S Lara-Reyna, JA Poulter, CH Williams-Gray, D Peckham, MF McDermott

    [18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.

    DOI: http://doi.org/10.1093/braincomms/fcab177
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, A Kouli, N Holland, N Nicastro, G Savulich, A Surendranathan, M Malpetti, R Manavaki, YT Hong, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien, CH Williams-Gray

    Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson’s disease

    DOI: http://doi.org/10.1038/s41588-021-00847-6
    Journal: Nat Genet
    E-pub date: 1 Jun 2021
    Authors: R Barker, C Williams-Gray

    Early constipation predicts faster dementia onset in Parkinson’s disease.

    DOI: http://doi.org/10.1038/s41531-021-00191-w
    Journal: NPJ Parkinsons Dis
    E-pub date: 26 May 2021
    Authors: M Camacho, AD Macleod, J Maple-Grødem, JR Evans, DP Breen, G Cummins, RS Wijeyekoon, JC Greenland, G Alves, OB Tysnes, RA Lawson, RA Barker, CH Williams-Gray

    [11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease.

    DOI: http://doi.org/10.1212/WNL.0000000000012033
    Journal: Neurology
    E-pub date: 21 Apr 2021
    Authors: J van den Ameele, Y Hong, R Manavaki, A Kouli, H Biggs, Z MacIntyre, R Horvath, P Yu-Wai-Man, E Reid, CH Williams-Gray, E Bullmore, F Aigbirhio, T Fryer, P Chinnery

    Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mds.28342
    Journal: Mov Disord
    E-pub date: 1 Feb 2021
    Authors: MMX Tan, MA Lawton, E Jabbari, RH Reynolds, H Iwaki, C Blauwendraat, S Kanavou, MI Pollard, L Hubbard, N Malek, KA Grosset, SL Marrinan, N Bajaj, RA Barker, DJ Burn, C Bresner, T Foltynie, NW Wood, CH Williams-Gray, J Hardy, MA Nalls, AB Singleton, NM Williams, Y Ben-Shlomo, MTM Hu, DG Grosset, M Shoai, HR Morris

    Differences in the Presentation and Progression of Parkinson’s Disease by Sex.

    DOI: http://doi.org/10.1002/mds.28312
    Journal: Mov Disord
    E-pub date: 1 Jan 2021
    Authors: H Iwaki, C Blauwendraat, HL Leonard, MB Makarious, JJ Kim, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, L Smolensky, N Amondikar, SJ Hutten, M Frasier, K-DH Nguyen, J Rick, S Eberly, F Faghri, P Auinger, KM Scott, R Wijeyekoon, VM Van Deerlin, DG Hernandez, RJ Gibbs, AG Day-Williams, A Brice, G Alves, AJ Noyce, O-B Tysnes, JR Evans, DP Breen, K Estrada, CE Wegel, F Danjou, DK Simon, OA Andreassen, B Ravina, M Toft, P Heutink, BR Bloem, D Weintraub, RA Barker, CH Williams-Gray, BP van de Warrenburg, JJ Van Hilten, CR Scherzer, AB Singleton, MA Nalls

    Parkinson’s disease

    DOI: http://doi.org/10.1016/j.mpmed.2020.06.001
    Journal: Medicine (United Kingdom)
    E-pub date: 1 Sep 2020
    Authors: CH Williams-Gray, PF Worth

    Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease

    DOI: http://doi.org/10.1101/2020.09.03.20176800
    Journal:
    E-pub date: 1 Aug 2020
    Authors: C O’Callaghan, F Hezemans, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, N Wolpe, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Senescence and Inflammatory Markers for Predicting Clinical Progression in Parkinson’s Disease: The ICICLE-PD Study.

    DOI: http://doi.org/10.3233/JPD-191724
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2020
    Authors: C Martin-Ruiz, CH Williams-Gray, AJ Yarnall, JJ Boucher, RA Lawson, RS Wijeyekoon, RA Barker, C Kolenda, C Parker, DJ Burn, T Von Zglinicki, G Saretzki

    Genome-wide association studies of cognitive and motor progression in Parkinson’s disease

    DOI: http://doi.org/10.1101/2020.05.07.20084343
    Journal:
    E-pub date: 1 Aug 2020
    Authors: MMX Tan, M Lawton, E Jabbari, R Reynolds, H Iwaki, C Blauwendraat, S Kanavou, M Pollard, L Hubbard, N Malek, K Grosset, S Marrinan, N Bajaj, R Barker, D Burn, C Bresner, T Foltynie, N Wood, C Williams-Gray, J Hardy, M Nalls, A Singleton, N Williams, Y Ben-Shlomo, MTM Hu, D Grosset, M Shoai, H Morris

    Differences in the presentation and progression of Parkinson’s disease by sex

    DOI: http://doi.org/10.1101/2020.04.08.20058370
    Journal:
    E-pub date: 1 Aug 2020
    Authors: H Iwaki, C Blauwendraat, H Leonard, M Makarious, J Kim, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, L Smolensky, N Amondikar, S Hutten, M Frasier, K-D Nguyen, J Rick, S Eberly, F Faghri, P Auinger, K Scott, R Wijeyekoon, V Van Deerlin, D Hernandez, R Gibbs, A Day-Williams, A Brice, G Alves, A Noyce, O-B Tysnes, J Evans, D Breen, K Estrada, C Wegel, F Danjou, D Simon, O Andreassen, B Ravina, M Toft, P Heutink, B Bloem, D Weintraub, R Barker, C Williams-Gray, B van de Warrenburg, J Van Hilten, C Scherzer, A Singleton, M Nalls

    Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson’s disease.

    DOI: http://doi.org/10.1016/j.parkreldis.2020.05.034
    Journal: Parkinsonism Relat Disord
    E-pub date: 1 Jul 2020
    Authors: N Ramsay, AD Macleod, G Alves, M Camacho, L Forsgren, RA Lawson, J Maple-Grødem, O-B Tysnes, CH Williams-Gray, AJ Yarnall, CE Counsell, Parkinson's Incidence Cohorts Collaboration, PINE Study, CamPaIGN study, PICNICS study, NYPUM Study, ParkWest Study: ParkWest Principal investigators, Study personnel, ICICLE-PD Study

    Timing Is Everything: The T-Cell Response to α-Synuclein Is Maximal in Early Parkinson’s.

