College Trinity College
Research Theme Beyond the Neuron
Research Focus


  • Schwann Cells
  • Axon Degeneration
  • Wallerian Degeneration
  • Peripheral Nerve Repair
  • Clinical Conditions

  • Other 
  • Equipment & Techniques

  • Cell culture
  • Confocal microscopy
  • Fluorescence microscopy
  • Immunohistochemistry
  • Calcium imaging
  • Microscopy
  • Back

    Clara Mutschler

    University Position
    PhD student


    My research focusses on the interaction of Schwann cells and neurons after peripheral nervous system injury. After injury, axons degenerate and Schwann cells transform into repair Schwann cells, which digest myelin using myelinophagy, attract macrophages, and support neuronal survival and axonal regeneration. Both axon degeneration and this repair phenotype are regulated by cell intrinsic molecular pathways, but their interaction and the Schwann cell injury response are incompletely understood. I am working on further characterising this injury response, and on understanding the transcriptional changes in Schwann cells after nerve injury. I work with a range of models, including an in vitro coculture model, mice, and zebrafish.

    Key Publications

    Schwann cells are axo-protective after injury irrespective of myelination status in mouse Schwann cell/neuron cocultures.

    Journal: J Cell Sci
    E-pub date: 15 Sep 2023
    Authors: C Mutschler, SV Fazal, N Schumacher, A Loreto, MP Coleman, P Arthur-Farraj

    SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice.

    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2023
    Authors: SV Fazal, C Mutschler, CZ Chen, M Turmaine, C-Y Chen, Y-P Hsueh, A Ibañez-Grau, A Loreto, A Casillas-Bajo, H Cabedo, RJM Franklin, RA Barker, KR Monk, BJ Steventon, MP Coleman, JA Gomez-Sanchez, P Arthur-Farraj


    Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration.

    Journal: Cell Metab
    E-pub date: 5 Dec 2023
    Authors: VK Sundaram, V Schütza, NH Schröter, A Backhaus, A Bilsing, L Joneck, A Seelbach, C Mutschler, JA Gomez-Sanchez, E Schäffner, EE Sánchez, D Akkermann, C Paul, N Schwagarus, S Müller, A Odle, G Childs, D Ewers, T Kungl, M Sitte, G Salinas, MW Sereda, K-A Nave, MH Schwab, M Ost, P Arthur-Farraj, RM Stassart, R Fledrich

    Emerging Role of HDACs in Regeneration and Ageing in the Peripheral Nervous System: Repair Schwann Cells as Pivotal Targets.

    Journal: International Journal of Molecular Sciences
    E-pub date: 10 Mar 2022
    Authors: JA Gomez-Sanchez, N Patel, F Martirena, SV Fazal, C Mutschler, H Cabedo