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College Magdalene College
Department
  • Clinical Neurosciences
    • School
  • Clinical Medicine
    • Institute
  • Wolfson Brain Imaging Centre
    • Click to view home page
    Research Theme Neurons, Circuits and Networks Lifelong Brain Development and Brain Ageing

    Other Interdiciplinary Incentives

  • Cancer
  • Cardiovascular Disease

    • Research Focus

    Keywords

  • 11C-Carbon
  • 18F-Fluoride
  • PET Radiochemistry
  • PET Imaging
  • PET/MRI
  • Molecular Imaging

    • Clinical Conditions

  • Traumatic brain injury
  • Multiple sclerosis
  • Cancers
  • Other 
  • Stroke
  • Dementia

    • Equipment & Techniques

  • Positron Emission Tomography (PET)
  • FPLC/HPLC
  • Immunohistochemistry
  • Magnetic resonance imaging (MRI)

    • Science Culture

  • Black in Neuro
  • Equality, Diversity, Inclusion and Wellbeing

    • Back

    Professor Franklin Aigbirhio FRSC FMedSci

    (he/him/his)
    University Position
    Professor
    Professor Franklin Aigbirhio is pleased to consider applications from prospective PhD students.

    Interests

    Research in the development and application of molecular imaging probes, in particular for the in vivo imaging technique of positron emission tomography. Objectives are to design, develop and apply imaging probes that are specific and selective to biological markers and are sensitivity to biochemical changes associated with disease mechanisms. In addition we research novel radiosynthetic methods with an objective of 1) developing rapid and efficient methods for the regular preparation of radiopharmaceuticals and 2) facilitating the discovery of new chemical entities for imaging.

    Key Publications

    Neuroinflammation is linked to dementia risk in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awad322
    Journal: Brain
    E-pub date: 1 Mar 2024
    Authors: A Kouli, LRB Spindler, TD Fryer, YT Hong, M Malpetti, FI Aigbirhio, SR White, M Camacho, JT O'Brien, CH Williams-Gray

    Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury.

    DOI: http://doi.org/10.1093/brain/awab255
    Journal: Brain
    E-pub date: 16 Dec 2021
    Authors: J Hermanides, YT Hong, M Trivedi, J Outtrim, F Aigbirhio, PJ Nestor, M Guilfoyle, S Winzeck, VFJ Newcombe, T Das, MM Correia, KLH Carpenter, PJA Hutchinson, AK Gupta, TD Fryer, JD Pickard, DK Menon, JP Coles

    Spatial and Temporal Pattern of Ischemia and Abnormal Vascular Function Following Traumatic Brain Injury.

    DOI: http://doi.org/10.1001/jamaneurol.2019.3854
    Journal: JAMA Neurol
    E-pub date: 1 Mar 2020
    Authors: Y Launey, TD Fryer, YT Hong, LA Steiner, J Nortje, TV Veenith, PJ Hutchinson, A Ercole, AK Gupta, FI Aigbirhio, JD Pickard, JP Coles, DK Menon

    Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury.

    DOI: http://doi.org/10.1001/jamaneurol.2016.0091
    Journal: JAMA Neurol
    E-pub date: 1 May 2016
    Authors: TV Veenith, EL Carter, T Geeraerts, J Grossac, VFJ Newcombe, J Outtrim, GS Gee, V Lupson, R Smith, FI Aigbirhio, TD Fryer, YT Hong, DK Menon, JP Coles

    Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest.

    DOI: http://doi.org/10.1016/j.neuroimage.2010.11.071
    Journal: NeuroImage
    E-pub date: 1 Mar 2011
    Authors: N del Campo, RJ Tait, J Acosta-Cabronero, YT Hong, D Izquierdo-Garcia, R Smith, FI Aigbirhio, BJ Sahakian, U Müller, TW Robbins, TD Fryer

    Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.

    DOI: http://doi.org/10.1126/science.1137073
    Journal: Science
    E-pub date: 2 Mar 2007
    Authors: JW Dalley, TD Fryer, L Brichard, ESJ Robinson, DEH Theobald, K Lääne, Y Peña, ER Murphy, Y Shah, K Probst, I Abakumova, FI Aigbirhio, HK Richards, Y Hong, J-C Baron, BJ Everitt, TW Robbins

    Diffusion limited oxygen delivery following head injury.

    DOI: http://doi.org/10.1097/01.ccm.0000127777.16609.08
    Journal: Crit Care Med
    E-pub date: 1 Jun 2004
    Authors: DK Menon, JP Coles, AK Gupta, TD Fryer, P Smielewski, DA Chatfield, F Aigbirhio, JN Skepper, PS Minhas, PJ Hutchinson, TA Carpenter, JC Clark, JD Pickard

    Incidence and mechanisms of cerebral ischemia in early clinical head injury.

    DOI: http://doi.org/10.1097/01.WCB.0000103022.98348.24
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Feb 2004
    Authors: JP Coles, TD Fryer, P Smielewski, DA Chatfield, LA Steiner, AJ Johnston, SPMJ Downey, GB Williams, F Aigbirhio, PJ Hutchinson, K Rice, TA Carpenter, JC Clark, JD Pickard, DK Menon

    Publications

    Are Central and Systemic Inflammation associated with Fatigue in Cerebral Small Vessel Disease?

    DOI: http://doi.org/10.1177/17474930241245613
    Journal: Int J Stroke
    E-pub date: 1 Jul 2024
    Authors: AA Jolly, RB Brown, DJ Tozer, YT Hong, TD Fryer, F Aigbirhio, J O'brien, HS Markus

    Differential Synaptic Loss in β‐Amyloid Positive Versus β‐Amyloid Negative Corticobasal Syndrome

    DOI: http://doi.org/10.1002/mds.29814
    Journal: Mov Disord
    E-pub date: 1 Jul 2024
    Authors: N Holland, G Savulich, PS Jones, DJ Whiteside, D Street, P Swann, M Naessens, M Malpetti, YT Hong, TD Fryer, T Rittman, E Mulroy, FI Aigbirhio, KP Bhatia, JT O'Brien, JB Rowe

    MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial

    DOI: http://doi.org/10.1002/alz.13830
    Journal: Alzheimers Dement
    E-pub date: 1 Jun 2024
    Authors: RB Brown, DJ Tozer, L Loubière, EL Harshfield, YT Hong, TD Fryer, GB Williams, MJ Graves, F Aigbirhio, JT O'Brien, HS Markus

    Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration.

