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  • Research Focus

    Keywords

  • Stroke
  • Stroke Risk
  • Dementia
  • Vascular Dementia
  • Neurodegenerative Dementia
  • Metabolomics
  • Proteomics
  • Mendelian Randomisation
  • Cardiometabolic
  • Lipid Metabolism
  • Human Genetics
  • Vascular Cognitive Impairment
  • Cerebrovascular Disease
  • Vascular Imaging
  • Cerebral Small Vessel Disease
  • Small Vessel Disease
  • Genomics
  • Functional Genomics
  • Genetic Polymorphisms
  • Genetic Epidemiology
  • Risk Prediction
  • Health
  • Brain
  • Brain Imaging
  • Magnetic Resonance Imaging
  • Diffusion Tensor Imaging
  • Blood Brain Barrier
  • Epidemiology
  • Clinical Epidemiology
  • Machine Learning
  • Artificial Intelligence
  • Neural Networks
  • Ageing
  • Alzheimer's Disease
  • Atherosclerosis
  • Cardiovascular Risks
  • Clinical Conditions

  • Alzheimer's disease
  • Cerebral small vessel disease
  • Cognitive impairment
  • Dementia
  • Genetic disorders
  • Stroke
  • Vascular dementia
  • Cerebrovascular disorders
  • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Neuropsychological testing
  • Statistical analysis
  • Cross-sectional and cohort studies
  • Randomised control trials
  • Computational modelling
  • Science Culture

  • Public Engagement
  • Public Outreach
  • Mentorship
  • Open Access
  • Reproducibility in Science
  • Equality, Diversity, Inclusion and Wellbeing
  • Back

    Dr Eric Harshfield

    University Position
    Assistant Research Professor
    Research Fellow
    Dr Eric Harshfield is pleased to consider applications from prospective PhD students.

    Interests

    I am an Assistant Research Professor at the University of Cambridge working at the intersection of human genetics, epidemiology, and neurodegeneration. My research is dedicated to unravelling the complex molecular mechanisms of vascular dementia to pioneer new approaches for prediction, prevention, and treatment. I possess deep expertise in the analysis of large-scale multi-omics and electronic health records datasets using advanced computational methods, and I specialise in translating high-dimensional data into biologically meaningful and clinically relevant insights. My track record demonstrates a clear trajectory from data analysis to translational impact. I am actively working towards establishing and leading an internationally recognised research group focused on pioneering precision medicine approaches for vascular dementia. My research programme focuses on identifying data-driven patient subtypes and discovering subtype-specific therapeutic targets, bridging the gap between population health discovery and clinical trial readiness. Research profile on other sites: PubMed ORCID Google Scholar PublicationsList

    Collaborators

    Cambridge
  • Hugh Markus
  • Key Publications

    Using metabolomics to identify novel risk factors for lacunar stroke and vascular cognitive impairment

    DOI: http://doi.org/10.1101/2025.03.11.25323678
    Journal:
    E-pub date: 14 Mar 2025
    Authors: WH Ng, E Aghakishiyeva, HS Markus, EL Harshfield

    Proteins Involved in Endothelial Function and Inflammation Are Implicated in Cerebral Small Vessel Disease

    DOI: http://doi.org/10.1161/STROKEAHA.124.049079
    Journal: Stroke
    E-pub date: 1 Mar 2025
    Authors: Z Sun, EL Harshfield, F-E de Leeuw, S Burgess, AS Butterworth, NP Riksen, Z Mallat, HS Markus

    Metabolomic profiling in small vessel disease identifies multiple associations with disease severity.

    DOI: http://doi.org/10.1093/brain/awac041
    Journal: Brain
    E-pub date: 29 Jul 2022
    Authors: EL Harshfield, CJ Sands, AM Tuladhar, FE de Leeuw, MR Lewis, HS Markus

    Association Between Depressive Symptoms and Incident Cardiovascular Diseases.