    DOI: http://doi.org/10.1002/mds.28122
    Journal: Mov Disord
    E-pub date: 1 Jul 2020
    Authors: A Kouli, CH Williams-Gray

    A common polymorphism in SNCA is associated with accelerated motor decline in GBA-Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp-2019-322210
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jun 2020
    Authors: TB Stoker, M Camacho, S Winder-Rhodes, G Liu, CR Scherzer, T Foltynie, RA Barker, CH Williams-Gray

    Disease modification and biomarker development in Parkinson disease: Revision or reconstruction?

    DOI: http://doi.org/10.1212/WNL.0000000000009107
    Journal: Neurology
    E-pub date: 17 Mar 2020
    Authors: AJ Espay, LV Kalia, Z Gan-Or, CH Williams-Gray, PL Bedard, SM Rowe, F Morgante, A Fasano, B Stecher, MA Kauffman, MJ Farrer, CS Coffey, MA Schwarzschild, T Sherer, RB Postuma, AP Strafella, AB Singleton, RA Barker, K Kieburtz, CW Olanow, A Lozano, JH Kordower, JM Cedarbaum, P Brundin, DG Standaert, AE Lang

    Progression of Neuropsychiatric Symptoms over Time in an Incident Parkinson’s Disease Cohort (ICICLE-PD).

    DOI: http://doi.org/10.3390/brainsci10020078
    Journal: Brain Sci
    E-pub date: 2 Feb 2020
    Authors: JK Dlay, GW Duncan, TK Khoo, CH Williams-Gray, DP Breen, RA Barker, DJ Burn, RA Lawson, AJ Yarnall

    DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits.

    DOI: http://doi.org/10.1016/j.nbd.2019.104629
    Journal: Neurobiol Dis
    E-pub date: 1 Feb 2020
    Authors: K Solti, W-L Kuan, B Fórizs, G Kustos, J Mihály, Z Varga, B Herberth, É Moravcsik, R Kiss, M Kárpáti, A Mikes, Y Zhao, T Imre, J-C Rochet, F Aigbirhio, CH Williams-Gray, RA Barker, G Tóth

    Motor complications in Parkinson’s disease: 13-year follow-up of the CamPaIGN cohort.

    DOI: http://doi.org/10.1002/mds.27882
    Journal: Mov Disord
    E-pub date: 1 Jan 2020
    Authors: H-J Kim, S Mason, T Foltynie, S Winder-Rhodes, RA Barker, CH Williams-Gray

    Genomewide association study of Parkinson’s disease clinical biomarkers in 12 longitudinal patients’ cohorts.

    DOI: http://doi.org/10.1002/mds.27845
    Journal: Mov Disord
    E-pub date: 1 Dec 2019
    Authors: H Iwaki, C Blauwendraat, HL Leonard, JJ Kim, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, SJ Hutten, K-DH Nguyen, J Rick, S Eberly, F Faghri, P Auinger, KM Scott, R Wijeyekoon, VM Van Deerlin, DG Hernandez, JR Gibbs, International Parkinson's Disease Genomics Consortium, KN Chitrala, AG Day-Williams, A Brice, G Alves, AJ Noyce, O-B Tysnes, JR Evans, DP Breen, K Estrada, CE Wegel, F Danjou, DK Simon, O Andreassen, B Ravina, M Toft, P Heutink, BR Bloem, D Weintraub, RA Barker, CH Williams-Gray, BP van de Warrenburg, JJ Van Hilten, CR Scherzer, AB Singleton, MA Nalls

    Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts.

    DOI: http://doi.org/10.1212/NXG.0000000000000348
    Journal: Neurol Genet
    E-pub date: 31 Aug 2019
    Authors: H Iwaki, C Blauwendraat, HL Leonard, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, SJ Hutten, K-DH Nguyen, J Rick, S Eberly, F Faghri, P Auinger, KM Scott, R Wijeyekoon, VM Van Deerlin, DG Hernandez, AG Day-Williams, A Brice, G Alves, AJ Noyce, O-B Tysnes, JR Evans, DP Breen, K Estrada, CE Wegel, F Danjou, DK Simon, B Ravina, M Toft, P Heutink, BR Bloem, D Weintraub, RA Barker, CH Williams-Gray, BP van de Warrenburg, JJ Van Hilten, CR Scherzer, AB Singleton, MA Nalls

    Inflammation in mild cognitive impairment due to Parkinson’s disease, Lewy body disease, and Alzheimer’s disease.

    DOI: http://doi.org/10.1002/gps.5124
    Journal: Int J Geriatr Psychiatry
    E-pub date: 31 Aug 2019
    Authors: E King, J O'Brien, P Donaghy, CH Williams-Gray, RA Lawson, CM Morris, N Barnett, K Olsen, C Martin-Ruiz, D Burn, AJ Yarnall, J-P Taylor, G Duncan, TK Khoo, A Thomas

    Using global team science to identify genetic parkinson’s disease worldwide.

    DOI: http://doi.org/10.1002/ana.25514
    Journal: Ann Neurol
    E-pub date: 31 Aug 2019
    Authors: E-J Vollstedt, M Kasten, C Klein, MJFF Global Genetic Parkinson's Disease Study Group

    Genome-wide association study of Parkinson’s disease progression biomarkers in 12 longitudinal patients’ cohorts

    DOI: http://doi.org/10.1101/585836
    Journal:
    E-pub date: 1 Aug 2019
    Authors: H Iwaki, C Blauwendraat, H Leonard, J Kim, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, S Hutten, N Khanh-Dung, J Rick, S Eberly, F Faghri, P Auinger, K Scott, R Wijeyekoon, V Van Deerlin, D Hernandez, R Gibbs, KN Chitrala, A Day-Williams, A Brice, G Alves, A Noyce, O-B Tysnes, J Evans, D Breen, K Estrada, C Wegel, F Danjou, D Simon, O Andreassen, B Ravina, M Toft, P Heutink, B Bloem, D Weintraub, R Barker, C Williams-Gray, B van de Warrenburg, J Van Hilten, C Scherzer, A Singleton, M Nalls

    Portrait of blood-derived extracellular vesicles in patients with Parkinson’s disease.