    DOI: http://doi.org/10.1038/s41467-023-44307-7
    Journal: Nat Commun
    E-pub date: 20 Dec 2023
    Authors: DJ Whiteside, N Holland, KA Tsvetanov, E Mak, M Malpetti, G Savulich, PS Jones, M Naessens, MA Rouse, TD Fryer, YT Hong, FI Aigbirhio, E Mulroy, KP Bhatia, T Rittman, JT O'Brien, JB Rowe

    Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

    DOI: http://doi.org/10.1093/brain/awad078
    Journal: Brain
    E-pub date: 1 Aug 2023
    Authors: M Malpetti, TE Cope, D Street, PS Jones, FH Hezemans, E Mak, KA Tsvetanov, T Rittman, WR Bevan-Jones, K Patterson, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [11 C]UCB-J Positron Emission Tomography Study.

    DOI: http://doi.org/10.1002/mds.29421
    Journal: Mov Disord
    E-pub date: 1 Jul 2023
    Authors: N Holland, PS Jones, G Savulich, M Naessens, M Malpetti, DJ Whiteside, D Street, P Swann, YT Hong, TD Fryer, T Rittman, E Mulroy, FI Aigbirhio, KP Bhatia, JT O'Brien, JB Rowe

    Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease.

    DOI: http://doi.org/10.1186/s12974-023-02769-y
    Journal: J Neuroinflammation
    E-pub date: 9 Apr 2023
    Authors: M Vicente-Rodríguez, R Mancuso, A Peris-Yague, C Simmons, NIMA Consortium, D Gómez-Nicola, VH Perry, F Turkheimer, S Lovestone, CA Parker, D Cash

    Do Regions of Increased Inflammation Progress to New White Matter Hyperintensities?: A Longitudinal Positron Emission Tomography-Magnetic Resonance Imaging Study.

    DOI: http://doi.org/10.1161/STROKEAHA.122.039517
    Journal: Stroke
    E-pub date: 1 Feb 2023
    Authors: DJ Tozer, RB Brown, J Walsh, YT Hong, GB Williams, JT O'Brien, FI Aigbirhio, TD Fryer, HS Markus

    Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.

    DOI: http://doi.org/10.1002/ana.26543
    Journal: Ann Neurol
    E-pub date: 1 Jan 2023
    Authors: M Malpetti, PS Jones, TE Cope, N Holland, M Naessens, MA Rouse, T Rittman, G Savulich, DJ Whiteside, D Street, TD Fryer, YT Hong, S Milicevic Sephton, FI Aigbirhio, JT O Brien, JB Rowe

    Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2022.07.003
    Journal: Neurobiol Aging
    E-pub date: 1 Nov 2022
    Authors: M Grigorova, E Mak, SSG Brown, J Beresford-Webb, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, B Ances, BL Handen, CM Laymon, WE Klunk, ICH Clare, AJ Holland, SH Zaman

    Mapping neurotransmitter systems to the structural and functional organization of the human neocortex.

    DOI: http://doi.org/10.1038/s41593-022-01186-3
    Journal: Nat Neurosci
    E-pub date: 1 Nov 2022
    Authors: JY Hansen, G Shafiei, RD Markello, K Smart, SML Cox, M Nørgaard, V Beliveau, Y Wu, J-D Gallezot, É Aumont, S Servaes, SG Scala, JM DuBois, G Wainstein, G Bezgin, T Funck, TW Schmitz, RN Spreng, M Galovic, MJ Koepp, JS Duncan, JP Coles, TD Fryer, FI Aigbirhio, CJ McGinnity, A Hammers, J-P Soucy, S Baillet, S Guimond, J Hietala, M-A Bedard, M Leyton, E Kobayashi, P Rosa-Neto, M Ganz, GM Knudsen, N Palomero-Gallagher, JM Shine, RE Carson, L Tuominen, A Dagher, B Misic

    Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease

    DOI: http://doi.org/10.1038/s41467-022-33252-6
    Journal: Nat Commun
    E-pub date: 20 Sep 2022
    Authors: D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman

    MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol.

    DOI: http://doi.org/10.1177/23969873221100338
    Journal: Eur Stroke J
    E-pub date: 1 Sep 2022
    Authors: RB Brown, DJ Tozer, L Loubière, YT Hong, TD Fryer, GB Williams, MJ Graves, FI Aigbirhio, JT O'Brien, HS Markus

    Synaptic loss in behavioural variant frontotemporal dementia revealed by [11C]UCB-J PET

    DOI: http://doi.org/10.1101/2022.01.30.22270123
    Journal:
    E-pub date: 1 Aug 2022
    Authors: M Malpetti, S Jones, T Cope, N Holland, M Naessens, M Rouse, G Savulich, T Fryer, Y Hong, SM Sephton, F Aigbirhio, J O’Brien, J Rowe

    In Vivo 18F-Flortaucipir PET Does Not Accurately Support the Staging of Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.2967/jnumed.121.262985
    Journal: J Nucl Med
    E-pub date: 1 Jul 2022
    Authors: M Malpetti, SS Kaalund, KA Tsvetanov, T Rittman, M Briggs, KSJ Allinson, L Passamonti, N Holland, PS Jones, TD Fryer, YT Hong, A Kouli, WR Bevan-Jones, E Mak, G Savulich, MG Spillantini, FI Aigbirhio, CH Williams-Gray, JT O'Brien, JB Rowe

    Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down’s syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2022.02.013
    Journal: Neurobiol Aging
    E-pub date: 1 Jul 2022
    Authors: SSG Brown, E Mak, I Clare, M Grigorova, J Beresford-Webb, M Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    Molecular pathology and synaptic loss in primary tauopathies: A [18F]AV-1451 and [11C]UCB-J PET study

    DOI: http://doi.org/10.1093/brain/awab282
    Journal: Brain
    E-pub date: 29 Mar 2022
    Authors: N Holland, M Malpetti, T Rittman, E Mak, L Passamonti, S Kaalund, F Hezemans, P Jones, G Savulich, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study.

    DOI: http://doi.org/10.1002/dad2.12288
    Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
    E-pub date: 1 Jan 2022
    Authors: C Padilla, V Montal, MJ Walpert, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, SL Hartley, AD Cohen, DL Tudorascu, BT Christian, BL Handen, WE Klunk, AJ Holland, SH Zaman

    Validation of a combined image derived input function and venous sampling approach for the quantification of [18F]GE-179 PET binding in the brain.