    DOI: http://doi.org/10.1001/jama.2020.23068
    Journal: JAMA
    E-pub date: 15 Dec 2020
    Authors: EL Harshfield, L Pennells, JE Schwartz, P Willeit, S Kaptoge, S Bell, JA Shaffer, T Bolton, S Spackman, S Wassertheil-Smoller, F Kee, P Amouyel, SJ Shea, LH Kuller, J Kauhanen, EM van Zutphen, DG Blazer, H Krumholz, PJ Nietert, D Kromhout, G Laughlin, L Berkman, RB Wallace, LA Simons, EM Dennison, ELM Barr, HE Meyer, AM Wood, J Danesh, E Di Angelantonio, KW Davidson, Emerging Risk Factors Collaboration

    Publications

    Optimizing treatment of cardiovascular risk factors in cerebral small vessel disease using genetics.

    DOI: http://doi.org/10.1093/brain/awae399
    Journal: Brain
    E-pub date: 3 Jun 2025
    Authors: F Koohi, EL Harshfield, D Gill, W Ge, S Burgess, HS Markus

    Antithrombotic Treatment for Cervical Artery Dissection: A Systematic Review and Individual Patient Data Meta-Analysis.

    DOI: http://doi.org/10.1001/jamaneurol.2024.1141
    Journal: JAMA Neurol
    E-pub date: 1 Jun 2024
    Authors: JE Kaufmann, EL Harshfield, H Gensicke, S Wegener, P Michel, G Kägi, K Nedeltchev, L Kellert, S Rosenbaum, CH Nolte, H Christensen, M Arnold, P Lyrer, C Levi, PM Bath, ST Engelter, C Traenka, HS Markus, CADISS and TREAT-CAD Investigators

    Does Thrombosis Play a Causal Role in Lacunar Stroke and Cerebral Small Vessel Disease?

    DOI: http://doi.org/10.1161/STROKEAHA.123.044937
    Journal: Stroke
    E-pub date: 1 Apr 2024
    Authors: F Koohi, EL Harshfield, A Shatunov, HS Markus

    Artificial intelligence for dementia-Applied models and digital health.

    DOI: http://doi.org/10.1002/alz.13391
    Journal: Alzheimers Dement
    E-pub date: 1 Dec 2023
    Authors: DM Lyall, A Kormilitzin, C Lancaster, J Sousa, F Petermann-Rocha, C Buckley, EL Harshfield, MH Iveson, CR Madan, R McArdle, D Newby, V Orgeta, E Tang, S Tamburin, LS Thakur, I Lourida, Deep Dementia Phenotyping (DEMON) Network, DJ Llewellyn, JM Ranson

    Artificial intelligence for biomarker discovery in Alzheimer’s disease and dementia.

    DOI: http://doi.org/10.1002/alz.13390
    Journal: Alzheimers Dement
    E-pub date: 1 Dec 2023
    Authors: LM Winchester, EL Harshfield, L Shi, A Badhwar, AA Khleifat, N Clarke, A Dehsarvi, I Lengyel, I Lourida, CR Madan, SJ Marzi, P Proitsi, AP Rajkumar, T Rittman, E Silajdžić, S Tamburin, JM Ranson, DJ Llewellyn

    Artificial intelligence for dementia genetics and omics.

    DOI: http://doi.org/10.1002/alz.13427
    Journal: Alzheimers Dement
    E-pub date: 1 Dec 2023
    Authors: C Bettencourt, N Skene, S Bandres-Ciga, E Anderson, LM Winchester, IF Foote, J Schwartzentruber, JA Botia, M Nalls, A Singleton, BM Schilder, J Humphrey, SJ Marzi, CE Toomey, AA Kleifat, EL Harshfield, V Garfield, C Sandor, S Keat, S Tamburin, CS Frigerio, I Lourida, Deep Dementia Phenotyping (DEMON) Network, JM Ranson, DJ Llewellyn

    Predicting incident dementia in cerebral small vessel disease: comparison of machine learning and traditional statistical models.

    DOI: http://doi.org/10.1016/j.cccb.2023.100179
    Journal: Cereb Circ Cogn Behav
    E-pub date: 1 Aug 2023
    Authors: R Li, EL Harshfield, S Bell, M Burkhart, AM Tuladhar, S Hilal, DJ Tozer, FM Chappell, SDJ Makin, JW Lo, JM Wardlaw, F-E de Leeuw, C Chen, Z Kourtzi, HS Markus

    Contribution of Conventional Cardiovascular Risk Factors to Brain White Matter Hyperintensities.

