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Research Focus

Keywords

  • Cardiometabolic
  • Lipid Metabolism
  • Human Genetics
  • Stroke
  • Dementia
  • Vascular Dementia
  • Vascular Cognitive Impairment
  • Metabolomics
  • Mendelian Randomisation
  • Clinical Conditions

  • Alzheimer's disease
  • Cerebral small vessel disease
  • Cognitive impairment
  • Dementia
  • Genetic disorders
  • Stroke
  • Vascular dementia
  • Cerebrovascular disorders
  • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Neuropsychological testing
  • Statistical analysis
  • Science Culture

  • Public Engagement
  • Public Outreach
  • Mentorship
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    Dr Eric Harshfield

    University Position
    Senior Research Associate
    Research Fellow
    Dr Eric Harshfield is pleased to consider applications from prospective PhD students.

    Interests

    I am a chronic disease and genetic epidemiologist with an interest in identifying novel causal pathways and new therapeutic targets for reducing risk of chronic diseases. My research particularly focuses on identifying improved ways to predict, prevent, and treat stroke and dementia. Since 2018 I have been working in the Stroke Research Group in the Department of Clinical Neurosciences, and I am currently a Research Fellow funded by the Alzheimer’s Society. My current programme of research has two main aims: (1) using metabolomics to enhance prediction of dementia, and (2) investigating the mechanistic pathways underlying dementia to prioritise therapeutic targets. PubMed ORCID Google Scholar PublicationsList

    Collaborators

    Cambridge
  • Hugh Markus
  • Key Publications

    Metabolomic profiling in small vessel disease identifies multiple associations with disease severity.

    DOI: http://doi.org/10.1093/brain/awac041
    Journal: Brain
    E-pub date: 29 Jul 2022
    Authors: EL Harshfield, CJ Sands, AM Tuladhar, FE de Leeuw, MR Lewis, HS Markus

    Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.

    DOI: http://doi.org/10.1212/WNL.0000000000011555
    Journal: Neurology
    E-pub date: 30 Mar 2021
    Authors: MK Georgakis, EL Harshfield, R Malik, N Franceschini, C Langenberg, NJ Wareham, HS Markus, M Dichgans

    Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.

    DOI: http://doi.org/10.1161/STROKEAHA.120.031710
    Journal: Stroke
    E-pub date: 1 Mar 2021
    Authors: EL Harshfield, MK Georgakis, R Malik, M Dichgans, HS Markus

    The role of haematological traits in risk of ischaemic stroke and its subtypes.

    DOI: http://doi.org/10.1093/brain/awz362
    Journal: Brain
    E-pub date: 1 Jan 2020
    Authors: EL Harshfield, MC Sims, M Traylor, WH Ouwehand, HS Markus

    Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis.

    DOI: http://doi.org/10.1016/S1474-4422(19)30149-8
    Journal: Lancet Neurol
    E-pub date: 1 Jul 2019
    Authors: HS Markus, EL Harshfield, A Compter, W Kuker, LJ Kappelle, A Clifton, HB van der Worp, P Rothwell, A Algra, Vertebral Stenosis Trialists' Collaboration

    Publications

    MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial

    DOI: http://doi.org/10.1002/alz.13830
    Journal: Alzheimers Dement
    E-pub date: 17 Apr 2024
    Authors: RB Brown, DJ Tozer, L Loubière, EL Harshfield, YT Hong, TD Fryer, GB Williams, MJ Graves, F Aigbirhio, JT O'Brien, HS Markus

    Artificial intelligence for dementia-Applied models and digital health.

    DOI: http://doi.org/10.1002/alz.13391
    Journal: Alzheimers Dement
    E-pub date: 1 Dec 2023
    Authors: DM Lyall, A Kormilitzin, C Lancaster, J Sousa, F Petermann-Rocha, C Buckley, EL Harshfield, MH Iveson, CR Madan, R McArdle, D Newby, V Orgeta, E Tang, S Tamburin, LS Thakur, I Lourida, Deep Dementia Phenotyping (DEMON) Network, DJ Llewellyn, JM Ranson

    Artificial intelligence for biomarker discovery in Alzheimer’s disease and dementia.