    DOI: http://doi.org/10.1016/j.neuroimage.2021.118194
    Journal: Neuroimage
    E-pub date: 15 Aug 2021
    Authors: M Galovic, K Erlandsson, TD Fryer, YT Hong, R Manavaki, H Sari, S Chetcuti, BA Thomas, M Fisher, S Sephton, R Canales, JJ Russell, K Sander, E Årstad, FI Aigbirhio, AM Groves, JS Duncan, K Thielemans, BF Hutton, JP Coles, MJ Koepp, NEST investigators

    [18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.

    DOI: http://doi.org/10.1093/braincomms/fcab177
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, A Kouli, N Holland, N Nicastro, G Savulich, A Surendranathan, M Malpetti, R Manavaki, YT Hong, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien, CH Williams-Gray

    Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

    DOI: http://doi.org/10.1093/braincomms/fcaa198
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index.

    DOI: http://doi.org/10.1016/j.bpsc.2020.12.017
    Journal: Biol Psychiatry Cogn Neurosci Neuroimaging
    E-pub date: 1 Jul 2021
    Authors: JJ Schubert, M Veronese, TD Fryer, R Manavaki, MG Kitzbichler, MA Nettis, V Mondelli, CM Pariante, ET Bullmore, NIMA Consortium, FE Turkheimer

    Neuroinflammation predicts disease progression in progressive supranuclear palsy.

    DOI: http://doi.org/10.1136/jnnp-2020-325549
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2021
    Authors: M Malpetti, L Passamonti, PS Jones, D Street, T Rittman, TD Fryer, YT Hong, P Vàsquez Rodriguez, WR Bevan-Jones, FI Aigbirhio, JT O'Brien, JB Rowe

    Synaptic density in carriers of C9orf72 mutations: a [11 C]UCB-J PET study.

    DOI: http://doi.org/10.1002/acn3.51407
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Jul 2021
    Authors: M Malpetti, N Holland, PS Jones, R Ye, TE Cope, TD Fryer, YT Hong, G Savulich, T Rittman, L Passamonti, E Mak, FI Aigbirhio, JT O'Brien, JB Rowe

    Microglial activation and blood-brain barrier permeability in cerebral small vessel disease.

    DOI: http://doi.org/10.1093/brain/awab003
    Journal: Brain
    E-pub date: 22 Jun 2021
    Authors: J Walsh, DJ Tozer, H Sari, YT Hong, A Drazyk, G Williams, NJ Shah, JT O'Brien, FI Aigbirhio, G Rosenberg, TD Fryer, HS Markus

    [11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease.

    DOI: http://doi.org/10.1212/WNL.0000000000012033
    Journal: Neurology
    E-pub date: 31 May 2021
    Authors: J van den Ameele, Y Hong, R Manavaki, A Kouli, H Biggs, Z MacIntyre, R Horvath, P Yu-Wai-Man, E Reid, CH Williams-Gray, E Bullmore, F Aigbirhio, T Fryer, P Chinnery

    In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2021.01.016
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Holland, PS Jones, G Savulich, A Low, M Malpetti, SS Kaalund, L Passamonti, T Rittman, R Romero-Garcia, R Manavaki, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

    In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.

    DOI: http://doi.org/10.1136/jnnp-2020-323698
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Mar 2021
    Authors: M Malpetti, T Rittman, PS Jones, TE Cope, L Passamonti, WR Bevan-Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    Relationship between tau, neuroinflammation and atrophy in Alzheimer’s disease: The NIMROD study

    DOI: http://doi.org/10.1016/j.inffus.2020.10.006
    Journal: Information Fusion
    E-pub date: 1 Mar 2021
    Authors: L Su, A Surendranathan, Y Huang, WR Bevan-Jones, L Passamonti, YT Hong, R Arnold, PV Rodríguez, Y Wang, E Mak, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien

    Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.1002/ana.25911
    Journal: Ann Neurol
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, L Passamonti, T Rittman, PS Jones, P Vázquez Rodríguez, WR Bevan-Jones, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Early-stage 11C-Flumazenil PET predicts day-14 selective neuronal loss in a rodent model of transient focal cerebral ischemia.

    DOI: http://doi.org/10.1177/0271678X19883040
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Oct 2020
    Authors: JL Hughes, JS Beech, PS Jones, D Wang, DK Menon, FI Aigbirhio, TD Fryer, J-C Baron

    Synaptic Loss in Primary Tauopathies Revealed by [11 C]UCB-J Positron Emission Tomography.

    DOI: http://doi.org/10.1002/mds.28188
    Journal: Mov Disord
    E-pub date: 1 Oct 2020
    Authors: N Holland, PS Jones, G Savulich, JK Wiggins, YT Hong, TD Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, FH Hezemans, FI Aigbirhio, JP Coles, J O'Brien, JB Rowe

    Gray matter changes related to microglial activation in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.06.010
    Journal: Neurobiol Aging
    E-pub date: 1 Oct 2020
    Authors: N Nicastro, M Malpetti, E Mak, GB Williams, WR Bevan-Jones, SF Carter, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

    Correlation of microglial activation with white matter changes in dementia with Lewy bodies.

    DOI: http://doi.org/10.1016/j.nicl.2020.102200
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2020
    Authors: N Nicastro, E Mak, GB Williams, A Surendranathan, WR Bevan-Jones, L Passamonti, P Vàzquez Rodrìguez, L Su, R Arnold, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

    Synaptic loss in primary tauopathies revealed by [11C]UCB-J positron emission tomography

    DOI: http://doi.org/10.1101/2020.01.24.20018697
    Journal:
    E-pub date: 1 Aug 2020
    Authors: N Holland, S Jones, G Savulich, J Wiggins, Y Hong, T Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, F Hezemans, F Aigbirhio, J Coles, J O’Brien, J Rowe

    In vivo PET imaging of neuroinflammation in familial frontotemporal dementia

    DOI: http://doi.org/10.1101/2020.05.11.20098046
    Journal:
    E-pub date: 1 Aug 2020
    Authors: M Malpetti, T Rittman, S Jones, T Cope, L Passamonti, R Bevan-Jones, K Patterson, T Fryer, Y Hong, F Aigbirhio, J O’Brien, J Rowe

    Neuroinflammation predicts disease progression in progressive supranuclear palsy

    DOI: http://doi.org/10.1101/2020.05.19.20106393
    Journal:
    E-pub date: 1 Aug 2020
    Authors: M Malpetti, L Passamonti, S Jones, D Street, T Rittman, T Fryer, Y Hong, P Vasquez-Rodriguez, WR Bevan-Jones, F Aigbirhio, J O'Brien, J Rowe

    11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies.

