Dr Daniel Tozer

University Position

Senior Research Associate

Interests

I use MRI and associated image processing techniques to investigate stroke and small vessel disease. I am interested in the application of quantitative MR techniques to neurological conditions and developing image processing tools to meet this aim.

Key Publications

Visualisation of lenticulostriate arteries using contrast-enhanced time-of-flight magnetic resonance angiography at 7 Tesla.

DOI: http://doi.org/10.1038/s41598-022-24832-z
Journal: Scientific Reports
E-pub date: 24 Nov 2022
Authors: CN Osuafor, C Rua, AD Mackinnon, M Egle, P Benjamin, DJ Tozer, CT Rodgers, HS Markus

Publications

Are Central and Systemic Inflammation associated with Fatigue in Cerebral Small Vessel Disease?

DOI: http://doi.org/10.1177/17474930241245613
Journal: Int J Stroke
E-pub date: 1 Jul 2024
Authors: AA Jolly, RB Brown, DJ Tozer, YT Hong, TD Fryer, F Aigbirhio, J O'brien, HS Markus

MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial

DOI: http://doi.org/10.1002/alz.13830
Journal: Alzheimers Dement
E-pub date: 1 Jun 2024
Authors: RB Brown, DJ Tozer, L Loubière, EL Harshfield, YT Hong, TD Fryer, GB Williams, MJ Graves, F Aigbirhio, JT O'Brien, HS Markus

Immune regulation and blood-brain barrier permeability in cerebral small vessel disease: study protocol of the INflammation and Small Vessel Disease (INSVD) study – a multicentre prospective cohort study.

DOI: http://doi.org/10.1136/bmjopen-2024-084303
Journal: BMJ Open
E-pub date: 26 Feb 2024
Authors: A Low, S van Winden, L Cai, RPC Kessels, MC Maas, RG Morris, M Nus, DJ Tozer, A Tuladhar, A van der Kolk, R Wolters, Z Mallat, NP Riksen, H Markus, F-E de Leeuw

Predicting incident dementia in cerebral small vessel disease: comparison of machine learning and traditional statistical models.

DOI: http://doi.org/10.1016/j.cccb.2023.100179
Journal: Cereb Circ Cogn Behav
E-pub date: 1 Aug 2023
Authors: R Li, EL Harshfield, S Bell, M Burkhart, AM Tuladhar, S Hilal, DJ Tozer, FM Chappell, SDJ Makin, JW Lo, JM Wardlaw, F-E de Leeuw, C Chen, Z Kourtzi, HS Markus

Do Regions of Increased Inflammation Progress to New White Matter Hyperintensities?: A Longitudinal Positron Emission Tomography-Magnetic Resonance Imaging Study.

DOI: http://doi.org/10.1161/STROKEAHA.122.039517
Journal: Stroke
E-pub date: 1 Feb 2023
Authors: DJ Tozer, RB Brown, J Walsh, YT Hong, GB Williams, JT O'Brien, FI Aigbirhio, TD Fryer, HS Markus

Association of Vascular Risk Factors and Genetic Factors With Penetrance of Variants Causing Monogenic Stroke.

DOI: http://doi.org/10.1001/jamaneurol.2022.3832
Journal: JAMA Neurol
E-pub date: 1 Dec 2022
Authors: BPH Cho, EL Harshfield, M Al-Thani, DJ Tozer, S Bell, HS Markus

MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol.

DOI: http://doi.org/10.1177/23969873221100338
Journal: Eur Stroke J
E-pub date: 1 Sep 2022
Authors: RB Brown, DJ Tozer, L Loubière, YT Hong, TD Fryer, GB Williams, MJ Graves, FI Aigbirhio, JT O'Brien, HS Markus

Both vascular risk factors and common genetic variants influence penetrance of variants causing monogenic stroke

DOI: http://doi.org/10.1101/2022.05.24.22275509
Journal:
E-pub date: 1 Aug 2022
Authors: BPH Cho, E Harshfield, M Al-Thani, D Tozer, S Bell, H Markus

Central obesity is selectively associated with cerebral gray matter atrophy in 15,634 subjects in the UK Biobank.

DOI: http://doi.org/10.1038/s41366-021-00992-2
Journal: Int J Obes (Lond)
E-pub date: 1 May 2022
Authors: C-P Pflanz, DJ Tozer, EL Harshfield, J Tay, S Farooqi, HS Markus

NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia: an analysis of 200 000 participants.

DOI: http://doi.org/10.1136/jnnp-2020-325838
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Jul 2021
Authors: BPH Cho, S Nannoni, EL Harshfield, D Tozer, S Gräf, S Bell, HS Markus

Microglial activation and blood-brain barrier permeability in cerebral small vessel disease.

DOI: http://doi.org/10.1093/brain/awab003
Journal: Brain
E-pub date: 22 Jun 2021
Authors: J Walsh, DJ Tozer, H Sari, YT Hong, A Drazyk, G Williams, NJ Shah, JT O'Brien, FI Aigbirhio, G Rosenberg, TD Fryer, HS Markus

NOTCH3 variants are common in the general population and associated with stroke and vascular dementia: an analysis of 200,000 participants

DOI: http://doi.org/10.1101/2020.12.14.20248151
Journal:
E-pub date: 1 Aug 2020
Authors: BPH Cho, S Nannoni, E Harshfield, D Tozer, S Gräf, S Bell, H Markus

A comparison of functional and tractography based networks in cerebral small vessel disease.

DOI: http://doi.org/10.1016/j.nicl.2018.02.013
Journal: Neuroimage Clin
E-pub date: 1 Aug 2018
Authors: AJ Lawrence, DJ Tozer, EA Stamatakis, HS Markus

Magnetization transfer imaging in multiple sclerosis treated with alemtuzumab.

DOI: http://doi.org/10.1177/1352458512444915
Journal: Mult Scler
E-pub date: 1 Feb 2013
Authors: T Button, D Altmann, D Tozer, C Dalton, K Hunter, A Compston, A Coles, D Miller