    DOI: http://doi.org/10.1002/alz.13390
    Journal: Alzheimers Dement
    E-pub date: 1 Dec 2023
    Authors: LM Winchester, EL Harshfield, L Shi, A Badhwar, AA Khleifat, N Clarke, A Dehsarvi, I Lengyel, I Lourida, CR Madan, SJ Marzi, P Proitsi, AP Rajkumar, T Rittman, E Silajdžić, S Tamburin, JM Ranson, DJ Llewellyn

    Artificial intelligence for dementia genetics and omics.

    DOI: http://doi.org/10.1002/alz.13427
    Journal: Alzheimers Dement
    E-pub date: 1 Dec 2023
    Authors: C Bettencourt, N Skene, S Bandres-Ciga, E Anderson, LM Winchester, IF Foote, J Schwartzentruber, JA Botia, M Nalls, A Singleton, BM Schilder, J Humphrey, SJ Marzi, CE Toomey, AA Kleifat, EL Harshfield, V Garfield, C Sandor, S Keat, S Tamburin, CS Frigerio, I Lourida, Deep Dementia Phenotyping (DEMON) Network, JM Ranson, DJ Llewellyn

    Predicting incident dementia in cerebral small vessel disease: comparison of machine learning and traditional statistical models.

    DOI: http://doi.org/10.1016/j.cccb.2023.100179
    Journal: Cereb Circ Cogn Behav
    E-pub date: 1 Aug 2023
    Authors: R Li, EL Harshfield, S Bell, M Burkhart, AM Tuladhar, S Hilal, DJ Tozer, FM Chappell, SDJ Makin, JW Lo, JM Wardlaw, F-E de Leeuw, C Chen, Z Kourtzi, HS Markus

    Contribution of Conventional Cardiovascular Risk Factors to Brain White Matter Hyperintensities.

    DOI: http://doi.org/10.1161/JAHA.123.030676
    Journal: J Am Heart Assoc
    E-pub date: 18 Jul 2023
    Authors: F Koohi, EL Harshfield, HS Markus

    Cerebrovascular Disorders.

    DOI: http://doi.org/10.1186/s12872-023-03225-8
    Journal: BMC Cardiovasc Disord
    E-pub date: 28 Apr 2023
    Authors: A Granata, EL Harshfield, JV Moxon

    Association of Vascular Risk Factors and Genetic Factors With Penetrance of Variants Causing Monogenic Stroke.

    DOI: http://doi.org/10.1001/jamaneurol.2022.3832
    Journal: JAMA Neurol
    E-pub date: 1 Dec 2022
    Authors: BPH Cho, EL Harshfield, M Al-Thani, DJ Tozer, S Bell, HS Markus

    Both vascular risk factors and common genetic variants influence penetrance of variants causing monogenic stroke

    DOI: http://doi.org/10.1101/2022.05.24.22275509
    Journal:
    E-pub date: 1 Aug 2022
    Authors: BPH Cho, E Harshfield, M Al-Thani, D Tozer, S Bell, H Markus

    The prevalence and penetrance of monogenic small vessel stroke variants in 450,000 UK Biobank participants

    DOI: http://doi.org/10.1177/17474930221125973
    Journal: International Journal of Stroke
    E-pub date: 1 Aug 2022
    Authors: P Cho, E Harshfield, M Al-Thani, D Tozer, S Bell, H Markus

    Central obesity is selectively associated with cerebral gray matter atrophy in 15,634 subjects in the UK Biobank.

    DOI: http://doi.org/10.1038/s41366-021-00992-2
    Journal: Int J Obes (Lond)
    E-pub date: 1 May 2022
    Authors: C-P Pflanz, DJ Tozer, EL Harshfield, J Tay, S Farooqi, HS Markus

    Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.

    DOI: http://doi.org/10.1186/s12916-021-02087-1
    Journal: BMC Med
    E-pub date: 10 Sep 2021
    Authors: EL Harshfield, EB Fauman, D Stacey, DS Paul, D Ziemek, RMY Ong, J Danesh, AS Butterworth, A Rasheed, T Sattar, Zameer-Ul-Asar, I Saleem, Z Hina, U Ishtiaq, N Qamar, NH Mallick, Z Yaqub, T Saghir, SNH Rizvi, A Memon, M Ishaq, SZ Rasheed, F-U-R Memon, A Jalal, S Abbas, P Frossard, D Saleheen, AM Wood, JL Griffin, A Koulman

    NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia: an analysis of 200 000 participants.