    DOI: http://doi.org/10.1186/s41824-020-00093-9
    Journal: Eur J Hybrid Imaging
    E-pub date: 1 Aug 2020
    Authors: N Nicastro, N Holland, G Savulich, SF Carter, E Mak, YT Hong, S Milicevic Sephton, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    Detection limit of 89Zr-labeled T cells for cellular tracking: an in vitro imaging approach using clinical PET/CT and PET/MRI.

    DOI: http://doi.org/10.1186/s13550-020-00667-5
    Journal: EJNMMI Res
    E-pub date: 14 Jul 2020
    Authors: LM Lechermann, R Manavaki, B Attili, D Lau, LB Jarvis, TD Fryer, N Bird, L Aloj, N Patel, B Basu, M Cleveland, FI Aigbirhio, JL Jones, FA Gallagher

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awaa088
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.

    DOI: http://doi.org/10.1093/brain/awaa033
    Journal: Brain
    E-pub date: 1 Mar 2020
    Authors: WR Bevan-Jones, TE Cope, PS Jones, SS Kaalund, L Passamonti, K Allinson, O Green, YT Hong, TD Fryer, R Arnold, JP Coles, FI Aigbirhio, AJ Larner, K Patterson, JT O'Brien, JB Rowe

    DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits.

    DOI: http://doi.org/10.1016/j.nbd.2019.104629
    Journal: Neurobiol Dis
    E-pub date: 1 Feb 2020
    Authors: K Solti, W-L Kuan, B Fórizs, G Kustos, J Mihály, Z Varga, B Herberth, É Moravcsik, R Kiss, M Kárpáti, A Mikes, Y Zhao, T Imre, J-C Rochet, F Aigbirhio, CH Williams-Gray, RA Barker, G Tóth

    18F-AV1451 PET imaging and multimodal MRI changes in progressive supranuclear palsy.

    DOI: http://doi.org/10.1007/s00415-019-09566-9
    Journal: J Neurol
    E-pub date: 1 Feb 2020
    Authors: N Nicastro, PV Rodriguez, M Malpetti, WR Bevan-Jones, P Simon Jones, L Passamonti, FI Aigbirhio, JT O'Brien, JB Rowe

    Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report.

    DOI: http://doi.org/10.1016/j.dadm.2019.04.006
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: E Mak, A Bickerton, C Padilla, MJ Walpert, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, SH Zaman, AJ Holland

    Assessing the Effects of Cytoprotectants on Selective Neuronal Loss, Sensorimotor Deficit and Microglial Activation after Temporary Middle Cerebral Occlusion.

    DOI: http://doi.org/10.3390/brainsci9100287
    Journal: Brain Sci
    E-pub date: 22 Oct 2019
    Authors: JV Emmrich, S Ejaz, DJ Williamson, YT Hong, S Sitnikov, TD Fryer, FI Aigbirhio, H Wulff, J-C Baron

    Delineating the topography of amyloid-associated cortical atrophy in Down syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2019.02.018
    Journal: Neurobiol Aging
    E-pub date: 31 Aug 2019
    Authors: E Mak, C Padilla, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, SH Zaman, AJ Holland

    Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.

    DOI: http://doi.org/10.1073/pnas.1902087116
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 16 Jul 2019
    Authors: AM Santangelo, SJ Sawiak, T Fryer, Y Hong, Y Shiba, HF Clarke, PJ Riss, V Ferrari, R Tait, J Suckling, FI Aigbirhio, AC Roberts

    In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.

    DOI: http://doi.org/10.1002/acn3.683
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Feb 2019
    Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FI Aigbirhio, JT O'Brien, JB Rowe

    Early microglial activation and peripheral inflammation in dementia with Lewy bodies.

    DOI: http://doi.org/10.1093/brain/awy265
    Journal: Brain
    E-pub date: 1 Dec 2018
    Authors: A Surendranathan, L Su, E Mak, L Passamonti, YT Hong, R Arnold, P Vázquez Rodríguez, WR Bevan-Jones, SAE Brain, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    [18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.

    DOI: http://doi.org/10.1136/jnnp-2017-316402
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Oct 2018
    Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, TD Fryer, R Arnold, KSJ Allinson, JP Coles, FI Aigbirhio, K Patterson, JT O'Brien, JB Rowe

    [18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.

    DOI: http://doi.org/10.1002/acn3.631
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Oct 2018
    Authors: RW Bevan-Jones, TE Cope, SP Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FA Aigbirhio, K Patterson, JT O'Brien, JB Rowe

    In vivo coupling of tau pathology and cortical thinning in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.dadm.2018.08.005
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Aug 2018
    Authors: E Mak, RAI Bethlehem, R Romero-Garcia, S Cervenka, T Rittman, S Gabel, A Surendranathan, RW Bevan-Jones, L Passamonti, P Vázquez Rodríguez, L Su, R Arnold, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man.

    DOI: http://doi.org/10.1093/brain/awy121
    Journal: Brain
    E-pub date: 1 Jul 2018
    Authors: RS Morris, P Simon Jones, JA Alawneh, YT Hong, TD Fryer, FI Aigbirhio, EA Warburton, J-C Baron

    [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1212/WNL.0000000000005610
    Journal: Neurology
    E-pub date: 29 May 2018
    Authors: L Passamonti, PV Rodríguez, YT Hong, KSJ Allinson, WR Bevan-Jones, D Williamson, PS Jones, R Arnold, RJ Borchert, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Brain hypoxia mapping in acute stroke: Back-to-back T2′ MR versus 18F-fluoromisonidazole PET in rodents.

    DOI: http://doi.org/10.1177/1747493017706221
    Journal: Int J Stroke
    E-pub date: 1 Oct 2017
    Authors: U Jensen-Kondering, R Manavaki, S Ejaz, SJ Sawiak, TA Carpenter, TD Fryer, FI Aigbirhio, DJ Williamson, J-C Baron

    Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

    DOI: http://doi.org/10.1016/j.chempr.2017.06.013
    Journal: Chem
    E-pub date: 14 Sep 2017
    Authors: H Ge, PJ Riss, V Mirabello, DG Calatayud, SE Flower, RL Arrowsmith, TD Fryer, Y Hong, S Sawiak, RMJ Jacobs, SW Botchway, RM Tyrrell, TD James, JS Fossey, JR Dilworth, FI Aigbirhio, SI Pascu

    Effects of hyperoxia on 18F-fluoro-misonidazole brain uptake and tissue oxygen tension following middle cerebral artery occlusion in rodents: Pilot studies.