    DOI: http://doi.org/10.1016/j.nbd.2018.11.002
    Journal: Neurobiol Dis
    E-pub date: 1 Apr 2019
    Authors: J Lamontagne-Proulx, I St-Amour, R Labib, J Pilon, HL Denis, N Cloutier, F Roux-Dalvai, AT Vincent, SL Mason, C Williams-Gray, A-C Duchez, A Droit, S Lacroix, N Dupré, M Langlois, S Chouinard, M Panisset, RA Barker, E Boilard, F Cicchetti

    The clinical heterogeneity of Parkinson’s disease and its therapeutic implications.

    DOI: http://doi.org/10.1111/ejn.14094
    Journal: Eur J Neurosci
    E-pub date: 1 Feb 2019
    Authors: JC Greenland, CH Williams-Gray, RA Barker

    The motor and cognitive features of Parkinson’s disease in patients with concurrent Gaucher disease over 2 years: a case series.

    DOI: http://doi.org/10.1007/s00415-018-8908-6
    Journal: J Neurol
    E-pub date: 31 Aug 2018
    Authors: LM Collins, CH Williams-Gray, E Morris, P Deegan, TM Cox, RA Barker

    A Systematic Review and Meta-Analysis of Alpha Synuclein Auto-Antibodies in Parkinson’s Disease.

    DOI: http://doi.org/10.3389/fneur.2018.00815
    Journal: Front Neurol
    E-pub date: 1 Aug 2018
    Authors: KM Scott, A Kouli, SL Yeoh, MR Clatworthy, CH Williams-Gray

    Targeting Aged Astrocytes May Be a New Therapeutic Strategy in Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mds.27387
    Journal: Mov Disord
    E-pub date: 1 May 2018
    Authors: KM Scott, CH Williams-Gray

    Excessive burden of lysosomal storage disorder gene variants in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awx285
    Journal: Brain
    E-pub date: 1 Dec 2017
    Authors: LA Robak, IE Jansen, J van Rooij, AG Uitterlinden, R Kraaij, J Jankovic, International Parkinson’s Disease Genomics Consortium (IPDGC), P Heutink, JM Shulman

    Associations between Lifestyle Factors and Parkinson’s Disease in an Urban Sri Lankan Clinic Study.

    DOI: http://doi.org/10.3823/2516
    Journal: Int Arch Med
    E-pub date: 15 Sep 2017
    Authors: R Wijeyekoon, V Suriyakumara, R Gamage, T Fernando, A Jayasuriya, D Amarasinghe, H Gunasekara, D Sirisena, D Amaratunga, C Muthukuda, RA Barker, C Williams-Gray, R De Silva

    Stability of mild cognitive impairment in newly diagnosed Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp-2016-315099
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 31 Aug 2017
    Authors: RA Lawson, AJ Yarnall, GW Duncan, DP Breen, TK Khoo, CH Williams-Gray, RA Barker, DJ Burn, ICICLE-PD study group

    Parkinson disease: Defining PD subtypes – a step toward personalized management?

    DOI: http://doi.org/10.1038/nrneurol.2017.98
    Journal: Nat Rev Neurol
    E-pub date: 31 Aug 2017
    Authors: CH Williams-Gray, RA Barker

    Prediction of cognition in Parkinson’s disease with a clinical-genetic score: a longitudinal analysis of nine cohorts.

    DOI: http://doi.org/10.1016/S1474-4422(17)30122-9
    Journal: Lancet Neurol
    E-pub date: 31 Aug 2017
    Authors: G Liu, JJ Locascio, J-C Corvol, B Boot, Z Liao, K Page, D Franco, K Burke, IE Jansen, A Trisini-Lipsanopoulos, S Winder-Rhodes, CM Tanner, AE Lang, S Eberly, A Elbaz, A Brice, G Mangone, B Ravina, I Shoulson, F Cormier-Dequaire, P Heutink, JJ van Hilten, RA Barker, CH Williams-Gray, J Marinus, CR Scherzer, HBS, CamPaIGN, PICNICS, PROPARK, PSG, DIGPD, PDBP

    Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.

    DOI: http://doi.org/10.1001/jamaneurol.2017.0469
    Journal: JAMA Neurol
    E-pub date: 1 Jul 2017
    Authors: A Witoelar, IE Jansen, Y Wang, RS Desikan, JR Gibbs, C Blauwendraat, WK Thompson, DG Hernandez, S Djurovic, AJ Schork, F Bettella, D Ellinghaus, A Franke, BA Lie, LK McEvoy, TH Karlsen, S Lesage, HR Morris, A Brice, NW Wood, P Heutink, J Hardy, AB Singleton, AM Dale, T Gasser, OA Andreassen, M Sharma, International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), and United Kingdom Brain Expression Consortium (UKBEC) Investigators

    No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease in nine ADHD candidate SNPs.

    DOI: http://doi.org/10.1007/s12402-017-0219-8
    Journal: Atten Defic Hyperact Disord
    E-pub date: 1 Jun 2017
    Authors: JM Geissler, International Parkinson Disease Genomics Consortium members, M Romanos, M Gerlach, D Berg, C Schulte

    The role of high-field magnetic resonance imaging in parkinsonian disorders: Pushing the boundaries forward.

    DOI: http://doi.org/10.1002/mds.26968
    Journal: Mov Disord
    E-pub date: 1 Apr 2017
    Authors: S Lehericy, DE Vaillancourt, K Seppi, O Monchi, I Rektorova, A Antonini, MJ McKeown, M Masellis, D Berg, JB Rowe, SJG Lewis, CH Williams-Gray, A Tessitore, HR Siebner, International Parkinson and Movement Disorder Society (IPMDS)-Neuroimaging Study Group

    Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing.