    DOI: http://doi.org/10.1136/jnnp-2020-325838
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2021
    Authors: BPH Cho, S Nannoni, EL Harshfield, D Tozer, S Gräf, S Bell, HS Markus

    Metabolomic profiling in small vessel disease identifies multiple associations with disease severity

    DOI: http://doi.org/10.1101/2021.05.13.21257190
    Journal:
    E-pub date: 14 May 2021
    Authors: EL Harshfield, CJ Sands, AM Tuladhar, F-E de Leeuw, MR Lewis, HS Markus

    Association Between Depressive Symptoms and Incident Cardiovascular Diseases.

    DOI: http://doi.org/10.1001/jama.2020.23068
    Journal: JAMA
    E-pub date: 15 Dec 2020
    Authors: EL Harshfield, L Pennells, JE Schwartz, P Willeit, S Kaptoge, S Bell, JA Shaffer, T Bolton, S Spackman, S Wassertheil-Smoller, F Kee, P Amouyel, SJ Shea, LH Kuller, J Kauhanen, EM van Zutphen, DG Blazer, H Krumholz, PJ Nietert, D Kromhout, G Laughlin, L Berkman, RB Wallace, LA Simons, EM Dennison, ELM Barr, HE Meyer, AM Wood, J Danesh, E Di Angelantonio, KW Davidson, Emerging Risk Factors Collaboration

    Modifiable lifestyle factors and risk of stroke: a Mendelian randomization analysis

    DOI: http://doi.org/10.1101/2020.03.17.20037549
    Journal:
    E-pub date: 1 Aug 2020
    Authors: EL Harshfield, MK Georgakis, R Malik, M Dichgans, HS Markus

    Genome-wide analysis of blood lipid metabolites in over 5,000 South Asians reveals biological insights at cardiometabolic disease loci

    DOI: http://doi.org/10.1101/2020.10.16.20213520
    Journal:
    E-pub date: 1 Aug 2020
    Authors: E Harshfield, E Fauman, D Stacey, D Paul, D Ziemek, R Ong, J Danesh, A Butterworth, A Rasheed, T Sattar, Zameer-ul-Asar, I Saleem, Z Hina, U Ishtiaq, N Qamar, NH Mallick, Z Yaqub, T Saghir, SN Hasan Rizvi, A Memon, M Ishaq, SZ Rasheed, F-U-R Memon, A Jalal, S Abbas, P Frossard, D Saleheen, A Wood, J Griffin, A Koulman

    Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study

    DOI: http://doi.org/10.1177/1747493020963387
    Journal: International Journal of Stroke
    E-pub date: 1 Aug 2020
    Authors: M Georgakis, E Harshfield, R Malik, N Franceschini, C Langenberg, N Wareham, H Markus, M Dichgans

    Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study

    DOI: http://doi.org/10.1101/2019.12.27.19015834
    Journal:
    E-pub date: 1 Aug 2019
    Authors: M Georgakis, E Harshfield, R Malik, N Franceschini, C Langenberg, N Wareham, H Markus, M Dichgans

    An Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors.

    DOI: http://doi.org/10.1021/acs.jproteome.8b00786
    Journal: J Proteome Res
    E-pub date: 7 Jun 2019
    Authors: EL Harshfield, A Koulman, D Ziemek, L Marney, EB Fauman, DS Paul, D Stacey, A Rasheed, J-J Lee, N Shah, S Jabeen, A Imran, S Abbas, Z Hina, N Qamar, NH Mallick, Z Yaqoob, T Saghir, SNH Rizvi, A Memon, SZ Rasheed, F-U-R Memon, IH Qureshi, M Ishaq, P Frossard, J Danesh, D Saleheen, AS Butterworth, AM Wood, JL Griffin

    The role of haematological traits in stroke and its subtypes

    DOI: http://doi.org/10.1177/2396987319845560
    Journal: European Stroke Journal
    E-pub date: 1 May 2019
    Authors: E Harshfield, M Sims, M Traylor, W Astle, W Ouwehand, H Markus

    Investigating the causal role of haematological traits on stroke and its subtypes

    DOI: http://doi.org/10.1212/nxg.0000000000000325
    Journal: Neurology Genetics
    E-pub date: 1 Apr 2019
    Authors: EL Harshfield, MC Sims, WJ Astle, M Traylor, WH Ouwehand, HS Markus

    Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

    DOI: http://doi.org/10.1212/WNL.0000000000006851
    Journal: Neurology
    E-pub date: 28 Jan 2019
    Authors: G Chauhan, HHH Adams, CL Satizabal, JC Bis, A Teumer, M Sargurupremraj, E Hofer, S Trompet, S Hilal, AV Smith, X Jian, R Malik, M Traylor, SL Pulit, P Amouyel, B Mazoyer, Y-C Zhu, S Kaffashian, S Schilling, GW Beecham, TJ Montine, GD Schellenberg, O Kjartansson, V Guðnason, DS Knopman, ME Griswold, BG Windham, RF Gottesman, TH Mosley, R Schmidt, Y Saba, H Schmidt, F Takeuchi, S Yamaguchi, T Nabika, N Kato, KB Rajan, NT Aggarwal, PL De Jager, DA Evans, BM Psaty, JI Rotter, K Rice, OL Lopez, J Liao, C Chen, C-Y Cheng, TY Wong, MK Ikram, SJ van der Lee, N Amin, V Chouraki, AL DeStefano, HJ Aparicio, JR Romero, P Maillard, C DeCarli, JM Wardlaw, MDCV Hernández, M Luciano, D Liewald, IJ Deary, JM Starr, ME Bastin, S Muñoz Maniega, PE Slagboom, M Beekman, J Deelen, H-W Uh, R Lemmens, H Brodaty, MJ Wright, D Ames, GB Boncoraglio, JC Hopewell, AH Beecham, SH Blanton, CB Wright, RL Sacco, W Wen, A Thalamuthu, NJ Armstrong, E Chong, PR Schofield, JB Kwok, J van der Grond, DJ Stott, I Ford, JW Jukema, MW Vernooij, A Hofman, AG Uitterlinden, A van der Lugt, K Wittfeld, HJ Grabe, N Hosten, B von Sarnowski, U Völker, C Levi, J Jimenez-Conde, P Sharma, CLM Sudlow, J Rosand, D Woo, JW Cole, JF Meschia, A Slowik, V Thijs, A Lindgren, O Melander, RP Grewal, T Rundek, K Rexrode, PM Rothwell, DK Arnett, C Jern, JA Johnson, OR Benavente, S Wasssertheil-Smoller, J-M Lee, Q Wong, BD Mitchell, SS Rich, PF McArdle, MI Geerlings, Y van der Graaf, PIW de Bakker, FW Asselbergs, V Srikanth, R Thomson, R McWhirter, C Moran, M Callisaya, T Phan, LCA Rutten-Jacobs, S Bevan, C Tzourio, KA Mather, PS Sachdev, CM van Duijn, BB Worrall, M Dichgans, SJ Kittner, HS Markus, MA Ikram, M Fornage, LJ Launer, S Seshadri, WT Longstreth, S Debette, Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

    ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci.

    DOI: http://doi.org/10.1093/nar/gky837
    Journal: Nucleic Acids Res
    E-pub date: 10 Jan 2019
    Authors: D Stacey, EB Fauman, D Ziemek, BB Sun, EL Harshfield, AM Wood, AS Butterworth, K Suhre, DS Paul

    From lipid locus to drug target through human genomics.

    DOI: http://doi.org/10.1093/cvr/cvy120
    Journal: Cardiovasc Res
    E-pub date: 15 Jul 2018
    Authors: SW van der Laan, EL Harshfield, D Hemerich, D Stacey, AM Wood, FW Asselbergs

    ProGeM: A framework for the prioritisation of candidate causal genes at molecular quantitative trait loci

    DOI: http://doi.org/10.1101/230094
    Journal:
    E-pub date: 8 Dec 2017
    Authors: D Stacey, E Fauman, D Ziemek, B Sun, E Harshfield, A Wood, A Butterworth, K Suhre, D Paul

    Genomics of lipid metabolism: Identifying novel causal pathways and new therapeutic targets for reducing risk of coronary heart disease

    DOI: http://doi.org/10.1002/gepi.22001
    Journal: Genetic Epidemiology
    E-pub date: 28 Sep 2016
    Authors: EL Harshfield, D Stacey, DS Paul, A Koulman, AM Wood, A Butterworth, EB Fauman, JL Griffin, J Danesh, D Saleheen

    Association of hypertension and hyperglycaemia with socioeconomic contexts in resource-poor settings: the Bangladesh Demographic and Health Survey.