    DOI: http://doi.org/10.1371/journal.pone.0187087
    Journal: PLoS One
    E-pub date: 1 Aug 2017
    Authors: TD Fryer, S Ejaz, U Jensen-Kondering, DJ Williamson, S Sitnikov, SJ Sawiak, FI Aigbirhio, YT Hong, J-C Baron

    Vascular Imaging With 18F-Fluorodeoxyglucose Positron Emission Tomography Is Influenced by Hypoxia.

    DOI: http://doi.org/10.1016/j.jacc.2017.01.050
    Journal: J Am Coll Cardiol
    E-pub date: 11 Apr 2017
    Authors: FR Joshi, R Manavaki, TD Fryer, NL Figg, JC Sluimer, FI Aigbirhio, AP Davenport, PJ Kirkpatrick, EA Warburton, JHF Rudd

    18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1093/brain/aww340
    Journal: Brain
    E-pub date: 1 Mar 2017
    Authors: L Passamonti, P Vázquez Rodríguez, YT Hong, KSJ Allinson, D Williamson, RJ Borchert, S Sami, TE Cope, WR Bevan-Jones, PS Jones, R Arnold, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses.

    DOI: http://doi.org/10.1136/bmjopen-2016-013187
    Journal: BMJ Open
    E-pub date: 7 Jan 2017
    Authors: WR Bevan-Jones, A Surendranathan, L Passamonti, P Vázquez Rodríguez, R Arnold, E Mak, L Su, JP Coles, TD Fryer, YT Hong, G Williams, F Aigbirhio, JB Rowe, JT O'Brien

    Neuroinflammatory and morphological changes in late-life depression: the NIMROD study.

    DOI: http://doi.org/10.1192/bjp.bp.116.190165
    Journal: BRITISH JOURNAL OF PSYCHIATRY
    E-pub date: 1 Dec 2016
    Authors: L Su, YO Faluyi, YT Hong, TD Fryer, E Mak, S Gabel, L Hayes, S Soteriades, GB Williams, R Arnold, L Passamonti, PV Rodríguez, A Surendranathan, RW Bevan-Jones, J Coles, F Aigbirhio, JB Rowe, JT O'Brien

    Hypoxia and tissue destruction in pulmonary TB.

    DOI: http://doi.org/10.1136/thoraxjnl-2015-207402
    Journal: Thorax
    E-pub date: 1 Dec 2016
    Authors: M Belton, S Brilha, R Manavaki, F Mauri, K Nijran, YT Hong, NH Patel, M Dembek, L Tezera, J Green, R Moores, F Aigbirhio, A Al-Nahhas, TD Fryer, PT Elkington, JS Friedland

    [18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.

    DOI: http://doi.org/10.1002/acn3.366
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Dec 2016
    Authors: WR Bevan Jones, TE Cope, L Passamonti, TD Fryer, YT Hong, F Aigbirhio, JJ Kril, SL Forrest, K Allinson, JP Coles, P Simon Jones, MG Spillantini, JR Hodges, JT O'Brien, JB Rowe

    The pattern of amyloid accumulation in the brains of adults with Down syndrome.

    DOI: http://doi.org/10.1016/j.jalz.2015.07.490
    Journal: Alzheimers Dement
    E-pub date: 1 May 2016
    Authors: T Annus, LR Wilson, YT Hong, J Acosta-Cabronero, TD Fryer, A Cardenas-Blanco, R Smith, I Boros, JP Coles, FI Aigbirhio, DK Menon, SH Zaman, PJ Nestor, AJ Holland

    Normobaric hyperoxia markedly reduces brain damage and sensorimotor deficits following brief focal ischaemia.

    DOI: http://doi.org/10.1093/brain/awv391
    Journal: Brain
    E-pub date: 1 Mar 2016
    Authors: S Ejaz, JV Emmrich, SL Sitnikov, YT Hong, SJ Sawiak, TD Fryer, FI Aigbirhio, DJ Williamson, J-C Baron

    Early-Phase 11C-PiB PET in Amyloid Angiopathy-Related Symptomatic Cerebral Hemorrhage: Potential Diagnostic Value?

    DOI: http://doi.org/10.1371/journal.pone.0139926
    Journal: PLoS One
    E-pub date: 1 Aug 2015
    Authors: K Farid, YT Hong, FI Aigbirhio, TD Fryer, DK Menon, EA Warburton, J-C Baron

    White matter perivascular spaces on magnetic resonance imaging: marker of cerebrovascular amyloid burden?

    DOI: http://doi.org/10.1161/STROKEAHA.115.009090
    Journal: Stroke
    E-pub date: 1 Jun 2015
    Authors: A Charidimou, YT Hong, HR Jäger, Z Fox, FI Aigbirhio, TD Fryer, DK Menon, EA Warburton, DJ Werring, J-C Baron

    Synthesis and Initial in Vivo Studies with [(11)C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3.

    DOI: http://doi.org/10.1021/acsmedchemlett.5b00044
    Journal: ACS Med Chem Lett
    E-pub date: 14 May 2015
    Authors: L Li, X Shao, EL Cole, SA Ohnmacht, V Ferrari, YT Hong, DJ Williamson, TD Fryer, CA Quesada, P Sherman, PJ Riss, PJH Scott, FI Aigbirhio

    Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum.

    DOI: http://doi.org/10.1523/JNEUROSCI.3890-14.2015
    Journal: J Neurosci
    E-pub date: 4 Mar 2015
    Authors: D Caprioli, B Jupp, YT Hong, SJ Sawiak, V Ferrari, L Wharton, DJ Williamson, C McNabb, D Berry, FI Aigbirhio, TW Robbins, TD Fryer, JW Dalley

    Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.

    DOI: http://doi.org/10.1523/JNEUROSCI.0718-14.2014
    Journal: J Neurosci
    E-pub date: 28 May 2014
    Authors: HF Clarke, RN Cardinal, R Rygula, YT Hong, TD Fryer, SJ Sawiak, V Ferrari, G Cockcroft, FI Aigbirhio, TW Robbins, AC Roberts

    Diffusion and perfusion correlates of the 18F-MISO PET lesion in acute stroke: pilot study.