    DOI: http://doi.org/10.1186/s13059-017-1147-9
    Journal: Genome Biol
    E-pub date: 30 Jan 2017
    Authors: IE Jansen, H Ye, S Heetveld, MC Lechler, H Michels, RI Seinstra, SJ Lubbe, V Drouet, S Lesage, E Majounie, JR Gibbs, MA Nalls, M Ryten, JA Botia, J Vandrovcova, J Simon-Sanchez, M Castillo-Lizardo, P Rizzu, C Blauwendraat, AK Chouhan, Y Li, P Yogi, N Amin, CM van Duijn, International Parkinson’s Disease Genetics Consortium (IPGDC), HR Morris, A Brice, AB Singleton, DC David, EA Nollen, S Jain, JM Shulman, P Heutink

    α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.

    DOI: http://doi.org/10.1016/j.expneurol.2016.09.003
    Journal: Exp Neurol
    E-pub date: 1 Nov 2016
    Authors: W-L Kuan, N Bennett, X He, JN Skepper, N Martynyuk, R Wijeyekoon, PV Moghe, CH Williams-Gray, RA Barker

    Specifically neuropathic Gaucher’s mutations accelerate cognitive decline in Parkinson’s.

    DOI: http://doi.org/10.1002/ana.24781
    Journal: Ann Neurol
    E-pub date: 1 Nov 2016
    Authors: G Liu, B Boot, JJ Locascio, IE Jansen, S Winder-Rhodes, S Eberly, A Elbaz, A Brice, B Ravina, JJ van Hilten, F Cormier-Dequaire, J-C Corvol, RA Barker, P Heutink, J Marinus, CH Williams-Gray, CR Scherzer, International Genetics of Parkinson Disease Progression (IGPP) Consortium

    Comparative epidemiology of incident Parkinson’s disease in Cambridgeshire, UK.

    DOI: http://doi.org/10.1136/jnnp-2015-312581
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Sep 2016
    Authors: JR Evans, G Cummins, DP Breen, T Foltynie, SL Mason, CEG Brayne, CH Williams-Gray, RA Barker

    Parkinson’s disease

    DOI: http://doi.org/10.1016/j.mpmed.2016.06.001
    Journal: Medicine (United Kingdom)
    E-pub date: 1 Sep 2016
    Authors: CH Williams-Gray, PF Worth

    The Genetic Basis of Cognitive Impairment and Dementia in Parkinson’s Disease.

    DOI: http://doi.org/10.3389/fpsyt.2016.00089
    Journal: Front Psychiatry
    E-pub date: 1 Aug 2016
    Authors: LM Collins, CH Williams-Gray

    Cognitive decline and quality of life in incident Parkinson’s disease: The role of attention.

    DOI: http://doi.org/10.1016/j.parkreldis.2016.04.009
    Journal: Parkinsonism Relat Disord
    E-pub date: 1 Jun 2016
    Authors: RA Lawson, AJ Yarnall, GW Duncan, DP Breen, TK Khoo, CH Williams-Gray, RA Barker, D Collerton, J-P Taylor, DJ Burn, ICICLE-PD study group

    Deletions at 22q11.2 in idiopathic Parkinson’s disease: a combined analysis of genome-wide association data.

    DOI: http://doi.org/10.1016/S1474-4422(16)00071-5
    Journal: Lancet Neurol
    E-pub date: 1 May 2016
    Authors: KY Mok, U Sheerin, J Simón-Sánchez, A Salaka, L Chester, V Escott-Price, K Mantripragada, KM Doherty, AJ Noyce, NE Mencacci, SJ Lubbe, International Parkinson's Disease Genomics Consortium (IPDGC), CH Williams-Gray, RA Barker, KD van Dijk, HW Berendse, P Heutink, J-C Corvol, F Cormier, S Lesage, A Brice, K Brockmann, C Schulte, T Gasser, T Foltynie, P Limousin, KE Morrison, CE Clarke, S Sawcer, TT Warner, AJ Lees, HR Morris, MA Nalls, AB Singleton, J Hardy, AY Abramov, V Plagnol, NM Williams, NW Wood

    Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy.

    DOI: http://doi.org/10.1016/j.ajhg.2016.01.014
    Journal: Am J Hum Genet
    E-pub date: 3 Mar 2016
    Authors: S Lesage, V Drouet, E Majounie, V Deramecourt, M Jacoupy, A Nicolas, F Cormier-Dequaire, SM Hassoun, C Pujol, S Ciura, Z Erpapazoglou, T Usenko, C-A Maurage, M Sahbatou, S Liebau, J Ding, B Bilgic, M Emre, N Erginel-Unaltuna, G Guven, F Tison, C Tranchant, M Vidailhet, J-C Corvol, P Krack, A-L Leutenegger, MA Nalls, DG Hernandez, P Heutink, JR Gibbs, J Hardy, NW Wood, T Gasser, A Durr, J-F Deleuze, M Tazir, A Destée, E Lohmann, E Kabashi, A Singleton, O Corti, A Brice, French Parkinson's Disease Genetics Study (PDG), International Parkinson's Disease Genomics Consortium (IPDGC)

    Review: The spectrum of clinical features seen with alpha synuclein pathology.

    DOI: http://doi.org/10.1111/nan.12303
    Journal: Neuropathol Appl Neurobiol
    E-pub date: 1 Feb 2016
    Authors: RA Barker, CH Williams-Gray

    A new biomarker for Parkinson’s disease?

    DOI: http://doi.org/10.1002/mds.26448
    Journal: Mov Disord
    E-pub date: 1 Jan 2016
    Authors: CH Williams-Gray

    Seeing Is Believing: Alpha-Synuclein Oligomers in Parkinson’s Disease Brain.

    DOI: http://doi.org/10.1002/mds.26335
    Journal: Mov Disord
    E-pub date: 1 Sep 2015
    Authors: C Williams-Gray

    Precompetitive Data Sharing as a Catalyst to Address Unmet Needs in Parkinson’s Disease.