    DOI: http://doi.org/10.1093/ije/dyv087
    Journal: Int J Epidemiol
    E-pub date: 1 Oct 2015
    Authors: E Harshfield, R Chowdhury, MN Harhay, H Bergquist, MO Harhay

    The Bangladesh Risk of Acute Vascular Events (BRAVE) Study: objectives and design.

    DOI: http://doi.org/10.1007/s10654-015-0037-2
    Journal: Eur J Epidemiol
    E-pub date: 1 Jul 2015
    Authors: R Chowdhury, DS Alam, II Fakir, SD Adnan, A Naheed, I Tasmin, MM Monower, F Hossain, FM Hossain, MM Rahman, S Afrin, AK Roy, M Akter, SA Sume, AK Biswas, L Pennells, P Surendran, RD Young, SA Spackman, K Hasan, E Harshfield, N Sheikh, R Houghton, D Saleheen, JMM Howson, AS Butterworth, Cardiology Research Group, R Raqib, AAS Majumder, J Danesh, E Di Angelantonio

    Covariate-adjusted measures of discrimination for survival data.

    DOI: http://doi.org/10.1002/bimj.201400061
    Journal: Biom J
    E-pub date: 1 Jul 2015
    Authors: IR White, E Rapsomaniki, Emerging Risk Factors Collaboration

    Life, health, and safety of industrial workers in bangladesh: should they be driven by economic rationale or moral imperative?

    DOI: http://doi.org/10.1097/JOM.0000000000000126
    Journal: J Occup Environ Med
    E-pub date: 1 Apr 2014
    Authors: R Chowdhury, E Harshfield, S Roy, MS Flora, KAHM Akram, A Bhuiya, H Ahsan

    Glycated hemoglobin measurement and prediction of cardiovascular disease.

    DOI: http://doi.org/10.1001/jama.2014.1873
    Journal: JAMA
    E-pub date: 26 Mar 2014
    Authors: Emerging Risk Factors Collaboration, E Di Angelantonio, P Gao, H Khan, AS Butterworth, D Wormser, S Kaptoge, SR Kondapally Seshasai, A Thompson, N Sarwar, P Willeit, PM Ridker, ELM Barr, K-T Khaw, BM Psaty, H Brenner, B Balkau, JM Dekker, DA Lawlor, M Daimon, J Willeit, I Njølstad, A Nissinen, EJ Brunner, LH Kuller, JF Price, J Sundström, MW Knuiman, EJM Feskens, WMM Verschuren, N Wald, SJL Bakker, PH Whincup, I Ford, U Goldbourt, A Gómez-de-la-Cámara, J Gallacher, LA Simons, A Rosengren, SE Sutherland, C Björkelund, DG Blazer, S Wassertheil-Smoller, A Onat, A Marín Ibañez, E Casiglia, JW Jukema, LM Simpson, S Giampaoli, BG Nordestgaard, R Selmer, P Wennberg, J Kauhanen, JT Salonen, R Dankner, E Barrett-Connor, M Kavousi, V Gudnason, D Evans, RB Wallace, M Cushman, RB D'Agostino, JG Umans, Y Kiyohara, H Nakagawa, S Sato, RF Gillum, AR Folsom, YT van der Schouw, KG Moons, SJ Griffin, N Sattar, NJ Wareham, E Selvin, SG Thompson, J Danesh

    Evaluating the sustained health impact of household chlorination of drinking water in rural Haiti.

    DOI: http://doi.org/10.4269/ajtmh.2012.12-0010
    Journal: Am J Trop Med Hyg
    E-pub date: 1 Nov 2012
    Authors: E Harshfield, D Lantagne, A Turbes, C Null

    Evaluating the Long-Term Health Impact of Household Chlorination of Drinking Water in Rural Haiti

    DOI: http://doi.org/10.2175/193864711802863571
    Journal: Proceedings of the Water Environment Federation
    E-pub date: 1 Jan 2011
    Authors: E Harshfield, A Turbes, M Ritter

    Water Purification in South Africa: Reflections on Curriculum Development Tools and Best Practices for Implementing Student-Led Sustainable Development Projects in Rural Communities

    DOI: http://doi.org/10.24908/ijsle.v4i1.2223
    Journal: International Journal for Service Learning in Engineering, Humanitarian Engineering and Social Entrepreneurship
    E-pub date: 1 May 2009
    Authors: E Harshfield, A Jemec, O Makhado, E Ramarumo