    DOI: http://doi.org/10.1007/s00259-013-2581-x
    Journal: Eur J Nucl Med Mol Imaging
    E-pub date: 1 Apr 2014
    Authors: JA Alawneh, RR Moustafa, ST Marrapu, U Jensen-Kondering, RS Morris, PS Jones, FI Aigbirhio, TD Fryer, TA Carpenter, EA Warburton, J-C Baron

    Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.

    DOI: http://doi.org/10.1001/jamaneurol.2013.4847
    Journal: JAMA Neurol
    E-pub date: 1 Jan 2014
    Authors: YT Hong, T Veenith, D Dewar, JG Outtrim, V Mani, C Williams, S Pimlott, PJA Hutchinson, A Tavares, R Canales, CA Mathis, WE Klunk, FI Aigbirhio, JP Coles, J-C Baron, JD Pickard, TD Fryer, W Stewart, DK Menon

    Diagnostic utility of amyloid PET in cerebral amyloid angiopathy-related symptomatic intracerebral hemorrhage.

    DOI: http://doi.org/10.1038/jcbfm.2014.43
    Journal: Journal of Cerebral Blood Flow and Metabolism
    E-pub date: 1 Jan 2014
    Authors: J-C Baron, K Farid, E Dolan, G Turc, ST Marrapu, E O'Brien, FI Aigbirhio, TD Fryer, DK Menon, EA Warburton, YT Hong

    A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment.

    DOI: http://doi.org/10.1093/brain/awt263
    Journal: Brain
    E-pub date: 10 Oct 2013
    Authors: N del Campo, TD Fryer, YT Hong, R Smith, L Brichard, J Acosta-Cabronero, SR Chamberlain, R Tait, D Izquierdo, R Regenthal, J Dowson, J Suckling, J-C Baron, FI Aigbirhio, TW Robbins, BJ Sahakian, U Müller

    Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls.

    DOI: http://doi.org/10.1016/j.conb.2013.04.003
    Journal: Current Opinion in Neurobiology
    E-pub date: 1 Aug 2013
    Authors: D Caprioli, TD Fryer, SJ Sawiak, FI Aigbirhio, JW Dalley

    Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome.

    DOI: http://doi.org/10.1038/npp.2013.44
    Journal: Neuropsychopharmacology
    E-pub date: 1 Jul 2013
    Authors: D Caprioli, YT Hong, SJ Sawiak, V Ferrari, DJ Williamson, B Jupp, T Adrian Carpenter, FI Aigbirhio, BJ Everitt, TW Robbins, TD Fryer, JW Dalley

    Is neural activation within the rescued penumbra impeded by selective neuronal loss?

    DOI: http://doi.org/10.1093/brain/awt112
    Journal: Brain
    E-pub date: 1 Jun 2013
    Authors: E Carrera, PS Jones, RS Morris, J Alawneh, YT Hong, FI Aigbirhio, TD Fryer, TA Carpenter, EA Warburton, J-C Baron

    Radiosynthesis and characterization of astemizole derivatives as lead compounds toward PET imaging of τ-pathology

    DOI: http://doi.org/10.1039/c3md00017f
    Journal: MedChemComm
    E-pub date: 1 May 2013
    Authors: PJ Riss, L Brichard, V Ferrari, DJ Williamson, TD Fryer, YT Hong, JC Baron, FI Aigbirhio

    A comparison of four PET tracers for brain hypoxia mapping in a rodent model of stroke.

    DOI: http://doi.org/10.1016/j.nucmedbio.2012.11.012
    Journal: Nucl Med Biol
    E-pub date: 1 Apr 2013
    Authors: DJ Williamson, S Ejaz, S Sitnikov, TD Fryer, SJ Sawiak, P Burke, J-C Baron, FI Aigbirhio

    Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study.

    DOI: http://doi.org/10.1016/j.nbd.2012.11.002
    Journal: Neurobiol Dis
    E-pub date: 1 Mar 2013
    Authors: S Ejaz, DJ Williamson, T Ahmed, S Sitnikov, YT Hong, SJ Sawiak, TD Fryer, FI Aigbirhio, J-C Baron

    Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging.

    DOI: http://doi.org/10.2967/jnumed.112.108688
    Journal: J Nucl Med
    E-pub date: 1 Feb 2013
    Authors: PJ Riss, YT Hong, J Marton, D Caprioli, DJ Williamson, V Ferrari, N Saigal, BL Roth, G Henriksen, TD Fryer, JW Dalley, FI Aigbirhio

    Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders.

    DOI: http://doi.org/10.1016/j.neubiorev.2012.01.009
    Journal: Neuroscience and Biobehavioral Reviews
    E-pub date: 1 Apr 2012
    Authors: K Virdee, P Cumming, D Caprioli, B Jupp, A Rominger, FI Aigbirhio, TD Fryer, PJ Riss, JW Dalley

    A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation.

    DOI: http://doi.org/10.1016/j.neuroimage.2011.10.060
    Journal: NeuroImage
    E-pub date: 1 Feb 2012
    Authors: JL Hughes, PS Jones, JS Beech, D Wang, DK Menon, FI Aigbirhio, TD Fryer, JC Baron

    Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling.

    DOI: http://doi.org/10.1038/jcbfm.2011.94
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Dec 2011
    Authors: PJ Riss, YT Hong, D Williamson, D Caprioli, S Sitnikov, V Ferrari, SJ Sawiak, J-C Baron, JW Dalley, TD Fryer, FI Aigbirhio

    Microembolism versus hemodynamic impairment in rosary-like deep watershed infarcts: a combined positron emission tomography and transcranial Doppler study.

    DOI: http://doi.org/10.1161/STROKEAHA.111.616334
    Journal: Stroke
    E-pub date: 1 Nov 2011
    Authors: RR Moustafa, I Momjian-Mayor, PS Jones, S Morbelli, DJ Day, FI Aigbirhio, TD Fryer, EA Warburton, J-C Baron

    Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility.

    DOI: http://doi.org/10.1001/archneurol.2011.36
    Journal: Arch Neurol
    E-pub date: 1 Jul 2011
    Authors: J Landt, JC D'Abrera, AJ Holland, FI Aigbirhio, TD Fryer, R Canales, YT Hong, DK Menon, J-C Baron, SH Zaman

    Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury.

    DOI: http://doi.org/10.1007/s12149-011-0480-4
    Journal: Annals of Nuclear Medicine
    E-pub date: 1 Jul 2011
    Authors: T Geeraerts, JP Coles, FI Aigbirhio, JD Pickard, DK Menon, TD Fryer, YT Hong

    Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?