    DOI: http://doi.org/10.3233/JPD-150570
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2015
    Authors: D Stephenson, MT Hu, K Romero, K Breen, D Burn, Y Ben-Shlomo, A Bhattaram, M Isaac, C Venuto, K Kubota, MA Little, S Friend, S Lovestone, HR Morris, D Grosset, M Sutherland, J Gallacher, C Williams-Gray, LJ Bain, E Avilés, K Marek, AW Toga, Y Stark, M Forrest Gordon, S Ford

    Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.

    DOI: http://doi.org/10.1038/mp.2014.107
    Journal: Mol Psychiatry
    E-pub date: 1 May 2015
    Authors: Coffee and Caffeine Genetics Consortium, MC Cornelis, EM Byrne, T Esko, MA Nalls, A Ganna, N Paynter, KL Monda, N Amin, K Fischer, F Renstrom, JS Ngwa, V Huikari, A Cavadino, IM Nolte, A Teumer, K Yu, P Marques-Vidal, R Rawal, A Manichaikul, MK Wojczynski, JM Vink, JH Zhao, G Burlutsky, J Lahti, V Mikkilä, RN Lemaitre, J Eriksson, SK Musani, T Tanaka, F Geller, J Luan, J Hui, R Mägi, M Dimitriou, ME Garcia, W-K Ho, MJ Wright, LM Rose, PK Magnusson, NL Pedersen, D Couper, BA Oostra, A Hofman, MA Ikram, HW Tiemeier, AG Uitterlinden, FJ van Rooij, I Barroso, I Johansson, L Xue, M Kaakinen, L Milani, C Power, H Snieder, RP Stolk, SE Baumeister, R Biffar, F Gu, F Bastardot, Z Kutalik, DR Jacobs, NG Forouhi, E Mihailov, L Lind, C Lindgren, K Michaëlsson, A Morris, M Jensen, K-T Khaw, RN Luben, JJ Wang, S Männistö, M-M Perälä, M Kähönen, T Lehtimäki, J Viikari, D Mozaffarian, K Mukamal, BM Psaty, A Döring, AC Heath, GW Montgomery, N Dahmen, T Carithers, KL Tucker, L Ferrucci, HA Boyd, M Melbye, JL Treur, D Mellström, JJ Hottenga, I Prokopenko, A Tönjes, P Deloukas, S Kanoni, M Lorentzon, DK Houston, Y Liu, J Danesh, A Rasheed, MA Mason, AB Zonderman, L Franke, BS Kristal, International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), UK Brain Expression Consortium (UKBEC), J Karjalainen, DR Reed, H-J Westra, MK Evans, D Saleheen, TB Harris, G Dedoussis, G Curhan, M Stumvoll, J Beilby, LR Pasquale, B Feenstra, S Bandinelli, JM Ordovas, AT Chan, U Peters, C Ohlsson, C Gieger, NG Martin, M Waldenberger, DS Siscovick, O Raitakari, JG Eriksson, P Mitchell, DJ Hunter, P Kraft, EB Rimm, DI Boomsma, IB Borecki, RJ Loos, NJ Wareham, P Vollenweider, N Caporaso, HJ Grabe, ML Neuhouser, BH Wolffenbuttel, FB Hu, E Hyppönen, M-R Järvelin, LA Cupples, PW Franks, PM Ridker, CM van Duijn, G Heiss, A Metspalu, KE North, E Ingelsson, JA Nettleton, RM van Dam, DI Chasman

    NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2014.07.028
    Journal: Neurobiol Aging
    E-pub date: 1 Mar 2015
    Authors: MA Nalls, J Bras, DG Hernandez, MF Keller, E Majounie, AE Renton, M Saad, I Jansen, R Guerreiro, S Lubbe, V Plagnol, JR Gibbs, C Schulte, N Pankratz, M Sutherland, L Bertram, CM Lill, AL DeStefano, T Faroud, N Eriksson, JY Tung, C Edsall, N Nichols, J Brooks, S Arepalli, H Pliner, C Letson, P Heutink, M Martinez, T Gasser, BJ Traynor, N Wood, J Hardy, AB Singleton, International Parkinson's Disease Genomics Consortium (IPDGC), Parkinson's Disease meta-analysis consortium

    The pathophysiological and prognostic heterogeneity of mild cognitive impairment in Parkinson’s disease

    DOI: http://doi.org/10.1093/med/9780199681648.003.0017
    Journal:
    E-pub date: 1 Jan 2015
    Authors: SE Winder-Rhodes, RA Barker, CH Williams-Gray

    Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease.

    DOI: http://doi.org/10.1038/ng.3043
    Journal: Nat Genet
    E-pub date: 1 Sep 2014
    Authors: MA Nalls, N Pankratz, CM Lill, CB Do, DG Hernandez, M Saad, AL DeStefano, E Kara, J Bras, M Sharma, C Schulte, MF Keller, S Arepalli, C Letson, C Edsall, H Stefansson, X Liu, H Pliner, JH Lee, R Cheng, International Parkinson's Disease Genomics Consortium (IPDGC), Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), Ashkenazi Jewish Dataset Investigator, Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE), North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC), Greek Parkinson's Disease Consortium, Alzheimer Genetic Analysis Group, MA Ikram, JPA Ioannidis, GM Hadjigeorgiou, JC Bis, M Martinez, JS Perlmutter, A Goate, K Marder, B Fiske, M Sutherland, G Xiromerisiou, RH Myers, LN Clark, K Stefansson, JA Hardy, P Heutink, H Chen, NW Wood, H Houlden, H Payami, A Brice, WK Scott, T Gasser, L Bertram, N Eriksson, T Foroud, AB Singleton

    Mild cognitive impairment and Parkinson’s disease–something to remember.

    DOI: http://doi.org/10.3233/JPD-140427
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2014
    Authors: RA Barker, CH Williams-Gray

    Parkinson’s disease mild cognitive impairment: application and validation of the criteria.

    DOI: http://doi.org/10.3233/JPD-130304
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2014
    Authors: GJ Geurtsen, J Hoogland, JG Goldman, BA Schmand, AI Tröster, DJ Burn, I Litvan, MDS Study Group on the Validation of PD-MCI Criteria

    Which patients with Parkinson’s disease participate in clinical trials? One centre’s experiences with a new cell based therapy trial (TRANSEURO).

