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College Trinity College
Research Theme Beyond the Neuron
Research Focus

Keywords

  • Schwann Cells
  • Axon Degeneration
  • Wallerian Degeneration
  • Peripheral Nerve Repair
  • Clinical Conditions

  • Other 
  • Equipment & Techniques

  • Cell culture
  • Confocal microscopy
  • Fluorescence microscopy
  • Immunohistochemistry
  • Calcium imaging
  • Microscopy
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    Clara Mutschler

    (she/her/hers)
    University Position
    PhD student

    Interests

    My research focusses on the interaction of Schwann cells and neurons after peripheral nervous system injury. After injury, axons degenerate and Schwann cells transform into repair Schwann cells, which digest myelin using myelinophagy, attract macrophages, and support neuronal survival and axonal regeneration. Both axon degeneration and this repair phenotype are regulated by cell intrinsic molecular pathways, but their interaction and the Schwann cell injury response are incompletely understood. I am working on further characterising this injury response, and on understanding the transcriptional changes in Schwann cells after nerve injury. I work with a range of models, including an in vitro coculture model, mice, and zebrafish.

    Key Publications

    Schwann cells are axo-protective after injury irrespective of myelination status in mouse Schwann cell/neuron cocultures.

    DOI: http://doi.org/10.1242/jcs.261557
    Journal: J Cell Sci
    E-pub date: 15 Sep 2023
    Authors: C Mutschler, SV Fazal, N Schumacher, A Loreto, MP Coleman, P Arthur-Farraj

    SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice.

    DOI: http://doi.org/10.3389/fncel.2023.1158388
    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2023
    Authors: SV Fazal, C Mutschler, CZ Chen, M Turmaine, C-Y Chen, Y-P Hsueh, A Ibañez-Grau, A Loreto, A Casillas-Bajo, H Cabedo, RJM Franklin, RA Barker, KR Monk, BJ Steventon, MP Coleman, JA Gomez-Sanchez, P Arthur-Farraj

    Publications

    Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration.

    DOI: http://doi.org/10.1016/j.cmet.2023.10.017
    Journal: Cell Metab
    E-pub date: 5 Dec 2023
    Authors: VK Sundaram, V Schütza, NH Schröter, A Backhaus, A Bilsing, L Joneck, A Seelbach, C Mutschler, JA Gomez-Sanchez, E Schäffner, EE Sánchez, D Akkermann, C Paul, N Schwagarus, S Müller, A Odle, G Childs, D Ewers, T Kungl, M Sitte, G Salinas, MW Sereda, K-A Nave, MH Schwab, M Ost, P Arthur-Farraj, RM Stassart, R Fledrich

    Emerging Role of HDACs in Regeneration and Ageing in the Peripheral Nervous System: Repair Schwann Cells as Pivotal Targets.

    DOI: http://doi.org/10.3390/ijms23062996
    Journal: International Journal of Molecular Sciences
    E-pub date: 10 Mar 2022
    Authors: JA Gomez-Sanchez, N Patel, F Martirena, SV Fazal, C Mutschler, H Cabedo