I use molecular genetic and neuroimaging (MRI and Transcranial Doppler) techniques to investigate the pathogenesis of, and develop treatments for, cerebrovascular disease. A particular interest is in cerebral small vessel disease, a major cause of stroke and the major cause of vascular cognitive impairment; here we are studying genetic determinants (for both monogenic and polygenic disease), the mechanisms of cognitive decline using advanced multimodal MRI, and evaluating new therapeutic approaches. I am involved in a number of international studies of stroke genetics including the WTCCC2 ischaemic stroke study and the International Stroke Genetics Consortium. I run a National clinical referral service for patients with the monogenic from of stroke CADASIL. My research is currently funded by the Wellcome Trust, NIHR, British Heart Foundation, Stroke Association, Alzheimers Research UK and the EU FP7.