    DOI: http://doi.org/10.3233/JPD-140432
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2014
    Authors: SF Moore, NV Guzman, SL Mason, CH Williams-Gray, RA Barker

    The spectrum of cognitive impairment in Lewy body diseases.

    DOI: http://doi.org/10.1002/mds.25866
    Journal: Mov Disord
    E-pub date: 15 Apr 2014
    Authors: JG Goldman, C Williams-Gray, RA Barker, JE Duda, JE Galvin

    Genetic comorbidities in Parkinson’s disease.

    DOI: http://doi.org/10.1093/hmg/ddt465
    Journal: Hum Mol Genet
    E-pub date: 1 Feb 2014
    Authors: MA Nalls, M Saad, AJ Noyce, MF Keller, A Schrag, JP Bestwick, BJ Traynor, JR Gibbs, DG Hernandez, MR Cookson, HR Morris, N Williams, T Gasser, P Heutink, N Wood, J Hardy, M Martinez, AB Singleton, International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2), North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC)

    Putative cortical dopamine levels affect cortical recruitment during planning.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2013.07.016
    Journal: Neuropsychologia
    E-pub date: 1 Sep 2013
    Authors: SJ Fallon, A Hampshire, CH Williams-Gray, RA Barker, AM Owen

    From molecule to clinic and community for neurodegeneration: research to bridge translational gaps.

    DOI: http://doi.org/10.3233/JAD-2012-129006
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2013
    Authors: C Brayne, RA Barker, D Harold, PG Ince, GM Savva, J Williams, CH Williams-Gray, SB Wharton

    Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study.

    DOI: http://doi.org/10.1371/journal.pmed.1001462
    Journal: PLoS Med
    E-pub date: 1 Aug 2013
    Authors: I Pichler, F Del Greco M, M Gögele, CM Lill, L Bertram, CB Do, N Eriksson, T Foroud, RH Myers, PD GWAS Consortium, M Nalls, MF Keller, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium 2, B Benyamin, JB Whitfield, Genetics of Iron Status Consortium, PP Pramstaller, AA Hicks, JR Thompson, C Minelli

    The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson’s disease with a sexual dimorphism.

    DOI: http://doi.org/10.1136/jnnp-2012-304475
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jun 2013
    Authors: S Klebe, J-L Golmard, MA Nalls, M Saad, AB Singleton, JM Bras, J Hardy, J Simon-Sanchez, P Heutink, G Kuhlenbäumer, R Charfi, C Klein, J Hagenah, T Gasser, I Wurster, S Lesage, D Lorenz, G Deuschl, F Durif, P Pollak, P Damier, F Tison, A Durr, P Amouyel, J-C Lambert, C Tzourio, C Maubaret, F Charbonnier-Beaupel, K Tahiri, M Vidailhet, M Martinez, A Brice, J-C Corvol, French Parkinson's Disease Genetics Study Group, International Parkinson's Disease Genomics Consortium (IPDGC)

    Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease.

    DOI: http://doi.org/10.1212/WNL.0b013e318294b434
    Journal: Neurology
    E-pub date: 28 May 2013
    Authors: G Hudson, M Nalls, JR Evans, DP Breen, S Winder-Rhodes, KE Morrison, HR Morris, CH Williams-Gray, RA Barker, AB Singleton, J Hardy, NE Wood, DJ Burn, PF Chinnery

    The Addenbrooke’s Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders.

    DOI: http://doi.org/10.1136/jnnp-2012-303618
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2013
    Authors: T Rittman, BC Ghosh, P McColgan, DP Breen, J Evans, CH Williams-Gray, RA Barker, JB Rowe

    A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson’s disease.

    DOI: http://doi.org/10.1093/hmg/dds492
    Journal: Hum Mol Genet
    E-pub date: 1 Mar 2013
    Authors: P Holmans, V Moskvina, L Jones, M Sharma, International Parkinson's Disease Genomics Consortium, A Vedernikov, F Buchel, M Saad, JM Bras, F Bettella, N Nicolaou, J Simón-Sánchez, F Mittag, JR Gibbs, C Schulte, A Durr, R Guerreiro, D Hernandez, A Brice, H Stefánsson, K Majamaa, T Gasser, P Heutink, NW Wood, M Martinez, AB Singleton, MA Nalls, J Hardy, HR Morris, NM Williams

    Prefrontal dopamine levels determine the balance between cognitive stability and flexibility.

    DOI: http://doi.org/10.1093/cercor/bhs025
    Journal: Cereb Cortex
    E-pub date: 1 Feb 2013
    Authors: SJ Fallon, CH Williams-Gray, RA Barker, AM Owen, A Hampshire

    Excessive daytime sleepiness and its risk factors in incident Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp-2012-304097
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Feb 2013
    Authors: DP Breen, CH Williams-Gray, SL Mason, T Foltynie, RA Barker

    Glucocerebrosidase mutations influence the natural history of Parkinson’s disease in a community-based incident cohort.

    DOI: http://doi.org/10.1093/brain/aws318
    Journal: Brain
    E-pub date: 1 Feb 2013
    Authors: SE Winder-Rhodes, JR Evans, M Ban, SL Mason, CH Williams-Gray, T Foltynie, R Duran, NE Mencacci, SJ Sawcer, RA Barker

    Use of support vector machines for disease risk prediction in genome-wide association studies: concerns and opportunities.

    DOI: http://doi.org/10.1002/humu.22161
    Journal: Hum Mutat
    E-pub date: 1 Dec 2012
    Authors: F Mittag, F Büchel, M Saad, A Jahn, C Schulte, Z Bochdanovits, J Simón-Sánchez, MA Nalls, M Keller, DG Hernandez, JR Gibbs, S Lesage, A Brice, P Heutink, M Martinez, NW Wood, J Hardy, AB Singleton, A Zell, T Gasser, M Sharma, International Parkinson’s Disease Genomics Consortium

    From molecule to clinic and community for neurodegeneration: Research to bridge translational gaps

    DOI: http://doi.org/10.3233/978-1-61499-154-0-385
    Journal: Advances in Alzheimer's Disease
    E-pub date: 1 Dec 2012
    Authors: C Brayne, RA Barker, D Harold, PG Ince, GM Savva, J Williams, CH Williams-Gray, SB Wharton

    Using genome-wide complex trait analysis to quantify ‘missing heritability’ in Parkinson’s disease.