    DOI: http://doi.org/10.1161/JAHA.123.030676
    Journal: J Am Heart Assoc
    E-pub date: 18 Jul 2023
    Authors: F Koohi, EL Harshfield, HS Markus

    Association of Vascular Risk Factors and Genetic Factors With Penetrance of Variants Causing Monogenic Stroke.

    DOI: http://doi.org/10.1001/jamaneurol.2022.3832
    Journal: JAMA Neurol
    E-pub date: 1 Dec 2022
    Authors: BPH Cho, EL Harshfield, M Al-Thani, DJ Tozer, S Bell, HS Markus

    Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.

    DOI: http://doi.org/10.1186/s12916-021-02087-1
    Journal: BMC Med
    E-pub date: 10 Sep 2021
    Authors: EL Harshfield, EB Fauman, D Stacey, DS Paul, D Ziemek, RMY Ong, J Danesh, AS Butterworth, A Rasheed, T Sattar, Zameer-Ul-Asar, I Saleem, Z Hina, U Ishtiaq, N Qamar, NH Mallick, Z Yaqub, T Saghir, SNH Rizvi, A Memon, M Ishaq, SZ Rasheed, F-U-R Memon, A Jalal, S Abbas, P Frossard, D Saleheen, AM Wood, JL Griffin, A Koulman

    NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia: an analysis of 200 000 participants.

    DOI: http://doi.org/10.1136/jnnp-2020-325838
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2021
    Authors: BPH Cho, S Nannoni, EL Harshfield, D Tozer, S Gräf, S Bell, HS Markus

    Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.

    DOI: http://doi.org/10.1212/WNL.0000000000011555
    Journal: Neurology
    E-pub date: 30 Mar 2021
    Authors: MK Georgakis, EL Harshfield, R Malik, N Franceschini, C Langenberg, NJ Wareham, HS Markus, M Dichgans

    Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.

    DOI: http://doi.org/10.1161/STROKEAHA.120.031710
    Journal: Stroke
    E-pub date: 1 Mar 2021
    Authors: EL Harshfield, MK Georgakis, R Malik, M Dichgans, HS Markus

    The role of haematological traits in risk of ischaemic stroke and its subtypes.

    DOI: http://doi.org/10.1093/brain/awz362
    Journal: Brain
    E-pub date: 1 Jan 2020
    Authors: EL Harshfield, MC Sims, M Traylor, WH Ouwehand, HS Markus

    Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis.

    DOI: http://doi.org/10.1016/S1474-4422(19)30149-8
    Journal: Lancet Neurol
    E-pub date: 1 Jul 2019
    Authors: HS Markus, EL Harshfield, A Compter, W Kuker, LJ Kappelle, A Clifton, HB van der Worp, P Rothwell, A Algra, Vertebral Stenosis Trialists' Collaboration

    An Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors.

    DOI: http://doi.org/10.1021/acs.jproteome.8b00786
    Journal: J Proteome Res
    E-pub date: 7 Jun 2019
    Authors: EL Harshfield, A Koulman, D Ziemek, L Marney, EB Fauman, DS Paul, D Stacey, A Rasheed, J-J Lee, N Shah, S Jabeen, A Imran, S Abbas, Z Hina, N Qamar, NH Mallick, Z Yaqoob, T Saghir, SNH Rizvi, A Memon, SZ Rasheed, F-U-R Memon, IH Qureshi, M Ishaq, P Frossard, J Danesh, D Saleheen, AS Butterworth, AM Wood, JL Griffin

    ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci.

    DOI: http://doi.org/10.1093/nar/gky837
    Journal: Nucleic Acids Res
    E-pub date: 10 Jan 2019
    Authors: D Stacey, EB Fauman, D Ziemek, BB Sun, EL Harshfield, AM Wood, AS Butterworth, K Suhre, DS Paul

    From lipid locus to drug target through human genomics.

    DOI: http://doi.org/10.1093/cvr/cvy120
    Journal: Cardiovasc Res
    E-pub date: 15 Jul 2018
    Authors: SW van der Laan, EL Harshfield, D Hemerich, D Stacey, AM Wood, FW Asselbergs