    DOI: http://doi.org/10.1161/STROKEAHA.110.606970
    Journal: Stroke
    E-pub date: 1 Jun 2011
    Authors: E Carrera, PS Jones, JA Alawneh, I Klærke Mikkelsen, T-H Cho, S Siemonsen, JV Guadagno, K Mouridsen, L Ribe, N Hjort, TD Fryer, TA Carpenter, FI Aigbirhio, J Fiehler, N Nighoghossian, EA Warburton, L Ostergaard, J-C Baron

    Single-subject statistical mapping of acute brain hypoxia in the rat following middle cerebral artery occlusion: a microPET study.

    DOI: http://doi.org/10.1016/j.expneurol.2011.02.005
    Journal: Experimental Neurology
    E-pub date: 1 Jun 2011
    Authors: M Takasawa, JS Beech, TD Fryer, PS Jones, T Ahmed, R Smith, FI Aigbirhio, J-C Baron

    The vascular mean transit time: a surrogate for the penumbra flow threshold?

    DOI: http://doi.org/10.1038/jcbfm.2010.197
    Journal: Journal of Cerebral Blood Flow and Metabolism
    E-pub date: 1 Apr 2011
    Authors: E Carrera, PS Jones, S Iglesias, JV Guadagno, EA Warburton, TD Fryer, FI Aigbirhio, J-C Baron

    FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis.

    DOI: http://doi.org/10.1007/s10554-009-9506-6
    Journal: Int J Cardiovasc Imaging
    E-pub date: 1 Jan 2010
    Authors: JR Davies, D Izquierdo-Garcia, JHF Rudd, N Figg, HK Richards, JLE Bird, FI Aigbirhio, AP Davenport, PL Weissberg, TD Fryer, EA Warburton

    Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.

    DOI: http://doi.org/10.1124/jpet.109.157909
    Journal: J Pharmacol Exp Ther
    E-pub date: 1 Jan 2010
    Authors: JR Atack, DF Wong, TD Fryer, C Ryan, S Sanabria, Y Zhou, RF Dannals, W-S Eng, RE Gibson, HD Burns, JM Vega, L Vessy, P Scott-Stevens, JS Beech, J-C Baron, B Sohal, ML Schrag, FI Aigbirhio, RM McKernan, RJ Hargreaves

    Modelling human drug abuse and addiction with dedicated small animal positron emission tomography.

    DOI: http://doi.org/10.1016/j.neuropharm.2008.05.029
    Journal: Neuropharmacology
    E-pub date: 1 Aug 2009
    Authors: JW Dalley, TD Fryer, FI Aigbirhio, L Brichard, HK Richards, YT Hong, J-C Baron, BJ Everitt, TW Robbins

    T2*-weighted MRI versus oxygen extraction fraction PET in acute stroke.

    DOI: http://doi.org/10.1159/000229017
    Journal: Cerebrovasc Dis
    E-pub date: 1 Aug 2009
    Authors: ML Donswijk, PS Jones, JV Guadagno, TA Carpenter, RR Moustafa, TD Fryer, FI Aigbirhio, EA Warburton, JC Baron

    Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory.

    DOI: http://doi.org/10.1523/JNEUROSCI.3266-08.2009
    Journal: J Neurosci
    E-pub date: 15 Apr 2009
    Authors: PL Clatworthy, SJG Lewis, L Brichard, YT Hong, D Izquierdo, L Clark, R Cools, FI Aigbirhio, J-C Baron, TD Fryer, TW Robbins

    Imaging regional variation of cellular proliferation in gliomas using 3′-deoxy-3′-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study.

    DOI: http://doi.org/10.1016/j.crad.2008.01.016
    Journal: Clin Radiol
    E-pub date: 1 Jan 2009
    Authors: SJ Price, TD Fryer, MC Cleij, AF Dean, J Joseph, R Salvador, DD Wang, PJ Hutchinson, JC Clark, NG Burnet, JD Pickard, FI Aigbirhio, JH Gillard

    Selective neuronal loss in rescued penumbra relates to initial hypoperfusion.

    DOI: http://doi.org/10.1093/brain/awn175
    Journal: Brain
    E-pub date: 1 Oct 2008
    Authors: JV Guadagno, PS Jones, FI Aigbirhio, D Wang, TD Fryer, DJ Day, N Antoun, I Nimmo-Smith, EA Warburton, JC Baron

    Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity.

    DOI: http://doi.org/10.1007/s12028-008-9119-2
    Journal: Neurocrit Care
    E-pub date: 1 Aug 2008
    Authors: MG Abate, M Trivedi, TD Fryer, P Smielewski, DA Chatfield, GB Williams, F Aigbirhio, TA Carpenter, JD Pickard, DK Menon, JP Coles

    How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET.

    DOI: http://doi.org/10.1161/STROKEAHA.107.500090
    Journal: Stroke
    E-pub date: 1 Mar 2008
    Authors: M Takasawa, PS Jones, JV Guadagno, S Christensen, TD Fryer, S Harding, JH Gillard, GB Williams, FI Aigbirhio, EA Warburton, L Østergaard, J-C Baron

    Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings.

    DOI: http://doi.org/10.1097/01.CCM.0000292014.60835.15
    Journal: Crit Care Med
    E-pub date: 1 Jan 2008
    Authors: J Nortje, JP Coles, I Timofeev, TD Fryer, FI Aigbirhio, P Smielewski, JG Outtrim, DA Chatfield, JD Pickard, PJ Hutchinson, AK Gupta, DK Menon

    Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study.

    DOI: http://doi.org/10.1038/sj.jcbfm.9600405
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Apr 2007
    Authors: M Takasawa, JS Beech, TD Fryer, YT Hong, JL Hughes, K Igase, PS Jones, R Smith, FI Aigbirhio, DK Menon, JC Clark, J-C Baron

    Synthesis and evaluation of fluorine-18 and copper-64 labelled PBR radioligands

    DOI: http://doi.org/10.1002/jlcr.1274
    Journal: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
    E-pub date: 1 Apr 2007
    Authors: KC Probst, D Izquierdo, JR Davies, JLE Bird, TD Fryer, HK Richards, JC Clark, EA Warburton, PL Weissberg, FI Aigbirhio

    Comparison of lorazepam [7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one] occupancy of rat brain gamma-aminobutyric acid(A) receptors measured using in vivo [3H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester) binding and [11C]flumazenil micro-positron emission tomography.