    DOI: http://doi.org/10.1093/hmg/dds335
    Journal: Hum Mol Genet
    E-pub date: 15 Nov 2012
    Authors: MF Keller, M Saad, J Bras, F Bettella, N Nicolaou, J Simón-Sánchez, F Mittag, F Büchel, M Sharma, JR Gibbs, C Schulte, V Moskvina, A Durr, P Holmans, LL Kilarski, R Guerreiro, DG Hernandez, A Brice, P Ylikotila, H Stefánsson, K Majamaa, HR Morris, N Williams, T Gasser, P Heutink, NW Wood, J Hardy, M Martinez, AB Singleton, MA Nalls, International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2)

    Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson’s disease.

    DOI: http://doi.org/10.1002/mds.25132
    Journal: Mov Disord
    E-pub date: 1 Oct 2012
    Authors: LL Kilarski, JP Pearson, V Newsway, E Majounie, MDW Knipe, A Misbahuddin, PF Chinnery, DJ Burn, CE Clarke, M-H Marion, AJ Lewthwaite, DJ Nicholl, NW Wood, KE Morrison, CH Williams-Gray, JR Evans, SJ Sawcer, RA Barker, MM Wickremaratchi, Y Ben-Shlomo, NM Williams, HR Morris

    Addenbrooke’s Cognitive Examination-Revised for mild cognitive impairment in Parkinson’s disease.

    DOI: http://doi.org/10.1002/mds.25084
    Journal: Movement Disorders
    E-pub date: 1 Aug 2012
    Authors: P McColgan, JR Evans, DP Breen, SL Mason, RA Barker, CH Williams-Gray

    LONGITUDINAL EVALUATION OF EXCESSIVE DAYTIME SLEEPINESS AND ITS RISK FACTORS IN PARKINSON’S DISEASE

    DOI: http://doi.org/10.1136/jnnp-2011-301993.149
    Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
    E-pub date: 1 Mar 2012
    Authors: DP Breen, JR Evans, CH Williams-Gray, SL Mason, T Foltynie, RA Barker

    THE UTILITY OF THE ADDENBROOKE’S COGNITIVE EXAMINATION-REVISED (ACE-R) IN PARKINSON’S DISEASE

    DOI: http://doi.org/10.1136/jnnp-2011-301993.3
    Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
    E-pub date: 1 Mar 2012
    Authors: P McColgan, J Evans, DP Breen, SL Mason, B Ghosh, T Rittman, J Rowe, P Nestor, RA Barker, CH Williams-Gray

    Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: Movement Disorder Society Task Force guidelines.

    DOI: http://doi.org/10.1002/mds.24893
    Journal: Mov Disord
    E-pub date: 1 Mar 2012
    Authors: I Litvan, JG Goldman, AI Tröster, BA Schmand, D Weintraub, RC Petersen, B Mollenhauer, CH Adler, K Marder, CH Williams-Gray, D Aarsland, J Kulisevsky, MC Rodriguez-Oroz, DJ Burn, RA Barker, M Emre

    Genetic and pathological links between Parkinson’s disease and the lysosomal disorder Sanfilippo syndrome.

    DOI: http://doi.org/10.1002/mds.24029
    Journal: Mov Disord
    E-pub date: 1 Feb 2012
    Authors: SE Winder-Rhodes, P Garcia-Reitböck, M Ban, JR Evans, TS Jacques, A Kemppinen, T Foltynie, CH Williams-Gray, PF Chinnery, G Hudson, DJ Burn, LM Allcock, SJ Sawcer, RA Barker, MG Spillantini

    Neuropsychological features of early cognitive impairment in Parkinson’s disease

    DOI: http://doi.org/10.1159/000331656
    Journal:
    E-pub date: 9 Jan 2012
    Authors: CH Williams-Gray, SL Mason

    The natural history of treated Parkinson’s disease in an incident, community based cohort.

    DOI: http://doi.org/10.1136/jnnp.2011.240366
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Oct 2011
    Authors: JR Evans, SL Mason, CH Williams-Gray, T Foltynie, C Brayne, TW Robbins, RA Barker

    The factor structure of the UPDRS as an index of disease progression in Parkinson’s disease.

    DOI: http://doi.org/10.3233/JPD-2011-0002
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2011
    Authors: JR Evans, SL Mason, CH Williams-Gray, T Foltynie, M Trotter, RA Barker

    A two-stage meta-analysis identifies several new loci for Parkinson’s disease.

    DOI: http://doi.org/10.1371/journal.pgen.1002142
    Journal: PLoS Genet
    E-pub date: 1 Jun 2011
    Authors: International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2)

    Imputation of sequence variants for identification of genetic risks for Parkinson’s disease: a meta-analysis of genome-wide association studies.

    DOI: http://doi.org/10.1016/S0140-6736(10)62345-8
    Journal: Lancet
    E-pub date: 19 Feb 2011
    Authors: International Parkinson Disease Genomics Consortium, MA Nalls, V Plagnol, DG Hernandez, M Sharma, U-M Sheerin, M Saad, J Simón-Sánchez, C Schulte, S Lesage, S Sveinbjörnsdóttir, K Stefánsson, M Martinez, J Hardy, P Heutink, A Brice, T Gasser, AB Singleton, NW Wood

    Catechol-O-methyltransferase val158met and cognitive function in Parkinson’s disease.

    DOI: http://doi.org/10.1002/mds.23319
    Journal: MOVEMENT DISORD
    E-pub date: 15 Nov 2010
    Authors: J Hoogland, RMA de Bie, CH Williams-Gray, D Muslimović, B Schmand, B Post

    Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis.

    DOI: http://doi.org/10.1212/WNL.0b013e3181f39d0e
    Journal: Neurology
    E-pub date: 21 Sep 2010
    Authors: D Aarsland, K Bronnick, C Williams-Gray, D Weintraub, K Marder, J Kulisevsky, D Burn, P Barone, J Pagonabarraga, L Allcock, G Santangelo, T Foltynie, C Janvin, JP Larsen, RA Barker, M Emre

    The val158met COMT polymorphism’s effect on atrophy in healthy aging and Parkinson’s disease.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2008.07.009
    Journal: Neurobiol Aging
    E-pub date: 1 Jun 2010
    Authors: JB Rowe, L Hughes, CH Williams-Gray, S Bishop, S Fallon, RA Barker, AM Owen

    The genetics of behavior and cognition in Parkinson’s disease

    DOI: http://doi.org/10.1017/CBO9781139856669.004
    Journal:
    E-pub date: 1 Jan 2010
    Authors: CH Williams-Gray, RA Barker

    BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp.2008.154294
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Feb 2009
    Authors: T Foltynie, B Cheeran, CH Williams-Gray, MJ Edwards, SA Schneider, D Weinberger, JC Rothwell, RA Barker, KP Bhatia

    No evidence for association between an MAOA functional polymorphism and susceptibility to Parkinson’s disease.

    DOI: http://doi.org/10.1007/s00415-009-0899-x
    Journal: J Neurol
    E-pub date: 1 Jan 2009
    Authors: C Williams-Gray, A Goris, T Foltynie, A Compston, S Sawcer, RA Barker

    Parkinson’s disease and dopaminergic therapy–differential effects on movement, reward and cognition.

    DOI: http://doi.org/10.1093/brain/awn112
    Journal: Brain
    E-pub date: 31 Aug 2008
    Authors: JB Rowe, L Hughes, BCP Ghosh, D Eckstein, CH Williams-Gray, S Fallon, RA Barker, AM Owen

    The Cambridge Behavioural Inventory revised.

    DOI: http://doi.org/10.1590/S1980-57642009DN20200005
    Journal: Dement Neuropsychol
    E-pub date: 1 Aug 2008
    Authors: HJ Wear, CJ Wedderburn, E Mioshi, CH Williams-Gray, SL Mason, RA Barker, JR Hodges

    The utility of the Cambridge Behavioural Inventory in neurodegenerative disease.

    DOI: http://doi.org/10.1136/jnnp.2007.122028
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2008
    Authors: C Wedderburn, H Wear, J Brown, SJ Mason, RA Barker, J Hodges, C Williams-Gray

    Attentional control in Parkinson’s disease is dependent on COMT val 158 met genotype.

    DOI: http://doi.org/10.1093/brain/awm313
    Journal: Brain
    E-pub date: 1 Feb 2008
    Authors: CH Williams-Gray, A Hampshire, RA Barker, AM Owen

    Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson’s disease.

    DOI: http://doi.org/10.1007/s00415-006-0414-6
    Journal: J Neurol
    E-pub date: 1 Jul 2007
    Authors: A Goris, CH Williams-Gray, T Foltynie, J Brown, M Maranian, A Walton, DAS Compston, RA Barker, SJ Sawcer

    Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinson’s disease.

    DOI: http://doi.org/10.1523/JNEUROSCI.0774-07.2007
    Journal: J Neurosci
    E-pub date: 2 May 2007
    Authors: CH Williams-Gray, A Hampshire, TW Robbins, AM Owen, RA Barker

    Visual hallucinations predict increased benefits from rivastigmine in Parkinson’s disease dementia.

    DOI: http://doi.org/10.1038/ncpneuro0471
    Journal: Nat Clin Pract Neurol
    E-pub date: 1 May 2007
    Authors: CH Williams-Gray, RA Barker

    Reversible parkinsonism in a patient with progressive multifocal leucoencephalopathy.

    DOI: http://doi.org/10.1136/jnnp.2006.103259
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Apr 2007
    Authors: CH Williams-Gray, SH Aliyu, AML Lever, AF Dean, GG Lennox

    Saccadic latency distributions in Parkinson’s disease and the effects of L-dopa.

    DOI: http://doi.org/10.1007/s00221-006-0412-z
    Journal: Exp Brain Res
    E-pub date: 1 Sep 2006
    Authors: AW Michell, Z Xu, D Fritz, SJG Lewis, T Foltynie, CH Williams-Gray, TW Robbins, RHS Carpenter, RA Barker

    Cognitive deficits and psychosis in Parkinson’s disease: a review of pathophysiology and therapeutic options.

    DOI: http://doi.org/10.2165/00023210-200620060-00004
    Journal: CNS Drugs
    E-pub date: 1 Aug 2006
    Authors: CH Williams-Gray, T Foltynie, SJG Lewis, RA Barker

    No evidence for association with Parkinson disease for 13 single-nucleotide polymorphisms identified by whole-genome association screening.

    DOI: http://doi.org/10.1086/504726
    Journal: Am J Hum Genet
    E-pub date: 1 Jun 2006
    Authors: A Goris, CH Williams-Gray, T Foltynie, DAS Compston, RA Barker, SJ Sawcer

    Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson’s disease cohort.

    DOI: http://doi.org/10.1136/jnnp.2005.085019
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2006
    Authors: CH Williams-Gray, A Goris, T Foltynie, J Brown, M Maranian, A Walton, DAS Compston, SJ Sawcer, RA Barker

    No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson’s disease.

    DOI: http://doi.org/10.1002/mds.20863
    Journal: Mov Disord
    E-pub date: 1 May 2006
    Authors: CH Williams-Gray, A Goris, T Foltynie, J Brown, M Maranian, A Walton, DA Compston, SJ Sawcer, RA Barker

    II.1 Cognitive dysfunction in early Parkinson’s Disease

    DOI: http://doi.org/10.1016/s1353-8020(07)70018-4
    Journal: Parkinsonism & Related Disorders
    E-pub date: 1 May 2006
    Authors: C Williams-Gray, RA Barker, R Swainson, TW Robbins