    DOI: http://doi.org/10.1124/jpet.106.114884
    Journal: J Pharmacol Exp Ther
    E-pub date: 1 Mar 2007
    Authors: JR Atack, P Scott-Stevens, JS Beech, TD Fryer, JL Hughes, MC Cleij, J-C Baron, JC Clark, RJ Hargreaves, FI Aigbirhio

    Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism.

    DOI: http://doi.org/10.1097/01.CCM.0000254066.37187.88
    Journal: Crit Care Med
    E-pub date: 1 Feb 2007
    Authors: JP Coles, TD Fryer, MR Coleman, P Smielewski, AK Gupta, PS Minhas, F Aigbirhio, DA Chatfield, GB Williams, S Boniface, TA Carpenter, JC Clark, JD Pickard, DK Menon

    How affected is oxygen metabolism in DWI lesions?: A combined acute stroke PET-MR study.

    DOI: http://doi.org/10.1212/01.wnl.0000233984.66907.db
    Journal: Neurology
    E-pub date: 12 Sep 2006
    Authors: JV Guadagno, EA Warburton, PS Jones, DJ Day, FI Aigbirhio, TD Fryer, S Harding, CJ Price, HA Green, O Barret, JH Gillard, J-C Baron

    Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke.

    DOI: http://doi.org/10.1161/01.STR.0000226980.95389.0b
    Journal: Stroke
    E-pub date: 1 Jul 2006
    Authors: CJS Price, D Wang, DK Menon, JV Guadagno, M Cleij, T Fryer, F Aigbirhio, J-C Baron, EA Warburton

    Local relationships between restricted water diffusion and oxygen consumption in the ischemic human brain.

    DOI: http://doi.org/10.1161/01.STR.0000232437.00621.86
    Journal: Stroke
    E-pub date: 1 Jul 2006
    Authors: JV Guadagno, PS Jones, TD Fryer, O Barret, FI Aigbirhio, TA Carpenter, CJ Price, JH Gillard, EA Warburton, J-C Baron

    Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury.

    DOI: http://doi.org/10.1093/brain/awh536
    Journal: Brain
    E-pub date: 31 Aug 2005
    Authors: AS Cunningham, R Salvador, JP Coles, DA Chatfield, PG Bradley, AJ Johnston, LA Steiner, TD Fryer, FI Aigbirhio, P Smielewski, GB Williams, TA Carpenter, JH Gillard, JD Pickard, DK Menon

    The diffusion-weighted lesion in acute stroke: heterogeneous patterns of flow/metabolism uncoupling as assessed by quantitative positron emission tomography.

    DOI: http://doi.org/10.1159/000084087
    Journal: Cerebrovasc Dis
    E-pub date: 1 Aug 2005
    Authors: JV Guadagno, EA Warburton, PS Jones, TD Fryer, DJ Day, JH Gillard, TA Carpenter, FI Aigbirhio, CJ Price, J-C Baron

    Imaging of cerebral blood flow and metabolism in brain injury in the ICU.

    DOI: http://doi.org/10.1007/3-211-32318-X_94
    Journal: Acta Neurochirurgica, Supplementum
    E-pub date: 1 Jan 2005
    Authors: JD Pickard, PJ Hutchinson, JP Coles, LA Steiner, AJ Johnston, TD Fryer, MR Coleman, P Smielewski, DA Chatfield, F Aigbirhio, GB Williams, K Rice, JC Clark, CH Salmond, BJ Sahakian, PG Bradley, TA Carpenter, R Salvador, A Pena, JH Gillard, AS Cunningham, S Piechnik, M Czosnyka, DK Menon

    Does induced hypertension reduce cerebral ischaemia within the traumatized human brain?

    DOI: http://doi.org/10.1093/brain/awh268
    Journal: Brain
    E-pub date: 1 Nov 2004
    Authors: JP Coles, LA Steiner, AJ Johnston, TD Fryer, MR Coleman, P Smieleweski, DA Chatfield, F Aigbirhio, GB Williams, S Boniface, K Rice, JC Clark, JD Pickard, DK Menon

    Does the acute diffusion-weighted imaging lesion represent penumbra as well as core? A combined quantitative PET/MRI voxel-based study.

    DOI: http://doi.org/10.1097/01.WCB.0000141557.32867.6B
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Nov 2004
    Authors: JV Guadagno, EA Warburton, FI Aigbirhio, P Smielewski, TD Fryer, S Harding, CJ Price, JH Gillard, TA Carpenter, J-C Baron

    Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure.

    DOI: http://doi.org/10.1097/01.WCB.0000090861.67713.10
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Nov 2003
    Authors: LA Steiner, JP Coles, AJ Johnston, M Czosnyka, TD Fryer, P Smielewski, DA Chatfield, R Salvador, FI Aigbirhio, JC Clark, DK Menon, JD Pickard

    Assessment of cerebrovascular autoregulation in head-injured patients: a validation study.

    DOI: http://doi.org/10.1161/01.STR.0000089014.59668.04
    Journal: Stroke
    E-pub date: 1 Oct 2003
    Authors: LA Steiner, JP Coles, AJ Johnston, DA Chatfield, P Smielewski, TD Fryer, FI Aigbirhio, JC Clark, JD Pickard, DK Menon, M Czosnyka

    Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury.

    DOI: http://doi.org/10.1136/jnnp.74.6.765
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jun 2003
    Authors: LA Steiner, JP Coles, M Czosnyka, PS Minhas, TD Fryer, FI Aigbirhio, JC Clark, P Smielewski, DA Chatfield, T Donovan, JD Pickard, DK Menon

    Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study.

    DOI: http://doi.org/10.1097/00004647-200206000-00012
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Jun 2002
    Authors: PJ Hutchinson, AK Gupta, TF Fryer, PG Al-Rawi, DA Chatfield, JP Coles, MT O'Connell, R Kett-White, PS Minhas, FI Aigbirhio, JC Clark, PJ Kirkpatrick, DK Menon, JD Pickard

    Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method.

    DOI: http://doi.org/10.3171/jns.2002.96.2.0263
    Journal: J Neurosurg
    E-pub date: 1 Feb 2002
    Authors: AK Gupta, PJ Hutchinson, T Fryer, PG Al-Rawi, DA Parry, PS Minhas, R Kett-White, PJ Kirkpatrick, JC Mathews, S Downey, F Aigbirhio, J Clark, JD Pickard, DK Menon